• 대한화학회지
• /
• 제67권4호
• /
• pp.241-252
• /
• 2023

이 연구는 학생들이 어려워하는 화학의 여러 개념 중 하나인 동적 평형에 대한 학생의 이해를 높이는 것을 목적으로 한다. 동적 평형은 입자들의 끊임없는 움직임과 상호 작용을 미시적으로 이해하고, 이를 통해 발현되는 거시적인 특성을 이해할 수 있도록 실제와 표상이 겹친 준미시적 수준으로 다루어야 한다. 하지만 9종의 화학 I 교과서를 분석한 결과 평형에 대한 표현 방식은 다소 한계가 있었다. 준미시적 표상 접근을 통해 평형을 이해할 수 있는 전략으로 스크래치를 활용한 수업을 4차시로 구안 하였고, 56명 학생을 대상으로 실행하였다. 4차시 수업은 6단계로 구성이 되며, 단계적으로 평형을 이해하도록 설계하였다. 사전 검사와 사후 검사를 비교한 결과, 학생들이 화학 평형에 대해 미시적 설명과 거시적 설명을 모두 옳게 하는 학생이 크게 증가하였다. 이를 통해 준미시적 표상의 접근 방식으로 스크래치를 활용한 수업의 적용 가능성을 엿볼 수 있었다.

• Journal of Korean Neurosurgical Society
• /
• 제44권3호
• /
• pp.151-155
• /
• 2008

Objective : Microscopic and endoscopic transsphenoidal approach (TSA) are major surgical techniques in the treatment of pituitary adenoma. Endoscopic endonasal transsphenoidal approach (EETSA) has been increasingly used for pituitary adenomas, however, its surgical outcome particularly in functioning pituitary adenoma has been debated. Here, we investigated the endocrine outcome of the patients with growth hormone (GH) and adrenocorticotropic hormone (ACTH) secreting pituitary adenoma treated by EETSA. Methods : We treated 80 patients with pituitary adenoma by EETSA since 2004, of which 12 patients were affected by functioning pituitary adenomas (9 GH, 3 ACTH, 0 PRL; 9 macro, 3 micro). Surgical outcome of those patients treated by EETSA was compared with that of the 11 functioning pituitary adenoma patients (8 GH, 3 ACTH; 8 macro, 3 micro) who underwent sublabial microscopic TSA between 1997 and 2003. Results : Imaging remission based on postoperative MRI was achieved in 8 (73%) and hormonal remission in 5 (45%) of 11 patients treated by sublabial microscopic TSA. Imaging remission was observed in 10 (83%, p=0.640) and hormonal remission in 10 (83%, p=0.081) of 12 patients by EETSA. CSF leakage was noticed in 2 (17%) of EETSA group and in 2 (18%) of sublabial microscopic TSA group. Panhypopituitarism was observed in 1 (9%) of EETSA group and in 3 (27%) of sublabial microscopic TSA group. Conclusion : EETSA appears to be an effective and safe method for the treatment of functioning pituitary adenomas.

• Journal of Korean Neurosurgical Society
• /
• 제54권4호
• /
• pp.317-322
• /
• 2013

Objective : The surgical approach for recurrent pituitary adenoma after trans-sphenoidal approach (TSA) is challenging. We report the outcomes of the endoscopic TSA for recurrent pituitary adenoma after microscopic TSA. Methods : From February 2010 to February 2013, endoscopic TSA was performed for removal of 30 recurrent pituitary adenomas after microscopic TSA. Twenty-seven (90%) patients had a clinically non-functioning pituitary adenoma. Twenty-four (80%) patients suffered from a visual disturbance related to tumor growth. The clinical features and surgical outcomes were retrospectively analyzed for the ophthalmological, endocrinological, and oncological aspects. Results : The mean tumor volume was 11.7 $cm^3$, and gross total resection was achieved in 50% of patients. The volumetric analysis based on the postoperative MR showed that the mean extent of resection rates were 90%. Vision was improved in 19 (79%) of 24 patients with visual symptoms, and endocrinological cure was achieved in all of three functioning pituitary adenomas; however, the post-operative follow-up endocrinological examination revealed a new endocrinological deficit in one patient. Two patients required antibiotics management for post-operative meningitis. Conclusion : The endoscopic TSA can be an effective treatment option for recurrent pituitary adenoma after microscopic TSA with acceptable outcome.

• 한국전자현미경학회:학술대회논문집
• /
• 한국현미경학회 2004년도 제35차 춘계학술대회
• /
• pp.15-17
• /
• 2004

• Advanced Composite Materials
• /
• 제17권4호
• /
• pp.373-407
• /
• 2008

This paper will examine the possibilities of the virtual tests of composite structures by simulating mechanical behaviors by using supercomputing technologies, which have now become easily available and powerful but relatively inexpensive. We will describe mainly the applications of large-scale finite element analysis using the direct numerical simulation (DNS), which describes composite material properties considering individual constituent properties. DNS approach is based on the full microscopic concepts, which can provide detailed information about the local interaction between the constituents and micro-failure mechanisms by separate modeling of each constituent. Various composite materials such as metal matrix composites (MMCs), active fiber composites (AFCs), boron/epoxy cross-ply laminates and 3-D orthogonal woven composites are selected as verification examples of DNS. The effective elastic moduli and impact structural characteristics of the composites are determined using the DNS models. These DNS models can also give the global and local information about deformations and influences of high local in-plane and interlaminar stresses induced by transverse impact loading at a microscopic level inside the materials. Furthermore, the multi-scale models based on DNS concepts considering microscopic and macroscopic structures simultaneously are also developed and a numerical low-velocity impact simulation is performed using these multi-scale DNS models. Through these various applications of DNS models, it can be shown that the DNS approach can provide insights of various structural behaviors of composite structures.

• 대한교통학회지
• /
• 제9권2호
• /
• pp.5-26
• /
• 1991

Concepts of passenger car equivalent(PCE) based on various philosophies is reviewed. The headway method is redefined in two ways namely a macroscopic headway method and a microscopic headway method of which the concepts are confused in literature. As definition of the microscopic headway method is from intuitive approach so theoretical basis for this method is explained in connection with the macroscopic headway method. In addition new classification and evaluation of complicated existing theories was conducted to make the reader understand more easily.

• 한국복합재료학회:학술대회논문집
• /
• 한국복합재료학회 2005년도 춘계학술발표대회 논문집
• /
• pp.249-252
• /
• 2005

Prediction of damage caused by low-velocity impact in laminated composite plate is an important problem faced by designers using composites. Not only the inplane stresses but also the interlaminar normal and shear stresses playa role in estimating the damage caused. The work reported here is an effort in getting better predictions of damage in composite plate using DNS approach. In the DNS model, we discretize the composite plates through separate modeling of fiber and matrix for the local microscopic analysis. Through comparison with the homogenized model. In the view of microscopic mechanics with DNS model, interlaminar stress behaviors in the inside of composite materials is investigated and compared with the results of the homogenized model which has been used in the conventional approach of impact analysis.

• 대한전자공학회논문지SP
• /
• 제42권4호
• /
• pp.167-176
• /
• 2005

본 논문에서는 멀티미디어 알고리즘이 갖는 처리단위 및 분포 특성을 활용하여 저전력 효과를 극대화 할 수 있는 새로운 형태의 Microscopic DVS(Dynmic Voltage Scaling) 기법을 제시하였고, MPEG 오디오 및 비디오를 대상으로 저전력을 위한 알고리즘 최적화 기법을 제시하였다. 통상적으로 긴 task 단위로 반영되는 macroscopic한 분포특성에 기반하여 저전력 제어가 이루어지는 기존의 DVS 기법과는 달리, 본 연구에서는 수십 밀리초(msec) 내외의 짧은 멀티미디어 신호 실시간 처리 단위, 즉 프레임 단위로 DVS 전력 제어를 수행하는 기법을 제시하고 이를 Microscopic DVS 기술이라 칭하였다. 특히 본 연구에서 제시한 microscopic DVS 기법은 멀티미디어 프레임별 연산량에 따라 단순히 전압-주파수를 가변 시켜주는 개념뿐만이 아니라, microscopic DVS에 의한 전력 절감 효과를 극대화 시킬 수 있도록 프레임별 연산량의 평균과 분산에 자유도를 확대 허용하는, 멀티미디어 알고리즘 자체에 대한 새로운 형태의 최적화 개념까지를 포함하였다. 제안한 전력절감기법의 타당성 검증을 위해 MPEG-2 video decoder와 MPEG-2 AAC audio encoder를 ARM9 processor 상에서 본 과제에서 제시한 전력절감기법을 적용하여 시뮬레이션 하였으며, 그 결과 video decoder의 경우 50$\%$, audio encoder의 경우 30$\%$ 정도의 전력 절감 효율을 얻을 수 있었다.

• Applied Microscopy
• /
• 제38권3호
• /
• pp.275-278
• /
• 2008

Electron tomography (ET) is an electron microscopic technique for obtaining a 3-D image from any electron microscopy specimen and its application in biomedical science has been increased thanks to development of electron microscopy and related technologies during the last decade. There are few researches on ET in Korea during this period. Although the importance of ET has been recognized recently by many researchers, initial approach to electron tomographic research is not easy for beginners. The 4th International Congress on Electron Tomography (4 ICET) was held on Nov $5{\sim}8$, 2006, at San Diego. The program dealt instrumentation, reconstruction algorithm, visualization/quantitative analysis and electron tomographic presentation of biological specimen and nano particles. 1 have summarized oral presentations and analyzed the posters presented on the meeting. Cryo-electron microscopic system was popular system for ET and followed conventional transmission electron microscopic system. Cultured cell line and tissue were most popular specimens analyzed and microorganisms including bacteria and virus also constituted important specimens. This analysis provides a current state of art in ET research and a guide line for practical application of ET and further research strategies.

• Multiscale and Multiphysics Mechanics
• /
• 제1권1호
• /
• pp.15-33
• /
• 2016

In this paper, an asymptotic method is employed to formulate nano- or micro-beams based on strain gradient elasticity. Although a basic theory for the strain gradient elasticity has been well established in literature, a systematic approach is relatively rare because of its complexity and ambiguity of higher-order elasticity coefficients. In order to systematically identify the strain gradient effect, an asymptotic approach is adopted by introducing the small parameter which represents the beam geometric slenderness and/or the internal atomistic characteristic. The approach allows us to systematically split the two-dimensional strain gradient elasticity into the microscopic one-dimensional through-the-thickness analysis and the macroscopic one-dimensional beam analysis. The first-order beam problem turns out to be different from the classical elasticity in terms of the bending stiffness, which comes from the through-the-thickness strain gradient effect. This subsequently affects the second-order transverse shear stress in which the surface shear stress exists. It is demonstrated that a careful derivation of a first strain gradient elasticity embraces "Gurtin-Murdoch traction" as the surface effect of a one-dimensional Euler-Bernoulli-like beam model.