• 한국가시화정보학회:학술대회논문집
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• 한국가시화정보학회 2007년도 추계학술대회
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• pp.63-65
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• 2007

The paper reports on a new type of combinatorial chaotic and serpentine micromixer. Such a new and novel micromixer is simple to fabricate and easy to use. The micromixer is characterized and visualized with the help of the Micro-LIF technique. The new micromixer will e further applied to lab-on-chip device. The mixing capabilities of this mixer is about 30-33%.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2003년도 유체기계 연구개발 발표회 논문집
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• pp.101-106
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• 2003

In this work, mixing phenomena in the mixing chamber of a ultrasonic micromixer are analyzed through an analytical approach. A simplified 2-dimensional model for the ultrasonic micromixer is presented. Analytical solutions for fluid flow induced by ultrasonic waves are obtained through successive approximations method. From simulation results on thermal diffusion in the mixing chamber, effects of relative location, size, and vibration frequency of a piezoelectric material and aspect ratio of the mixing chamber on mixing performance of the ultrasonic micromixer are investigated. Finally, design guidelines for the ultrasonic micromixer are suggested based on the parametric study.

• 대한기계학회논문집B
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• 제31권2호
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• pp.159-166
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• 2007

Mixing between two or more reagents is one of important processes in biochemical microfluidics. In efficient micromixer design, it is essential to analyze flow pattern and evaluate mixing efficiency with good precision. In this work, mixing efficiency for Y-channel micromixer is measured by fluorescence intensity using LIF(Laser Induced Fluorescence) Confocal Microscope. The Y-channel micromixers are fabricated with polydimethylsiloxane(PDMS) and those are bonded to glass plate through Plasma bonding. Nile Blue A is injected into the micromixer as a fluorescence dye for measuring of fluorescence intensity by He/Ne laser. For visualization of the flow pattern, dynamic image capturing is carried out using CAM scope. For the comparison with computer simulation, modified SIMPLE algorithm for incompressible flow equation is solved for the same geometry as in the experiment. Throughout the experiments and computer simulation, accurate mixing efficiency evaluation process for a PDMS Y-channel micromixer is established.

• 한국가시화정보학회:학술대회논문집
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• 한국가시화정보학회 2006년도 추계학술대회 논문집
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• pp.96-101
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• 2006

3-D visualization using confocal laser scanning microscopy (CLSM) in a chaotic micromixer was performed as a reproduction experiment and the feasibility of 3-0 imaging technique in the microscale was confirmed. For diagonal micromixer (DM) and two types of staggered herringbone micromixers (SHM) designed by Whitesides et al., to verify the evolution of mixing, cross sectional images are reconstructed at the end of every cycle. In a DM, clockwise rotational flow motion generated by diagonal ridges placed on the floor of micromixer is observed and this motion makes the fluid commingle. On the contrary, there are two rotational flow structures in the SHM and the centers of rotation exchange their position each other every half cycle because of the V shape of ridges varying their orientation every half cycle. Local rotational flow and local extensional flow generated by the complicate ridge pattern make the flow be chaotic and accelerate the mixing of fluid. The dominant parameter that influences on the mixing characteristic of SHM is not the length of micromixer but the number of ridges under the same flow configurations.

• 대한기계학회논문집A
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• 제29권10호
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• pp.1289-1297
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• 2005

The flow in a microchannel is usually characterized as a low Reynolds number (Re) so that good mixing is quite difficult to be achieved. In this regard, we developed a novel chaotic micromixer, named Serpentine Laminating Micromixer (SLM) in the present study, Part 1. In the SLM, the higher level of chaotic mixing can be achieved by combining two general chaotic mixing mechanisms: splitting/recombination and chaotic advection. The splitting and recombination (in other term, lamination) mechanism is obtained by the successive arrangement of 'F'-shape mixing units in two layers. The chaotic advection is induced by the overall three-dimensional serpentine path of the microchannel. Chaotic mixing performance of the SLM was fully characterized numerically. To compare the mixing performance, a T-type micromixer which has the same width, height and length of the SLM was also designed. The three-dimensional numerical mixing simulations show the superiority of the SLM over the T-type micromixer. From the cross-sectional simulation results of mixing patterns, the chaotic advection effect from the serpentine channel path design acts favorably to realize the ideal lamination of fluid flow as Re increases. Chaotic mixing mechanism, proposed in this study, could be easily integrated in Micro-Total-Analysis-System, Lab-on-a-Chip and so on.

• 대한기계학회논문집B
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• 제34권1호
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• pp.53-59
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• 2010

본 논문에서는, 자기유체역학(MHD)을 기반으로 마이크로 채널 내부에 다중 와류 유동을 발생시키는 새로운 형태의 카오스 마이크로 믹서를 제안한다. 제안된 마이크로 믹서의 마이크로 채널 내부에는 양측면과 바닥면에 전극들이 배치되어 있다. 배치된 전극들에 인가되는 전압 조건에 따라 다양한 형태로 로렌츠 힘이 유도되며, 이렇게 유도된 로렌츠 힘은 마이크로 채널 내부 유체의 추진 및 혼합을 야기할 수 있다. 제안된 MHD 마이크로 믹서의 혼합 양상을 평가하기 위해 3 차원 전산유체역학 시뮬레이션을 수행하였다. 이를 통해 다양한 유동 조건에 대해 MHD 마이크로 믹서의 혼합 성능을 평가하였다.

• 한국융합학회논문지
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• 제9권10호
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• pp.237-242
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• 2018

마이크로 믹서는 랩-온-어-칩이나 마이크로 유체 기기의 하나의 구성품으로 두 가지의 화학 물질을 혼합(융합)하는 장치이다. 본 연구는 다양한 형상의 패시브 마이크로 믹서의 성능을 평가하는 것을 목적으로 한다. 다양한 형상의 마이크로 믹서는 총 6가지의 형상을 비교하였고, 서로 동일한 수력 직경을 갖도록 3차원 모델링하였다. 내부 혼합 유동을 전산모사하기 위해여 상용 유동해석 프로그램인 ANSYS Fluent를 사용하였다. 수치해석 방법은 본 논문에 자세하게 기술하였다. 마이크로 믹서의 성능 평가는 혼합 지수와 압력 강하로 비교하였고, 결론적으로 CDM-8T은 합리적인 혼합성능과 상대적으로 낮은 압력 강하를 갖는 것으로 나타났다.

• 대한기계학회논문집A
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• 제29권6호
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• pp.904-912
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• 2005

The flow in a microchannel is usually characterized as a low Reynolds number (Re) so that good mixing is quite difficult to be achieved. In this regard, we developed a novel chaotic micromixer, named Barrier Embedded Kenics Micromixer (BEKM). In the BEKM, the higher level of chaotic mixing can be achieved by combining two general chaotic mixing mechanisms: (i) splitting/reorientation by helical elements inside the microchannel and (ii) stretching/folding via periodically located barriers on the channel wall. The fully three-dimensional geometry of BEKM was realized by a micro-stereolithography technology, in this study, along with a Kenics micromixer and a circular T-pipe. Mixing performances of three micromixers were experimentally characterized in terms of an average mixing color intensity of phenolphthalein. Experimental results show that BEKM has better mixing performance than other two micromixers. Chaotic mixing mechanism, proposed in this study, could be integrated as a mixing component with Micro-Total-Analysis-System, Lab-on-a-chip and so on.

• 대한기계학회논문집A
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• 제32권8호
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• pp.624-632
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• 2008

In this research, we developed new PDMS-glass based microbiochip consisted of the micromixer and microreactor for DNA ligation. The micromixer was composed of a straight channel integrated with nozzles and pillars, and the microreactor was composed of a serpentine channel. We coated the PDMS chip surface with the 0.25wt.% PVP solution to prevent the bubble generation which was caused by the hydrophobicity of the PDMS. The new micomixer was passive type and the mixing was enhanced by a convective diffusion using the nozzle and pillar. The 10.33mm long micromixer showed the good mixing efficiency of 87.7% at 500 l/min flow rate. We could perform the DNA ligation successfully in the microbiochip, and the ligation time was shortened from 4 hours in conventional laboratory method to 5 min in the microbiochip.

• 대한기계학회논문집B
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• 제29권12호
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• pp.1369-1376
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• 2005

Effective mixing gives strong advantageous impact on microfluidic applications since mixing is in general very slow process motivated by molecular diffusion transport only on the micro-scale. In this work, the mixing characteristics are analyzed in a Y-channel micromixer with obstacles. For the through analysis, our laboratory in-house unstructured grid CFD code is validated through solving a concentration transport in a uniform microchannel. The solutions well correspond to both exact solutions and those from MemCFD. Mixing in a Y-channel micromixer with obstacles is numerically investigated by the in-house code to search the optimal radius and layout of obstacles. From the simulations, the mixing efficiency appears to be proportional to the magnitude of the formation of lateral velocity component. It is also shown that the asymmetric layout and radius enlargement of obstacles greatly improves mixing efficiency.