• Title/Summary/Keyword: microparticle

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Electrospraying of Polymeric Microparticles and its Application to Fabrication of Porous Membrane (고분자 미세입자의 전기분사와 다공성 박막 제작에의 응용)

  • Jeong, Young Hun;Oh, Hana
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.14 no.5
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    • pp.126-133
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    • 2015
  • Recently, there has been demand for polymeric porous membranes in various fields, such as environmental engineering, pharmaceutics, tissue engineering, drug delivery, biology, and fuel cells. In this study, it is proposed that a polymer particle-based porous membrane can be fabricated using electrospraying and sintering processes. Electrospraying can fabricate polymeric particles with diameters ranging from several micrometers to tens of nanometers without the cumbersome particle aggregation problem. Additionally, the particles can be sintered through thermo-compression under the glass transition temperature. In this study, a polymethyl methacrylate particle-based porous membrane with an average pore size of less than 500 nm is fabricated using the proposed method.

Thermosensitive Chitosan as an Injectable Carrier for Local Drug Delivery

  • Bae Jin-Woo;Go Dong-Hyun;Park Ki-Dong;Lee Seung-Jin
    • Macromolecular Research
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    • v.14 no.4
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    • pp.461-465
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    • 2006
  • Two types of injectable system using thermosensitive chitosan (chitosan-g-NIPAAm), hydrogel and microparticles (MPs)-embedded hydrogel were developed as drug carriers for controlled release and their pharmaceutical potentials were investigated. 5-Fluorouracil (5-FU)-loaded, biodegradable PLGA MPs were prepared by a double emulsion method and then simply mixed with an aqueous solution of thermosensitive chitosan at room temperature. All 5-FU release rates from the hydrogel matrix were faster than bovine serum albumin (BSA), possibly due to the difference in the molecular weight of the drugs. The 5-FU release profile from MPs-embedded hydrogel was shown to reduce the burst effect and exhibit nearly zero-order release behavior from the beginning of each initial stage. Thus, these MPs-embedded hydrogels, as well as thermosensitive chitosan hydrogel, have promising potential as an injectable drug carrier for pharmaceutical applications.

Eco-Friendly and Thermal Conductivity Properties of Magnesium oxide Matrix Utilizing Bentonite (벤토나이트를 활용한 산화마그네슘 경화체의 친환경성 및 열저항 특성)

  • Gwon, Oh-Han;Lim, Hyun-Ung;Lee, Dong-Hoon;Lee, Sang-Soo
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2016.10a
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    • pp.64-65
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    • 2016
  • This study that prevent cancer using absorbent to inflow Radon gas in the room existing soil and rock is making board to absorb the Radon gas as a fundamental study. So, we use bentonite as a absorbent. So, we use bentonite as a absorbent. Bentonite is a 'clay mineral' composed to montmorillonite of main component that volcanic ash denatured to a clay mineral. Bentonite has fine microparticle of nano level, abundant mineral 66 of kinds, adsorbability, swelling, a positive ion(heavy metal adsorption reaction) as a bentonite's property. Using magnesia cement for oxide of magnesiuma and magnesium chloride as a main binder, we measure Radon gas absorbent efficiency and thermal conductivity.

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Dynamic Flow Lithography Technologies (역학적 유체 리소그래피 기술)

  • Chung, Su-Eun;Park, Wook;Kwon, Sung-Hoon
    • Journal of Biomedical Engineering Research
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    • v.30 no.6
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    • pp.453-460
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    • 2009
  • In this review paper, concepts in optofluidics are applied to an advanced manufacturing technology based on self-assembled microparts. The "optical" aspect of optofluidics will be described in the context of photolithography, and the "fluidic" aspect will be discussed in the context of self-assembly. First, optofluidic maskless lithography will be introduced as a dynamic fabrication method to generate microparticles in microfluidic channels. Next, the history and application of optofluidic lithography will be presented.

Performance of Cationic Guar Gums in Closed Papermaking Systems (고폐쇄화 제지공정에서의 양이온성 구아 검 활용 효과)

  • Ham, Choong-Hyun;Lee, Hak-Lae
    • Journal of Korea Technical Association of The Pulp and Paper Industry
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    • v.40 no.3
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    • pp.1-8
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    • 2008
  • The efficiency of retention systems including compozil-G, hydrocol, compozil-S, and micropolymer under highly closed papermaking system was evaluated using contaminated white waters prepared in the laboratory. Compozil-G and compozil-S performed better in retention than hydrocol and micropolymer systems. This suggested that stronger hydrogen bonding between fiber and guar gum or starch was formed to give stronger flocculation and better retention. Especially compozil-G outperformed compozil-S in retention, and this indicated the presence of stronger interaction between guar and cellulose fibers probably due to their similarity in chemical structure. Two compozil retention systems decreased the cationic demand and COD more effectively than hydrocol and microparticle systems. In particular, compozil-G that uses guar gum was highly effective in decreasing anionic trashes at low dosage.

Fabrication of Biodegradable Polyphosphazene Microparticles by Electrohydrodynamic Atomization (전기분무에 의한 생분해성 폴리포스파젠 마이크로입자의 제조)

  • Xue, Li-Wei;Cai, Qing;Ryu, Seung-Kon;Jin, Ri-Guang
    • Polymer(Korea)
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    • v.35 no.5
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    • pp.424-430
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    • 2011
  • Biodegradable poly[(glycine ethyl ester)-(phenylalanine ethyl ester) phosphazene](PGPP) microparticles were fabricated by electrohydrodynamic atomization to apply drug release test. Atomization parameters such as applied voltage, polymer concentration, and molecular weight were investigated to inspect their effects on the size and morphology of microparticles. The average diameter of PGPP microparticles decreased as increasing applied voltage and solution flow rate. Dichloromethane/dioxane mixture shows better results for the preparation of microparticles than single solvent owing to the different PGPP solubility in solvent. Blending PGPP polymers with proper molecular weights not only favored the production of spherical PGPP microparticles via electrohydrodynamic atomization, but also provided a way to adjust drug (rifampicin) release behavior. Drug-loaded biodegradable polyphosphazene microspheres can be fabricated via electrohydrodynamic atomization, which has potential use in biomedical applications.

Preparation of Prolonged Release Clarithromycin Microparticles for Oral Use and Their In Vitro Evaluation

  • Genc, Lutfi;Demirel, Muzeyyen;Yazan, Yasemin
    • Archives of Pharmacal Research
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    • v.29 no.10
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    • pp.921-927
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    • 2006
  • Prolonged release micro particles of clarithromycin (CL) were prepared using Eudragit RL 100 and RS 100 by spray-drying and casting-drying techniques. For the characterization of those microparticles, preparation yield, particle size distribution, X-ray diffraction, thermal behavior, active agent content and in vitro dissolution from the microparticles were performed. HPLC was used for the assay of clarithromycin and the assay method was validated. All the formulations obtained showed prolonged release when compared to pure clarithromycin. Microparticles prepared by spray-drying method had a slower release compared to those of casting drying method. Spray-drying method seems to be a more suitable method to prepare microparticles for prolongation in release.

Application of Micropaticle Systems in Water Circuit Closure Programs

  • Howard Johnson;Ha, Derek A.rrington
    • Journal of Korea Technical Association of The Pulp and Paper Industry
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    • v.33 no.5
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    • pp.12-20
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    • 2001
  • The consequence of water system closure and reduced water consumption in Paper Mills is increased white-water conductivity associated with increased total dissolved solids. This leads to difficulties man-aging the wet end chemistry of paper machines, mainly due to stearic hindrance effects on wet end chemical additives. This in turn causes poor productivity and Inefficient chemicals usage. The success of a number of projects is reported. The application and development of new multi-component micro-particle systems which can further assist in achieving a significant degree of system closure or Zero Effluent is described.

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Development of Silica Based Microgels and Evaluation of Their Performance in Microparticle Retention System

  • Kim, Tae-Young;Lee, Hak-Lae
    • Journal of Korea Technical Association of The Pulp and Paper Industry
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    • v.32 no.1
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    • pp.33-40
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    • 2000
  • The effectiveness of silica-based microgels prepared through the reaction of sulfuric acid and sodium silicate as a component of Compozil system has been evaluated . Silica based microgels with better performance in retention and drainage than a commercial colloidal silica sol have been successfully prepared. Silica gels with the highest charge density were obtained when product pH was controlled to 9. And highly charged silica-based microgels showed greater retention and freeness performance than a commerical product. In particular the difference in retention, turbidity , and freeness between these microgels and a commercial product was eminent at low addition rate. The effects of reaction conditions including reaction temperature, process water quality and feeing rate on product efficiency in improving retention and drainage were also investigated and discussed.

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Analysis of Machined Surface Morphology According to Changes of Surface Condition in Micro Particle Blasting (미세입자 분사가공 시 표면 조건 변화에 따른 가공 표면 형상 분석)

  • Choi, Sung-Yun;Hwang, Cheol-Ung;Kwon, Dae-Gyu
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.17 no.5
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    • pp.70-75
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    • 2018
  • This study analyzes the change of Al 6061-T6 specimen surface shape when undergoing microparticle spraying and analyzes the influence of factors on the experiment. Fine particle spraying is applied to the specimen and the surface shape of the processed surface is measured through a surface shape measuring device. The measured data was analyzed by the ANOVA method to investigate the effect of factors such as particle, nozzle diameter, pressure, injection height, and injection time on the injection depth and injection diameter.