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The Mechanical Antiallodynic Effect of Intrathecal Lamotrigine in Rats with Spinal Nerve Ligation  

Song, Jun Gol (Department of Anesthesiology and Pain Medicine, Seoul Asan Medical Center, College of Medicine, University of Ulsan)
Jun, In Gu (Department of Anesthesiology and Pain Medicine, Seoul Asan Medical Center, College of Medicine, University of Ulsan)
Kwon, Mi Young (Department of Anesthesiology and Pain Medicine, Seoul Asan Medical Center, College of Medicine, University of Ulsan)
Park, Jong Yeon (Department of Anesthesiology and Pain Medicine, Seoul Asan Medical Center, College of Medicine, University of Ulsan)
Publication Information
The Korean Journal of Pain / v.18, no.2, 2005 , pp. 118-123 More about this Journal
Abstract
Background: A nerve ligation injury may produce a tactile allodynia. The effects of intrathecally delivered lamotrigine on allodynia induced due to fifth and sixth lumbar spinal nerves ligation in rats, using lumbar intrathecal catheters were examined. Methods: Sprague-Dawley rats (body weight 160-180 g) were prepared by tightly ligating the fifth and sixth left lumbar spinal nerves, with the implantation of a chronic intrathecal catheter for drug administration. Mechanical allodynia and allodynic threshold were measured using von Frey filaments and the updown method, respectively. After the baseline hind paw withdrawal thresholds had been obtained, lamotrigine (10, 30, 100 and $300{\mu}g$) was administered intrathecally. Thereafter, the dose-response curves and 50% effective dose ($ED_{50}$) were obtained. Motor dysfunction was assessed by observing the righting/stepping reflex responses and abnormal weight bearing. Results: Intrathecal administration of lamotrigine produced a dose-dependent antiallodynic action ($ED_{50}=61.7{\mu}g$). Mild motor weakness was observed with $300{\mu}g$ lamotrigine, but no severe motor impairment was found. Conclusions: It is suggested that intrathecal lamotrigine could produce moderate antagonism of mechanical allodynia at the spinal level in a rat neuropathic pain model with minimal motor weakness.
Keywords
allodynia; antiallodynia; intrathecal; lamotrigine; motor weakness;
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Times Cited By KSCI : 1  (Citation Analysis)
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