• 대한수학회논문집
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• 제36권4호
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• pp.835-840
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• 2021

In this paper, we compute the rational evaluation subgroup of the Hopf fibration S²ⁿ⁺¹ ↪ ℂP(n). We show that, for the Sullivan model 𝜙 : A → B, where A and B are the minimal Sullivan models of ℂP(n) and S²ⁿ⁺¹ respectively, the evaluation subgroup G_n(A, B; 𝜙) and the relative evaluation subgroup G^rel_n (A, B; 𝜙) of 𝜙 are generated by single elements.

• 대한수학회지
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• 제50권3호
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• pp.579-589
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• 2013

A finite group G is called an NSN-group if every proper subgroup of G is either normal in G or self-normalizing. In this paper, the non-NSN-groups whose proper subgroups are all NSN-groups are determined.

• 대한수학회보
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• 제43권4호
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• pp.805-812
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• 2006

In this paper we find a suitable bound for the number of commutators which is required to express every element of the derived group of a solvable group satisfying the maximal condition for normal subgroups. The precise formulas for expressing every element of the derived group to the minimal number of commutators are given.

• The Korean journal of internal medicine
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• 제39권1호
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• pp.34-56
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• 2024

Acute lymphoblastic leukemia (ALL) is one of the most rapidly changing hematological malignancies with advanced understanding of the genetic landscape, detection methods of minimal residual disease (MRD), and the development of immunotherapeutic agents with good clinical outcomes. The annual incidence of adult ALL in Korea is 300-350 patients per year. The WHO classification of ALL was revised in 2022 to reflect the molecular cytogenetic features and suggest new adverse-risk subgroups, such as Ph-like ALL and ETP-ALL. We continue to use traditional adverse-risk features and cytogenetics, with MRD-directed post-remission therapy including allogeneic hematopoietic cell transplantation. However, with the introduction of novel agents, such as ponatinib, blinatumomab, and inotuzumab ozogamicin incorporated into frontline therapy, good MRD responses have been achieved, and overall survival outcomes are improving. Accordingly, some clinical trials have suggested a possible era of chemotherapy-free or transplantation-free approaches in the near future. Nevertheless, relapse of refractory ALL still occurs, and some poor ALL subtypes, such as Ph-like ALL and ETP-ALL, are unsolved problems for which novel agents and treatment strategies are needed. In this review, we summarize the currently applied diagnostic and therapeutic practices in the era of advanced genetic analysis and targeted immunotherapies in United States and Europe and introduce real-world Korean data.

• 대한기관윤리심의기구협의회지
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• 제1권1호
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• pp.5-21
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• 2019

Purpose: Institutional review board (IRB) classifies risks of clinical trials into less than minimal risk, minor increase over minimal risk, and more than minimal risk. Based on classification and evaluation for risk, IRB decides whether permitting consent exemption or asking additional protection for clinical research subject or not. The purpose of this study is to analyze how IRB members evaluate minimal risk by sending questionnaire survey with 12 predetermined scenarios. Methods: IRB members and researchers (pediatrician, gastroenterologist, neurologist, and neurosurgeon) in 11 different hospitals were asked to answer survey questions via email or online. We analyzed the differences of answers among several subgroups in each predetermined scenarios. Result: Responders were 212 personnel(110 researchers and 102 IRB members) from 11 centers. There were significant differences between IRB members and researchers in response such as blood sampling, skin prick test, one time catheterization in a girl, spinal tapping in child, non-enhance MRI in child, non-enhance MRI with chrolal hydrate in a child, spinal tapping without anesthesia in adult, bioequivalence test, gastric endoscopy, and non-enhance CT. significant differences between medical IRB members and non-medical members were also revealed in one time catheterization in a girl, spinal tapping in a child, non-enhance MRI in a child, bioequivalence test. Depending on researchers' department, they responded differently in several questionnaires as well. Conclusions: We have found that IRB members and researchers evaluate the risks differently. Researchers compared to IRB members, medical IRB members compared to non-medical members answered less than minimal risk in many cases. In assessing and evaluating the risks associated with the study, medical IRB members answered predetermined scenarios as less dangerous compared to non-medical IRB members. Difference among researchers where also revealed significantly. Researchers answered predetermined scenarios as less dangerous compare to other department researchers, especially in predetermined scenarios containing procedures they are familiar with.

• Journal of Nutrition and Health
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• 제51권1호
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• pp.73-86
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• 2018

본 연구는 선형계획법을 이용하여 현재의 식품섭취패턴에서 크게 벗어나지 않으면서 영양섭취기준을 충족하는 한국 성인의 최적 식품섭취패턴을 설계하였고, 주요 결과는 다음과 같다. 식품품목별 실제섭취량과 최적섭취량을 비교하였을 때 실제섭취량보다 최적섭취량이 높게 나타나 영양섭취기준을 충족하기 위해서 현재보다 섭취량을 더 늘릴 필요가 있는 식품품목으로 모든 집단에서 공통적으로 채소류, 50 ~ 64세 남성을 제외한 집단에서 우유 유제품류인 것으로 나타났다. 50 ~ 64세를 제외한 여성에서는 채소류, 우유 유제품류 이외에도 과일류도 섭취량을 더 높여야 하는 식품품목으로 나타났다. 모든 남성 집단과 19 ~ 29세를 제외한 여성 집단에서 김치의 최적섭취량이 실제 섭취량보다 낮게 나타나 김치는 덜 섭취해야 하는 식품품목인 것으로 파악되었다. 또한 조미료에 대해서는 모든 집단에서 공통적으로 최적섭취량이 0 g으로 산출되었다. 이에 선형계획법을 이용해서 설계한 최적 식품섭취패턴에서 조미료의 최적섭취량이 실생활에서 실현 불가능한 0 g으로 산출되었기 때문에 설계한 최적 식품섭취패턴의 실현성을 높이기 위해서는 나트륨의 목표섭취량을 실제섭취량이 고려된 보다 현실적인 기준으로 재설정할 필요가 있다.

• 대한수학회논문집
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• 제23권2호
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• pp.257-268
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• 2008

Let G and K be compact subgroups of orthogonal groups and $0{\leq}r<x<{\infty}$. We prove that every topological fiber bundle over a definable $C^r$ manifold whose structure group is K admits a unique strongly definable $C^r$ fiber bundle structure up to definable $C^r$ fiber bundle isomorphism. We prove that every G vector bundle over an affine definable $C^rG$ manifold admits a unique strongly definable $C^rG$ vector bundle structure up to definable $C^rG$ vector bundle isomorphism.

• Annals of Clinical Neurophysiology
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• 제19권1호
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• pp.13-19
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• 2017

Background: Median F-wave latencies are physiologically shorter than ulnar latencies, but they are often longer relative to ulnar latencies in carpal tunnel syndrome (CTS). This study aimed to investigate the value of absolute F-waves and relative latency changes compared to ulnar latencies in the diagnosis of CTS. Methods: F-wave latencies of median and ulnar nerves in 339 hands from 339 patients with CTS and 60 hands from 60 control subjects were investigated. Mean F-wave minimal latencies of median and ulnar nerves were compared between groups. Patients were further divided into subgroups based on Canterbury grading and then analyzed using F-wave latency differences (FWLD) and F-wave ratio (FWR). Results: Of 339 hands in the CTS group, 236 hands exhibited F-wave inversion based on the FWLD criterion and 277 hands had F-wave inversion based on the FWR criterion. F-wave inversion had a sensitivity of 81.7% using the FWR criterion to diagnose CTS. The mean FWLD and FWR were significantly greater in all patient subgroups compared to the control group (p < 0.001). In addition, mean FWLD and FWR showed significant correlations (r = -0.683 and r = 0.674, respectively, p < 0.001) with disease severity. Conclusions: F-wave studies are effective supplementary diagnostic tools comparing to other standard electrophysiologic criteria for screening patients with CTS.

• 한국방사선학회논문지
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• 제10권4호
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• pp.285-290
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• 2016

이 연구는 관상동맥 CT 석회화점수 검사를 2회 이상 받은 자 중에서, 이전에 비하여 점수가 낮아진 원인을 후향적으로 분석하였다. 건강검자 환자 100명(남자 85명 $60.6{\pm}6.9$세, 여자 15명 $67.2{\pm}7.3$세)을 대상으로 하였다. 석회화점수 감소가 발생한 경우를 Agatston의 분류 방법에 따라 minimal (1-10), mild(11-100), moderate(101-400), severe (400< ) 4개 그룹으로 분류하였다. Mild 그룹에서 49명으로 가장 많았으며, minimal 그룹에서 감소율 변동이 가장 크게 나타났다. 석회화점수 감소 요인은 Scan location 불일치 51%, Motion artifact 26%, 장비변동 14%, 작업자의 실수 5%, 입력 miss 2%, Image loss 1%, 부정맥 1% 로 나타났다. Scan location의 불일치는 scan된 석회화의 slice 위치에 따른 부분체적 효과로 생각되며, 관상동맥 석회화 점수가 작은 100 이하 그룹에서는 높은 변화폭(19.7%)이 나타났고 100 이상의 그룹에서는 낮은 변화폭(2.2%)을 보여 석회화 점수에 따라 허용될 수 있는 변화폭이 달라진다는 것을 알 수 있었다. Motion artifact 요인은 26%로 나타났으며, 이는 높은 심박동에 의한 것으로 심박동이 높거나 검사 전 폐기능, 운동부하 등 심박동에 영향을 미치는 선행검사와 밀접한 관련이 있었다.

• The Journal of Korean Physical Therapy
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• 제22권4호
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• pp.1-6
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• 2010

Purpose: This study was designed to evaluate the clinical utility of the Four square step test (FSST) for predicting falls in stroke patients, to compare the ability of the FSST test to discriminate between subgroups of fallers, and to determine if the test has any predictive value in identifying stroke patients who will fall. Methods: Stroke patients (N=37) who could walk at least 50 m with minimal assistance were recruited consecutively when attending a physical therapy session during their rehabilitation. Dynamic standing balance was measured using the FSST. The main outcome measures were FSST time and fall number. Numbers of falls were compared with FSST scores. Differences between the groups in FSST scores were examined using a t-test and 1-way analysis of variance. Post hoc analysis using the Tukey B procedure was used to identify specific group differences. Alpha was set at 0.05. Results: A total of 15 participants (40.5%) reported falls 6 had recurrent falls (2 falls) and 9 fell once. The mean FSST time differed significantly between groups with zero and multiple falls. A cutoff score of greater than 17 seconds on the FSST was associated with a sensitivity of 83% and a specificity of 84% for the identification of subjects with multiple risk factors for falls. Conclusion: The FSST is a feasible and valid clinical test of dynamic standing balance and can predict falls in post-stroke patients.