• 유기물자원화
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• 제18권4호
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• pp.45-53
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• 2010

여러 가지 방법으로 전처리된 느타리 버섯 폐배지에 대한 줄지렁이 개체군의 섭식률 및 생장률을 조사하였다. 갓 발생한 버섯폐배지의 부숙기간을 달리하여 지렁이에게 급이하였을 경우, 20일 이상 부숙된 버섯 폐배지보다 10일 이하로 부숙된 버섯 폐배지에 대한 지렁이 개체군의 섭식량 및 생장률이 높았다. 분변토를 첨가한 버섯폐배지나 질소영양원으로서 요소비료를 첨가하여 부숙한 버섯폐배지는 지렁이 개체군의 섭식률과 생장률을 증대시키지 못하는 것으로 나타났다. 그러나 버섯폐배지를 분쇄하여 공급하였을 경우에는 섭식량 및 생장률이 증가하였다. 특히 분쇄된 버섯폐배지에 미강을 첨가하였을 경우에는 분쇄하지 않은 단순 버섯폐배지보다 생장률이 1.85배 증가하였다.

• Ocean and Polar Research
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• 제30권3호
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• pp.261-275
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• 2008

The profile of a fixed site at station M ($34.77^{\circ}N,\;129.13^{\circ}E$) in the Korea Strait was studied from March 2006 to February 2007. The aim was to understand the relationship between the annual thermal stratification pattern and seasonal variation in phytoplankton community structure. Physicochemical factors including temperature, salinity and nutrient concentrations, which strongly influence the proliferation and diversity of phytoplankton, were measured. The study period was divided into three due to the characteristic of thermohaline structures; mixed I (March-May 2006), stratified (June-November 2006) and mixed II(December 2006-Feburuary 2007). Diatoms dominated during the mixed I (89%) and II (48%) periods, while nanoplankton group occupied over 83% of total population during the stratified period. The dominant species during the mixed I and II was Chaetoceros socialis (47% and 29%, respectively), while during the stratified period Gyrodinium sp.(4%) was the most dominant. Averaged total chl a concentrations during the mixed I and II periods were 0.61 mg $m^{-3}$ and 0.72 mg $m^{-3}$, respectively, which were at least two-fold higher than that during the stratified period (0.30 mg $m^{-3}$). The vertical mixing and convection process of the water column induced nutrient supply from the bottom layer to the euphotic zone. It also led to the dominance of diatoms during the mixed periods, whereas small phytoplankton prevailed over large phytoplankton as stratification blocked the upward movement of nutrients to subsurface during the stratified period. During the mixed I and II periods, microplanktonic chl a dominated concentrations (50% and 48%, respectively), while picoplanktonic chl a occupied over 37% of total chl a during the stratified period.

• 국제초고층학회논문집
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• 제9권2호
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• pp.197-212
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• 2020

In this study, POE(Post Occupancy Evaluation) evaluation indexes were selected into six categories through the consideration of theories and prior research. Therefore, qualitative supply can be achieved through POE according to the aspect of residential environment after the quantitative supply of mixed-use apartment complex by the population concentration in Seoul due to industrialization and urbanization. As the evaluation elements, detailed survey contents were selected for livability, convenience, comfort, safety, economy, and sociality. Based on the survey contents, six elements were evaluated and analyzed using Data coding and Likert scale after surveying 12 complexes (Urban areas and non-urban areas) in Seoul. As a result of the study, six categories selected as the POE showed that importance of quality of life and safety was developed in high recognition according to high satisfaction with convenience and safety. Sociality showed the lowest satisfaction in the following order : livability, comfort, economy and sociality. Residents' sense of community, interaction with neighborhood, etc., showed low satisfaction, and it seems that it is necessary to improve and supplement the system for the development of mixed-use apartment complex in the future. The detailed characteristics of livability showed high satisfaction of the living room, the front door and the main room which are main uses of housing, and low satisfaction in storage size. The analysis of convenience is that convenient public transportation was the highest, and educational environment and additional facilities were the lowest, showing the advantages and disadvantages of location characteristics. As a result of the analysis of comfort, satisfaction with the landscape area was low and it seems that green space is needed for the development of mixed-use apartment complex in the future. Lastly, regarding the safety, the satisfaction of the access control, the location of security office, etc. were high, however separation of circulation was low. Therefore, it is necessary to clearly separate the circulation between the residence and other facilities in the mixed-use apartment complex.

• 한국임상약학회지
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• 제28권1호
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• pp.24-29
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• 2018

Background: Cyclosporine is an immunosuppressive agent used to treat and prevent graft versus host reaction (GVHR)-a complication associated with stem cell transplantation. This study aimed to develop a population pharmacokinetic model of cyclosporine and investigate factors affecting cyclosporine clearance in pediatric hematopoietic stem cell transplant patients. Methods: A total of 650 cyclosporine concentrations recorded in 65 patients who underwent hematopoietic stem cell transplantation were used. Data including age, sex, weight, height, body surface area (BSA), type of disease, chemotherapy before stem cell transplantation, type of donor, serum creatinine levels, total bilirubin concentration, hematocrit value, and type of concomitant anti-fungal agents and methylprednisolone used were retrospectively collected. Data related to cyclosporine dosage, administration time, and blood concentration were also collected. All data were analyzed using the non-linear mixed effect model; a two-compartment model with first-order elimination was used. Results: The population pharmacokinetic model of cyclosporine using the NONMEM program was as follows: $CL(L/h)=5.9{\times}(BSA/1.2)^{0.9}$, V2 (L) = 54.5, Q (L/h) = 3.5, V3 (L) = 1080.0, $k_a(h^{-1})=0.000377$. BSA was selected as a covariate of cyclosporine clearance, which increased with an increase in BSA. Conclusion: A population pharmacokinetic model for Korean pediatric hematopoietic stem cell transplant patients was developed, and the important factor affecting cyclosporine clearance was found to be BSA. The model might contribute to the development of the most appropriate dosing regimen for cyclosporine. Further studies on population pharmacokinetics should be carried out, prospectively targeting pediatric patients.

• 응용통계연구
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• 제31권1호
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• pp.123-137
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• 2018

비선형 혼합효과 모형은 다양한 분야에서 반복 측정 자료를 분석할 때 주로 사용된다. 비선형 혼합효과 모형은 개체 내 변동(intra-individual variation)에 대해 고려하는 제 1단계 개별수준모델(individual-level model)과 개체간 변동(inter-individual variation)에 대해 고려하는 제 2단계 개체군모델(population model)의 두 단계로 구성되어 있다. 비선형 혼합효과 모형의 첫 번째 단계인 개별수준모델은 비선형 회귀모형의 모수를 추정하는 것으로 일반적인 비선형 회귀모형과 같고, 주로 보통최소제곱추정 방법을 사용하여 모수를 추정한다. 그러나 최소제곱추정방법은 가정된 비선형 함수가 자료에 의해 명시적으로 드러나지 않는 경우 모수의 추정값과 그 표준오차가 극단적으로 커지는 문제가 발생할 수 있다. 본 논문에서는 최근에 비선형 회귀모형에서 제안된 능형회귀(ridge regression) 방법을 비선형 혼합효과 모형의 제 1단계 개별수준모델에 도입함으로써 이러한 문제를 해결할 수 있는 새로운 추정방법을 제안하였다. 제안된 추정량은 모의실험 연구를 통하여 기존의 표준적인 추정량과 그 성능을 비교하였다. 또한 미국의 National Toxicology Program으로부터 얻어진 정량적 대량고속 스크리닝(quantitative high throughput screening) 실제 자료를 사용하여 추정 방법들을 비교하였다.

• 한국주거학회:학술대회논문집
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• 한국주거학회 2009년도 추계학술발표대회 논문집
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• pp.77-81
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• 2009

The elderly population ratio of domestic is the actual condition where the countermeasure which is various for there is a possibility of saying that is already experiencing the aging society, is considered. The expansion of the elderly welfare facility of the area where is located among the rest in the situation as a matter of metropolitan area of domestic ephemerality and the price of land which the earth has, duplication operation etc. is having a problem point and the ephemerality which are various. About of composition different facility and leads with alternative and expansion and function of function and facility leads and the synergy effect which is various shows. So this study is consequently does the school facility which is located in life circle of the city center in middle of composition of the elderly welfare facility and other facility and in the object and under proposing boil the complex at the time of spatial composition blueprint with the elderly welfare facility and the school.

• 한국시스템다이내믹스연구
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• 제11권2호
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• pp.5-28
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• 2010

The purpose of this paper is to review relationship between spatial characteristics of compact city and urban sustainabiliy from system dynamics perspective using causal loop analysis. It has been argued that spatial characteristics of compact city, high population density and mixed land use, are positively related to urban sustainability. However, research results that are not consistent with pros of compact city argument have been accumulated too. It is especially true when spatial characteristics of compact city are examined with regard to each dimension of sustainablility: economic, social, and environmental sustainability. Reviewing each dimension of sustainability with regard to spatial characteristics based on causal loop analysis, this paper provides more clear understanding on relationship between compact city and sustainability. Also this paper provides a base for system dynamics simulation for future study.

• 대한산업공학회지
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• 제25권3호
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• pp.310-320
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• 1999

A mixed model assembly line (MMAL) is a special type of production line where a variety of product models similar in product characteristics are assembled. Determining the model sequence is an important problem for the efficient use of MMALs. This paper considers interactive multiobjective decision making problems for MMAL sequencing. Evolution program is employed as an underlying framework. In this study, a way of approximating the linear utility function is first studied. To improve its search efficiency to the solution space preferred by a decision maker, some modifications of a standard evolution program are made: operating several subpopulations instead of a single population and merging two or more subpopulations to a single subpopulation, and using a Pareto pool. Extensive computational experiments are carried out to verify the performance of the proposed approach. The computational results show that our approach is promising in solution quality.

• Journal of Microbiology and Biotechnology
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• 제23권8호
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• pp.1140-1146
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• 2013

Bioelectrochemical systems (BESs) have been suggested as a new technology for wastewater treatment while accomplishing energy and chemical generation. This study describes the performance of BESs based on mixed culture that are capable of reducing carbon dioxide to acetate. The cathode potential was a critical factor that affected the performance of the BESs. The rate of acetate production increased as the electrode potential became more negative, from 0.38 mM $d^{-1}$ (-900 mV vs. Ag/AgCl) to 2.35 mM $d^{-1}$ (-1,100 mV), while the electron recovery efficiency of carbon dioxide reduction to acetate increased from 53.6% to 89.5%. The microbial population was dominated by relatives of Acetobacterium woodii when a methanogenic inhibitor was added to the BESs initially.

• International Journal of Human Ecology
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• 제9권1호
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• pp.41-51
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• 2008

A rapidly aging Korean population highlights the importance of investigating the actual state and needs of clothing for the elderly to provide basic information for a future senior industry. This paper surveyed clothing purchasing behaviors. The sample of this survey consisted of 210 females aged 55 over who live in Dajeoun and Nonsan. The data were analyzed by using SPSS. The major findings are as follows. First, most elderly women have bought the ready-made clothes in local markets. Second, the major consideration of clothing purchasing behavior was the possibility of outdoor wearing and color. They were satisfied with ready-made clothes because of the convenience to buy, design, and the necessity of the clothing brands for aged people. Third, they preferred pure cotton or mixed cotton even though they possessed the mixed cotton or synthetic fiber in clothing materials. Respondents preferred the feeling, heat-retaining property, and absorptiveness in textiles. The result indicates the demand for various material applications of functional textiles for elderly women.