• Parasites, Hosts and Diseases
• /
• 제49권2호
• /
• pp.145-151
• /
• 2011

The comparative efficacy of 2 anthelmintics (ivermectin and levamisole) against Baylisascaris transfuga migrating and encapsulated larvae was studied in mice. A total of 60 BALB/c mice inoculated each with about 1,000 embryonated B. transfuga eggs were equally divided into 6 groups (A-F) randomly. Mice of groups A and B were treated with ivermectin and levamisole, respectively, on day 3 post-infection (PI). Mice of groups A-C were killed on day 13 PI. Similarly, groups D and E were treated with ivermectin and levamisole, respectively, on day 14 PI, and all mice of groups D-F were treated on day 24 PI. The groups C and F were controls. Microexamination was conducted to count the larvae recovering from each mouse. The percentages of reduction in the number of migrating larvae recovered from group A (ivermectin) and B (levamisole) were 88.3% and 81.1%, respectively. In addition, the reduction in encapsulated larvae counts achieved by ivermectin (group D) and levamisole (group E) was 75.0% and 49.2%, respectively. The results suggested that, to a certain extent, both anthelmintics appeared to be more effective against migrating larvae than encapsulated larvae. However, in the incipient stage of infection, ivermectin may be more competent than levamisole as a larvicidal drug for B. transfuga.

• Parasites, Hosts and Diseases
• /
• 제37권2호
• /
• pp.101-107
• /
• 1999

Rats were immunized through an initial infection with 1,000 filariform larvae (L3) of Nippostrongylus brasiliensis and after complete expulsion of worms they were challenged with 1,000 L3 of Strongyloides venezuelensis to investigate whether cross-resistance developed against a heterologous parasite. Nippostrongylus brasiliensis immunized rats developed a partial cross-resistance against S.venezuelensis migrating larvae (MSL3) in the lungs and adult worms in the small intestine. The population of MSL3 in the lungs were significantly lower (p<0.05) in immunized rats($22.0{\;}{\pm}{\;}7.4$) compared with controls ($105.0{\;}{\pm}{\;}27.6$). The populations of adult worms, egg output and fecundity were initially decreased but from day 14 post-challenge they did not show any significant difference between immunized and control rats. However, the length of worm in immunized rat was revealed as retardation. Peripheral blood eosinophilia was significantly decreased (P<0.05) on day 7 post-challenge and then gradually increased which peaked on da 42 post-challenge when most of the worms were expelled. these results suggest that peripheral blood eosinophilia is strongly involved in the worm establishment and expulsion mechanisms.

• 한국어병학회지
• /
• 제23권1호
• /
• pp.123-129
• /
• 2010

2006년부터 2008년까지 국내로 회귀하는 연어(O. keta)의 소상위치, 암수 및 근육 부위별 아니사키스형 유충의 감염상을 조사하였다. 3년 동안강에서 채집된 연어 17마리와 바다에서 채집된 13마리의 아니사키스형 유충의 감염율을 조사한 결과, 강에서 채집된 연어의 수컷 및 암컷은 마리 당 아니사키스형 유충이 각각 평균 $98{\pm}27$ 및 $103{\pm}27$ 마리씩 감염되어져 있었다. 바다에서 채집된 연어의 수컷 및 암컷은 마리 당 아니사키스형 유충이 각각 평균 $63{\pm}18$ 및 $108{\pm}17$ 마리씩 감염되어져 있었고, 암수 및 소상위치간의 아니사키스형 유충의 감염 마리수에서 통계학적 차이는 없는 것으로 나타났다. 아니사키스형 유충의 근육 부위별로 조사하면 복강내측근육 (abdominal muscle)에 85%가 기생하며, 내장기관에는 거의 유충이 발견되지 않았다. 동정된 아니사키스형 유충은 Anisakis type이 74%며, 나머지는 Contracacecum type로 분류되었다. 연어 근육내에서 아니사키스형 유충의 저온처리에 따른 생존율을 조사하였을시에 최소 6시간 이상의 냉동보존 ($-20^{\circ}C$)만이 아니사키스형 유충이 죽는다는 사실을 알 수 있었다.

• Parasites, Hosts and Diseases
• /
• 제51권3호
• /
• pp.297-304
• /
• 2013

Trichinosis is a parasitic zoonosis caused by the nematode Trichinella spiralis. Anthelmintics are used to eliminate intestinal adults as well as tissue-migrating and encysted larvae. This study aimed to investigate the effects of ivermectin and myrrh obtained from the aloe-gum resin of Commiphora molmol on experimental trichinosis. Ninety albino mice were orally infected with 300 T. spiralis larvae. Drugs were tested against adult worms at day 0 and day 5 and against encysted larvae on day 15 and day 35 post-infection (PI). Mature worms and encysted larvae were counted in addition to histopathological examination of muscle specimens. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein, albumin, globulin, urea, and creatinine values were estimated. Significant reductions in mean worm numbers were detected in ivermectin treated mice at day 0 and day 5 PI achieving efficacies of 98.5% and 80.0%, while efficacies of myrrh in treated mice were 80.7% and 51.5%, respectively. At days 15 and 35 post-infection, ivermectin induced significant reduction in encysted larval counts achieving efficacies of 76.5% and 54.0%, respectively, while myrrh efficacies were 76.6% and 35.0%, respectively. AST, ALT, urea, and creatinine levels were reduced, while total proteins were increased in response to both treatments compared to their values in the infected non-treated mice. Ivermectin use for controlling T. spiralis could be continued. Myrrh was effective and could be a promising drug against the Egyptian strains of T. spiralis with results nearly comparable to ivermectin.

• Tuberculosis and Respiratory Diseases
• /
• 제67권3호
• /
• pp.229-233
• /
• 2009

Sparganosis is a zoonosis caused by the migrating larvae of cestode genus Spirometra. We report a rare form of sparganosis that invades the lung. A 44-year-old man presented with newly appeared pulmonary nodules that were found accidentally on regular medical checkup, and on sequential chest CT, which we checked at an interval of every 2 months, revealed that the pulmonary lesion had migrated. The patient had a medical history of having undergone surgical excisions for sparganosis in muscles and in subcutaneous tissues of the lower abdomen, perianus, thigh, right axilla, and scapula area, several times over 7 years. A right middle lobectomy was performed and the lesion was diagnosed as sparganosis based on the characteristic histological findings.

• 한국응용곤충학회지
• /
• 제50권2호
• /
• pp.115-123
• /
• 2011

굴업도는 면적 $1.71\;km^2$의 작은 섬이지만 멸종위기종인 왕은점표범나비가 많이 서식하고 있다. 이 연구는 굴업도에서 왕은점표범나비의 서식실태 파악을 위해 2010년에 방형구법, 표시-포획법과 선조사법으로 조사하였다. 조사가 충분하지 않았지만, 왕은점표범나비의 유충은 4,467마리 또는 6,700마리, 성충은 약 1,000마리가 서식하는 것으로 추정되었다. 왕은점표범나비는 최우점종으로 전체 나비 개체수의 32%를 차지하였다. 또한 총 28종의 나비가 발견되었고, 이 중 3종은 미접이었다. 1938년부터 2010년까지 전국의 왕은점표범나비 분포지를 시대별로 비교한 결과 2000년대 이후 급감하였으며, 현재 중북부 지역과 서해 도서지역에 제한적으로 서식하는 것으로 나타났다. 굴업도에서 왕은점표범나비가 많이 서식하는 것은 자연상태의 초지가 많으며, 가축의 방목이 적당한 서식처를 제공하기 때문이다.