• 대한의용생체공학회:의공학회지
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• 제44권3호
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• pp.176-181
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• 2023

During cancer treatment, the patient's response to drugs appears differently at the cellular level. In this paper, an image-based cell phenotypic feature quantification and key feature selection method are presented to predict the response of patient-derived cancer cells to a specific drug. In order to analyze the viability characteristics of cancer cells, high-definition microscope images in which cell nuclei are fluorescently stained are used, and individual-level cell analysis is performed. To this end, first, image stitching is performed for analysis of the same environment in units of the well plates, and uneven brightness due to the effects of illumination is adjusted based on the histogram. In order to automatically segment only the cell nucleus region, which is the region of interest, from the improved image, a superpixel-based segmentation technique is applied using the fluorescence expression level and morphological information. After extracting 242 types of features from the image through the segmented cell region information, only the features related to cell viability are selected through the ReliefF algorithm. The proposed method can be applied to cell image-based phenotypic screening to determine a patient's response to a drug.

• 한국환경과학회지
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• 제32권9호
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• pp.627-634
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• 2023

Tire wear particles(TWPs), regarded as a microplastic, is generated in significant quantities each year and exist in various spaces and have a negative impact on the surrounding environment. Particularly, roadside environments fall within the direct influence of TWPs, necessitating proactive investigation for contamination management and response. Therefore, this study aimed to investigate the soil acidity and electrical conductivity(EC) and TWPs in the roadside soil of six sites based on traffic volume. The analysis revealed that the soil in all sites exhibited subacidity, and there were no significant differences in EC. Microscopic and FT-IR analysis revealed the presence of microscopic particles in soil samples that exhibited common visual characteristics of TWPs. In the road with the highest traffic volume, 48,300 TWPs were detected per unit area. Furthermore, a proportional relationship between traffic volume and TWPs particles was established. However, influences other than traffic volume on TWPs particle count within the soil were observed. Therefore, for the management of TWPs contaminated roadside soil, a proactive response is necessary in areas with high traffic volumes. However, in order to effectively address the factors contributing to the generation and dispersion of TWPs, further research is required with a multidimensional approach.

• 한국자원식물학회지
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• 제8권3호
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• pp.303-318
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• 1995

금강초롱꽃과 근연분류군 4속 9분류군에 대한 표피 및 화분의 미세구조, 동위효소 분석을 통하여 금강초롱꽃속(屬)이 특산속으로서 구분이 가능한가를 알아보았다. 표피는 미세구조에서는 잎이 표면과 이면세포의 모양, 화피의 세포형태, 종피의 미세구조 등이 속과 종을 구분하는데 유용한 형질로 나타났으며, 화분학적 형질에서는 표면무늬와 전체 형태에 많은 변이가 있어 속내 분류군들의 유집 및 분류가 불가능하였다. 동위효소 분석에서는 분류군에 따라 지역, 집단간 변이가 매우 심하게 나타났지만 금강초롱꽃과 가장 유사한 분류군은 초롱꽃과 섬초롱꽃으로 유집되어 나타났다. 이상의 결과에서 금강초롱꽃속(屬)은 근연 분류군과 표피의 형질, 동위효소 분석등에서 근연 분류군과 뚜렷한 차이가 있어 특산속으로서 잘 구분되었다.

• 대한기계학회논문집B
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• 제22권1호
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• pp.1-11
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• 1998

For the analysis of phonon heat transfer within short time and spatial scales, conventional macroscopic heat conduction equations with jump boundary conditions are tried and the results are compared to those of equation of phonon radiative transport(EPRT), which is one of microscopic transport equation. In transient state the macroscopic temperatures show far different behavior from EPRT. In steady state the hyperbolic temperatures with temperature jump at the wall from time relaxation model agrees well with EPRT temperatures. Since EPRT is also an approximate form of microscopic transport equation and there are no experimental results to verify the proposed model in this study, we can not conclude whether the approaching method from this study is valid or not. To the authors' knowledge, there are no experimental results available which can be used to test the validity of these models. Such an experiment, while difficult to conduct, would be invaluable.

• Journal of the Korean Wood Science and Technology
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• 제44권6호
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• pp.903-912
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• 2016

Morphological and anatomical evaluation of grafted P. merkusii have been undertaken to obtain the information about compatible and incompatible symptoms of 18 years old grafts based on morphological observation and microscopic analysis. Samples of compatible and incompatible grafts were obtained from previous research conducted by the Silviculture Departement Team in 1994. Result showed that compatible grafts have normal stem form and secondary growth (diameter growth), but some abnormality symptoms like undulated pattern of annual growth rings, phloem thickening and abnormality resin ducts in inner and middle parts of the union area occurred. Incompatible ones showed abnormality of the stem form, cortex-bark necrosis and swelling in the union area. Microscopic observation showed abnormality of all parts of the union, undulated pattern of annual growth rings, phloem thickening, abnormal resin ducts, low numbers and discontinuity of vascular elements in the union area.

• 한국해양공학회지
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• 제4권1호
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• pp.81-87
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• 1990

Fatigue crack closure levels based on the behavior of residual displacements on crack surfaces, are determined analytically according to the microscopic crack closure mechanisms, i.e., whether the first contact of crack surfaces takes place at the very crack tip or on the surfaces near the tip. The comparative analysis on the two models is carried out empirically by the constant amplitude fatigue tests on 2024-T3 aluminum alloy plate, and it shows that under negative stress ratio, the case of the first contact at crack tip gives better agreement with the experimental results than the other.

• 한국해양공학회지
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• 제4권1호
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• pp.87-87
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• 1990

Fatigue crack closure levels based on the behavior of residual displacements on crack surfaces, are determined analytically according to the microscopic crack closure mechanisms, i.e., whether the first contact of crack surfaces takes place at the very crack tip or on the surfaces near the tip. The comparative analysis on the two models is carried out empirically by the constant amplitude fatigue tests on 2024-T3 aluminum alloy plate, and it shows that under negative stress ratio, the case of the first contact at crack tip gives better agreement with the experimental results than the other.

• Journal of Multimedia Information System
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• 제1권1호
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• pp.87-93
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• 2014

The aim of microscopic image restoration is to recover the image by applying the inverse process of degradation, and the results facilitate automated and improved analysis of the image. In this work, we consider the problem of image restoration as a minimization problem of convex cost function, which consists of a least-squares fitting term and regularization terms with non-negative constraints. The finite step method is proposed to solve this constrained convex optimization problem. We demonstrate the convergence of this method. Efficiency and restoration capability of the proposed method were tested and illustrated through numerical experiments.

• Journal of Welding and Joining
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• 제10권1호
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• pp.20-34
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• 1992

Characteristics of two correcting methods, a new Autogeneous GTAW heating (TIG) method and the conventional GMAW bead-on plate welding(MIG) method, for distorted aluminum fabrication structures were studied. As a result of microscopic study of Autogeneous GTAW heating and GMAW bead-on plate welding areas, porosities in weld metal and surface cracks in local heating zone were found. Through the mechanical tests, it was verified that porosities decrease tensile strength and surface of distortion, angular displacement and transeverse shrinkage were measures and compared. In order to investigate changes of material properties in heating area and cause of defects such thermal stresses were calculated by ADINA. Through the computations of transient thermal stresses and microscopic observation of fracture surface, thermal stress was found to be the cause of crack during Autogeneous GTAW heating.

• 제어로봇시스템학회논문지
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• 제15권8호
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• pp.798-803
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• 2009

This paper proposes a grating scanner which is driven by a stack-type piezoelectric element. The mechanism of the grating scanner is based on flexure hinges. Using some constraints, the compliant mechanism is designed and then verified by Finite Element Analysis. The designed compliant mechanism is manufactured by wire electro-discharge machining, and then integrated with a stack-type piezoelectric element for actuation and a capacitance displacement sensor for measuring ultra-precision displacement. Experiments demonstrates the characteristics and the performances of the grating scanner using the terms of working range, resonance frequency, bandwidth and resolution. The grating scanner is applicable to a Moire interferometry for measuring 3-dimensional microscopic surface.