• KSBB Journal
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• v.17 no.4
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• pp.326-332
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• 2002

The quality of biopharmaceutical proteins is strongly affected by a manufacturing process employed to produce Et, and thus validation of the manufacturing bioprocess is a very important issue. Chromatography is probably the most widely used bioprocess unit operation for protein purification. In this study, a miniaturized automatic chromatography system was designed and constructed for scale-down studies for process chromatography validation. This system, named MiniValChrom, has the following features: automatic and repeated operation, flexible sequences and intervals among the steps, on-line and real-time monitoring and control, method files savings, etc. Using the MiniValChrom, we peformed a case study of an abbreviated experiment to estimate chromatographic resin lifetime. BSA (bovine serum albumin) and Cibacron Blue 3G-A were used as the model protein and the resin, respectively. The resin deterioration was evaluated by determining and monitoring the HETP and NTP values from the chromatograms every 5 cycles. It was observed that the HETP and the NTP values were changed by 9% after 15 cycles. The resin lifetime validation could be completed by repeating this experiment until the HETP value reached a predetermined value. The MiniValChrom's concept and the protocol suggested in this study can serve as a rapid and economical tool for the validation studies of bioprocess chromatography system.

• Nuclear Engineering and Technology
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• v.20 no.1
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• pp.47-53
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• 1988

The objective of this study is to evaluate the reliability of the High Head Safety Injection System (HHIS) of KNU 5, 6, 7 and 8 following the removal of safety injection signal (s-signal) from the mini-flow bypass line valves of charging/safety injection pumps. The unavailability of HHSIS and the rupture probability of a charging/safety injection pump have been computed for two different cases; with s-signal on and removed. The results show that when the s-signal is removed from the mini-flow bypass line valves, the unavailability of HHSIS slightly increases while the rupture probability of a charging/safety injection pump is significantly reduced. Hence, based upon the results of this study we conclude that it is more reasonable to remove the s-signal from the mini-flow bypass line valves of KNU 5, 6, 7 and 8 in the normal plant operation. And to improve the availability of HHSIS, the modification of operational procedures and the emphasis on operator training are recommended.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.16 no.10
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• pp.946-951
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• 2003

A high-Tc superconducting cable(HTS cable) is expected as an underground power line supplying the electrical power the densely populated city in future. The electrical insulation is very important for develop HTS cable system because it is operated a high voltage and in cryogenic temperature. We manufactured a mini-model cable and measured a tan$\delta$ of cable using schering bridge. The tan$\delta$ of PPLP was lower than that of Tyvek and Kraft at a given temperature, the tan$\delta$ of PPLP was 1.16${\times}$10-3. According to the increase of electric stress the tan$\delta$ increased because partial discharge occurred inside butt gap of mini-model cable. However, the tan$\delta$ decreased by increase of liquid nitrogen pressure. This reason is thought by decrease of part discharge between butt gap by increase of liquid nitrogen pressure.

• Journal of Korean Ophthalmic Optics Society
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• v.14 no.4
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• pp.39-44
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• 2009

Purpose: To design a mini optical system photographing the iris, which is used in the iridology. Methods: We designed a mini optical system photographing the iris by using the Sigma 2000 design program. Results: We designed a mini optical system photographing the iris, which is suitable in the CCD using a micro actuator for auto-focusing, of which characteristics have the TCL of 30 mm, a magnification of -0.65, about 8.0 mm distance from the 1st lens to the last lens, the max barrel diameter of 11 mm, and about 1 mm of the effective stop diameter. Also the resolution line width of this system is characterised by 92 lps/mm at the 30% MTF value criterion. Conclusions: By designing an optical system of which characteristics have the TCL of 30 mm, about 8.0 mm distance from the 1st lens to the last lens, the max barrel diameter of 11 mm, and the resolution line width of $5.4{\mu}m$ at the 30% MTF value criterion, we could miniaturize the iris photographing optical system.

• IE interfaces
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• v.16 no.2
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• pp.240-247
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• 2003

Generally, the assembly system relied on conveyor lines is efficient for mass production. But it is not efficient when the product types are often varying and their lot sizes are small. Especially, it is much inefficient for the assembly lines for the electronic products whose types are varying very often. This paper suggests the design of U-shaped assembly lines to replace the existing conveyor systems. The assembly line for the mini-cassette production is dealt with as a case study. The proposed procedure was successfully applied for the design of U-shaped lines. The developed method resulted in the improvement of the productivity such as the decrease of the man power and the cycle time, and the increase of the line utility.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.4 no.1
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• pp.85-102
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• 1980

Accepting the necessity for maintaining the objectives of the existing circulation system, the computer-based system could be designed by the system analyst and librarians to gain a variety of improvements in the maintenance, accessibility of circulation records and more meaningful statistical records. If the terminal can be operated on-line, then this circulation data is transmitted directly to the computer, where it may update to the circulation file immediately or alternatively be kept in direct access file for updating in batch mode. on-line system in the circulation operations is "data-collection system" and "Bar-coded label system" Bar-coded label system is simple, quick, and error-free input of data. Attached to CRT terminal is a "light pen" which is hand held and will read a bar-coded label as the pen is passed over the labels (one affixed to the book itself, other carried on the borrower cards). Instantaneously the data concerning transaction is stored in the central mini-computer. It is useful, economical for us to co-operate many libraries in Korea and design borrower's ID code, book no., classification code in the Bar-coded label system by the members of the computer center and the library staff at every stage. As for book loan, the borrowers ID code, book number and classification code are scanned by the bar-code scanner or light pen and the computer decides whether to loan and store the data. The visual display unit shows the present status of a borrowers borrowing and decides whether borrower can borrow.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.30B no.9
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• pp.9-17
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• 1993

There are multiple controllers (PLC. LOOP Controller ) which are operating in product line and fabrication line. In those lines, it is necessary to connect various multilple controllers with integrity and coordination. The ways to connect those devices are specified by ISO network standard. In this paper, real time network is designed and implemented for factory automation at lowest possible cost that meets the small and middle size MINI-MAP specifications. Network performance is evaluated by simulation method on data link layer implemented interfacing modules has efficiency in throughput by reducing processing time. The system designed in this paper can be also applied to the field of distributed systems for real time processing.

• 제어로봇시스템학회:학술대회논문집
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• 1996.10b
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• pp.516-519
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• 1996

Sub-assembly in ship manufacturing is a sequence of filet joint welding of stiffeners on metal panels and the process is different depending on companies. In this paper, we introduce a new intelligent robotic system of the sub-assembly process in Samsung Heavy Industry, where one shift of 22m * 9m workspace includes one to ten panels and each panel includes up to 10 stiffeners. The inherent problems such as several hundreds of different panels, unstructured task environment and the large scale do not allow a fixed automation, but needs highly intelligent versatile automation. The robotic system is composed of four 14DOF macro-mini robots and a task recognition system. Application of this system has verified the task specification such as low temperature environment(-10.deg. C) and productivity is satisfied successfully.

• The KIPS Transactions:PartD
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• v.9D no.5
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• pp.915-924
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• 2002

Conventional Systems for parcel sorting consist of two sequences as loading the parcel into conveyor belt system and post-code input. Using bar code information, the parcels to be recorded and managed are recognized. This paper describes a 32 $\times$ 32 sized mini-block inspection to extract bar code Region of Interest (ROI) from the line Charged Coupled Device (CCD) camera capturing image of moving parcel at 2m/sec speed. Firstly, the Min-Max distribution of the mini-block has been applied to discard the background of parcel and region of conveying belts from the image. Secondly, the diagonal inspection has been used for the extraction of letters and bar code region. Five horizontal line scanning detects the number of edges and sizes and ROI has been acquired from the detection. The wrong detected area has been deleted by the comparison of group size from labeling processes. To correct excluded bar code region in mini-block processes and for analysis of bar code information, the extracted ROI 8 boundary points and decline distribution have been used with central axis line adjustment. The ROI extraction and central axis creation have become enable within 60～80msec, and the accuracy has been accomplished over 99.44 percentage.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.34 no.4
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• pp.189-196
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• 2011

In this paper, we propose a logical control-based actor-critic algorithm as an efficient approach for the approximation of the capacitated fab scheduling problem. We apply the average reward temporal-difference learning method for estimating the relative value functions of system states, while avoiding deadlock situation by Banker's algorithm. We consider the Intel mini-fab re-entrant line for the evaluation of the suggested algorithm and perform a numerical experiment by generating some sample system configurations randomly. We show that the suggested method has a prominent performance compared to other well-known heuristics.