• 벤처창업연구
• /
• 제19권2호
• /
• pp.27-43
• /
• 2024

최근 제품과 서비스를 보호하고 차별화하기 위한 기업 경쟁력의 핵심 자원으로서 상표의 중요성이 증대되고 있다. 글로벌 기업들은 자사의 핵심가치가 투영된 브랜드 관리와 점차 빈발하고 있는 상표권 분쟁 대응을 위해 상표권 확보에 매진하고 있고, 창업기업과 개인은 안정적 사업 영위와 투자금 유치를 위해 상표권 확보에 매진하고 있다. 이러한 가운데 본 연구는 국내 벤처창업기업의 상표와 비즈니스 전략간 연관성 규명을 위한 실증분석을 실시한다. 분석데이터는 2021년 벤처기업정밀실태조사 중 2,230개의 법인기업 응답데이터가 활용되었고, 분석방법으로는 성향점수매칭법, 구조방정식모형분석, 이항로짓분석이 활용되었다. 분석 결과 국내 벤처창업기업의 상표 보유는 비즈니스 전략의 수준 측면에서 큰 차이를 만들지는 않는 것으로 확인되었다. 이는 국내 벤처창업기업의 상표는 주로 내부역량화 과정을 통해서만 비즈니스 전략을 고도화하는 반면 외부역량화 과정을 통한 비즈니스 전략 고도화는 매우 미미하기 때문인 것으로 확인되었다. 한편 벤처창업기업의 비즈니스 전략 수준 중 원가우위전략 수준이 상표 보유성향을 강화하는 것으로 확인되었는데 이는 원가우위수준의 완성도가 높아 지면 높아질수록 상표보유를 통해 제품·서비스의 안정적 판매·공급을 위해, 그리고 향후 고부가가치화로 전환하기 위해 상표보유를 확대하는 경향이 있음을 보여준다.

• 대한영상의학회지
• /
• 제85권2호
• /
• pp.372-380
• /
• 2024

목적 콜레스테롤 식이 및 기계적 혈관 내막 손상 유발을 통한 토끼 장골동맥 협착 모델을 개발하고 서로 다른 내막 손상 방법에 따른 협착 유발 정도를 평가하고자 한다. 대상과 방법 18마리의 토끼를 콜레스테롤 식이 후 풍선으로 당김 손상(pullover injury)을 가한 군(group A, 6마리), 콜레스테롤 식이 후 국소 확장 손상(localized balloon dilatation) 군(group B, 6마리), 일반 사료 식이 후 당김 손상을 가한 군(group C, 6마리)로 나누었다. 모든 군에서 혈관조영술을 시행하고 좌측 장골동맥에 직경 3 mm, 길이 10 mm의 비순응성(noncompliant) 풍선 카테터를 이용하여 당김 손상(group A, C) 또는 국소 확장 손상(group B)를 가하였다. 실험 시작 후 9주째 추적 혈관조영술을 시행하여 혈관조영술상 장골동맥의 협착 정도(후기 내강 손실, 협착 비율)을 정량적으로 비교 평가하였다. 결과 A군이 9주째 추적 혈관조영술에서 가장 심한 후기 내강 손실을 보였고 32.02% ± 6.54%의 협착이 확인되었다(A군 vs. B군: 0.67 ± 0.13 mm vs. 0.04 ± 0.13 mm, p < 0.0001; A군 vs. C군: 0.67 ± 0.13 mm vs. 0.26 ± 0.29 mm, p < 0.05). B군에서는 혈관조영술상 협착이 1.75% ± 6.55%로 매우 낮게 나타났다. 결론 콜레스테롤 식이 및 당김 손상 기법을 이용한 기계적 내막 손상이 토끼 장골 동맥에서 유의한 협착을 유발함을 확인하였다. 이 전임상 모델은 전임상 말초동맥 질환의 질병 모델로 사용될 수 있을 것으로 예상된다.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제14권9호
• /
• pp.3782-3796
• /
• 2020

A three-dimensional (3D) reconstruction is an important research area in computer vision. The ability to detect and match features across multiple views of a scene is a critical initial step. The tracking matrix W obtained from a 3D reconstruction can be applied to structure from motion (SFM) algorithms for 3D modeling. We often fail to generate an acceptable number of features when processing face or medical images because such images typically contain large homogeneous regions with minimal variation in intensity. In this study, we seek to locate sufficient matching points not only in general images but also in face and medical images, where it is difficult to determine the feature points. The algorithm is implemented on an adaptive threshold value, a scale invariant feature transform (SIFT), affine SIFT, speeded up robust features (SURF), and affine SURF. By applying the algorithm to face and general images and studying the geometric errors, we can achieve quasi-dense matching points that satisfy well-functioning geometric constraints. We also demonstrate a 3D reconstruction with a respectable performance by applying a column space fitting algorithm, which is an SFM algorithm.

• Journal of Microbiology and Biotechnology
• /
• 제27권4호
• /
• pp.791-807
• /
• 2017

The type II secretion system (T2SS), which transports selected periplasmic proteins across the outer membrane, has rarely been studied in nonpathogens or in organisms classified as Betaproteobacteria. Therefore, we studied Cupriavidus metallidurans (Cme), a facultative chemilithoautotroph. Gel analysis of extracellular proteins revealed no remarkable differences between the wild type and the T2SS mutants. However, enzyme assays revealed that native extracellular alkaline phosphatase is a T2SS substrate, because activity was 10-fold greater for the wild type than a T2SS mutant. In Cme engineered to produce three Ralstonia solanacearum (Rso) exoenzymes, at least 95% of their total activities were extracellular, but unexpectedly high percentages of these exoenzymes remained extracellular in T2SS mutants cultured in rich broth. These conditions appear to permit an alternative secretion process, because neither cell lysis nor periplasmic leakage was observed when Cme produced a Pectobacterium carotovorum exoenzyme, and wild-type Cme cultured in minimal medium secreted 98% of Rso polygalacturonase, but 92% of this exoenzyme remained intracellular in T2SS mutants. We concluded that Cme has a functional T2SS despite lacking any abundant native T2SS substrates. The efficient secretion of three foreign exoenzymes by Cme is remarkable, but so too is the indication of an alternative secretion process in rich culture conditions. When not transiting the T2SS, we suggest that Rso exoenzymes are probably selectively packaged into outer membrane vesicles. Phylogenetic analysis of T2SS proteins supports the existence of at least three T2SS subfamilies, and we propose that Cme, as a representative of the Betaproteobacteria, could become a new useful model system for studying T2SS substrate specificity.

• Journal of Microbiology and Biotechnology
• /
• 제30권3호
• /
• pp.427-438
• /
• 2020

Middle East respiratory syndrome coronavirus (MERS-CoV) infects the lower respiratory airway of humans, leading to severe acute respiratory failure. Unlike human dipeptidyl peptidase 4 (hDPP4), a receptor for MERS-CoV, mouse DPP4 (mDPP4) failed to support MERS-CoV infection. Consequently, diverse transgenic mouse models expressing hDPP4 have been developed using diverse methods, although some models show no mortality and/or only transient and mild-to-moderate clinical signs following MERS-CoV infection. Additionally, overexpressed hDPP4 is associated with neurological complications and breeding difficulties in some transgenic mice, resulting in impeding further studies. Here, we generated stable hDPP4-transgenic mice that were sufficiently susceptible to MERS-CoV infection. The transgenic mice showed weight loss, decreased pulmonary function, and increased mortality with minimal perturbation of overexpressed hDPP4 after MERS-CoV infection. In addition, we observed histopathological signs indicative of progressive pulmonary fibrosis, including thickened alveolar septa, infiltration of inflammatory monocytes, and macrophage polarization as well as elevated expression of profibrotic molecules and acute inflammatory response in the lung of MERS-CoV-infected hDPP4-transgenic mice. Collectively, we suggest that this hDPP4-transgenic mouse is useful in understanding the pathogenesis of MERS-CoV infection and for antiviral research and vaccine development against the virus.

• 한국통신학회논문지
• /
• 제40권11호
• /
• pp.2188-2195
• /
• 2015

전술 무선랜 환경에서의 재밍 공격은 연속적인 전자기파를 발생시킴으로서 손쉽게 구현이 가능하며 주파수가 일치할 경우 그 피해는 매우 심각해질 수 있다. 무선 채널 환경은 누구나 공유할 수 있기 때문에 재밍 공격에 대한 완벽한 해결방법은 존재할 수 없으나 그 피해를 줄일 수 있는 방법으로 잘 알려진 기법이 채널도약 기법이다. 본 논문에서는 기존에 제안된 채널도약 기법들에 관하여 노드들의 데이터 전송용량과 노드들간의 형평성 측면에서 비교 분석하여 문제점들을 도출한 후 전술 무선랜 재밍 환경에 적합한 새로운 채널도약 기법을 제안한다. 또한 재밍 환경에서의 데이터 전송용량을 계산할 수 있는 분석 모델을 제안하여 채널도약 기법 적용시 규준화된 네트워크 데이터 전송용량을 쉽게 계산 할 수 있도록 하였다. 분석 모델을 이용한 수치 결과들은 제안된 채널도약 기법 적용시 규준화된 네트워크 데이터 전송용량은 다소 감소하지만 노드들간의 형평성 문제는 큰 폭으로 향상됨을 보여준다.

• Journal of Preventive Medicine and Public Health
• /
• 제37권2호
• /
• pp.120-126
• /
• 2004

Objectives : This study sought to examine relationships between alcohol drinking and cardiovascular disease mortality and all-cause mortality. Methods : From March 1985 through December 1999, 2,696 males and 3,595 females aged 55 or over as of 1985 were followed up for their mortality until 31 December 1999. We calculated the mortality risk ratios by level of alcohol consumption. Among the drinker, the level of alcohol consumption was calculated by the frequency of alcohol comsumption and the type of alcohol. Cox proportional hazard model was used to adjust for confounding factors. Results : Among males, compared to abstainer, heavy drinker had significantly higher mortality in all cause(Risk ratio=1.35), cardiovascular disease(Risk ratio=1.52) and cerebrovascular disease(Risk ratio =1.66). Although not significant, moderate drinker had lower ischemic heart disease mortality(Risk ratio =0.38). Among females, there was no statistically significant association between alcohol comsumption and mortality. Conclusion : The results of this study suggest that alcohol drinking has harmful effect on all-cause mortality, cardiovascular disease mortality and cerebrovascular disease mortality among males, especially in heavy drinker among males. Minimal evidence on protective effect for cardiovascular disease mortality in low or moderate drinker is observed.

• 한국정보처리학회논문지
• /
• 제4권1호
• /
• pp.137-148
• /
• 1997

고장진단 문제는 지식기반 시스템를 이용해 해결하려는 시도가 많이 있어왔다. 그러나 대부분의 방식은 휴리스틱 또는 모델기반 방식으로 단일 오류에 대한 문제에 많은 노력이 이루어져 왔다. 단일 오류에 대한 고장진단문제 해결방식을 다중 오류진 단으로 확대할 때 발생하는 지수적인 계산비용은 피할 수 없는 문제점으로 지적되어 왔다. 이 논문에서는 시스템 구성에 따라 블록으로 구분하면 전체 탐색 영역을 국소 화할 수 있다는 점에 착안하여 다중 오류 진단을 위한 효율적인 알고리즘을 제안한 다. 이 알고리즘의 기본 원리는 오류진단을 위한 출력값 측정 지점에 따라 전체 회로 를 블록으로 나누고 다중오류에 대한 발생원인의 지수적 증가를 줄임으로 효율화 시 킬 수 있다. 각각의 블럭으로부터 발생하는 오류에 대해 결합하는 규칙을 개발하고 이를 통해 상호 논리적인 모순이 없는 최소 오류원인 집합을 구한다.

• Journal of Nutrition and Health
• /
• 제29권10호
• /
• pp.1059-1071
• /
• 1996

This study was performed to investigate the effect of dietary protein level on renal senescence. Male rats of 337.8$\pm$5.7g body weight were underlateral nephrectomy or shamoperation. The rats were divided into high protein(40% casein), normal protein(15% casein) and low protein(8% casein)diets and fed experimental diets ad libitum for 24 weeks. The results are summarized as follows. There was a hypertophy of the remnant kidney of uninephrectomized rats of 40% or 15% protein group, coming up to the comparable weights of both kidneys of sham-operated rats. However, the hypertrophic effect was not seen in uninephrectomized rats of 8% protein group. Serum albumin was lower in uninephrectomized rats. With increasing dietary protein level blood urea nitrogen was increased, whereas, urinary urea nitrogen excretion was decreased. Urinary solute excretion was higher in uninephrectomized group than in sham-operated group. However, effect of dietary protein level on urinary solute excretion varied dpending on th solutes tested. GFR and urinary protein excretion, throughout experiment, increased with feeding period and with dietary protein level. Proteinuria was most severe in uninephrectomized rats fed 40% casein diet. Maximum urine concentration ability measured after dehydration was not different among the experimental groups. Light microscopic examination showed focal segmental glomerulosclerosis and mild increas of glomerular mesangial matrix in uninephrectomized rats fed 40% and 15% protein diet, however, which was not observed in uninephrectomized rats fed 8% protein diet and in sham-operated rats fed 40% diet. Immunofluorescence studies revealed segmental deposits of albumin in the mesangium and capillary loops in high protein and uninephrectomized groups. Minimal granular deposition of IgG was noted in the mesangium of all experimental groups. In conclusion, high protein intake accelerated deterioration of renal function and it was correlated with morphological change. Low protein intake was effective in preventing these changes.

• The Korean Journal of Pain
• /
• 제18권2호
• /
• pp.118-123
• /
• 2005

Background: A nerve ligation injury may produce a tactile allodynia. The effects of intrathecally delivered lamotrigine on allodynia induced due to fifth and sixth lumbar spinal nerves ligation in rats, using lumbar intrathecal catheters were examined. Methods: Sprague-Dawley rats (body weight 160-180 g) were prepared by tightly ligating the fifth and sixth left lumbar spinal nerves, with the implantation of a chronic intrathecal catheter for drug administration. Mechanical allodynia and allodynic threshold were measured using von Frey filaments and the updown method, respectively. After the baseline hind paw withdrawal thresholds had been obtained, lamotrigine (10, 30, 100 and $300{\mu}g$) was administered intrathecally. Thereafter, the dose-response curves and 50% effective dose ($ED_{50}$) were obtained. Motor dysfunction was assessed by observing the righting/stepping reflex responses and abnormal weight bearing. Results: Intrathecal administration of lamotrigine produced a dose-dependent antiallodynic action ($ED_{50}=61.7{\mu}g$). Mild motor weakness was observed with $300{\mu}g$ lamotrigine, but no severe motor impairment was found. Conclusions: It is suggested that intrathecal lamotrigine could produce moderate antagonism of mechanical allodynia at the spinal level in a rat neuropathic pain model with minimal motor weakness.