• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.2B
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• pp.179-189
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• 2010

This paper presents a numerical investigation of vorticity generation in fully vegetated open-channel flows. The Reynolds stress model is used for the turbulence closure. Open-channel flows with rough bed-smooth sidewalls and smooth bed-rough sidewalls are simulated. The computed vectors show that in channel flows with rough bed and rough sidewalls, the free-surface secondary currents become relatively smaller and larger, respectively, compared with that of plain channel flows. Also, open-channel flows over vegetation are simulated. The computed bottom vortex occupies the entire water depth, while the free-surface vortex is reduced. The contours of turbulent anisotropy and Reynolds stress are presented with different density of vegetation. The budget analysis of vorticity equation is carried out to investigate the generation mechanism of secondary currents. The results of the budget analysis show that in plain open-channel flow, the production by anisotropy is important in the vicinity of the wall and free-surface boundaries, and the production by Reynolds stress is important in the region away from the boundaries. However, this rule is not effective in vegetated channel flows. Also, in plain channel flows, the vorticity is generated mainly in the vicinity of the free-surface and the bottom, while in vegetated channel flows, the regions of the bottom and vegetation height are important to generate the vorticity.

• Journal of Veterinary Science
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• v.24 no.4
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• pp.52.1-52.13
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• 2023

Background: Mesenchymal stem cells (MSCs) have been investigated as therapeutic agents for inflammatory bowel disease (IBD). Stimulation of MSCs with pro-inflammatory cytokines is an approach to enhance their immunomodulatory effects. However, further investigation is required to support their application in immune-mediated disorders and companion animals. Objectives: This study aimed to assess the therapeutic effect of tumor necrosis factor (TNF)-α-stimulated feline adipose tissue-derived MSCs (fAT-MSCs) in a dextran sulfate sodium (DSS)-induced colitis mouse model. Methods: Colitis mice was made by drinking water with 3% DSS and fAT-MSCs were injected intraperitoneally. Colons were collected on day 10. The severity of the disease was evaluated and compared. Raw 264.7 cells were cultured with the conditioned medium to determine the mechanism, using quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay. Results: TNF-α-stimulated fAT-MSCs more improved severity of DSS-induced colitis in disease activity, colon length, histologic score, and inflammatory cytokine. In sectionized colon tissues, the group comprising TNF-α-stimulated fAT-MSCs had higher proportion of CD11b⁺CD206⁺ macrophages than in the other groups. In vitro, TNF-α-stimulation increased cyclooxygenase-2 (COX-2) expression and prostaglandin E₂ (PGE₂) secretion from fAT-MSCs. The conditioned medium from TNF-α-stimulated fAT-MSCs enhanced the expression of interleukin-10 and arginase-1 in LPS-activated Raw 264.7 cells. Conclusions: These results represent that TNF-α-stimulated fat-mscs ameliorate the inflamed colon more effectively. Furthermore, we demonstrated that the effectiveness was interlinked with the COX-2/PGE₂ pathway.

• Korean Journal of Social Welfare Studies
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• v.41 no.3
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• pp.443-475
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• 2010

Despite the rapidly increased concern on the circularity of the program development activities in the social service agencies, there are only a few studies about the phenomena. This study is to describe the characteristics of program development in the process of adopting, developing, and disseminating the social programs and to figure out the factors influencing differences in the 3 activities in social service agencies. The researchers constructed an explanative model including each 12-13 independent variables with 3 consecutive dependent variables on the basis of reviewing the related literatures. A multiple regression analysis was applied to predict the features of the program development using 195 questionaries responded from social workers in community service centers. As the result of the descriptive analysis, the two noticeable features are found; (1) the agencies have very actively adopted outside programs, developed appropriate programs for the agency, and disseminated the programs into other agencies in the community. (2) there are some positive aspects of the factors in related to the process of the program development. The results of the regression analysis show that the three dependent variables of the adoption, development, and dissemination are very closely interconnected with each others, showing the evidence of the circularity in the agencies. In addition, the 5 independent variables at the value of p .01 are statistically related with the circularity of the three dependent activities. The implication of major findings were discussed in academic and practical perspectives in Korea, including future research works in the area.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.2
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• pp.58.1-59
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• 2021

Exploration of asteroids' internal structure is essential for understanding their evolutional history. It also provides a fundamental information about the history of coalescence and collision of the solar system. Among several models of the internal structures, the rubble-pile model, confirmed by the near-Earth asteroid (25143) Itokawa by Hayabusa mission [1], is now widely regarded as the most common to asteroids with size ranging from 200 m to 10 km [2]. On the contrary, monolithic and core-mantle structures are also possible for small asteroids [3]. It is, however, still challenging to look through the interior of a target object using remote-sensing devices. In this presentation, we introduce our ongoing research conducted at Seoul National and propose an idea to infer the internal structure of Apophis using available instruments. Itokawa's research provides an important benchmark for Apophis exploration because both asteroids have similar size and composition [4][5]. We have conducted research on Itokawa's evolution in terms of collision and space weathering. Space weathering is the surface alteration process caused by solar wind implantation and micrometeorite bombardment [6]. Meanwhile, resurfacing via a collision acts as a counter-process of space weathering by exposing fresh materials under the matured layer and lower the overall degree of space weathering. Therefore, the balance of these two processes determine the space weathering degrees of the asteroid. We focus on the impact evidence on the boulder surface and found that space weathering progresses in only 100-10,000 years and modifies the surface optical properties (Jin & Ishiguro, KAS 2020 Fall Meeting). It is important to note that the timescale is significantly shorter than the Itokawa's age, suggesting that the asteroid can be totally processed by space weathering. Accordingly, our result triggers a further discussion about why Itokawa indicates a moderately fresh spectrum (Sq-type denotes less matured than S-type). For example, Itokawa's smooth terrains show a weaker degree of space weathering than other S-type asteroids [7]. We conjecture that the global seismic shaking caused by collisions with >1 mm-sized interplanetary dust particles induces granular convection, which hinders the progression of space weathering [8]. Note that the efficiency of seismic wave propagation is strongly dependent on the internal structure of the asteroid. Finally, we consider possible approaches to investigate Apophis's internal structure. The first idea is studying the space weathering age, as conducted for Itokawa. If Apophis indicates a younger age, the internal structure would have more voids [9]. In addition, the 2029 close encounter with Earth provides a rare natural opportunity to witness the contrast between before and after the event. If the asteroid exhibits a slight change in shape and space weathering degree, one can determine the physical structure of the internal materials (e.g., rubble-pile monolithic, thick or thin regolith layer, the cohesion of the materials). We will also consider a possible science using a seismometer.

• The Journal of the Acoustical Society of Korea
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• v.42 no.6
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• pp.519-528
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• 2023

The aim of this study was to enhance the flow rate and noise performance of a centrifugal pump in dishwashers by designing an optimized impeller shape through numerical and experimental investigations. To evaluate the performance of the target centrifugal pump, experiment was conducted using a pump performance tester and noise experiment was carried out in a semi-anechoic chamber with microphones and a reflecting wall behind the dishwasher. Through the use of advanced computational fluid dynamics techniques, numerical simulations were performed to analyze the flow and aeroacoustics performance of our target centrifugal pump impeller. To achieve this, numerical simulations were carried out using the Reynolds-Average Navier-Stokes equations and Ffowcs-Willliams and Hawkings equations as governing equations. In order to ensure the validity of numerical methods, a thorough comparison of numerical results with experimental results. After having confirmed the reliability of the current numerical method of this study, the optimization of the target centrifugal pump impeller was conducted. An improvement in flow rate was confirmed numerically, and a manufactured proto-type of the optimized model was used for experimental investigation. Furthermore, it was observed that by applying the fan law, we could effectively reduce noise levels without reducing the flow rate.

• Journal of the Korea institute for structural maintenance and inspection
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• v.27 no.6
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• pp.102-110
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• 2023

PSC-I girder bridges constitute the largest proportion among highway bridges in Korea. According to the precision safety diagnosis data for the past 10 years, approximately 41.3% of the PSC-I bridges have been graded as C. Furthermore, with the increase in the aging of bridges, preemptive management is becoming more important. Damage and deterioration to the deck and girder with a long replacement cylce can have considerable impacts on the service and deterioration of a bridge. In addition, the high rate of device damages, including expansion joints and bearings, necessitates an investigation into the influence of the device damage in the structural members of the bridge. Therefore, this study defined representative PSC-I girder bridges with single and multiple spans to evaluate heterogeneous damages that incorporate the damage of the bridge member and device with the deterioration of the deck. The heterogeneous damages increased a crack area ratio compared to the individual single damage. For the single-span bridge, the occurrence of bearing damage leads to the spread of crack distribution in the girder, and in the case of multi-span bridges, expansion joint damage leads to the spread of crack distribution in the deck. The research underscores that bridge devices, when damaged, can cause subsequent secondary damage due to improper repair and replacement, which emphasizes the need for continuous observation and responsive action to the damages of the main devices.

• Journal of Korean Elementary Science Education
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• v.43 no.1
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• pp.108-121
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• 2024

In this study, we developed a sustainability education program employing a project-based learning strategy for prospective teachers and investigated its effectiveness. A total of 23 senior students from a university of education participated in the study. The investigation involved a pretest on their pro-environmental behavior and attitudes, followed by a five-week implementation of the program, during which students individually engaged in energy-saving projects. Following the program, a post-test, which used the same questionnaire as the pretest, was administered. In addition, we conducted individual interviews with nine students who actively engaged in the projects. We analyzed the interview contents, portfolios, and reports; identified sub-concepts related to the program's effectiveness and its causes; and then organized them into subcategories. Then, we extracted recurring relationships among the subcategories to formulate a tentative explanatory model. The results indicate that the program positively impacted students' pro-environmental behavior and values/attitudes. Notably, the students' "sense of achievement gained through success" emerged as a significant factor influencing their pro-environmental behavior. Furthermore, some causes were found to indirectly affect pro-environmental behavior through pro-environmental values and attitudes.

• Journal of The Korean Association For Science Education
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• v.26 no.2
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• pp.167-176
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• 2006

The purpose of this study was to explore the effects of a visual-analogical learning model based on theoretical research on visual thinking and analogical learning. To examine the effect of visual-analogical learning, both an experimental group and a control group were selected from 6th graders at H elementary school in Yeonsugu, Incheon and tested on creativity and science achievement Results of this study showed as that visual-analogical learning produced statistically significant differences for changes in student creativity, For the individual components of creativity; openness, fluency, and originality, results showed greater increases for the experimental group, whereas flexibility showed only statistically significant differences. In regards to science achievement, the experimental group showed a bigger increase than the control group, but these findings were statistically nonsignificant For changes to creativity in the group divided according to creativity score, this instructional method was more effective in the middle and lower group than the higher group, An investigation of attitude, revealed a positive student reaction students felt these science classes to be more interesting than previous science classes. Moreover, students wanted to create new innovative product themselves.

• Food Science and Preservation
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• v.30 no.4
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• pp.716-728
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• 2023

The anti-adipogenic activity of Glycyrrhiza uralensis was investigated by examining the effects of its ethanol extract (GUE) on a mouse model with a high-fat diet (HFD) and 3T3-L1 preadipocytes during adipocyte differentiation. GUE administration for eight weeks significantly reduced weight gain in mice fed an HFD. GUE effectively inhibited 3T3-L1 preadipocyte differentiation and lipid droplet accumulation. This inhibitory effect is associated with the downregulation of key adipogenic regulators, including PPARγ and C/EBPα, and the modulation of adipose metabolism regulators, such as Fasn and Fabp4. LC-Q-TOF-MS analysis identified twelve phenolic and flavonoid compounds, including liquiritigenin and licorice saponin, in the GUE. These findings demonstrate that the anti-obesity effect of the GUE is attributed to the biological activity of its phenolic and flavonoid compounds. Therefore, the GUE has potential anti-obesity activity. Moreover, further studies on the isolation of bioactive components from the GUE and the investigation of the underlying molecular mechanisms of the GUE are required to establish its efficacy in metabolic disorders, including obesity.

• Structural Engineering and Mechanics
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• v.90 no.6
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• pp.611-633
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• 2024

This study intends to investigate the response of multi-cell (MC) beams to flexural loads in which the primary reinforcement is composed of both metallic and non-metallic materials. "Multi-cell" describes beam sections with multiple longitudinal voids separated by thin webs. Seven reinforced concrete MC beams measuring 300×200×1800 mm were tested under flexural loadings until failure. Two series of beams are formed, depending on the type of main reinforcement that is being used. A control RC beam with no openings and six MC beams are found in these two series. Series one and two are reinforced with metallic and non-metallic main reinforcement, respectively, in order to maintain a constant reinforcement ratio. The first crack, ultimate load, deflection, ductility index, energy absorption, strain characteristics, crack pattern, and failure mode were among the structural parameters of the beams under investigation that were documented. The primary variables that vary are the kind of reinforcing materials that are utilized, as well as the kind and quantity of mesh layers. The outcomes of this study that looked at the experimental and numerical performance of ferrocement reinforced concrete MC beams are presented in this article. Nonlinear finite element analysis (NLFEA) was performed with ANSYS-16.0 software to demonstrate the behavior of composite MC beams with holes. A parametric study is also carried out to investigate the factors, such as opening size, that can most strongly affect the mechanical behavior of the suggested model. The experimental and numerical results obtained demonstrate that the FE simulations generated an acceptable degree of experimental value estimation. It's also important to demonstrate that, when compared to the control beam, the MC beam reinforced with geogrid mesh (MCGB) decreases its strength capacity by a maximum of 73.33%. In contrast, the minimum strength reduction value of 16.71% is observed in the MC beams reinforced with carbon reinforcing bars (MCCR). The findings of the experiments on MC beams with openings demonstrate that the presence of openings has a significant impact on the behavior of the beams, as there is a decrease in both the ultimate load and maximum deflection.