• Journal of Applied Biological Chemistry
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• 제49권1호
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• pp.24-27
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• 2006

Four ursane-type triterpenoids, 2${\alpha}$,3${\alpha}$,19${\alpha}$-trihydroxy-24-norurs-4(23),12-dien-28-oic acid (1), 4(R),23-epoxy-2${\alpha}$,3${\alpha}$,19${\alpha}$-trihydroxy-24-norurs-12-en-28-oic acid (2), myrianthic acid (3), and tormentic acid (4), and a phenolic compound, ethyl gallate (5), from an EtOAc-soluble extract of the stems of Rumex japonicus, were subjected to in vitro bioassays to evaluate advanced glycation end products (AGEs) and rat lens aldose reductase (RLAR) inhibitory activity. Compounds 1 and 5 exhibited a significant inhibitory activity on AGEs formation with $IC_{50}$ value of 87 ${\mu}M$ and on RLAR with $IC_{50}$ value of 14.3 ${\mu}M$, respectively. Ethyl gallate (5) was isolated for the first time from this plant.

• Food Science and Biotechnology
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• 제27권6호
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• pp.1811-1821
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• 2018

Obesity is generally caused by quantitative changes in adipocyte differentiation and fat metabolism. Only a few studies have been determined the effect of red beans extract on obesity and plasma cholesterol concentration. We have been studied the functional activities of red-bean extracts including anti-oxidative effect against DNA and cell damages. Histological study including micro CT analysis showed that the accumulation of fat in hepatocytes and intestines was significantly decreased in red bean extract treated group. In addition, plasma cholesterol and triglyceride levels were decreased in blood samples. In addition, it was confirmed that the red bean extract inhibited the expression of $PPAR{\gamma}$, Fabp4 and RETN genes, which regulate total adipocyte differentiation and lipid metabolism. Red bean extract inhibits the expressions of transcription factors associated with adipocyte differentiation in a dose-dependent manner, thereby inhibiting fat accumulation and decreasing blood lipid levels in obese mice induced by high fat diet.

• Restorative Dentistry and Endodontics
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• 제27권2호
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• pp.150-157
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• 2002

One of the latest concepts in bonding are "total etch", in which both enamel and dentin are etched with an acid to remove the smear layers, and "wet dentin" in which the dentin is not dry but left moist before application of the bonding primer Ideally the application of a bonding agent to tooth structure should be insensitive to minor contamination from oral fluids. Clinically, contaminations such as saliva, gingival fluid, blood and handpiece lubricant are often encountered by dentists during cavity preparation. The aim of this study was to evaluate the effect of contamination by hemostatic agents on shear bond strength of compomer restorations. One hundred and ten extracted human maxillary and mandibular molar teeth were collected. The teeth were removed soft tissue remnant and debris and stored in physiologic solution until they were used. Small flat area on dentin of the buccal surface were wet ground serially with 400, 800 and 1200 abrasive papers on automatic polishing machine. The teeth were randomly divided into 11 groups. Each group was conditioned as follows : Group 1: Dentin surface was not etched and not contaminated by hemostatic agents. Group 2: Dentin surface was not etched but was contaminated by Astringedent$^{\circledR}$(Ultradent product Inc., Utah, U.S.A.) Group 3: Dentin surface was not etched but was contaminated by Bosmin$^{\circledR}$(Jeil Pharm, Korea.). Group 4: Dentin surface was not etched but was contaminated by Epri-dent$^{\circledR}$(Epr Industries, NJ, U.S.A.). Group 5: Dentin surface was etched and not contaminated by hemostatic agents. Group 6: Dentin sorface was etched and contaminated by Astringedent$^{\circledR}$. Group 7 : Dentin surface was etched and contaminated by Bosmin$^{\circledR}$. Group 8: Dentin surface was etched and contaminated by Epri-dent$^{\circledR}$. Group 9: Dentin surface was contaminated by Astringedent$^{\circledR}$. The contaminated surface was rinsed by water and dried by compressed air. Group 10: Dentin surface was contaminated by Bosmin$^{\circledR}$. The contaminated surface was rinsed by water and dried by compressed air. Group 11 : Dentin surface was contaminated by Epri-dent$^{\circledR}$. The contaminated surface was rinsed by water and dried by compressed air. After surface conditioning, F2000$^{\circledR}$ was applicated on the conditoned dentin surface The teeth were thermocycled in distilled water at 5$^{\circ}C$ and 55$^{\circ}C$ for 1,000 cycles. The samples were placed on the binder with the bonded compomer-dentin interface parallel to the knife-edge shearing rod of the Universal Testing Machine(Zwick Z020, Zwick Co., Germany) running at a cross head speed or 1.0 mm/min. Group 2 showed significant decrease in shear bond strength compared with group 1 and group 6 showed significant decrease in shear bond strength compared with group 5. There were no significant differences in shear bond strength between group 5 and group 9, 10 and 11.

• 간호행정학회지
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• 제8권2호
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• pp.249-259
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• 2002

Purpose: This study was to identify the relationship between transformational leadership of nurse managers and autonomy, empowerment of nurses. Method: The subjects were 468 nurses and 19 head nurses were working at the 3 general hospitals in seoul. The data were collected from July 6 to September 14, 2001 by the structured questionnaires. For data analysis, descriptive statistics, ANOVA, Pearson correlation coefficient, and stepwise multiple regression with SAS package were used. Result: 1) 'Autonomy' and 'Empowerment' were positively related to 'Total Transformational Leadership', 'Charisma', 'intellectual stimulation', 'individual consideration'($r=.18{\sim}24$, $r=.26{\sim}36$, p<.001). 2) 'Transformational leadership' showed a significant difference according to major field of practice(F=4.47, p<.001). 3) 'Autonomy' showed a significant difference according to age, education level, total numbers of years in nursing practice, and position in present(F=3.68, 3.27, 3.13, 4.34, p<.05). 4) 'Empowerment' showed a significant difference according to age, marital status, education level, major field of practice, total numbers of years in nursing practice, and position in present(F=16.02, t=9.04, F=6.97, 1.86, 15.71, 11.38, p<.05). 5) As a result of regression analysis, the key determinants of 'autonomy' were 'Charisma' and this explained 10.61% of the total variance of it. And the key determinants of 'empowerment' were 'intellectual stimulation' and this explained 16.01% of the total variance of it.

• 공업화학
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• 제27권6호
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• pp.573-576
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• 2016

친환경 냉매인 R-1234yf를 제조하기 위하여 오불화프로펜인 1,2,3,3,3-pentafluoropropene의 수소화반응을 수행하였다. 수소화반응 촉매로 팔라듐이 담지된 탄소입자를 제조하여 실험에 사용하였다. 반응조건에 따른 수소화반응 활성을 규명하기 위하여 WHSV, 반응온도 및 반응물의 조성에 따른 반응성능에 대하여 조사하였다. 일정한 실험 조건에서 WHSV는 주 생성물의 선택도에 영향이 없으며, 반응온도의 경우 높은 온도에서 우수한 생성물 선택도를 보였다. 수소와 반응물의 비의 경우 1.5 미만에서 우수한 생성물 선택도를 보였다. 또한 반응조건에 따른 생성물의 수율을 예측할 수 있는 모델식을 통계학적 접근을 통해 완성하였다.

• 중환자간호학회지
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• 제12권2호
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• pp.85-96
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• 2019

Purpose : The purpose of this study was to examine the mediating effect of perceptions regarding the importance of patient safety management in the relationship between incident reporting attitudes and patient safety care activities for nurses in small-and medium-sized general hospitals. The objective was to provide a basis for planning tailored training programs aimed at improving patient safety care activities. Methods : This study was conducted with 187 participants in small- and medium-sized general hospitals in K city in South Korea from March 15 to March 31, 2019. The data collected from participants were analyzed using descriptive statistics, a t-test, ANOVA, Pearson's correlation coefficients, and a multiple regression using IBM SPSS/WIN 21.0 software. Results : Patient safety care activities were found to be correlated with incident reporting attitudes (r=.27, p < .001) and perceptions of the importance of patient safety management (r=.59, p < .001). Further, perceptions of the importance of patient safety management had a complete mediating effect (${\beta}=.409$, p < .001) on the relationship between incident reporting attitudes and patient safety care activities. Conclusion : Based on the findings of this study, tailored training programs regarding patient safety care activities focused on boosting perceptions of the importance of patient safety management are highly recommended to improve nurses' patient safety care activities in small- and medium-sized general hospitals.

• 정신신체의학
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• 제27권2호
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• pp.164-172
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• 2019

연구목적 성격 5요인설을 기반으로 한 성격 특성 평가 도구인 NEO 성격검사를 이용해 우울증 환자 내에서 자살 증상(과거 자살 시도 또는 자살 사고)의 유무에 따라 성격 특성의 차이를 보이는지 분석하고자 하였다. 방 법 일 대학병원 정신건강의학과에서 외래 또는 입원치료를 받은 환자 중 우울증으로 진단된 186명의 의무기록을 조사하여 자살 증상군 70명과, 대조군 116명으로 분류하였다. NEO 성격검사를 사용하여 두 집단의 성격 특성의 차이를 비교하였다. 결 과 자살 증상군에서 신경증(Neuroticism)이 높았으며(p=0.041) 나이, 성별, 결혼 상태, 교육수준, 과거 입원 치료 병력 등을 보정한 다변량 로지스틱 회귀 분석에서도 신경증은 자살 증상에 유의한 영향을 주는 변수였다(Odds Ratio=1.04, 95% Confidence Interval 1.01~1.07, p=0.0145). 결 론 정높은 신경증은 우울증 환자 내에서 자살 위험이 높은 개인을 식별하는데 유용한 정보로 자살 예방에 있어 효율적인 의사결정을 돕는 지표로서의 활용 가능성이 시사된다.

• 한국지역사회생활과학회지
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• 제22권2호
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• pp.299-310
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• 2011

To establish good dietary behavior for middle school students, this study was conducted to analyze the needs of nutrition education and eating attitudes of 373 middle school students(boys 171, girls 202) in Hwaseong city. Using questionnaires, results were gathered and analyzed. Dietary behavior, food group intake and the needs of nutrition education were scored by a five-point Likert scale. Chi-square and student t-test were done for significant gender difference. The correlation between the needs of nutrition education with dietary behavior and food group intake was obtained by Pearson's r. The dietary attitude of 'try to eat first' and 'eating fast' were higher score in boys than in girls(p<0.05). Most of the students thought they didn't have any nutritional problems(71.8%). Nutrition education was considered necessary(54.9%) for proper growth and development(53.0%) in middle school. But 45.1% of students did not suggest by the reasons of 'short time to change'(28.2%), 'more effective in home'(27.4%). The appropriate time of nutrition education was pre-school(28.2%) or elementary school(27.4%), once a week(boys 51%, girls 71.3%) in frequency(p<0.001), and the information acquired by TV/Radio(30.0%) and internet(26.6%). Students(46.0%) wanted to know about 'growth and nutrition'. They were to learn information on the 'healthy growth'(4.10) and 'adolescent nutrition'(4.03). The vegetables group consumption and the thought of dietary attitude 'try to modify bad eating habits' were correlated with almost all categories of desired nutrition education. Through these results, good eating habits would be attained by nutrition education. A nutrition education program would require an expert teacher for middle school students.

• 한국컴퓨터정보학회논문지
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• 제27권8호
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• pp.23-30
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• 2022

딥러닝은 주가 및 농산물 가격 예측과 같이 데이터를 분석해 일련의 규칙을 발견하고 미래를 예상해 우리의 삶에서 다양한 도움을 주고 있다. 본 연구는 태양광 에너지 사용의 중요성이 늘어나는 상황에서 기상에 따른 태양광 발전 실적을 딥러닝을 통해 분석하고 발전량을 예측한다. 본 연구에서는 시계열 데이터 예측에서 두각을 나타내고 있는 LSTM(Long Short Term Memory network)을 사용한 모델을 제안하며 이미지를 비롯한 다양한 차원의 데이터를 분석할 때 사용되는 CNN(Convolutional Neural Network)과 두 모델을 결합한 CNN-LSTM과의 성능을 비교한다. 세 가지 모델의 성능은 태양광 발전 실적의 실제값과 딥러닝을 통해 예측한 값으로 MSE, RMSE, 결정계수를 계산하여 비교하였고 그 결과 LSTM 모델의 성능이 가장 우수한 것으로 나타났다. 따라서 본 연구는 LSTM을 사용한 태양광 발전량 예측을 제안한다.

• Clinical and Experimental Pediatrics
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• 제49권5호
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• pp.475-481
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• 2006

목 적 : 소아 비만의 빈도가 점점 증가하면서 비만으로 인한 고혈압, 관상동맥 질환, 고지혈증, 인슐린 저항, 당뇨병 등의 합병증이 문제가 되고 있다. 관상동맥 질환에서 호모시스테인 치의 증가, 비타민 $B_{12}$ 섭취의 감소가 중요한 역할을 하고 있음이 보고되고 있으나, 비만에서는 아직 호모시스테인, 인슐린, 비타민 $B_{12}$에 대한 연구가 많지 않은 실정이다. 저자들은 호모시스테인, 인슐린, 비타민 $B_{12}$, 엽산이 비만아에서 어떤 연관성을 갖고 있는지를 알아보기 위하여 본 연구를 실시하였다. 방 법 : 8세부터 11세 사이에 비만도가 130 이상인 중등도 비만아 27명을 대상군으로 하였고, 같은 연령의 30명의 정상 소아를 대조군으로 하였다. 신장, 체중을 이용하여 비만도와 체질량 지수를 산출하였고, 안정된 상태에서 수축기, 이완기 혈압을 측정하였다. 10시간 이상 금식 후 총 콜레스테롤, 중성지방, 호모시시테인, 인슐린, 비타민 $B_{12}$, 엽산을 측정하였다. 생체전기저항법을 이용하여 세포내액, 세포외액, 단백질, 무기질, 근육량, 체지방량, 체지방률, 복부지방률 등을 분석하였다. 결 과 : 호모시스테인은 비만군에서 $8.1{\pm}2.1{\mu}mol/mL$로 $4.9{\pm}1.0{\mu}mol/mL$인 정상군보다 유의하게 높았고, 인슐린도 비만군에서 $26.8{\pm}11.2{\mu}IU/mL$로 $12.5{\pm}5.24{\mu}IU/mL$인 정상군보다 유의하게 높았다. 비타민 $B_{12}$는 비만군에서 $798.6{\pm}174.3pg/mL$로 $967.8{\pm}405.0pg/mL$인 정상군보다 유의하게 낮았다. 그러나 엽산은 두 군 사이에 유의한 차이가 없었다. 비만군에서 인슐린은 수축기 혈압(r=0.535), 중성 지방(r=0.517), 총 콜레스테롤(r=0.408), 복부지방률(r=0.306)과 양의 상관관계가 있었다. 결 론 : 비만아에서 호모시스테인, 인슐린과 비타민 $B_{12}$가 의미있는 혈중 농도 차이를 보였으나 심혈관 질환 등의 성인병을 예방하는 예측 인자로 사용할 수 있는지 알기 위해 더 많은 연구가 필요하겠다.