• Title/Summary/Keyword: microemulsions

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A new versatile Microemulsion Gel Technology with flexible Viscosity

  • Ulrich Kux;Jorg Schreiber;Diec, Khiet-Hien;Sabine Ripke;Wittern, Klaus-Peter
    • Proceedings of the SCSK Conference
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    • 2003.09a
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    • pp.232-257
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    • 2003
  • It has been shown that transparent microemulsion gels of flexibly adjustable viscosity containing less than 10% w/w surfactants can be obtained just by cooling down through a new 1-step preparation procedure (via 4 different in-situ colloidal systems) using PIT-technology with a range of emulsifiers, co-emulsifiers and lipids. They can be used for a wide scope of applications. Specific examples have been given with antiperspirant formulas that proof the stability of these thickened microemulsions even with high content of electrolytes and low pH. We propose that the structure of these microemulsion gels can be described by cross-linking of nano-fine oil droplets via an ABA-triblock copolymer. A new generation of transparent antiperspirant roll-ons with significantly improved skin tolerance can now be formulated as an attractive alternative to alcohol-based products.

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Microemulsifieation of Chlorinated Hydrocarbon/water with Mixed Surfactant Systems (혼합 계면활성제를 이용한 염소화 탄화수소l물의 마이크로에멀젼 연구)

  • 김천희
    • Journal of the Korean Society of Clothing and Textiles
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    • v.22 no.3
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    • pp.265-265
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    • 1998
  • The phase behavior of chlorinated hydrocarbon/mixed surfactants/water microemulsion systems were investigated for dry cleaning solvent properties. With appropriate surfactant mixtures, Winsor type I-III-II microemulsions were generated which is the same as hydrocarbon systems. For perchloroethylene(PCE) with mixed Tween systems, the optimum salinity(S*) decreases and the optimum solubilization parameter(o*) increases with decreas- ing HLB. For PCE with mixed Aerosol MA and ethoxylated alcohol systems, S* and o* both increase with increasing ethylene oxide moles. For dichlorobenzene(DCB) with mixed Aerosol MA and ethoxylated or propoxylated sulfate systems, S* and o* both increase with increasing ethylene oxide moles or propylene oxide moles.

Microemulsifieation of Chlorinated Hydrocarbon/water with Mixed Surfactant Systems (혼합 계면활성제를 이용한 염소화 탄화수소l물의 마이크로에멀젼 연구)

  • 김천희
    • Journal of the Korean Society of Clothing and Textiles
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    • v.22 no.3
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    • pp.365-373
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    • 1998
  • The phase behavior of chlorinated hydrocarbon/mixed surfactants/water microemulsion systems were investigated for dry cleaning solvent properties. With appropriate surfactant mixtures, Winsor type I-III-II microemulsions were generated which is the same as hydrocarbon systems. For perchloroethylene(PCE) with mixed Tween systems, the optimum salinity(S*) decreases and the optimum solubilization parameter(o*) increases with decreas- ing HLB. For PCE with mixed Aerosol MA and ethoxylated alcohol systems, S* and o* both increase with increasing ethylene oxide moles. For dichlorobenzene(DCB) with mixed Aerosol MA and ethoxylated or propoxylated sulfate systems, S* and o* both increase with increasing ethylene oxide moles or propylene oxide moles.

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Transdermal Delivery of Piroxicam Using Microemulsions

  • Park Eun-Seak;Cui Yu;Yun Bum-Jin;Ko In-Ja;Chi Sang-Cheol
    • Archives of Pharmacal Research
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    • v.28 no.2
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    • pp.243-248
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    • 2005
  • To improve the skin permeability of piroxicam, a new oil-in-water microemulsion containing $0.5\%$ piroxicam was developed. Among various oils investigated for their suitability as an oil phase for the microemulsion system, oleic acid showed both excellent solubility and skin permeation enhancing effect for piroxicam. Microemulsion existence ranges were identified through the construction of the pseudo-ternary phase diagram. The effect of the content of oleic acid and the ratio of the surfactant/cosurfactant on skin permeation of piroxicam were evaluated with excised rat skins. The optimum formulation with the highest skin permeation rate ($47.14\;{\mu}g/cm^2/h$) consisted of $0.5\%$ piroxicam, $10\%$ oleic acid, $60\%$ Labrasol/ethanol (1:5) and water.

Effect of Additives on Preparation of Silver Chloride Nanoparticles using AOT-Based W/O Microemulsions (AOT W/O 마이크로에멀젼을 이용한 AgCl 나노입자 제조에서 첨가제의 영향)

  • Jung, KilYong;Lim, JongChoo
    • Korean Chemical Engineering Research
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    • v.46 no.2
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    • pp.330-339
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    • 2008
  • Effect of additives such as NP series nonionic surfactant and cosurfactant on AgCl nanoparticles was investigated where nanoparticles were prepared using two different types of water-in-oil (W/O) microemulsions containing silver nitrate and sodium chloride, respectively. Phase behavior experiments showed that the region of one phase W/O microemulsion was found to be broadened with an increase in the ethylene oxide length of a nonionic surfactant mainly due to an increase in hydrophilic nature of a surfactant. Photomicrographs obtained by transmission electron microscopy indicated that an increase in ethylene oxide length of a nonionic surfactant results in both increases in particle size and size distribution. Phase behavior experiments for the systems containing AOT surfactant, isooctane and aqueous solution of an inorganic salt showed that addition of a cosurfactant caused a shrinkage in phase region of one phase W/O microemulsion, especially water contents contained in W/O microemulsion with an increase in the chain length or the concentration of a cosurfactant used. Photomicrographs obtained by transmission electron microscopy indicated that characteristics of AgCl nanoparticles produced were dependent both on the radius of spontaneous curvature and film rigidity of a microemulsion.

A review: Synthetic strategy control of magnetite nanoparticles production

  • Yusoff, Ahmad H.M.;Salimi, Midhat N.;Jamlos, Mohd F.
    • Advances in nano research
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    • v.6 no.1
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    • pp.1-19
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    • 2018
  • Iron oxide nanoparticles excite researcher interest in biomedical applications due to their low cost, biocompatibility and superparamagnetism properties. Magnetic iron oxide especially magnetite ($Fe_3O_4$) possessed a superparamagnetic behaviour at certain nanosize which beneficial for drug and gene delivery, diagnosis and imaging. The properties of nanoparticles mainly depend on their synthesis procedure. There has been a massive effort in developing the best synthetic strategies to yield appropriate physico-chemical properties namely co-precipitation, thermal decomposition, microemulsions, hydrothermal and sol-gel. In this review, it is discovered that magnetite nanoparticles are best yielded by co-precipitation method owing to their simplicity and large production. However, its magnetic saturation is within range of 70-80 emu/g which is lower than thermal decomposition and hydrothermal methods (80-90 emu/g) at 100 nm. Dimension wise, less than 100 nm is produced by co-precipitation method at $70^{\circ}C-80^{\circ}C$ while thermal decomposition and hydrothermal methods could produce less than 50 nm but at very high temperature ranging between $200^{\circ}C$ and $300^{\circ}C$. Thus, co-precipitation is the optimum method for pre-compliance magnetite nanoparticles preparation (e.g., 100 nm is fit enough for biomedical applications) since thermal decomposition and hydrothermal required more sophisticated facilities.

Preparation and Evaluation of Paclitaxel Nano-particle Delivery System for Parenteral Formulations (나노입자수송시스템을 이용한 파클리탁셀 정맥주사제의 제조 및 평가)

  • Jeon Il-Soon;Kim Jeong-Soo;Lee Gye-Won;Jee Ung-Kil
    • YAKHAK HOEJI
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    • v.49 no.4
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    • pp.268-274
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    • 2005
  • Paclitaxel is an effective antineoplastic agent against ovarian, colon and breast tumors. But there have been many difficulties to formulate this drug due to the extremely low aqueous solubility. Paclitaxel is currently formulated in a vehicle composed of Cremophor EL and absolute ethanol mixture which is $5\~20$ fold diluted in normal saline or $5\%$ dextrose solution before I.V. injection. However, this formulation has many problems such as allergic reactions and drug precipitation on aqueous dilution. To overcome these problems, we prepared the micelle and microemulsion systems for parenteral administration of paclitaxel by using glycofurol, $Soluto^{(R)}lHS$ 15 and oleic acid. Phase diagram, pH-rate stability, particle size distributions and pharmacokinetics of the systems were studied. Micelles and microemulsions formulated as nano-particle delivery system were physically and chemically stable. Therefore, these formulations might be the promising alternative candidate for the parenteral delivery of paclitaxel.

Preparation and Evaluation of Propofol Microemulsion for Parenteral Use (마이크로에멀젼을 이용한 프로포폴 주사제의 개발 및 평가)

  • 이종화;박선영;김동우;조미현;조인숙;이계원;박목순;지웅길
    • YAKHAK HOEJI
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    • v.46 no.5
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    • pp.337-342
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    • 2002
  • Propofol(2,6-diisopropyl phenol) is a phenol derivative that is chemically distinct from other intravenous sedative hypnotics. It has been extensively used as a short term anesthetic agent, because of the rapid onset and short duration of action. Propofol microemulsion system was prepared with different concentrations of ethyl oleate, $Solutol^{(R)}$ HS 15 and $Kollidon^{(R)}$ 17 PF. Propofol microemulsions were studied by transmittance, viscosity, particle size, in vitro release and pharmacokinetics. The range of transmittance of A group with 4% ethyl oleate and that of B group with 5% ethyl oleate were 92.6~95.1 and 91.3~94.2%, respectively. Transmittance 1~2% decreased as concentration of $Kollidon^{(R)}$ 17 PF was increased and increased 0.8~3.3% when 10 times diluted with normal saline. The viscosity of A and B group were in the range of 3.9~4.1 mPaㆍsec and 4.4~5.3 mPaㆍsec, respectively. The particle sizes of A and B group increased as amount of $Kollidon^{(R)}$ 17 PF. Also, release of propofol was slowly increased as the amount of $Kollidon^{(R)}$ 17 PF was increased. Propofol plasma concentration by i.v injection showed 2-compartment model. Pharmacokinetics of A-5 was similar to that of commercial emuision(POFOL).

Properties of Microemulsion Containing Quaternary Ammonium Salt as Polishing Wax (광택용 왁스로서 4차 암모늄염을 함유한 마이크로에멀젼의 특성)

  • Lee, Jang-Weon;Kim, Myung-Soo;Jeong, Noh-Hee
    • Journal of the Korean Applied Science and Technology
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    • v.21 no.4
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    • pp.335-344
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    • 2004
  • In this work, the properties as polishing wax for automobile of O/W type microemulsion containing wax, liquid paraffine and quaternaryammonium salt was investigated. The microemulsions were prepared at $96{\sim}97^{\circ}C$ by the phase inversion method, and polyoxyethylene(20) sorbitan monooleate (POE(20)SMO) and distearyl dimethyl ammonium chloride(D.D.A.C) as the emulsifiers were used. The mean particle size of the rnicroemulsions was about 7${\pm}$0.5nm and as the properties of polishing wax, gloss increased degree, water resistant gloss degree, initial and final contact angle after water resistance were tested. The result was that the value of water resistantance and contact angle were decreased with increasing amount of POE(20)SMO and D.D.A.C., while the gloss degree values did not affected. And the rnicroemulsion blended with mono ethylene glycol(MEG) of 5${\sim}$15wt% showed smaller particle size and more stable particle size distribution than without MEG. Finally, this microemulsion showed more excellent values of gloss degree, the water resistant gloss degree and contact angle, than two kinds of commercial polishing wax for automobile.

Characteristics of Non-ionic Micellar and O/W Microemulsion Systems and Solubilization of Sudan IV (비이온성 미셀용액과 수중유형 마이크로에멀젼계의 특성 및 수단 IV의 가용화)

  • 지웅길;황성주;장은옥;현종목
    • YAKHAK HOEJI
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    • v.39 no.5
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    • pp.495-505
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    • 1995
  • The O/W microemulsion systems were made from 2 or 4% (w/w) oil (soybean oil, olive oil or isopropyl myristate) and 10, 15 or 20% (w/w) Brij 96. They were compared with micellar solution of equivalent surfactant concentration m therms of physicochemical properties, and the solubilization of sudan IV. They were characterized by dynamic light scattering, stability, surface tension, viscosity and rheogram. The mean diameters of O/W microemulsion systems were 10-15nm, and those of Brij 96 micellar solutions were 18-19 nm. Both of them were monodisperse systems. The O/W microemulsion systems showed Newtonian flow and their apparent viscosities were lower than those of micellar solutions. The surface tensions of O/W microemulsion systems were increased or decreased depending on the types of oil used, when compared with those of micellar solutions. The O/W microemulsion systems were very stable, and did not show any flocculation or aggregation. Their mean diameters were not changed after three months. But oxidation was observed in microemulsions without nitrogen gas at high temperature. There was a significant improvement in the sudan IV solubffimtion in micromulsion compared with that m the micellar solution containing equivalent concentration of surfactant. The size distribution and mean diameters of O/W micromulsions were not changed when sudan IV was solubilized.

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