Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Comparative Efficacy of Ivermectin and Levamisole for Reduction of Migrating and Encapsulated Larvae of Baylisascaris transfuga in Mice

  • Fu, Yan (Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University) ;
  • Nie, Hua-Ming (Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University) ;
  • Niu, Li-Li (Chengdu Zoological Garden) ;
  • Xie, Yue (Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University) ;
  • Deng, Jia-Bo (Chengdu Zoological Garden) ;
  • Wang, Qiang (Chengdu Zoological Garden) ;
  • Yang, Guang-You (Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University) ;
  • Gu, Xiao-Bin (Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University) ;
  • Wang, Shu-Xian (Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University)
  • Received : 2010.12.28
  • Accepted : 2011.01.30
  • Published : 2011.06.30
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Abstract

The comparative efficacy of 2 anthelmintics (ivermectin and levamisole) against Baylisascaris transfuga migrating and encapsulated larvae was studied in mice. A total of 60 BALB/c mice inoculated each with about 1,000 embryonated B. transfuga eggs were equally divided into 6 groups (A-F) randomly. Mice of groups A and B were treated with ivermectin and levamisole, respectively, on day 3 post-infection (PI). Mice of groups A-C were killed on day 13 PI. Similarly, groups D and E were treated with ivermectin and levamisole, respectively, on day 14 PI, and all mice of groups D-F were treated on day 24 PI. The groups C and F were controls. Microexamination was conducted to count the larvae recovering from each mouse. The percentages of reduction in the number of migrating larvae recovered from group A (ivermectin) and B (levamisole) were 88.3% and 81.1%, respectively. In addition, the reduction in encapsulated larvae counts achieved by ivermectin (group D) and levamisole (group E) was 75.0% and 49.2%, respectively. The results suggested that, to a certain extent, both anthelmintics appeared to be more effective against migrating larvae than encapsulated larvae. However, in the incipient stage of infection, ivermectin may be more competent than levamisole as a larvicidal drug for B. transfuga.

Keywords

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