• Experimental and Molecular Medicine
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• v.50 no.12
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• pp.12.1-12.14
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• 2018

Osteoporosis develops with high prevalence in both postmenopausal women and hypogonadal men. Osteoporosis results in significant morbidity, but no cure has been established. Mesenchymal stem cells (MSCs) critically contribute to bone homeostasis and possess potent immunomodulatory/anti-inflammatory capability. Here, we investigated the therapeutic efficacy of using an infusion of MSCs to treat sex hormone-deficient bone loss and its underlying mechanisms. In particular, we compared the impacts of MSC cytotherapy in the two genders with the aim of examining potential gender differences. Using the gonadectomy (GNX) model, we confirmed that the osteoporotic phenotypes were substantially consistent between female and male mice. Importantly, systemic MSC transplantation (MSCT) not only rescued trabecular bone loss in GNX mice but also restored cortical bone mass and bone quality. Unexpectedly, no differences were detected between the genders. Furthermore, MSCT demonstrated an equal efficiency in rectifying the bone remodeling balance in both genders of GNX animals, as proven by the comparable recovery of bone formation and parallel normalization of bone resorption. Mechanistically, using green fluorescent protein (GFP)-based cell-tracing, we demonstrated rapid engraftment but poor inhabitation of donor MSCs in the GNX recipient bone marrow of each gender. Alternatively, MSCT uniformly reduced the $CD3^+T$-cell population and suppressed the serum levels of inflammatory cytokines in reversing female and male GNX osteoporosis, which was attributed to the ability of the MSC to induce T-cell apoptosis. Immunosuppression in the microenvironment eventually led to functional recovery of endogenous MSCs, which resulted in restored osteogenesis and normalized behavior to modulate osteoclastogenesis. Collectively, these data revealed recipient sexually monomorphic responses to MSC therapy in gonadal steroid deficiency-induced osteoporosis via immunosuppression/anti-inflammation and resident stem cell recovery.

• Journal of the Korea Institute of Military Science and Technology
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• v.17 no.6
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• pp.718-724
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• 2014

Insensitive Munition(IM) reduces the explosive weakness of munitions, at the same time, maintains its performances in the moment of discharge, which improves safety of soldiers and minimizes unexpected accidents and casualties from being shot in case of transportation, storage and military operation. Development of IM has been focused as the global trend, which was required to satisfy the demand of army that is to minimize the loss of non-battle forces and to retain the competitiveness in export abroad. In this study, we categorize all the munitions used by ROK Army, then determine the priority of IM by deploying AHP(Analytic Hierarchy Process) method. In conclusion, we suggest the priority of IM which is suitable to the affairs of ROK Army.

• Industrial Engineering and Management Systems
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• v.14 no.1
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• pp.88-93
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• 2015

In this paper, we identify the characteristics of modeling and simulation (M&S) for military and defense and propose the method of verification, validation, and accreditation (VV&A) using the identified characteristics. M&S has been widely used for many different applications in military and defense, including training, analysis, and acquisition. Various methods and processes of VV&A have been proposed by researchers and M&S practitioners to guarantee the correctness of M&S. The notion of applying formal credibility assessment in VV&A originated in software engineering reliability testing and the systems engineering development process. However, the VV&A techniques and processes proposed for M&S by the research community have not addressed the characteristics and issues specific to military and defense. We first identify the characteristics and issues of military/defense M&S and then propose techniques and methods for VV&A that are specific for military/defense M&S. Possible approaches for the development of VV&A are also proposed.

• Journal of the Korea Institute of Military Science and Technology
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• v.22 no.3
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• pp.341-352
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• 2019

LTV(Light Tactical vehicle) operating in our military requires higher levels of performance and durability to withstand harsher conditions than ordinary vehicles, as they must travel on both rough-train and off-road as well as on public roads. Recently, developed light tactical vehicle is developed by a variety of test evaluations in order to satisfy ROC(Required Operational Capability) by the requirement military group. However, there is no standardized driving test condition for satisfying the durability performance of Korean tactical vehicle. Therefore, this study aims to provide basic data to establish reliable driving test conditions by analyzing the maneuver conditions and the driving data in order to select the representative drive course required. To do this, we analyzed the future operational environment, the area of operation analysis and the driving information of light tactical vehicle.

• BMB Reports
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• v.49 no.10
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• pp.548-553
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• 2016

Mesenchymal stem cells (MSCs) are widely used in cartilage tissue engineering to repair articular cartilage defects. However, hypertrophy of chondrocytes derived from MSCs might hinder the stabilization of hyaline cartilage. Thus, it is very important to find a suitable way to maintain the chondrogenic phenotype of chondrocytes. It has been reported that cordycepin has anti-inflammatory and anti-tumor functions. However, the role of cordycepin in chondrocyte hypertrophy remains unclear. Therefore, the objective of this study was to determine the effect of cordycepin on chondrogenesis and chondrocyte hypertrophy in MSCs and ATDC5 cells. Cordycepin upregulated chondrogenic markers including Sox9 and collagen type II while down-regulated hypertrophic markers including Runx2 and collagen type X. Further exploration showed that cordycepin promoted chondrogenesis through inhibiting Nrf2 while activating BMP signaling. Besides, cordycepin suppressed chondrocyte hypertrophy through PI3K/Bapx1 pathway and Notch signaling. Our results indicated cordycepin had the potential to maintain chondrocyte phenotype and reconstruct engineered cartilage.

• Korean Journal of Construction Engineering and Management
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• v.17 no.2
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• pp.110-117
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• 2016

This paper shows procedure and strategies to improve military facilities and local residents' welfare through a civil-military sustainable cooperation project. Military installations tend to impede urban developments, so that a few civil compliant have been often filed. Meanwhile, it is sometimes impossible to relocate military units due to their own unique purpose, even though they belong to core sites of civil developments, which are generally indispensible due to urban expansion, magnified road networks and so on. The solution to offset these conflicts between civil and military demands, which are associated with military units and urbanization surrounding them, is to establish sustainable strategies which enable both civil and military be beneficial. In this study, it is described, decision making procedure to make some facilities of a military unit be better as well as promote local residents' welfare through securing high-quality sports facilities. Delphi-technique and Paired Comparison Method are used to collect civil and military opinions regarding sustainable agreements. As a case study, a civil military cooperation project between a military unit and a local government is introduced. With successful projects, it is expected that the better installations could lead positive images of a military unit, provide advanced athletic environments for both local residents and military personnels, and lessen defense cost to maintain them. Moreover, this project will go down as a paragon of civil military sustainable cooperation.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.28 no.3
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• pp.707-716
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• 2018

Recently, instead of technical cyber operations that directly attack the target information system by using cyber attack techniques, social engineering techniques that indirectly invade the system by exploiting the vulnerabilities of persons who manage the system are being watched. Despite this trend, there is a lot of confusion because there is no clear concept about the relationship between cyber operations and social engineering techniques. Therefore, this paper aims at establishing a clear concept of a social engineering cyber operation, helping future researchers in this literature.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.43 no.3
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• pp.228-242
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• 2020

In recent years, interest in the welfare of soldiers is increasing. More specifically, soldiers enlisted to fulfill their military service obligations live a group life that is controlled by group life, unlike military officers selected by their will. Therefore, this study aims to verify whether there is an effect of improving the morale of soldiers by increasing the satisfaction of military service meals along with the trend of increasing morale through enhancement of soldier welfare. In order to achieve the purpose of this study, we surveyed 145 army soldiers working in the front and rear areas and used 137 valid samples for analysis. The results of this study are as follows. First, both SERVQUAL (Responsiveness·Assurance, Tangibles) and Servicescape (Spatial Environment, Spatial Design) had a positive (+) effect on military meal satisfaction. Second, military service satisfaction and emotional commitment have a positive (+) effect on morale. Third, satisfaction with military meals has a positive effect on emotional commitment. This research has also shown that improvements in SERVQUAL (Responsiveness·Assurance, Tangibles) and Servicescape (Spatial Environment, Spatial Design) improve military service satisfaction and emotional engagement. Military food service SERVQUAL (Responsiveness·Assurance, Tangibles) and Servicescape (Spatial Environment, Space Design) must pay attention to increase military morale.

• Journal of the Korean Society of Safety
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• v.37 no.6
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• pp.71-80
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• 2022

Since the 2000s, the demand for private demolition works has been gradually increasing as the apartment housing market has been led by redevelopment and reconstruction. In the case of the military, the Ministry of National Defense is consolidating troops from each military unit to reorganize the unit structure in accordance with Defense Reform 2.0; the plan includes reducing the garrison used by each unit to 70% of its current level. Accordingly, the demand for demolition work in the military is also expected to increase. However, the military regulations do not reflect the relevant laws that have been revised recently. This study identifies regulations and system improvements for demolition work suitable for the military based on an analysis of accident cases that have occurred during demolition work, of domestic and foreign laws and regulations related to military demolition work, and of the problems with current military safety management at each stage of planning, design, and construction. The study subsequently proposes improvements for military demolition work, including budget execution adjustment, the establishment of training courses, on-site inspections, the development of guidelines for military demolition work, the provision of risk assessment standards, and the need for the qualification of equipment operators.

• Proceedings of the Korea Information Processing Society Conference
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• 2012.04a
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• pp.279-282
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• 2012

본 연구에서는 혼합형 온톨로지 구축방법론을 이용하여 ATCIS 체계에 활용 가능한 국방온톨로지의 구축 과정을 보여주고자 한다. 이를 위해, 실제 ATCIS의 데이터베이스 정보들을 활용하였고 해당 방법론이 ATCIS 체계에 적용될 때 추가적으로 고려해야 할 사항들을 함께 분석하였다. 이러한 연구 결과는 향후 보다 실용적인 국방온톨로지 구축을 위한 기반 자료로 활용될 것으로 기대된다.