• 제목/요약/키워드: miR-27a

검색결과 286건 처리시간 0.026초

수술실 간호사의 직무스트레스, 회복탄력성, 전문직 정체성이 소진에 미치는 영향 (Influence of the Job Stress, Resilience, and Professional Identity on Burnout in Operation Room Nurses)

  • 임은진;이윤미
    • 중환자간호학회지
    • /
    • 제10권1호
    • /
    • pp.31-40
    • /
    • 2017
  • Purpose: The purpose of this study was to identify the factors influencing on burnout in operating room nurses. Methods: Using a cross-sectional design, a total of 109 operating room nurses working at 7 general hospitals with 300 beds or more in B city were analyzed. The instruments used for this study assessed job stress, resilience, professional identity, and burnout. Data was analyzed using descriptive statistics, a t-test, an ANOVA, a Pearson's correlation coefficient and a multiple regression analysis. Results: There was a statistically significant correlation between burnout and job stress (r=.53, p<.001), resilience (r=-.59, p<.001), and professional identity (r=-.47, p<.001). The factors influencing burnout include job stress (${\beta}=.27$, p<.001), resilience(${\beta}=-.37$, p<.001), dissatisfaction with the nursing job (${\beta}=.32$, p<.001), and moderate satisfaction with the nursing job (${\beta}=.19$, p=.014), and the explanatory power was 53.0%. Conclusions: The results suggest that intervention to reduce job stress and to improve resilience, which were the factors influencing burnout in operating room nurses, is necessary.

  • PDF

Identification of Hub Genes in the Pathogenesis of Ischemic Stroke Based on Bioinformatics Analysis

  • Yang, Xitong;Yan, Shanquan;Wang, Pengyu;Wang, Guangming
    • Journal of Korean Neurosurgical Society
    • /
    • 제65권5호
    • /
    • pp.697-709
    • /
    • 2022
  • Objective : The present study aimed to identify the function of ischemic stroke (IS) patients' peripheral blood and its role in IS, explore the pathogenesis, and provide direction for clinical research progress by comprehensive bioinformatics analysis. Methods : Two datasets, including GSE58294 and GSE22255, were downloaded from Gene Expression Omnibus database. GEO2R was utilized to obtain differentially expressed genes (DEGs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs were performed using the database annotation, visualization and integrated discovery database. The protein-protein interaction (PPI) network of DEGs was constructed by search tool of searching interactive gene and visualized by Cytoscape software, and then the Hub gene was identified by degree analysis. The microRNA (miRNA) and miRNA target genes closely related to the onset of stroke were obtained through the miRNA gene regulatory network. Results : In total, 36 DEGs, containing 27 up-regulated and nine down-regulated DEGs, were identified. GO functional analysis showed that these DEGs were involved in regulation of apoptotic process, cytoplasm, protein binding and other biological processes. KEGG enrichment analysis showed that these DEGs mediated signaling pathways, including human T-cell lymphotropic virus (HTLV)-I infection and microRNAs in cancer. The results of PPI network and cytohubba showed that there was a relationship between DEGs, and five hub genes related to stroke were obtained : SOCS3, KRAS, PTGS2, EGR1, and DUSP1. Combined with the visualization of DEG-miRNAs, hsa-mir-16-5p, hsa-mir-181a-5p and hsa-mir-124-3p were predicted to be the key miRNAs in stroke, and three miRNAs were related to hub gene. Conclusion : Thirty-six DEGs, five Hub genes, and three miRNA were obtained from bioinformatics analysis of IS microarray data, which might provide potential targets for diagnosis and treatment of IS.

중재의 준거법 선택과 당사자 자치의 제한 - 국제스포츠중재를 중심으로 - (The Choice of Applicable Law and the Limitations of Party Autonomy - Focusing on International Sports Arbitration -)

  • 유소미
    • 한국중재학회지:중재연구
    • /
    • 제31권2호
    • /
    • pp.23-46
    • /
    • 2021
  • Sports disputes have specific characteristics compared to disputes that arise in the field of commerce. One particularity is the judicial system in which the CAS plays a key role as the International Supreme Court for sports-related matters. The CAS Code applies whenever the parties agree to submit a sports-related dispute to the CAS(Art. R27). Once the parties to the arbitration agreement have decided that the CAS Code should govern their proceedings. The parties' autonomy is, however, limited to the provisions of the CAS Code that provide for such a corresponding autonomy. The application of the mandatory rules contained in the CAS Code cannot be excluded. In CAS appeals arbitration proceedings, the Panel shall decide the dispute according to the applicable sports regulations and, subsidiarily, to the rules of law chosen by the parties(Art. R58). In international sports disputes, the uniform application and interpretation of the relevant regulations are essential. Therefore, Art. R58 should be applied as a mandatory rule without any changes. Regulations of the sports organizations are to be qualified as valid rules of law. CAS panels may also apply the so-called lex sportiva to the merits before considering statutory provisions of national jurisdictions. In this way, the specificities in (international) sports disputes can be taken into account without the need to further examine the application of national legal standards.

한국 성인의 연령에 따른 각막 전후면 구면수차에 관한 분석 (Analysis of anterior and posterior corneal spherical aberration with age in the korean)

  • 송윤영;정미아;강인산;최지영
    • 디지털융복합연구
    • /
    • 제11권1호
    • /
    • pp.315-320
    • /
    • 2013
  • 20~71세 성인을 연령에 따라 5군으로 분류하여 연령에 의한 정상 한국인의 각막 전후면 수차를 알아보기 위하여 수행되었다. 본 연구의 취지에 동의한 사람 가운데 전신질환이나 안질환이 없으며, 굴절이상 수술을 포함하여 안과 관련 수술병력이 없는 성인 290안을 대상으로 Pentacam 을 사용하여 각막곡률반경, 비구면도, 각막 구면수차를 측정하였다. 전체 대상군의 평균 전면 곡률반경과 구면수차 사이에는 음의 상관관계가 나타났고(r = -0.22, p < 0.0001), 평균 후면 곡률반경과 구면수차 사이 또한 음의 상관관계가 나타났다(r = -0.27, p < 0.0001). 또한, 평균 전면 비구면도와 구면수차 사이에는 양의 상관관계가 나타났으나(r = 0.24, p < 0.0001), 평균 후면 비구면도와 구면수차 사이에는 음의 상관관계가 나타났다(r = -0.17, p = 0.00288) 전체 대상군의 전면 구면수차의 평균 값은 $0.482{\pm}0.099{\mu}m$, 후면 구면수차의 평균값은 $-0.098{\pm}0.029{\mu}m$이고, 전체 구면수차의 평균값은 $0.385{\pm}0.097{\mu}m$로 나타났다. 연령에 따른 구면수차의 상관관계를 분석한 결과 전면수차는 연령과 유의한 양의 상관관계(r = 0.227, p<0.0001)를 보였고, 후면 또한 연령과 유의한 양의 상관관계(r = 0.349, p<0.0001)를 나타났다. 한국 정상인의 각막 구면수차 분석을 통하여 한국 정상인 눈의 광학적 부분의 더 나은 이해를 제시하였으며, 현대인의 시력의 질을 향상시키기 위한 추가적인 연구에 활용될 수 있는 기초 자료로 활용 할 수 있을 것으로 사료된다.

물류트랙킹 장비에 활용되는 WCDMA/GSM 이중 대역 안테나 설계 및 성능 검증 (Efficient Multicasting Mechanism for Mobile Computing Environment)

  • 이은규;최성필;문영식;전미진;조재희;김재중;최형림
    • 한국정보통신학회:학술대회논문집
    • /
    • 한국정보통신학회 2013년도 추계학술대회
    • /
    • pp.896-897
    • /
    • 2013
  • 최근에는 WCDMA와 GSM를 함께 이동통신 기술을 이용하여 물류운송의 효율성을 향상시키기 위한 방안이 연구되고 있다. 본 논문에서는 컨테이너화물 안전수송에 사용되는 컨테이너 이동통신 안테나로 활용하여 물류시스템을 효율적으로 운영할 수 있도록 광대역 원편파 특성을 나타내는 WCDMA/GSM 듀얼 주파수 지원 가능한 안테나를 설계 및 제작하였다. 설계된 안테나는 WCDMA(1920~2170MHz), GSM(824~960MHz)에 동작되며 VSWR 3:1에서 리턴로스가 -10dB이하로 나왔으며 이득이 27dB이 나왔다. 제작된 안테나는 실제 러시아 물류 환경에 적용함으로써 WCDMA/GSM 신호가 국가 간 이동에도 정상적으로 수신됨을 검증하였다.

  • PDF

둥근금감 (깔라몬딘 오렌지)의 이네푸 추출공정의 최적화를 통한 화장품 기능성 활성 증가 연구 (Improved cosmetic activity by optimizing the Citrus madurensis (Citrofortunella microcarpa) INEFU extraction process.)

  • 김유미;배경석;크리스 문
    • 한국자원식물학회:학술대회논문집
    • /
    • 한국자원식물학회 2019년도 춘계학술대회
    • /
    • pp.98-98
    • /
    • 2019
  • This study was expand the use of Citrus madurensis (Citrofortunella microcarpa), which is a good source of skin whitening and antioxidants activation cosmetics. The goal was to provide cosmeceutical activity data about the extraction yield and total phenol of this calamondin orange by optimizing the focused high ultrasound(INEFU) and ultrasound extraction(UE) conditions. Under optimal extraction conditions, which consisted of 1800W for 45min and 500W for 45 min, 21.55 and 13.27 % (w/w) of the highest extractions yield and polyphenol contents were obtained. For the skin whitening activity, tyrosinase inhibitory activity was observed at 69.24 % in the INEFU extracts, which was ca. 18 % higher than that of the UE extracts (58.82 %). To reduce melanin production in Clone M-3 cells, 86.9 % melanin production was observed following the addition of control, WE(water extraction) relative to the control without a sample, and 81.2 and 78.9 % were found in the UE and INEFU conditions. The highest total phenol secretion was conclusively obtained under the optimal conditions and resulted in a significant improvement of the cosmetic activities of Citrus madurensis(Citrofortunella microcarpa) extracts.

  • PDF

여대생의 측두하악장애에 따른 T-scan III System을 이용한 교합분석 및 구강행동유형과의 관련성 (Relationship between occlusion analysis using the T-scan III system and oral behavior checklist according to temporomandibular joint disorder in female college students)

  • 이선미;김창희;전미경
    • 한국치위생학회지
    • /
    • 제19권2호
    • /
    • pp.317-327
    • /
    • 2019
  • Objectives: This study aimed to evaluate the effects of occlusion patterns using the T-scan $III^{(R)}$ system and oral parafunctional behaviors on temporomandibular joint disorder (TMD) in female college students. Methods: A questionnaire survey assessed TMD symptoms and oral behavioral checklist (OBC) scores in 120 female college students in their early twenties. Occlusion was evaluated using the T-scan $III^{(R)}$ system. Logistic regression analysis was performed to investigate the relationship between occlusion and OBC scores based on patients' symptoms of TMD and to determine whether OBC scores were a predictor of TMD. Results: A total of 101 participants with an average age of 22 (${\pm}2.17$) years were included in the analysis. The reported symptoms of TMD were categorized as moderate (28.8%), slight (27.7%), severe (25.7%), and asymptomatic (17.8%). Occlusion was analyzed using the T-scan $III^{(R)}$ system, and the mean occlusion time was 0.42(${\pm}0.5$) seconds. The results of logistic regression analysis showed that the group that would 'clench or grind teeth' during sleep showed an odds ratio for TMD that was 8.9 times higher than that in the group without this behavior. The group that would 'hold, tighten, or tense muscles without clenching' while awake showed an odds ratio for TMD that was 21.3 times higher than that in the group without this behavior. Conclusions: We confirmed that oral parafunctional behavior affects TMD. Therefore, we would like to continue studying the diagnosis and treatment of TMD by evaluating occlusion patterns and related OBC scores.

가야산의 저서성 대형무척추동물 섭식기능군 및 서식습성군 분포와 생물학적 수질평가 (Distribution of Functional Feeding and Habitat Trait Groups of Benthic Macroinvertebrates and Biological Evaluation of Water Quality in Gayasan National Park)

  • 문태영;안미순;김형곤;윤춘식;정선우
    • 한국환경과학회지
    • /
    • 제27권6호
    • /
    • pp.383-399
    • /
    • 2018
  • In the present study, the community distribution, functional feeding groups, and habitat groups of the benthic macroinvertebrates from Gayasan National Park were investigated at eight different sites from 2015 to 2016. The correlation between habitat altitude and each group type was analyzed statistically. Biodiversity indices, including dominance, diversity, richness, and evenness indices, were calculated. The results showed a total of 4,216 individual benthic macroinvertebrates were collected, including 4 phyla, 6 classes, 16 orders, 40 families, and 100 species. Gammarus sobaegensis was dominant with 0.141% dominance, and the subdominant species was Epeorus nipponicus with 0.088% dominance. The EPT group(Ephemeroptera, Plecoptera and Tricoptera) accounted for 71.00% of the total species and 67.69% of the total individuals. The number of scraper species was highest, and the number of gathering collector individuals was highest among functional feeding groups. The individual number of scrapers(r=-0.358, p < 0.05) and gathering collectors(r=-0.343, p < 0.05) decreased with increasing altitude. The numbers of species and individuals of clingers and sprawlers were highest among the habitat groups. The individual number of clingers(r=-0.547, p < 0.01) and burrowers(r=-0.331, p < 0.05) significantly decreased with increasing altitude. The diversity and richness indices were higher in St. 3 than in the other sites. The dominance index was highest in St. 2, and the evenness index was highest in St. 7. We evaluated the biological water quality with several known methods, and concluded that ESB(Ecological score of benthic macrovertebrates community) and GPI(Group polution index) were more suitable than KSI(Korean saprobic index) and BMI (Benthic macrovertebrate index) to assess the biological water quality of Gayasan mountain stream water.

천연 소재 복합물이 고지방사료로 유도된 비만 생쥐의 조직형태 및 조직병리학적 변화에 미치는 영향 (The Effect of Natural Mixture Supplementation on Histopathological and Histomorphometrical aspects in High Fat Diet-induced Obese Mice)

  • 신인순;최혜민;구세광;김미려
    • 대한본초학회지
    • /
    • 제27권4호
    • /
    • pp.53-58
    • /
    • 2012
  • Objective : Obesity is often defined as a condition associated with accumulations of excessive body fats which resulting from disorder of energy balance in term of energy intake and energy expenditure. Methods : The effects of natural mixture (T) for inhibition of lipid metabolism on the liver, epididymal fat pads and pancreatic zymogen granules of high fat diet (HFD) supplied rats were observed by histopathology and histomorphometry. Results : As results of HFD supply, severe steatohepatitis such as increases of mean diameters of hepatocytes and the percentages regions of fatty changes was detected. In addition, hypertrophy of adipocytes (increase of mean diameters of epididymal fat pads) was also detected with dramatic decreases of pancreatic zymogen granules at histopathological and histomorphometrical observations. However, theses steatohepatitis and hypertrophy of adipocytes induced by HFD supply were inhibited by treatment of 5 % and 10 % T (T5, T10), respectively. Well corresponded as the results of adipocyte hypertrophy and steatohepatitis, the decreases of pancreatic zymogen granules were also dose-dependently inhibited by T treatment as compared with HFD control, respectively. Conclusion : In conclusion, based on the results, it is considered that test materials, T5 and T10, will be showed hepatoprotective and anti-obese effects, may be directly and/or indirectly mediated by pancreatic zymogen granules because they dose-dependently inhibited steatohepatitis, hypertrophy of adipocytes and decreases of pancreatic zymogen granules induced by HFD supply, respectively.

아토피피부염 아동 어머니의 지식, 치료지시이행 및 삶의 질 (Knowledge, Compliance and Quality of Life of Mothers of Children with Atopic Dermatitis)

  • 김민주;최미혜
    • Child Health Nursing Research
    • /
    • 제17권4호
    • /
    • pp.272-280
    • /
    • 2011
  • Purpose: This study was conducted to survey knowledge, compliance, and quality of life of mothers who have children with atopic dermatitis, and to determine whether above mentioned factors influence each other. Methods: The participants in this study were 165 mothers of children with atopic dermatitis recruited from one out-patient clinic in a hospital in Seoul. The data were collected between March 8, and April 16, 2010 using a structured questionnaire. Results: The mean score for participants' knowledge was 4.17/5, for compliance, 4.27/5 and for quality of life, 3.42/5. Among the five domains of quality of life, emotional status had the lowest score (3.20/5). Knowledge was significantly correlated with compliance (r=.215, p<.005). However, quality of life was not correlated with knowledge (r=-.069) and compliance (r=-.077). Conclusion: Accurate knowledge affects compliance of mothers of children with atopic dermatitis. Therefore, to increase the level of compliance, it is necessary to enhance the knowledge of the mothers. Results also suggest that interventions are needed to improve poor quality of life, particularly the emotional condition of mothers of children with atopic dermatitis.