• 대한전자공학회논문지
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• 제23권1호
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• pp.83-90
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• 1986

A micro pH-ISFET probe, which can be applied to the in vivo measurements of the hydrogen ion concentration in blood, has been developed, and a measuring system equiped with this probe also developed. The pH-ISFET has been fatricated by employing the techniques of integrated circuit fabrication. Two kinds of micro electrode formed around the sensing gate during the wafer process, and the other is a capillary type of Ag/AfCl/sat. KCI reduced in size. This capillary electrode has shown its good performance characteristics so far in the application with ISFET as well as a commercial one. In order to form a micro pH-ISFET probe, this pH-ISFET and well as a commercial one. In order to form a micro pH-ISFET probe, this pH-ISFET and the capillary electrode were built together into a needle tip having 1 mm inner diameter. The chip size of a twin pH-ISFET is 0.8 mmx1.4 mm, the material of the sensing gate membrane is Si3N4, and the sensitivity of the developed probe is about 52mV/pH.

• 한국식품영양과학회지
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• 제35권4호
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• pp.507-509
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• 2006

미량확산법에 의한 휘발성 염기질소 분석에서 고체소자센서가 부착된 마이크로 pH 전극을 사용하여 적정 과정을 자동화하기 위하여 자동적정시스템을 구성하고 자동적정 프로그램을 작성하였다. 자동적정시스템으로 돈육시료의 휘발성염기질소 분석을 수행한 결과 부패도가 서로 다른 모든 시료에서 자동적정과 수동적정의 평균들 간에 유의수준 15%에서도 유의차가 인정되지 않았으며, 두 방법의 평균치들 사이에 높은 상관성이 확인되었다.

• Bulletin of the Korean Chemical Society
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• 제26권10호
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• pp.1565-1568
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• 2005

A surface renewable pH electrode was prepared by utilizing composite electrode technique. Iridium oxide micro-fine particles was prepared by hydrolysis of $(NH_4)_2IrCl_6$ at elevated temperature. The iridium oxide particles were mixed with well-dispersed carbon black and then filtered. The mixture was suspended in DMF containing PVC as a binder. The mixture was precipitated rapidly by adding large amount of water. The precipitate was ground and pressure-molded to iridium oxide composite electrode material. The electrode showed linear response between pH 1-13 with 50 to 60 mV/pH slope. The electrode maintained the pH response without appreciable slope drift for 170 days if stored in deionized water. The electrode surface can be renewed reproducibly by simple grinding process whenever contaminated or deactivated.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 추계학술대회 논문집
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• pp.585-588
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• 2005

The dissolution characteristic of metal shows the different tendency according to the applied electrical potential, the kind of electrolyte and pH value, etc. In the micro electrochemical machining (ECM), unfavorable oxide/passive layer formation and overall corrosion of electrodes must be prevented. The anodic polarization curve of nickel has distinct three dissolution regions, i.e. two active regions and the transpassive dissolution region. In this paper, the stable electrode potentials of workpiece and tool were determined in sulfuric acid and hydrochloric acid solution, respectively. In each solution, different machining property was shown and possible electrochemical reactions were discussed. On the basis of this experiment, the methodology to obtain the proper electrode potential was suggested.

• 전자공학회논문지D
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• 제35D권4호
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• pp.78-83
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• 1998

A small size cartrideg for FET type electrolyte sensor is designed and faricated with much simplified process by using micromachining tenchiques such as silicon etching andglass bonding. Size of the whole cartideg is 2.4cm*2.5cm, and the dead volume of a micro flow-channel in the cartrideg is only 8.5.mu.l. The photosensitive polymer(THB 30) is used to define a micropool and to encapsulate the sensor surface for standardizationof electrolyte sensors. To miniaturize micro flow-channel conventional reference electrode(Ag/AgCl) a differential amplification is introduced using REFET and quasi reference electrode. Refet was fabricated using photosensitive polymer(OMR 83). The fabricated cartridge with built-in pH-ISFET showed good operational characteristics such as linearity and high sensitivity (55.4mV/pH) in a wide pH range(pH2-pH12).

• 대한의용생체공학회:의공학회지
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• 제38권6호
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• pp.277-284
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• 2017

This paper presents an implantable pH measurement electrode for wireless gastroesophageal reflux measurement. Usually, gastroesophageal reflux is diagnosed by a catheter-type wire connection between the esophagus and the diagnostic device which brings many side effects such as restriction of daily living, pain, and discomfort in the nasal cavity and pharynx of patients. In order to solve these issues, researchers have been studied a wireless measurement method and a micro-sized pH electrode for human body insertion is necessary. Commercial glass packaged pH meter is formed by a sensing and a reference electrodes in a KCl solution. However, if the glass meter is inserted into the human body, there are risks of leakage of the solution, breakage of the glass package, injury of the body elements. Therefore, the solution should be solidified on the micro-sized noble metal wire which has a characteristic of biocompatible. After solidified wire fabrication, the designed meter was tested for feasibility of measurement and the result was well agreed with pH values of commercial pH meter. Potentials in pH 1 to 12 solution was measured to obtain the sensitivity of the sensor with linearity. And we have designed a simulation of gastroesophageal reflux with symptom frequency, interval, and duration time in pH 2 solution. The proposed sensor has capable to get the same potential for 24 measurements in 3 days, and it has sensed same pH values of 2 for one hour with every 10 minutes. Furthermore, the sensor was survived for 48 hours with reasonable potentials in the acid solution.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2003년도 하계학술대회 논문집 Vol.4 No.2
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• pp.950-952
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• 2003

This paper have been studied fabrication and characteristics of disposable pH sensor using MEMS technology. The sensor has two open-well structure, the container for the internal electrolyte and electrode were formed by anisotropically etching a silicon substrate. unlike currently used KCI saturated solution, the structure was introduced hydrogel which take an advantage of miniaturization, bulk product, a low price. PU and CA/TP used to measurement ion detection, one is reference membrane and the other is pH. fabricated sensor is encapsulated entirely with epoxy, finally sensor was estimated various ion sorts and pH ranges.

• Bulletin of the Korean Chemical Society
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• 제27권10호
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• pp.1581-1586
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• 2006

A La (III) ion-selective membrane sensor has been fabricated from poly vinyl chloride (PVC) matrix membrane, containing 3-hydroxy-N'-(pyridin-2-ylmethylene)-2-naphthohydrazide (HPMN) as a neutral carrier, potassium tetrakis (p-chlorophenyl) borate (KTpClPB) as an anionic excluder and ortho-nitrophenyloctyl ether (NPOE) as a plasticizing solvent mediator. The effects of membrane composition and pH as well as the influence of the anionic additive on the response properties were investigated. The sensor with 30% PVC, 62% solvent mediator, 6% ionophore and 2% anionic additive, shows the best potentiometric response characteristics. It displays a Nernstian behavior (19.2 mV per decade) across the range of $1.0{\times}10^{-2}-1.0{\times}10^{-7}$ M. The detection limit of the electrode is $7.0{\times}10^{-8}$ M ($\sim$10 ng/mL) and the response time is 15 s from $1.0{\times}10^{-2}$ up to $1.0{\times}10^{-4} $M and 30 s in the range of $1.0 {\times}10^{-5}-1.0{\times}10^{-7}$ M. The sensor can be used in the pH values of 3.0-9.0 for about seven weeks. The membrane sensor was used as an indicator electrode in the potentiometric titration of lanthanum ions with EDTA. It was successfully applied to the lanthanum determination in some mouth wash preparations.

• 한국식품과학회지
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• 제27권4호
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• pp.520-524
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• 1995

보리새우를 얼음저장과 냉동저장시 새우의 품질을 측정하기 위하여 ATP 관련물질, K value, 암모니아, 휘발성 염기질소, 관능검사를 실시하였으며, 각 품질지표간의 상관관계를 알아보았다. 얼음저장시 AMP와 IMP는 초기에 증가하다가 감소하였고, HxR 및 Hx는 증가하는 경향을 보였다. 냉동저장의 경우 AMP와 IMP는 8개월간 계속 증가하였고, HxR과 Hx는 7개월 후 약간 증가하였다. K value는 얼음저장의 경우 8일까지 초기 조직손상 단계인 20% 이하를 유지하다가 급속히 증가하였고, 냉동저장의 경우 7개월까지 서서히 증가하였다. 암모니아는 얼음저장 6일까지 완만히 증가하다가 8일부터 급속히 증가하였고, 냉동저장의 경우 8개월까지 서서히 증가하였다. VBN은 얼음저장 10일까지 조금씩 증가하다가 그 후 급속히 증가하였고, 냉동저장 6개월까지 별로 큰 변화가 없었다. 관능검사 결과 얼음저장 새우의 맛과 외관은 6일부터 나빠지기 시작하였고, 냉동저장한 경우 $6{\sim}7$개월이 지나면서 맛과 외관이 나빠졌다. K value, 암모니아, VBN 및 관능평가간의 상관관계는 얼음저장의 경우 모두 유의성이 있었고, 냉동저장의 경우는 관능검사와 암모니아 및 VBN과 유의성있는 상관관계가 있었다. 그리고 암모니아와 관능검사 결과간에 높은 상관관계가 있는 것으로 보아 ion-specific ammonia electrode를 사용하여 간편하고 단시간에 새우의 품질을 측정할 수 있을 것으로 평가되었다.

• 센서학회지
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• 제8권4호
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• pp.320-326
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• 1999

센서의 감지막 표면에 흡착되어 있는 이물질을 세척하기 위해 노즐 원리를 도입하여 소형 카트리지를 제작하였다. 세척용 노즐구조는 유동 해석 프로그램(CFD-ACE)의 검증을 통하여 소형 카트리지에 적합하도록 설계하였다. 미세가공기술을 이용하여 제작된 카트리지의 전체 크기는 약 $2.6\;cm{\times}1.5\;cm$이고 세척용 노즐의 크기는 $0.2\;mm{\times}600\;mm$이며, 측정에 필요한 시료의 양은 약 $20\;{\mu}l$이다. REFET과 의사기준전극을 이용한 차동증폭법을 사용하여 기준전극을 소형화하였다. 또한, 미세채널에서 기포로 인한 센서의 오동작을 감지하기 위해 채널 양단에 금속전극을 증착하였다. 제작된 카트리지에 pH-ISFET를 장착하여 노즐에 의한 세척효과를 조사하였다.