• Title/Summary/Keyword: mitigate

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Animal Models of Cognitive Deficits for Probiotic Treatment

  • Kwon, Oh Yun;Lee, Seung Ho
    • Food Science of Animal Resources
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    • v.42 no.6
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    • pp.981-995
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    • 2022
  • Cognitive dysfunction is a common symptom of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, and is known to be caused by the structural and functional loss of neurons. Many natural agents that can improve cognitive function have been developed and assessed for efficacy using various cognitive deficit animal models. As the gut environment is known to be closely connected to brain function, probiotics are attracting attention as an effective treatment target that can prevent and mitigate cognitive deficits as a result of neurodegenerative diseases. Thus, the objective of this review is to provide useful information about the types and characteristics of cognitive deficit animal models, which can be used to evaluate the anti-cognitive effects of probiotics. In addition, this work reviewed recent studies describing the effects and treatment conditions of probiotics on cognitive deficit animal models. Collectively, this review shows the potential of probiotics as edible natural agents that can mitigate cognitive impairment. It also provides useful information for the design of probiotic treatments for cognitive deficit patients in future clinical studies.

System-on-chip single event effect hardening design and validation using proton irradiation

  • Weitao Yang;Yang Li;Gang Guo;Chaohui He;Longsheng Wu
    • Nuclear Engineering and Technology
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    • v.55 no.3
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    • pp.1015-1020
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    • 2023
  • A multi-layer design is applied to mitigate single event effect (SEE) in a 28 nm System-on-Chip (SoC). It depends on asymmetric multiprocessing (AMP), redundancy and system watchdog. Irradiation tests utilized 70 and 90 MeV proton beams to examine its performance through comparative analysis. Via examining SEEs in on-chip memory (OCM), compared with the trial without applying the multi-layer design, the test results demonstrate that the adopted multi-layer design can effectively mitigate SEEs in the SoC.

Applications and Challenges of Lithium-Sulfur Electrochemical Batteries

  • Mohammed Jasim M. Al Essa
    • Journal of Electrochemical Science and Technology
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    • v.15 no.1
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    • pp.1-13
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    • 2024
  • This paper presents applications of lithium-sulfur (Li-S) energy storage batteries, while showing merits and demerits of several techniques to mitigate their electrochemical challenges. Unmanned aerial vehicles, electric cars, and grid-scale energy storage systems represent main applications of Li-S batteries due to their low cost, high specific capacity, and light weight. However, polysulfide shuttle effects, low conductivities, and low coulombic efficiencies signify key challenges of Li-S batteries, causing high volumetric changes, dendritic growths, and limited cycling performances. Solid-state electrolytes, interfacial interlayers, and electrocatalysts denote promising methods to mitigate such challenges. Moreover, nanomaterials have capability to improve kinetic reactions of Li-S batteries based on several properties of nanoparticles to immobilize sulfur in cathodes, stabilizing lithium in anodes while controlling volumetric growths. Li-S energy storage technologies are able to satisfy requirements of future markets for advanced rechargeable batteries with high-power densities and low costs, considering environmentally friendly systems based on renewable energy sources.

Self-control of high rise building L-shape in plan considering soil structure interaction

  • Farghaly, A.A.
    • Coupled systems mechanics
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    • v.6 no.3
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    • pp.229-249
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    • 2017
  • A new technique to mitigate irregular buildings with soil structure interaction (SSI) effect subjected to critical seismic waves is presented. The L-shape in plan irregular building for various reasons was selected, subjected to seismic a load which is a big problem for structural design especially without separation gap. The L-shape in plan building with different dimensions was chosen to study, with different rectangularity ratios and various soil kinds, to show the effect of the irregular building on the seismic response. A 3D building subjected to critical earthquake was analyzed by structural analysis program (SAP2000) fixed and with SSI (three types of soils were analyzed, soft, medium and hard soils) to find their effect on top displacement, base shear, and base torsion. The straining actions were appointed and the treatment of the effect of irregular shape under critical earthquake was made by using tuned mass damper (TMD) with different configurations with SSI and without. The study improve the success of using TMDs to mitigate the effect of critical earthquake on irregular building for both cases of study as fixed base and raft foundation (SSI) with different TMDs parameters and configurations. Torsion occurs when the L-shape in plan building subjected to earthquake which may be caused harmful damage. TMDs parameters which give the most effective efficiency in the earthquake duration must be defined, that will mitigate these effects. The parameters of TMDs were studied with structure for different rectangularity ratios and soil types, with different TMD configurations. Nonlinear time history analysis is carried out by SAP2000 with El Centro earthquake wave. The numerical results of the parametric study help in understanding the seismic behavior of L-shape in plan building with TMDs mitigation system.

Comparison of Home Automation System Using IPV-4 and IPV-6 Based On Mitigate Reconnaissance Attacks

  • Ali, Muhammad Shujat;Siddiq, Imran;Faisal, Abdullah;Awan, Muhammad Zubair
    • International Journal of Computer Science & Network Security
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    • v.22 no.2
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    • pp.341-347
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    • 2022
  • This research is designed to help and offer hold up to complete the requirements of aged and disable in a home. The control approach and the tone approach are used to manage the house appliances. The major organize system implementation in technology of wireless to offer distant contact from a phone Internet Protocol connectivity for access and calculating strategy and appliance remotely. The planned system no need a committed server PC with value of parallel systems and offers a new communication-protocol to observe and control a house environment with more than just the switch functionality. To express the possibility and efficiency of this system, devices like as lights switches, power plugs, and motion-sensors have been included with the planned home control system and supply more security manage on the control with low electrical energy activate method. The rank of switches is corresponding in all this control system whereby all user interfaces indicate the real time existing status. This system planned to manage electrical-appliances and devices in house with reasonably low cost of design, user friendly interface, easily install and provide high security. Research community generally specified that the network "Reconnaissance Attacks" in IPv6 are usually impossible due to they will take huge challenge to carry out address scanning of 264 hosts in an IPv6 subnet."It being deployed of IPv6 shows that it definitely enhances security and undermines the probability". This research of the IPv6 addressing-strategies at present utilizes and planned a new strategy and move toward to "mitigate reconnaissance attacks".

Some Prophylactic Options to Mitigate Methane Emi ssion from Animal Agriculture in Japan

  • Takahashi, Junichi
    • Asian-Australasian Journal of Animal Sciences
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    • v.24 no.2
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    • pp.285-294
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    • 2011
  • The abatement of methane emission from ruminants is an important global issue due to its contribution to greenhouse gas with carbon dioxide. Methane is generated in the rumen by methanogens (archaea) that utilize metabolic hydrogen ($H_2$) to reduce carbon dioxide, and is a significant electron sink in the rumen ecosystem. Therefore, the competition for hydrogen used for methanogenesis with alternative reductions of rumen microbes should be an effective option to reduce rumen methanogenesis. Some methanogens parasitically survive on the surface of ciliate protozoa, so that defaunation or decrease in protozoa number might contribute to abate methanogenesis. The most important issue for mitigation of rumen methanogenesis with manipulators is to secure safety for animals and their products and the environment. In this respect, prophylactic effects of probiotics, prebiotics and miscellaneous compounds to mitigate rumen methanogenesis have been developed instead of antibiotics, ionophores such as monensin, and lasalocid in Japan. Nitrate suppresses rumen methanogenesis by its reducing reaction in the rumen. However, excess intake of nitrate causes intoxication due to nitrite accumulation, which induces methemoglobinemia. The nitrite accumulation is attributed to a relatively higher rate of nitrate reduction to nitrite than nitrite to ammonia via nitroxyl and hydroxylamine. The in vitro and in vivo trials have been conducted to clarify the prophylactic effects of L-cysteine, some strains of lactic acid bacteria and yeast and/or ${\beta}$1-4 galactooligosaccharide on nitrate-nitrite intoxication and methanogenesis. The administration of nitrate with ${\beta}$1-4 galacto-oligosaccharide, Candida kefyr, and Lactococcus lactis subsp. lactis were suggested to possibly control rumen methanogenesis and prevent nitrite formation in the rumen. For prebiotics, nisin which is a bacteriocin produced by Lactococcus lactis subsp. lactis has been demonstrated to abate rumen methanogenesis in the same manner as monensin. A protein resistant anti-microbe (PRA) has been isolated from Lactobacillus plantarum as a manipulator to mitigate rumen methanogenesis. Recently, hydrogen peroxide was identified as a part of the manipulating effect of PRA on rumen methanogenesis. The suppressing effects of secondary metabolites from plants such as saponin and tannin on rumen methanogenesis have been examined. Especially, yucca schidigera extract, sarsaponin (steroidal glycosides), can suppress rumen methanogenesis thereby improving protein utilization efficiency. The cashew nutshell liquid (CNSL), or cashew shell oil, which is a natural resin found in the honeycomb structure of the cashew nutshell has been found to mitigate rumen methanogenesis. In an attempt to seek manipulators in the section on methane belching from ruminants, the arrangement of an inventory of mitigation technologies available for the Clean Development Mechanism (CDM) and Joint Implementation (JI) in the Kyoto mechanism has been advancing to target ruminant livestock in Asian and Pacific regions.

A Study on the Buyer's Duty to Mitigate Seller's Damages in CISG (CISG상의 매수인의 손해경감의무에 관한 고찰)

  • HA, Kang-Hun
    • THE INTERNATIONAL COMMERCE & LAW REVIEW
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    • v.66
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    • pp.1-23
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    • 2015
  • A party who relies on a breach of contract must take such measures as are reasonable in the circumstances to mitigate the loss, including loss of profit, resulting from the breach. Appropriate measures are those aimed at lessing the loss as far as reasonably possible. Such measures will typically be a resale of the goods by the seller or a cover purchase by the buyer. The measures the injured party is expected to take in order to mitigate the loss must be reasonable in the circumstances. Article 77 will be applied to the difference between the amount by which the loss should have been mitigated under Article 77. A reduction of damages is the only remedy available to the party in breach in cases covered by Article 77. If the buyer has received the goods and intends to exercise any right under the contract or this Convention to reject them, he must take such steps to preserve them as are reasonable in the circumstances. If goods dispatched to the buyer have been placed at his disposal at their destination and he exercises the right to reject them, he must take possession of them on behalf of the seller. Article 86(1) requires that the buyer manifest his intention at the moment of receipt of the goods. Article 86(2) envisages that the goods have been dispatched to the buyer and that they have been placed at his disposal at their destination. Article 87 allows him to deposit them in the warehouse of a third person. It is not necessary that the warehouse by public, or that it be a general warehouse for storage. A party who is bound to preserve the goods in accordance with articles 86 may sell them by any appropriate means taking possession of the goods or in taking them back or in paying the price or the cost of preservation. If the goods are subject to rapid deterioration or their preservation world involve unreasonable expense, a party who is bound to preserve the goods must take reasonable measures to sell them. A difference exists between paragraph Article 88 (1) which grants the right to sell, and paragraph (2 )which imposes the duty to take reasonable measures to sell the goods. According to Article 88(2), the party who wishes to sell must give notice to the other party of such intention, to the extent possible.

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Planting Design Strategies and Green Space Planning to Mitigate Respirable Particulate Matters - Case Studies in Beijing, China - (미세먼지 저감을 위한 식재기법 및 도시 녹지계획 방향 - 중국 베이징시 사례를 중심으로 -)

  • Xu, Xi-ran;Kim, Jin-Oh
    • Journal of the Korean Institute of Landscape Architecture
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    • v.45 no.6
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    • pp.40-49
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    • 2017
  • The purpose of the research is to analyze the recent cases of green space planning and planting design in Beijing, one of the cities having the worst particulate matters (PM) pollution. This study comprehensively reviewed Chinese academic literature addressing green space planning to reduce PM pollution. In addition, we conducted field observations and interviews with public officials from Beijing Municipal Bureau of Landscape Design in charge of planning and management of green spaces in Beijing. After the extensive review of literature we derived tree planting principles to mitigate the impact of PM from urban road system, residential area, and industrial district. Using the principles we evaluated the three recent cases of planting design to mitigate PM: Beijing Fuxing Road, Fu Run Residential Area and Beijing Beiqi Multipurpose Vehicle Factory. We conclude that green space planning and trees planting are not effective in mitigating negative impact of PM pollution because of inadequate selection of trees and inconsiderate planting composition. We proposed to replace the tree species with the ones capable of reducing the spread of PM, and reorganize planting compositions that consider the directions and characteristics of urban wind flow. This study suggests desirable types of tree species and planting compositions for road, residential and industrial districts, and we expect that it provides helpful guidelines for making planting design and species selection to mitigate the impact of PM in urban landscape.