• The Journal of the Korea Contents Association
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• v.11 no.1
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• pp.411-421
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• 2011

This study aims to analyze the trend of migration and to find the factors which influence to migration in Chuncheon, Wonju and Gangneung. The results are as follows. First, the employment chance and education chance give positive effect to migration. And it agrees with the results of the preceeding researches. Second, Though the statistical significance is low, the result that urbanized degree gives positive effect to migration indicates the possibility of positive effect of urban convenience to migratioin. Third, the pavement rate of the roads which is substituted for public goods service gives the negative effect to migratioin, though the statistical significance is low. This result shows the possibility that the road building has influenced the extending of traffic distance and the spreading of residence area. In conclusion, this study identifies the positive effect of employment chance and education chance to migration, and the results of this study are supposed to be considered in the regional plan in Gangwon-do.

• Journal of Agricultural Extension & Community Development
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• v.23 no.3
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• pp.335-346
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• 2016

For the purpose, this study examines to identify factors influencing urban to rrual migration for farming. This study analyzed 217 urban to rural migrant farmers. The result of this study were as follows: the influence of the main variables on the agricultural challenges of the urban to rural migrant farmers were observed as the relationship of the level of financial preparations, the motivations of urban to rural migration, the agricultural income, the annual of urban to rural migration, the size of agricultural, gender, and age. This study result show that urban to rural migrant farmers' agricultural challenges is influenced by almost economical factors. Therefore, for the successful agricultural activities of the urban to rural migrant farmers show significant impact to need on the composite effort of all such as the individual, the family, the rural society, local autonomous entity, the government.

• Geomechanics and Engineering
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• v.35 no.6
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• pp.627-636
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• 2023

The essence of subgrade mud pumping under train load is the migration of fine particles in subgrade soil. The migration of fine particles will change the pore structure of overlying ballast, thus affecting the mechanical properties and hydraulic properties of ballast layer. It is of great theoretical significance and engineering value to study the effect of fine particle migration on the pore structure of ballast layer under cyclic loading. In this paper, a tailor-made subgrade mud pumping test model and an X-ray computed tomography (CT) scanning equipment were used to study the influence of migration of fine particles in subgrade soil on the pore parameters (plane porosity, volume porosity, pore distribution and pore connectivity) of overlying ballast under cyclic loading. The results show that the compression of ballast pores and the blockage of migrated fine particles make the porosity of ballast layer decreases gradually. And the percentage of small pores in ballast layer increases, while the percentage of large pores decreases; the connectivity of pores also gradually decreases. Based on the test results, an empirical model of ballast porosity evolution under cyclic loading is established and verified.

• Journal of Food Hygiene and Safety
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• v.12 no.2
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• pp.132-140
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• 1997

Additives in plastics are capable of migrating from the packaging materials into the foodstuffs, thereby presenting a source of contamination and a potential health risk to the consumer. The migration from packaging materials into foodstuffs is first of all regulated by examining the amounts of global and specific migrated components. Besides, there is worldwide still a need for practical methods for measuring and monitoring migration from polymers, especially for the testing of migration into fatty foodstuffs. Therefore, these studies were undertaken to investigate the safety status of domestic plastic packaging materials with respect to migration. Another objective of this study was to examine the applicability of ethanol as an alternative fatty food simulant substituting for olive oil and n-heptane. The evaporation residues for various dometic plastic samples determined as described in Korean food laws were in the level from 4.3 to 14.5 mg/$\ell$, which were much lower than the limit value of 150 mg/$\ell$. The global migration values into 95 % ethanol showed to be comparable to those into n-heptane, while the olive oil migration values were comparably higher than those into ethanol or n-heptane and moreover they were not reproducible. The kinetic migration begavior of additives in polyolefin samples into 95% ethanol showed a Fickian diffusion process. The results of these studies on global migration and kinetic testings demonstrate that the ethanol could be successfully substitute for the olive oil and n-heptane as an alternative fatty food simulant, at least in contact with polyoefins.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.10
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• pp.4239-4243
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• 2014

Background: This study investigated the influence of curcumin on HOX transcript antisense RNA (HOTAIR)-mediated migration of cultured renal cell carcinoma (RCC) cells. Materials and Methods: Five RCC cell lines (769-P, 769-P-vector, 769-P-HOTAIR, 786-0, and Kert-3 ) were maintained in vitro. The expression of HOTAIR mRNA was determined by quantitative real-time PCR and cell migration was measured by transwell migration assay. The effects of different concentrations of curcumin (0 to $80{\mu}mol/L$) on cell proliferation was determined by the CCK-8 assay and influence of non-toxic levels (0 to $10{\mu}M$) on the migration of RCC cells was also determined. Results: Comparison of the 5 cell lines indicated a correlation between HOTAIR mRNA expression and cell migration. In particular, the migration of 769-P-HOTAIR cells was significantly higher than that of 769-P-vector cells. Curcumin at $2.5-10{\mu}M$ had no evident toxicity against RCC cells, but inhibited cell migration in a concentration-dependent manner. Conclusions: HOTAIR expression is correlated with the migration of RCC cells, and HOTAIR may be involved in the curcumin-induced inhibition of RCC metastasis.

• IMMUNE NETWORK
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• v.5 no.4
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• pp.247-251
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• 2005

Background: Natural killer (NK) cells are CD3 (-) CD14 (-) CD56 (+) lymphocytes. They play an important role in the body's innate immune response. They can induce spontaneous killing of cancer cells or virus-infected cells via the Fas/Fas ligand or the granzyme/perforin systems. The corticotropin-releasing hormone (CRH) is an important regulator for the body's stress response. It promotes proliferation and migration of various cancer cells through the CRH type 1 receptor under stress, and also inhibits NK or T cell activity. However, the relationship of CRH and NK cell migration to the target has not been confirmed. Herein, we study the effect of CRH on NK cell migration. Methods: We used the human NK cell line, NK-92MI, and tested the expression of CRH receptor type 1 on NK-92MI by RT-PCR. This was to examine the effect of CRH on tumor and NK cell migration, thus NK cells (NK-92MI) were incubated with or without CRH and then each CRH treated cell's migration ability compared to that of the CRH untreated group. Results: We confirmed that CRH receptor type 1 is expressed in NK-92MI. CRH can decrease NK cell migration in a time-/dose-dependent manner. Conclusion: These data suggest CRH can inhibit NK cell migration to target cells.

• The Korean Journal of Community Living Science
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• v.20 no.2
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• pp.193-204
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• 2009

Although the majority of elderly are residentially stable, many western studies have recently reported that there has been a gradual growth of retirement migration. However, little is known about that in Korea. Therefore, this study intended to examine the trend and nature of elderly migration. For this purpose, inter- and intra-province migration among the aged 65 and over were analyzed, using the migration data of the Korea National Statistical Office, compiled from the 2000 and 2006 resident registration records. The results were as follows. First, there was an increase of elderly migrants to 531 thousand persons in 2006 from 383 thousand persons in 2000. Secondly, the migration rate of elderly has steadily grown with a 11.7% in 2000 and 12% in 2006. Also, the move of female among old population was active but this trend tended to decrease in 2006. Thirdly, the number of provinces which showed a positive net inter-province migration of old population increased from 7 provinces in 2000 to 8 provinces in 2006. Fourthly, we found that the destinations of elderly migrants were mostly neighboring province except the Chungnam, Jeonbuk, and Jeju. These results suggested that elderly migration would be expected to increase gradually and be important in the future of Korea.

• Geophysics and Geophysical Exploration
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• v.6 no.3
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• pp.153-159
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• 2003

Using reciprocity theorem, one direction aperture of seismogram can be extended to full aperture seismogram. Modified seismogram is applied to reverse time migration only to acquire improved migration image. In this paper, we tested reverse time migration with the Marmousi velocity data to examine efficiency of modified seismogram. And linearly increasing velocity model is selected and examined for a case where velocity data is insufficient. When true velocity is applied, using modified seismogram enhances the reverse time migration image more than using original seismogram. In the case of using linearly increasing velocity model, migration image is distorted. So low frequency source is brought in migration process. Reverse time migration image with low frequency source and linearly increasing velocity model is improved when modified seismogram is used. From the result of study, seismogram modification by reciprocity theorem is useful and migration image can be enhanced.

• IMMUNE NETWORK
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• v.11 no.6
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• pp.342-347
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• 2011

Background: Glial cells are involved in immune and inflammatory responses in the central nervous system (CNS). Glial cells such as microglia and astrocytes also provide structural and functional support for neurons. Migration and morphological changes of CNS cells are associated with their physiological as well as pathological functions. The secreted protein lipocalin-2 (LCN2) has been previously implicated in regulation of diverse cellular processes of glia and neurons, including cell migration and morphology. Methods: Here, we employed a zebrafish model to analyze the role of LCN2 in CNS cell migration and morphology in vivo. In the first part of this study, we examined the indirect effect of LCN2 on cell migration and morphology of microglia, astrocytes, and neurons cultured in vitro. Results: Conditioned media collected from LCN2-treated astrocytes augmented migration of glia and neurons in the Boyden chamber assay. The conditioned media also increased the number of neuronal processes. Next, in order to further understand the role of LCN2 in the CNS in vivo, LCN2 was ectopically expressed in the zebrafish spinal cord. Expression of exogenous LCN2 modulated neuronal cell migration in the spinal cord of zebrafish embryos, supporting the role of LCN2 as a cell migration regulator in the CNS. Conclusion: Thus, LCN2 proteins secreted under diverse conditions may play an important role in CNS immune and inflammatory responses by controlling cell migration and morphology.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.9
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• pp.4019-4023
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• 2014

Metformin has been shown to be useful in reducing insulin resistance by restoring sensitivity. Recent evidence suggests that metformin might also possess anti-tumour activity. This study aimed to investigate the effects of cisplatin combined with metformin on the proliferation, invasion and migration of HNE1/DDP human nasopharyngeal carcinoma (NPC) cells, and to provide a new target for treating metastasis. The MTT assay was used to assess viability of HNE1/DDP cells after exposure to different concentrations of 2, 5-diaminopyrimidine-4, 6-diol (DDP; 2, 4, 8, 16, and $32{\mu}mol{\cdot}L^{-1}$), metformin (5, 10, 15, 20, and $25{\mu}mol{\cdot}L^{-1}$), and $4{\mu}mol{\cdot}L^{-1}$ of DDP combined with metformin. Wound healing and transwell migration assays were performed to assess cell migration and invasion, and expression of E-cadherin and MMP-9 was detected using Western blotting. MTT assay results showed that DDP could inhibit the proliferation of HNE1/DDP cells in a time- and concentration-dependent manner, with an IC50 of $32.0{\mu}mol{\cdot}L^{-1}$ at 24 h (P < 0.05), whereas low concentrations of DDP had almost no inhibitory effects on cell invasion and migration. DDP combined with metformin significantly inhibited cell invasion and migration. In addition, genes related to migration and invasion, such as those of E-cadherin and MMP-9, showed differential expression in the NPC cell line HNE1/DDP. In the present study, with an increasing concentration of metformin, the expression of MMP-9 was downregulated whereas that of E-cadherin was significantly upregulated. Taken together, our results show that cisplatin combined with metformin has effects on proliferation, invasion, and migration of human NPC cells.