• Biotechnology and Bioprocess Engineering:BBE
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• v.7 no.3
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• pp.163-170
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• 2002

This report describes the use of a transtubular bioreactor to study the relative effects of diffusion versus perfusion of medium on antibody production by a hybridoma cell line. The study was performed with a high-density cell culture maintained in a serum-free, low-protein medium for 77 days. It was determined that the reactor possessed a macro-mixing pattern residence time distribution similar to a continuous stirred tank reactor (CSTR), However, due to the arrangement of the medium lines in the reactor, the flow patterns for nutrient distribution consist of largely independent medium path lengths ranging from short to long. When operated with cyclic, reversing, transtubular medium flow, some regions of the reactor (with short residence times) are more accessible to medium than others (with long residence times). From this standpoint, the reactor can be divided into three regions: a captive volume, which consists of medium primarily delivered via diffusion; a lapped volume, which provides nutrients through unilateral convection; and a swept volume, which operates through bilateral convection. The relative sizes of these three volumes were modified experimentally by changing the period over which the direction of medium flow was reversed from 15 min (larger captive volume) to 9 h (larger swept volume). The results suggest that antibody concentration increases as the size of the diffusion-limited (captive) volume is increased to a maximum at around 30 min with a sharp decrease thereafter. As reflected by changes in measured consumption of glucose and production of lactate, no significant difference in cellular metabolism occurred as the reactor was moved between these different states. These results indicate that the mode of operation of the transtubular bioreactor may influence antibody productivity under serum-free, low-protein conditions with minimal effects on cellular metabolism.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.53.2-53.2
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• 2015

Fiber Bragg gratings (FBGs) are the most compact and reliable method of suppressing atmospheric emission lines in the infrared for ground-based telescopes. It has been proved that real FBGs based filters were able to eliminate 63 bright sky lines with minimal interline losses in 2011 (GNOSIS). Inscribing FBGs on multi-core fibers offers advantages. Compared to arrays of individual SMFs, the multi-core fiber Bragg grating (MCFBG) is greatly reduced in size, resistant to damage, simple to fabricate, and easy to taper into a photonics lantern (PRAXIS). Multi-mode fibers should be used and the number of modes has to be large enough to capture a sufficient amount of light from the telescope. However, the fiber Bragg gratings can only be inscribed in the single-mode fiber. A photonic lantern bi-directionally converts multi-mode to single-mode. The number of cores in MCFBGs corresponds to the mode. For a writing system consisting of a single ultra-violet (UV) laser and phase mask, the standard writing method is insufficient to produce uniform MCFBGs due to the spatial variations of the field at each core within the fiber. Most significant technical challenges are consequences of the side-on illumination of the fiber. Firstly, the fiber cladding acts as a cylindrical lens, narrowing the incident beam as it passes through the air-cladding interface. Consequently, cores receive reduced or zero illumination, while the focusing induces variations in the power at those that are exposed. The second effect is the shadowing of the furthest cores by the cores nearest to the light source. Due to a higher refractive index of cores than the cladding, diffraction occurs at each core-cladding interface as well as cores absorb the light. As a result, any core that is located directly behind another in the beam path is underexposed or exposed to a distorted interference pattern from what phase mask originally generates. Technologies are discussed to overcome the problems and recent experimental results are presented as well as simulation results.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.15 no.4
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• pp.105-117
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• 2015

In this paper, we consider 19 cells with the two tiers for polar-rectangular coordinates (PRCs) and provide the cell edge performance of cellular networks based on distance from cell center i.e., BS (base station). When FFR is applied(or adopted) to cell edge, it is expected that BS cooperation, or a coordinated multipoint (CoMP) multiple access strategy will further improve the system performance. We proposed a new method to evaluate the sum rate capacity of the MIMO DC of multicell system. We improve the performance of cell edge users for intercell interference cancelation in cooperative downlink multicell systems. Simulation results show that the proposed scheme outperforms the reference schemes, in terms of cell edge SINR (signal-to-interference-noise ratio) with a minimal impact on the network path loss exponent. We show 13 dB improvements in cell-edge SINR by using reuse of three relative to reuse of one. BS cooperation has been proposed to mitigate the cell edge effect.

• KIPS Transactions on Software and Data Engineering
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• v.4 no.9
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• pp.419-424
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• 2015

As Internet of Things (IoT) is recently serviced in several fields, the reliability and safety issues for IoT embedded systems are emerged. During the development of embedded systems, it is not easy to build the virtual execution environment and to test the developing version. Therefore, it is difficult to ensure its reliability due to lack of unit testing. In this paper, we propose a log-based unit testing framework for embedded software, which performs on real target board by extracting information of function execution. And, according to execution paths, duplicated logs are eliminated to keep a minimal log size. As a result, during system testing, testers can efficiently decide whether the executed paths of each function are correctly performed or not.

• Journal of Korea Game Society
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• v.4 no.1
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• pp.58-66
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• 2004

This paper uses counterexamples for solving reachability games. An objective. of the game we consider here is to find out a minimal path from an initial state to the goal state. We represent initial states and game rules as finite state model and the goal state as temporal logic formula. Then, model checking is used to determine whether the model satisfies the formula. In case the model does not satisfy the formula, model checking generates a counterexample that shows how to reach the goal state from an initial state. In this way, we solve many of small-sized Push Push games. However, we cannot handle larger-sized games due to the state explosion problem. To mitigate the problem, abstraction is used to reduce the state space to be che cked. As a result, unsolved games are solved with the abstraction technique we propose inthis paper.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.5 no.5
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• pp.892-901
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• 2001

Despite of many advantages over conventional radio paths, application of the Meteor Burst Path in commercial communication system is so far limited to a few extent because of its low duty rate, which is, less than several percent at best. In order to get through maximum number of data bits during the short interval of each burst, which normally lives a fractions of a second, a sophisticated communication protocol is called for. In this paper, author introduces a communication protocol which can effectively locate and fetch burst signal by sending out periodic detection signal from master station and, with minimal delay, switch over to transmission states so as to put as many data bits through the detected burst as the burst length permits. By analyzing time period required for each transaction steps, the author derives optimal packet length for various bursts which assures to get a message string through in minimum delay. According to the analysis, the author proposes a protocol including a routine which automatically accesses average length of bursts at each environment and automatically adapt length of data packet so as to maximize data throughput under Riven burst conditions.

• Journal of Communications and Networks
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• v.6 no.3
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• pp.269-279
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• 2004

A new online multi-layer integrated routing (MLIR) scheme that combines IP (electrical) layer routing with WDM (optical) layer routing is investigated. It is a highly efficient and cost-effective routing scheme viable for the next generation integrated optical Internet. A new simplified weighted graph model for the integrated optical Internet consisted of optical routers with multi-granularity optical-electrical hybrid switching capability is firstly proposed. Then, based on the proposed graph model, we develop an online integrated routing scheme called differentiated weighted fair algorithm (DWFA) employing adaptive admission control (routing) strategies with the motivation of service/bandwidth differentiation, which can jointly solve multi-layer routing problem by simply applying the minimal weighted path computation algorithm. The major objective of DWFA is fourfold: 1) Quality of service (QoS) routing for traffic requests with various priorities; 2) blocking fairness for traffic requests with various bandwidth granularities; 3) adaptive routing according to the policy parameters from service provider; 4) lower computational complexity. Simulation results show that DWFA performs better than traditional overlay routing schemes such as optical-first-routing (OFR) and electrical-first-routing (EFR), in terms of traffic blocking ratio, traffic blocking fairness, average traffic logical hop counts, and global network resource utilization. It has been proved that the DWFA is a simple, comprehensive, and practical scheme of integrated routing in optical Internet for service providers.

• Restorative Dentistry and Endodontics
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• v.43 no.1
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• pp.9.1-9.6
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• 2018

The objective of this case report is to introduce a simple technique for simultaneously taking a closed-mouth impression and functionally generated path (FGP) for a full coverage crown restoration. A monolithic zirconia crown was the restoration of choice. An alginate impression of the abutment tooth was taken to fabricate a custom-made closed-mouth impression tray covering the abutment tooth and the adjacent teeth. The tray had an FGP table and an abutment tray in cameo and intaglio surfaces, respectively. The impression was taken with silicone impression material after adjusting the abutment tray and inscribing the FGP using self-curing acrylic resins. Plaster casts were made from the impression, and a zirconia crown was fabricated. The crown was cemented to the abutment tooth with minimal adjustments. This simple technique resulted in a well-fitting crown that accounted for mandibular movements. Using the custom closed-mouth impression tray incorporating an FGP table simultaneously aids in fabricating an accurately fitting restoration that incorporates harmonious mandibular movements using a single impression capture.

• Journal of Korean Association for Spatial Structures
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• v.12 no.2
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• pp.89-98
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• 2012

This study investigates the optimum structural design of space truss considering global buckling, and is to obtain the minimal weight of the structure. The mathematical programming method is used for optimization of each member by member force. Besides, dynamic programming method is adapted for consideration in snap-through buckling. The mathematical modeling for optimum design of truss members consists of objective function of total weight and constrain equations of allowable tensile (or compressive) stress and slenderness. The tangential stiffness matrix is examined to find the critical point on equilibrium path, and a ratio of the buckling load to design load is reflected in iteration procedures of dynamic programming method to adjust the stiffness of space truss. The star dome is examined to verify the proposed optimum design processor. The numerical results of the model are conversed well and satisfied all constrains. This processor is a relatively simple method to carry out optimum design with consideration in global buckling, and is viable in practice with respect to structural design.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.7
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• pp.103-110
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• 2014

Recent TSV based 3D Integrated Circuit (IC) technology needs more powerful thermal management techniques. However, because cooling cost and form factor are restricted, thermal management are emphasis on software based techniques. But in case of throttling thermal management which one of the most candidate technique, increasing bus occupation induce total performance decrease. To solve communication bottleneck issue in TSV based 3D SoC, we proposed adaptive throttling technique Experimental results show that the proposed method can improve throughput by about 72% compare with minimal path routing.