• Title/Summary/Keyword: microsphere

검색결과 223건 처리시간 0.023초

생분해성 Microgel로부터 약물을 담지한 Microsphere의 제조 및 그의 생분해성 (Preparation and Biodegradability of Microsphere Prepared from Biodegradable Microgel)

  • 김공수;강석호;김정묵
    • 공업화학
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    • 제9권4호
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    • pp.591-594
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    • 1998
  • Poly(caprolactone diol)을 기초로하여 합성한 microgel을 이용하여 bovine serum albumine (BSA)를 담지한 생분해성 microsphere를 용매증발법으로 제조하였다. 교반속도, microgel의 농도, 폴리비닐알콜의 농도등이 microsphere의 입도분포에 주는 영향을 조사하였다. Microsphere의 크기는 교반속도가 증가함에 따라 감소하였으나, 염화메틸렌 내의 microgel의 농도가 증가함에 따라서는 거의 비례적으로 증가하는 경향을 나타내었다. 100 unit/mL의 효소용액에서 microsphere의 생분해성에 관하여 조사한 결과, 3시간이 경과한 후에 microsphere의 표면에 작은 세공들이 나타나기 시작하였으며, 24시간 후에는 세공이 발달하고 크랙이 발생하기 시작하였다. 그리고 36시간 경과한 후에는 microsphere의 구형이 일그러짐을 관찰할 수 있었다.

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은 나노입자를 담지한 collagen/silica microsphere 복합체의 제조 (Preparation of Silica/collagen Microsphere Composit Doped with Silver Nanoparticles)

  • 정효정;김연범;장윤호
    • Korean Chemical Engineering Research
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    • 제46권4호
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    • pp.722-726
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    • 2008
  • 실리카 microsphere는 HPLC를 위한 흡착 충진제와 같은 용도로 사용하기에 적합한 혁신적인 소재로 널리 알려져 있다. microsphere을 기능성고분자나 금속, 생리활성 물질과 같은 특정한 성질을 지닌 물질로 표면 개질시키므로 다양한 용도로 활용할 수 있다. 콜라겐은 생체조직을 구성하는 기본 단백질로 생체적합성이 뛰어난 물질로 주목받고 있는 기능성 소재이다. 본 연구에서는 50% 이상의 세공부피를 지닌 다공성 silica microsphere를 고분자 응집법인 PICA 법을 이용하여 colloidal silica로부터 제조하고 콜라겐 hydrogel을 사용하여 표면 개질시키므로 생체적합성을 증진시키는 방법을 연구하였다. 실리카/콜라겐 microsphere 에 은 나노입자를 담지시킨 microsphere 복합체를 만들고 특성을 조사하므로 생체소재로의 활용 가능성을 조사하였다.

마이크로캡슐의 제조와 응용 - 분산중합에 의한 core/shell 구조를 지닌 Poly(vinyl alcohol) Microsphere의 제조와 특성 - (Preparation and Application of Microcapsule - Preparation and Properties of Suspension-Polymerized Poly(vinyl alcohol) Microsphere with Core-Shell Structure -)

  • 김혜인;김효정;박수민
    • 한국염색가공학회지
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    • 제15권4호
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    • pp.65-72
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    • 2003
  • Poly(ethylene-co-vinylacetate) (EVA) microspheres were prepared by a thermally induced phase separation. Poly(vinyl Alcohol) (EVAL) microsphere with Core-Shell Structure were synthesized by a saponification on sheath of EVA microspheres. The size of EVA core/EVAL shell microsphere was decreased from $4.09\mu{m}\;to\;2.55\mu{m}$ by partial saponification of $NaOH/Na_2SO_4$/methanol(2 : 1 : 1 by weight) at $60^\circ{C}$ for 4h to produce a saponified surface layer of about 60% of original radius. In this process, the surface layer of EVAL microsphere was dissolved partially and morphology of surface was not showed. Add-on of cotton and silk printed with EVA core/EVAL shell microsphere was increased and that of printed PET was decreased. In case of EVA core/EVAL shell microsphere, Hand of cotton and silk printed was flexible and fullness.

기능성 microsphere의 개발(II) - EVA Microsphere의 표면개질과 특성 - (Development of Functional Microsphere( II ) - Surface Modification and Properties of EVA Microsphere -)

  • 김혜인;박형섭;박수민
    • 한국염색가공학회지
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    • 제17권3호
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    • pp.26-33
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    • 2005
  • EVA microsphere was prepared by a thermally induced phase separation. EVAL microsphere was made by a saponification on sheath of EVA microsphere. And microcapsule with EVA core-PU shell structure was synthesized by interfacial polymerization using diisocyanates with PEG in gelatin aqueous solution as the stabilizing agent. The effects of chemical structure of diisocyanate on the average particle size and distribution, morphology, color strength and friction fastness of core-shell particles were investigated to design microcapsule. The friction fastness of the fabrics printed with EVA core-PU shell microcapsules had the 4-5 grade.

p-Aminosalicylic acid를 포함하고 있는 Chitin, Chitosan-Microsphere의 용출특성 (Dissolution properties of Chitin or Chitosan Microsphere Containing p-Aminosalicylic Acid)

  • 임정수;김공수
    • 대한의용생체공학회:의공학회지
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    • 제10권1호
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    • pp.59-66
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    • 1989
  • The Applicability of chitin or chitosan microsphere as means to achieve sustained release of p-aminosalicylic acid(PAS) has been examined. The microsphere of chitin or chitosan containing PAS were prepared by coacervation in acidic aqueous system in range of pH 2.0-4.0. The dissolution test of PAS from polymeric drug system was carried out in vitro test. The dissolution rate of PAS from the microsphere with chitin was significanthly lower than that from the microsphere with chitosan.The dissolution rate of PAS from the microsphere was decreased with increasing of concentration of chitin and chitosan. The sustained release of PAS from the microsphere was more effective at pH 1.2 than pH 6.8.

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PLGA 미립구를 이용한 새로운 단회 접종 항원 전달 시스템의 개발 (Improved Antigen Delivery Systems with PLGA Microsphere for a Single-Step Immunization)

  • 윤미경;최영욱
    • Journal of Pharmaceutical Investigation
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    • 제34권1호
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    • pp.1-14
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    • 2004
  • A promising approach to the development of a new single-step vaccine, which would eliminate the requirement for multiple injections, involves the encapsulation of antigens into microspheres. Biodegradable poly(lactide-co-glycolide) (PLGA) microspheres gave us a bright insight for controling antigen release in a pulsatile fashion, thereby mimicking two or tree boosting injections. However, in spite of the above merits, the level of immunization induced by a single-shot vaccination is often lower tan two doses of alum-adsorbed antigen. Therefore, optima modification of the microsphere is essential for the development of single-step vaccines. In the review, we discuss the stability of antigen in microsphere, safety and non-toxic in human and encapsulation technology. Also, we attempted to outline relevant physicochemical properties on the immunogenicity of microsphere vaccine and attainment of pulsatile release pater by combination of different microsphere, as well as to analyze immunological data associated with antigen delivery by microsphere. Although a lot of variables are related to the optimized microsphere formulation, we could conclude that judicious choice of proper polymer type, adjustment of particles size, and appropriate immunization protocol along with a suitable adjuvant might be a crucial factor for the generation of long-lasting immune response from a single-step vaccine formulation employing PLGA microsphere.

기능성 마이크로스피어의 개발(II) - 안료를 함유한 에틸렌-비닐아세테이트 공중합체의 마이크로스피어 제조와 특성 - (Development of functional microsphere(II) - Formation and Characteristics of Poly(ethylene-co-vinylacetate) Microsphere with Pigment -)

  • 이신희;박수민
    • 한국염색가공학회지
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    • 제17권4호
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    • pp.15-20
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    • 2005
  • Poly(ethylene-co-vinylacetate)(EVA) microspheres were prepared by thermally induced phase separation in toluene. The microsphere formation occurred by the nucleation and growth mechanism in metastable region. The effects of the polymer or pigment weight percentage and cooling rate on microsphere formation were investigated. The microsphere formation and growth were followed by the cloud point of the optical microscope measurement. The microsphere size distribution, which was obtained by particle size analyzer, became broader when the polymer concentration was higher, the pigment concentration and the cooling rate of EVA copolymer solution were lower.

Chemically Bonded Thermally Expandable Microsphere-silica Composite Aerogel with Thermal Insulation Property for Industrial Use

  • Lee, Kyu-Yeon;Phadtare, Varsha D.;Choi, Haryeong;Moon, Seung Hwan;Kim, Jong Il;Bae, Young Kwang;Park, Hyung-Ho
    • 마이크로전자및패키징학회지
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    • 제26권2호
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    • pp.23-29
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    • 2019
  • Thermally expandable microsphere and aerogel composite was prepared by chemical compositization. Microsphere can produce synergies with aerogel, especially an enhancement of mechanical property. Through condensation between sulfonated microsphere and hydrolyzed silica sol, chemically-connected composite aerogel could be prepared. The presence of hydroxyl group on the sulfonated microsphere was observed, which was the prime functional group of reaction with hydrolyzed silica sol. Silica aerogel-coated microsphere was confirmed through microstructure analysis. The presence of silicon-carbon absorption band and peaks from composite aerogel was observed, which proved the chemical bonding between them. A relatively low thermal conductivity value of $0.063W/m{\cdot}K$ was obtained.

기능성 마이크로스피어의 제조와 응용(II) 분산염료를 함유한 에틸렌-비닐아세테이트 중합체의 마이크로스피어 제조와 특성 (Preparation and Application of Functional Microsphere (II) Formation and Characteristics of Poly(ethylene-co-vinylacetate) Microsphere with Disperse Dye)

  • 이신희;조현;박수민
    • 한국의류산업학회지
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    • 제10권3호
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    • pp.371-376
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    • 2008
  • Poly(ethylene-co-vinylacetate) (EVA) microspheres were prepared by thermally induced phase separation (TIPS) in toluene. The microsphere formation occurred by the nucleation and growth mechanism in metastable region. The effects of the concentration and component of the polymer and cooling rate on microsphere formation were investigated. The microsphere formation and growth were followed by the cloud point of the optical microscope measurement. The microsphere size distribution, which was obtained by particle size analyzer, became broader when the polymer concentration was higher, the content of vinyl acetate in EVA copolymer was higher, the cooling rate of EVA copolymer solution were lower. The content of disperse dye in EVA microsphere was obtained by TGA thermal analysis, the dye content of EVA15 and EVA18 were 3.5 and 2.0 wt% respectively.

자성 폴리스티렌-폴리이미드 Core-Shell 마이크로스피어의 합성 (Synthesis of Magnetic Polystyrene-Polyimide Core-Shell Microsphere)

  • 안병현
    • Elastomers and Composites
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    • 제47권2호
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    • pp.168-173
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    • 2012
  • 폴리아미드산을 안정제로 사용한 스티렌의 분산중합에 의해 core-shell 구조를 갖는 폴리스티렌-폴리이미드 core-shell 마이크로스피어를 얻었다. Iron pentacarbonyl을 마이크로스피어에 함침시킨 후 열분해하여 산화철 나노 입자를 갖는 자성 폴리스티렌-폴리이미드 마이크로스피어를 제조하였다. 자성 폴리스티렌-폴리이미드 마이크로스피어의 크기와 구조, 열적 특성 및 자성 특성을 조사하였는데, 자성 폴리스티렌-폴리이미드 마이크로스피어는 크기가 약 500 nm 정도로 균일하였으며 40%의 산화철 나노 입자를 가졌다. 산화철은 X선 회절시험에 의해 $Fe_3O_4$임이 확인되었다.