• 한국환경농학회지
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• 제40권2호
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• pp.142-147
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• 2021

BACKGROUND: Agricultural use and pest control purposes of pesticides may lead to livestock products contamination. Thiodicarb and its degraded product, methomyl, are carbamate insecticides that protect soya bean, maize, fruit, and vegetables and control flies in animal and poultry farms. For maximum residue limit enforcement and monitoring, the JMPR residue definition of thiodicarb in animal products is the sum of thiodicarb and methomyl, expressed as methomyl. This residue definition was set to consider the fact that thiodicarb was readily degraded to methomyl in animal commodities. And therefore the simultaneous analytical method of thiodicarb and methomyl is required for monitoring in livestock products. METHODS AND RESULTS: The study was conducted using a quick, easy, cheap, effective, rugged, and safe (QuEChERS) method and HPLC-MS/MS to determine the thiodicarb and methomyl in livestock products. The limit of quantitation (LOQ) was 0.01 mg/kg for livestock products, including beef, pork, chicken, milk, and egg. The coefficient of determinations (r²) for the calibration curve were > 0.99, which was acceptable values for linearity. Average recoveries at spiked levels (LOQ, 10LOQ, and 50LOQ, n=5) in triplicate ranged from 73.2% to 102.1% and relative standard deviations (RSDs) were less than 10% in all matrices. CONCLUSION: The analytical method was validated for the performance parameters (specificity, linearity, accuracy, and precision) in livestock products to be acceptable by the CODEX guidelines.

• Journal of Preventive Medicine and Public Health
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• 제54권5호
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• pp.293-300
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• 2021

The study aims to examine the current status and differences in the burden of disease in Korea during 2008-2018. We calculated the burden of disease for Koreans from 2008 to 2018 using an incidence-based approach. Disability adjusted life years (DALYs) were expressed in units per 100 000 population by adding years of life lost (YLLs) and years lived with disability (YLDs). DALY calculation results were presented by gender, age group, disease, region, and income level. To explore differences in DALYs by region and income level, we used administrative district and insurance premium information from the National Health Insurance Service claims data. The burden of disease among Koreans showed an increasing trend from 2008 to 2018. By 2017, the burden of disease among men was higher than that among women. Diabetes mellitus, low back pain, and chronic lower respiratory disease were ranked high in the burden of disease; the sum of DALY rates for these diseases accounted for 18.4% of the total burden of disease among Koreans in 2018. The top leading causes associated with a high burden of disease differed slightly according to gender, age group, and income level. In this study, we measured the health status of Koreans and differences in the population health level according to gender, age group, region, and income level. This data can be used as an indicator of health equity, and the results derived from this study can be used to guide community-centered (or customized) health promotion policies and projects, and for setting national health policy goals.

• Wind and Structures
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• 제32권4호
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• pp.355-369
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• 2021

Shape optimization of tall buildings is an efficient approach to mitigate wind-induced effects. Several studies have demonstrated the potential of shape modifications to improve the building's aerodynamic properties. On the other hand, it is well-known that the cross-section geometry has a direct impact in the floor area availability and subsequently in the building's profitability. Hence, it is of interest for the designers to find the balance between these two design criteria that may require contradictory design strategies. This study proposes a surrogate-based multi-objective optimization framework to tackle this design problem. Closed-form equations provided by the Eurocode are used to obtain the wind-induced responses for several wind directions, seeking to develop an industry-oriented approach. CFD-based surrogates emulate the aerodynamic response of the building cross-section, using as input parameters the cross-section geometry and the wind angle of attack. The definition of the building's modified plan shapes is done adopting the reduced basis approach, advancing the current strategies currently adopted in aerodynamic optimization of civil engineering structures. The multi-objective optimization problem is solved with both the classical weighted Sum Method and the Weighted Min-Max approach, which enables obtaining the complete Pareto front in both convex and non-convex regions. Two application examples are presented in this study to demonstrate the feasibility of the proposed strategy, which permits the identification of Pareto optima from which the designer can choose the most adequate design balancing profitability and occupant comfort.

• 한국산학기술학회논문지
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• 제20권6호
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• pp.402-409
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• 2019

치매 환자나 혼자 힘으로 전혀 움직이지 못하는 노인 환자는 간병 인력 부족으로 낙상 사고 및 욕창 발생 가능성이 매우 크다. 본 논문에서는 이러한 문제를 해결하기 위해 일정 주기마다 감지한 압력 세기를 기준으로 머리, 어깨, 엉덩이 등 주요 신체 부위를 판별하여 환자의 누운 자세를 판별할 수 있는 알고리즘을 제안한다. 신체적 특성에 무관하게 신체 부위 판별이 가능하도록 격자 구조로 압력 센서를 배치한 스마트 매트를 제작하였다. 스마트 매트는 $7{\times}7$ 배열 크기의 2개 모듈을 조합하여 구성하였다. 각 모듈은 모두 49개의 FSR-406 센서로 구성되며 독립적으로 압력을 감지한다. 각 모듈에 대해 필터를 사용한 누적 압력 합 등 압력 분포를 이용해 상체 또는 하체에 해당하는 신체 부위를 순차적으로 판별한다. 제안한 알고리즘은 머리, 어깨, 엉덩이 부위 등 계층-1에 속한 신체 부위간 포함 관계를 조사해 5가지 누운 자세를 판별할 수 있다.

• 국제지역연구
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• 제14권2호
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• pp.205-227
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• 2010

생산입지의 결정으로 인한 투자, 생산 및 마케팅에 이르기까지 사업의 성과에 미치는 영향은 장기간 지속되기 때문에 합리적인 의사결정이 매우 중요하다. 특히 우리가 잘 알지 못하는 지역에서의 생산입지는 더욱 체계적이고 합리적인 방법을 적용할 필요가 있다. 본 실증연구의 대상 지역인 중국은 2050부터 미국을 앞지르는 세계최대의 경제대국을 표방하고 있는 상황임을 감안할 때, 수출의존도가 매우 높은 한국으로서는 대중국 직접 투자에 대한 연구가 매우 필요하다고 볼 수 있다. 본 논문에서는 생산입지선정에 대한 선행연구에서 중요요인으로 고려된 바 있는 요인들을 정리하고, 한국 및 중국의 기업인들 및 전문가들에 의한 브레인스토밍(brain storming)방식의 설문을 통해서 평가 항목 대상들을 선정하였다. 생산입지 결정을 비롯한 다양한 분야에서 활용되고 있는 계층분석과정(AHP: Analytic Hierarchy Process)을 이용하여 양국 기업인들 간 생산입지선정 시 고려하는 요인들에 대한 중요도 인식에 차이가 있는지 실증적으로 규명하기 위해서 중국의 상해 및 심양 지역을 대상으로 실증적인 연구를 하였다.

• Journal of Microbiology and Biotechnology
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• 제32권5호
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• pp.638-644
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• 2022

Probiotics modulate the gut microbiota, which in turn regulate immune responses to maintain balanced immune homeostasis in the host. However, it is unclear how probiotic bacteria regulate immune responses. In this study we investigated the immunomodulatory effects of heat-killed probiotics, including Lactiplantibacillus plantarum KC3 (LP3), Lactiplantibacillus plantarum CKDB008 (LP8), and Limosilactobacillus fermentum SRK414 (LF4), via phagocytosis, nitric oxide (NO), and pro-inflammatory cytokine production in macrophages. We thus found that heat-killed LP8 could promote the clearance of foreign pathogens by enhancing the phagocytosis of macrophages. Treatment with heat-killed LP8 induced the production of NO and pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β. In addition, heat-killed LP8 suppressed the production of NO and cytokines in LPS-induced RAW264.7 cells, suggesting that heat-killed LP8 exerts immunomodulatory effects depending on the host condition. In sum, these results indicate that heat-killed LP8 possesses the potential for immune modulation while providing a molecular basis for the development of functional probiotics prepared from inactivated bacterial cells.

• 한국인터넷방송통신학회논문지
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• 제22권1호
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• pp.163-170
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• 2022

본 논문은 실생활 속 정제되지 않은 입력으로 인해 안면의 특징점을 추출하여 객체 인식 모델의 이상적인 성능과 속도를 보증해주지 못하는 문제점을 가중치 합산을 통한 저장 알고리즘을 통해 개선하는 방법을 소개한다. 많은 안면인식 프로세스들은 이상적인 상황에서의 정확도를 보장해주지만, 실생활에서 발생할 수 있는 수많은 방해요인에 대해서는 대처하지 못한다는 문제점이 주목받고 있으며 이는 곧 보안과 밀접하게 관련된 안면인식 프로세스에서 심각한 문제를 발생할 수도 있다. 본 논문에서는 사람의 고유한 특징점은 사진의 구도 등의 여러 변수가 있어도 결국 평균적인 하나의 형태를 띤다는 점을 이용하여 입력으로 추출된 특징점을 여러 방해 요인에 과적합 되어있지 않은 소수의 특징점과 비교를 통해 실시간으로 빠르게, 그리고 정확하게 안면인식을 할수 있는 방법을 가중치 합산방식을 통하여 제시한다.

• The Korean Journal of Physiology and Pharmacology
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• 제26권2호
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• pp.125-133
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• 2022

Carbon monoxide (CO) is a known gaseous bioactive substance found across a wide array of body systems. The administration of low concentrations of CO has been found to exert an anti-inflammatory, anti-apoptotic, anti-hypertensive, and vaso-dilatory effect. To date, however, it has remained unknown whether CO influences atrial natriuretic peptide (ANP) secretion. This study explores the effect of CO on ANP secretion and its associated signaling pathway using isolated beating rat atria. Atrial perfusate was collected for 10 min for use as a control, after which high atrial stretch was induced by increasing the height of the outflow catheter. Carbon monoxide releasing molecule-2 (CORM-2; 10, 50, 100 μM) and hemin (HO-1 inducer; 0.1, 1, 50 μM), but not CORM-3 (10, 50, 100 μM), decreased high stretch-induced ANP secretion. However, zinc porphyrin (HO-1 inhibitor) did not affect ANP secretion. The order of potency for the suppression of ANP secretion was found to be hemin > CORM-2 >> CORM-3. The suppression of ANP secretion by CORM-2 was attenuated by pretreatment with 5-hydroxydecanoic acid, paxilline, and 1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one, but not by diltiazem, wortmannin, LY-294002, or NG-nitro-L-arginine methyl ester. Hypoxic conditions attenuated the suppressive effect of CORM-2 on ANP secretion. In sum, these results suggest that CORM-2 suppresses ANP secretion via mitochondrial K_ATP channels and large conductance Ca²⁺-activated K⁺ channels.

• 한국인터넷방송통신학회논문지
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• 제22권4호
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• pp.95-102
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• 2022

본 논문은 NP-완전으로 다항시간 알고리즘이 알려져 있지 않은 3-분할 문제(TPP)에 대한 선형시간 알고리즘을 제안하였다. 본 논문은 기존에 알려진 다항시간 알고리즘인 최대-최소치와 제3의 숫자 합을 이용하는 MM법이 갖고 있는 해를 구하지 못하는 문제점을 개선한 역추적 법을 제안하였으며, 또한 역추적 법을 적용한 MM의 문제점도 개선하였다. 제안된 알고리즘은 내림차순 정렬된 S 집합을 3-분할하여 순방향, 역방향과 최대 여유량 순서인 최적합 배정 법으로 배정한 결과 10개 데이터 중 5개 데이터인 50.00%에 대해서는 최적 해를 찾을 수 있었다. 나머지 5개 데이터에 대해서도 최소 1회, 최대 7회의 잉여 상자와 부족 상자 간 숫자 교환으로 최적 해를 찾을 수 있는 성능을 보였다. 제안된 알고리즘은 n개 데이터를 3-분할한 m=n/3 보다도 적은 O(k)의 선형시간 수행 복잡도로 단순 배정과 교환 최적화를 수행하는 알고리즘으로 TPP가 NP-완전이 아닌 P-문제인 다항시간 알고리즘이 존재할 수 있음을 보였다.

• 한국농공학회논문집
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• 제65권3호
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• pp.29-42
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• 2023

Universal Soil Loss Equation (USLE) is suggested and employed in the policy to conserve soil resources and to manage the impact of development, since soil loss is very essential to nonpoint source pollution management. The equation requires only five factors to estimate average annual potential soil loss, USLE is simplicity provides benefits in use of the equation. However, it is also limitation of the model, since the estimated results are very sensitive to the five factors. There is a need to examine the application procedures. Three approaches to estimate potential soil loss were examined, In the first approach, all factors were prepared with raster data, soil loss were computed for each cell, and sum of all cell values was determined as soil loss for the watersheds. In the second approach, the mean values for each factor were defined as representing USLE factors, and then the five factors were multiplied to determine soil loss for the watersheds. The third approach was same as the second approach, except that the Vegetative and Mechanical measure was used instead of the Cover and management factor and Support practice factor. The approaches were applied in 38 watersheds, they displayed significant difference, moreover no trends were detected for the soil loss at watersheds with the approaches. Therefore, it was concluded that there is a need to be developed and provided a typical guideline or public systems so that soil loss estimations have consistency with the users.