Macromolecular Research

The Polymer Society of Korea (한국고분자학회)
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Thermosensitive Chitosan as an Injectable Carrier for Local Drug Delivery

  • Bae Jin-Woo (Dept. of Molecular Science & Technology, Ajou University) ;
  • Go Dong-Hyun (Dept. of Molecular Science & Technology, Ajou University) ;
  • Park Ki-Dong (Dept. of Molecular Science & Technology, Ajou University) ;
  • Lee Seung-Jin (Dept. of Pharmacy, College of Pharmacy, Ewha Womans University)
  • Published : 2006.08.01
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Abstract

Two types of injectable system using thermosensitive chitosan (chitosan-g-NIPAAm), hydrogel and microparticles (MPs)-embedded hydrogel were developed as drug carriers for controlled release and their pharmaceutical potentials were investigated. 5-Fluorouracil (5-FU)-loaded, biodegradable PLGA MPs were prepared by a double emulsion method and then simply mixed with an aqueous solution of thermosensitive chitosan at room temperature. All 5-FU release rates from the hydrogel matrix were faster than bovine serum albumin (BSA), possibly due to the difference in the molecular weight of the drugs. The 5-FU release profile from MPs-embedded hydrogel was shown to reduce the burst effect and exhibit nearly zero-order release behavior from the beginning of each initial stage. Thus, these MPs-embedded hydrogels, as well as thermosensitive chitosan hydrogel, have promising potential as an injectable drug carrier for pharmaceutical applications.

Keywords

References

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