• Title/Summary/Keyword: minimal model

Search Result 657, Processing Time 0.025 seconds

A Study on the Relationship between Branding and Business Strategies of Korean Start-ups (한국 벤처창업기업의 상표와 비즈니스 전략간 연관성 분석)

  • Hyukjoon Kim;Yoo-Jin Han
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
    • /
    • v.19 no.2
    • /
    • pp.27-43
    • /
    • 2024
  • Recently, the importance of trademarks as a core resource of corporate competitiveness to protect and differentiate products and services is increasing. Global companies are focusing hard to secure trademark rights to manage brands that reflect their core values and to respond to increasingly frequent trademark disputes, while start-ups and individuals are working hard to secure trademark to run stable businesses and attract investment funds. Meanwhile, this study conducts an empirical analysis to identify the relationship between the brand and business strategy of domestic venture startups. The analysis data used was the response data of 2,230 corporate companies from the 2021 Venture Business Precision Survey, and the propensity score matching method, structural equation model analysis, and binomial logit analysis were used as analysis methods. As a result of the analysis, it was confirmed that domestic venture startups' trademark ownership does not make a significant difference in terms of the level of business strategy. This was confirmed to be because the brands of domestic venture start-ups mainly advance their business strategies only through the internal competency process, while the advancement of business strategies through the external competency process is very minimal. Meanwhile, it was confirmed that the level of cost advantage strategy among the business strategy levels of venture start-ups strengthens the tendency to hold trademarks, indicating that the higher the completeness of the cost advantage level, the more likely it is to expand trademark ownership for stable sales and supply of products and services through trademark ownership and to convert to high value-added in the future.

  • PDF

Development of a Rabbit Iliac Arterial Stenosis Model Using a Controlled Cholesterol Diet and Pullover Balloon Injury (콜레스테롤 식이 및 내막 손상을 통한 토끼 장골동맥 협착 전임상 모델 개발)

  • Hooney D. Min;Chong-ho Lee;Jae Hwan Lee;Kun Yung Kim;Chang Jin Yoon;Minuk Kim
    • Journal of the Korean Society of Radiology
    • /
    • v.85 no.2
    • /
    • pp.372-380
    • /
    • 2024
  • Purpose This study aimed to develop a rabbit iliac stenosis model and evaluate the effects of different mechanical injury techniques on the degree of arterial stenosis. Materials and Methods Eighteen rabbits were divided into three groups: cholesterol-fed with pullover balloon injury (group A; n = 6), cholesterol-fed with localized balloon dilatation (group B; n = 6), and chow-diet with pullover balloon injury (group C; n = 6). After baseline angiography, the left iliac arteries of all rabbits were injured with a 3 × 10 mm noncompliant balloon using either a wide pullover technique (groups A and C) or a localized balloon dilatation technique (group B). A nine-week follow-up angiography was performed, and the angiographic late lumen loss and percentage of stenosis were compared. Results Group A exhibited the most severe late lumen loss (A vs. B, 0.67 ± 0.13 vs. 0.04 ± 0.13 mm, p < 0.0001; A vs. C, 0.67 ± 0.13 vs. 0.26 ± 0.29 mm, p < 0.05; stenosis percentage 32.02% ± 6.54%). In contrast, group B showed a minimal percentage of stenosis (1.75% ± 6.55%). Conclusion Pullover-balloon injury can lead to significant iliac artery stenosis in rabbits with controlled hypercholesterolemia. This model may be useful for elucidating the pathogenesis of atherosclerosis and for evaluating the efficacy of novel therapeutic interventions.

A reliable quasi-dense corresponding points for structure from motion

  • Oh, Jangseok;Hong, Hyunggil;Cho, Yongjun;Yun, Haeyong;Seo, Kap-Ho;Kim, Hochul;Kim, Mingi;Lee, Onseok
    • KSII Transactions on Internet and Information Systems (TIIS)
    • /
    • v.14 no.9
    • /
    • pp.3782-3796
    • /
    • 2020
  • A three-dimensional (3D) reconstruction is an important research area in computer vision. The ability to detect and match features across multiple views of a scene is a critical initial step. The tracking matrix W obtained from a 3D reconstruction can be applied to structure from motion (SFM) algorithms for 3D modeling. We often fail to generate an acceptable number of features when processing face or medical images because such images typically contain large homogeneous regions with minimal variation in intensity. In this study, we seek to locate sufficient matching points not only in general images but also in face and medical images, where it is difficult to determine the feature points. The algorithm is implemented on an adaptive threshold value, a scale invariant feature transform (SIFT), affine SIFT, speeded up robust features (SURF), and affine SURF. By applying the algorithm to face and general images and studying the geometric errors, we can achieve quasi-dense matching points that satisfy well-functioning geometric constraints. We also demonstrate a 3D reconstruction with a respectable performance by applying a column space fitting algorithm, which is an SFM algorithm.

Native and Foreign Proteins Secreted by the Cupriavidus metallidurans Type II System and an Alternative Mechanism

  • Xu, Houjuan;Denny, Timothy P.
    • Journal of Microbiology and Biotechnology
    • /
    • v.27 no.4
    • /
    • pp.791-807
    • /
    • 2017
  • The type II secretion system (T2SS), which transports selected periplasmic proteins across the outer membrane, has rarely been studied in nonpathogens or in organisms classified as Betaproteobacteria. Therefore, we studied Cupriavidus metallidurans (Cme), a facultative chemilithoautotroph. Gel analysis of extracellular proteins revealed no remarkable differences between the wild type and the T2SS mutants. However, enzyme assays revealed that native extracellular alkaline phosphatase is a T2SS substrate, because activity was 10-fold greater for the wild type than a T2SS mutant. In Cme engineered to produce three Ralstonia solanacearum (Rso) exoenzymes, at least 95% of their total activities were extracellular, but unexpectedly high percentages of these exoenzymes remained extracellular in T2SS mutants cultured in rich broth. These conditions appear to permit an alternative secretion process, because neither cell lysis nor periplasmic leakage was observed when Cme produced a Pectobacterium carotovorum exoenzyme, and wild-type Cme cultured in minimal medium secreted 98% of Rso polygalacturonase, but 92% of this exoenzyme remained intracellular in T2SS mutants. We concluded that Cme has a functional T2SS despite lacking any abundant native T2SS substrates. The efficient secretion of three foreign exoenzymes by Cme is remarkable, but so too is the indication of an alternative secretion process in rich culture conditions. When not transiting the T2SS, we suggest that Rso exoenzymes are probably selectively packaged into outer membrane vesicles. Phylogenetic analysis of T2SS proteins supports the existence of at least three T2SS subfamilies, and we propose that Cme, as a representative of the Betaproteobacteria, could become a new useful model system for studying T2SS substrate specificity.

Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis

  • Kim, Ju;Yang, Ye Lin;Jeong, Yongsu;Jang, Yong-Suk
    • Journal of Microbiology and Biotechnology
    • /
    • v.30 no.3
    • /
    • pp.427-438
    • /
    • 2020
  • Middle East respiratory syndrome coronavirus (MERS-CoV) infects the lower respiratory airway of humans, leading to severe acute respiratory failure. Unlike human dipeptidyl peptidase 4 (hDPP4), a receptor for MERS-CoV, mouse DPP4 (mDPP4) failed to support MERS-CoV infection. Consequently, diverse transgenic mouse models expressing hDPP4 have been developed using diverse methods, although some models show no mortality and/or only transient and mild-to-moderate clinical signs following MERS-CoV infection. Additionally, overexpressed hDPP4 is associated with neurological complications and breeding difficulties in some transgenic mice, resulting in impeding further studies. Here, we generated stable hDPP4-transgenic mice that were sufficiently susceptible to MERS-CoV infection. The transgenic mice showed weight loss, decreased pulmonary function, and increased mortality with minimal perturbation of overexpressed hDPP4 after MERS-CoV infection. In addition, we observed histopathological signs indicative of progressive pulmonary fibrosis, including thickened alveolar septa, infiltration of inflammatory monocytes, and macrophage polarization as well as elevated expression of profibrotic molecules and acute inflammatory response in the lung of MERS-CoV-infected hDPP4-transgenic mice. Collectively, we suggest that this hDPP4-transgenic mouse is useful in understanding the pathogenesis of MERS-CoV infection and for antiviral research and vaccine development against the virus.

Channel-Hopping Scheme for Enhancing Fairness Performance under Smart Jammer Attacks in Tactical WLANs (전술 무선랜 재밍 환경에서의 형평성 성능 향상을 위한 채널도약 기법)

  • Kim, Yongchul
    • The Journal of Korean Institute of Communications and Information Sciences
    • /
    • v.40 no.11
    • /
    • pp.2188-2195
    • /
    • 2015
  • In tactical wireless local area networks, jamming attack can easily occur by sending out continuous radio signals. The damage will be serious when the channel frequency is identical. Since wireless channel environment is open to everyone, the perfect solution for jamming attack does not exist. However, a channel-hopping scheme is well known for mitigating those jamming attacks. In this paper, I consider various channel-hopping schemes in order to analyze the throughput and fairness performance under smart jammer attack. Also an analytical model is introduced to evaluate the throughput performances of channel-hopping schemes. After analyzing well known channel-hopping schemes, I propose a simple channel-hopping scheme that can enhance fairness significantly at minimal throughput degradation expense.

Association between Alcohol Drinking and Cardiovascular disease Mortality and All-cause Mortality - Kangwha Cohort Study - (음주와 순환기계질환 사망 및 전체사망과의 관련성)

  • Yi, Sang-Wook;Yoo, Sang-Hyun;Sull, Jae-Woong;Ohrr, Hee-Choul
    • Journal of Preventive Medicine and Public Health
    • /
    • v.37 no.2
    • /
    • pp.120-126
    • /
    • 2004
  • Objectives : This study sought to examine relationships between alcohol drinking and cardiovascular disease mortality and all-cause mortality. Methods : From March 1985 through December 1999, 2,696 males and 3,595 females aged 55 or over as of 1985 were followed up for their mortality until 31 December 1999. We calculated the mortality risk ratios by level of alcohol consumption. Among the drinker, the level of alcohol consumption was calculated by the frequency of alcohol comsumption and the type of alcohol. Cox proportional hazard model was used to adjust for confounding factors. Results : Among males, compared to abstainer, heavy drinker had significantly higher mortality in all cause(Risk ratio=1.35), cardiovascular disease(Risk ratio=1.52) and cerebrovascular disease(Risk ratio =1.66). Although not significant, moderate drinker had lower ischemic heart disease mortality(Risk ratio =0.38). Among females, there was no statistically significant association between alcohol comsumption and mortality. Conclusion : The results of this study suggest that alcohol drinking has harmful effect on all-cause mortality, cardiovascular disease mortality and cerebrovascular disease mortality among males, especially in heavy drinker among males. Minimal evidence on protective effect for cardiovascular disease mortality in low or moderate drinker is observed.

Diagnosing Multiple Faults using Multiple Context Spaces (다중 상황공간을 이용한 다중 오류의 고장 진단)

  • Lee, Gye-Sung;Gwon, Gyeong-Hui
    • The Transactions of the Korea Information Processing Society
    • /
    • v.4 no.1
    • /
    • pp.137-148
    • /
    • 1997
  • Diagnostic problem solving is a major application area of knowledge-based systems research. However, most of the current approaches, both heuristic and model-based, are designed to identify single faults, and do not generalize easily to multiple fault diagnosis without exhibiting exponential behavior in the amount of computation required. In this paper, we employ a decomposition approach based on system configuration to generate an efficient algorithm for multiple fault diagnosis. The basic idea of the algorithm is to reduce the inherent combinatorial explosion that occurs in generating multiple faults by partitioning the circuit into groups that correspond to output measurement points. Rules are multiple faults by partitioning the circuit into groups that correspond to output measurement points. rules are developed for combining candidates from individual groups, and forming consistent sets of minimal candidates.

  • PDF

Effect of Dietary Protein Level on Renal Functions and Structure in Uninephrectomized Aging Model in Rat (식이 단백질 수준이 한쪽 신장을 절제한 흰쥐에서 나이 증가에 따른 신장의 기능 및 조직 변화에 미치는 영향)

  • 김화영
    • Journal of Nutrition and Health
    • /
    • v.29 no.10
    • /
    • pp.1059-1071
    • /
    • 1996
  • This study was performed to investigate the effect of dietary protein level on renal senescence. Male rats of 337.8$\pm$5.7g body weight were underlateral nephrectomy or shamoperation. The rats were divided into high protein(40% casein), normal protein(15% casein) and low protein(8% casein)diets and fed experimental diets ad libitum for 24 weeks. The results are summarized as follows. There was a hypertophy of the remnant kidney of uninephrectomized rats of 40% or 15% protein group, coming up to the comparable weights of both kidneys of sham-operated rats. However, the hypertrophic effect was not seen in uninephrectomized rats of 8% protein group. Serum albumin was lower in uninephrectomized rats. With increasing dietary protein level blood urea nitrogen was increased, whereas, urinary urea nitrogen excretion was decreased. Urinary solute excretion was higher in uninephrectomized group than in sham-operated group. However, effect of dietary protein level on urinary solute excretion varied dpending on th solutes tested. GFR and urinary protein excretion, throughout experiment, increased with feeding period and with dietary protein level. Proteinuria was most severe in uninephrectomized rats fed 40% casein diet. Maximum urine concentration ability measured after dehydration was not different among the experimental groups. Light microscopic examination showed focal segmental glomerulosclerosis and mild increas of glomerular mesangial matrix in uninephrectomized rats fed 40% and 15% protein diet, however, which was not observed in uninephrectomized rats fed 8% protein diet and in sham-operated rats fed 40% diet. Immunofluorescence studies revealed segmental deposits of albumin in the mesangium and capillary loops in high protein and uninephrectomized groups. Minimal granular deposition of IgG was noted in the mesangium of all experimental groups. In conclusion, high protein intake accelerated deterioration of renal function and it was correlated with morphological change. Low protein intake was effective in preventing these changes.

  • PDF

The Mechanical Antiallodynic Effect of Intrathecal Lamotrigine in Rats with Spinal Nerve Ligation (척추신경결찰 흰쥐에서 척수강내로 투여한 Lamotrigine의 기계적 항이질통 효과)

  • Song, Jun Gol;Jun, In Gu;Kwon, Mi Young;Park, Jong Yeon
    • The Korean Journal of Pain
    • /
    • v.18 no.2
    • /
    • pp.118-123
    • /
    • 2005
  • Background: A nerve ligation injury may produce a tactile allodynia. The effects of intrathecally delivered lamotrigine on allodynia induced due to fifth and sixth lumbar spinal nerves ligation in rats, using lumbar intrathecal catheters were examined. Methods: Sprague-Dawley rats (body weight 160-180 g) were prepared by tightly ligating the fifth and sixth left lumbar spinal nerves, with the implantation of a chronic intrathecal catheter for drug administration. Mechanical allodynia and allodynic threshold were measured using von Frey filaments and the updown method, respectively. After the baseline hind paw withdrawal thresholds had been obtained, lamotrigine (10, 30, 100 and $300{\mu}g$) was administered intrathecally. Thereafter, the dose-response curves and 50% effective dose ($ED_{50}$) were obtained. Motor dysfunction was assessed by observing the righting/stepping reflex responses and abnormal weight bearing. Results: Intrathecal administration of lamotrigine produced a dose-dependent antiallodynic action ($ED_{50}=61.7{\mu}g$). Mild motor weakness was observed with $300{\mu}g$ lamotrigine, but no severe motor impairment was found. Conclusions: It is suggested that intrathecal lamotrigine could produce moderate antagonism of mechanical allodynia at the spinal level in a rat neuropathic pain model with minimal motor weakness.