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Constituents of the Stems of Rumex japonicus with Advanced Glycation End Products (AGEs) and Rat Lens Aldose Reductase (RLAR) Inhibitory Activity  

Kim, Jong-Min (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Lee, Yun-Mi (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Jang, Dae-Sik (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Kim, Jin-Sook (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Publication Information
Journal of Applied Biological Chemistry / v.49, no.1, 2006 , pp. 24-27 More about this Journal
Abstract
Four ursane-type triterpenoids, 2${\alpha}$,3${\alpha}$,19${\alpha}$-trihydroxy-24-norurs-4(23),12-dien-28-oic acid (1), 4(R),23-epoxy-2${\alpha}$,3${\alpha}$,19${\alpha}$-trihydroxy-24-norurs-12-en-28-oic acid (2), myrianthic acid (3), and tormentic acid (4), and a phenolic compound, ethyl gallate (5), from an EtOAc-soluble extract of the stems of Rumex japonicus, were subjected to in vitro bioassays to evaluate advanced glycation end products (AGEs) and rat lens aldose reductase (RLAR) inhibitory activity. Compounds 1 and 5 exhibited a significant inhibitory activity on AGEs formation with $IC_{50}$ value of 87 ${\mu}M$ and on RLAR with $IC_{50}$ value of 14.3 ${\mu}M$, respectively. Ethyl gallate (5) was isolated for the first time from this plant.
Keywords
Rumex japonicus; Polygonaceae; 24-nor-Triterpenoid; Ethyl gallate; AGEs; Aldose reductase;
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1 Makita, Z., Radoff, S., Rayfield, E. J., Yang, Z. H., Skolnik, E., Delaney, V., Friedman, E. A., Cerami, A. and Vlassara, H. N. (1993) Advanced glycosylation end products in patients with diabetic nephropathy. N. Eng. J. Med. 325, 836-842
2 Yabe-Nishimura, C. (1998) Aldose reductase in glucose toxicity: a potential target for the prevention of diabetic complications. Pharmacol. Rev. 50, 21-33
3 Jang, D. S., Kim, J. M., Kim, J. H. and Kim, J. S. (2005) 24-nor-ursane type triterpenoids from the stems of Rumex japonicus. Chem. Pharm. Bull. 53, 1594-1596   DOI   ScienceOn
4 Vinson, J. A. and Howard III, T. B. (1996) Inhibition of protein glycation and advanced glycation end products by ascorbic acid and other vitamins and nutrients. J. Nutr. Biochem. 7, 659-663   DOI   ScienceOn
5 Matsuda, H., Wang, T., Managi, H. and Yoshikawa, M.(2003) Structural requirements of flavonoids for inhibition of protein glycation and radical scavenging activities. Bioorg. Med. Chem. 11, 5317-5323   DOI   ScienceOn
6 Kim, D. K., Choi, S. U., Ryu, S. Y., Lee, K. R. and Zee, O. P. (1998) Cytotoxic constituents of Rumex japonicus. Yakhak Hoeji 42, 233-237
7 Shinohara, R., Mano, T., Nagasaka, A., Sawai, Y., Uchimura, K., Hayashi, R., Hayakawa, N., Nagata, M., Makino, M., Kakizawa, H., Itoh, Y., Nakai, A. and Itoh, M. (1998) Effects of thyroid hormone on the sorbitol pathway in streptozotocin-induced diabetic rats. Biochim. Biophys. Acta 1425, 577-586   DOI   ScienceOn
8 Larkins, R. G. and Dunlop, M. E. (1992) The link between hyperglycaemia and diabetic nephropathy. Diabetologia 35, 499-504   DOI
9 Bucala, R. and Vlassara, H. (1995) Advanced glycosylation end products in diabetic renal and vascular disease. Am. J. Kidney Dis. 26, 875-888   DOI   ScienceOn
10 Kim, J. S., Kim, H. and Ko, J. H. (2002) Studies on the processing of herbal medicines (III)-HPLC analysis of magnolol and inhibitory effects on the formation of advanced glycation endproducts (AGEs) in vitro of unprocessed and processed Magnolia Bark. Kor. J. Pharmacogn. 33, 308-311   과학기술학회마을
11 Park, W. Y. (1996) Phenolic compounds from Acer ginnala Maxim. Kor. J. Pharmacog. 27, 212-218   과학기술학회마을
12 Bae, K., Medicinal Plants of Korea, Kyo-Hak Publishing Co., Seoul, 2000, p 92
13 The Diabetes Control and Complication Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329, 977-986   DOI   ScienceOn
14 Kalousova, M., Zima, T., Tesar, V., Stipek, S. and Sulkova, S. (2004) Advanced glycation end products in clinical nephrology. Kidney Blood Press Res. 27, 18-28   DOI   ScienceOn
15 Forbes, J. M., Cooper, M. E., Oldfield, M. D. and Thomas, M. C. (2003) Role of advanced glycation end products in diabetic nephropathy. J. Am. Soc. Nephrol. 14, S254-S258   DOI
16 Matsuda, H., Morikawa, T., Toguchida, I. and Yoshikawa, M. (2002) Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity. Chem. Pharm. Bull. 50, 788-795   DOI   ScienceOn
17 Hwang, S. W., Ha, T. J., Lee, J. R., Lee, J., Nam, S. H., Park, K. H. and Yang, M. S. (2004) Isolation of anthraquinone derivatives from the root of Rumex japonicus H. J. Korean Soc. Appl. Biol. Chem. 47, 274-278   과학기술학회마을
18 Zee, O. P., Kim, D. K., Kwon, H. C. and Lee, K. R. (1998) A new epoxynaphthoquinol from Rumex japonicus, Arch.Pharm. Res. 21, 485-486   DOI   ScienceOn
19 Nishina, A., Kubota, K. and Osawa, T. (1993) Antimicrobial components, trachrysone and 2-methoxystypandrone, in Rumex japonicus Houtt. J. Agric. Food Chem., 41, 1772-1775   DOI   ScienceOn
20 Beyer-Mears, A. and Cruz, E. (1985) Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor. Diabetes 34, 15-21   DOI   ScienceOn
21 Aritomi, M., Kiyota, I. and Mazaki, T. (1965) Flavonoid constituents in leaves of Rumex acetosa and R. japonicus, Chem. Pharm. Bull. 13, 1470-1471   DOI   ScienceOn
22 Kim, H. Y. and Oh, J. H. (1999) Screening of Korean forest plants for rat lens aldose reductase inhibition. Biosci. Biotechnol. Biochem. 63, 184-188   DOI   ScienceOn
23 Li, Y. P., Takamiyagi, A., Ramzi, S. T. and Nonaka, S. (2000) Inhibitory effect of Rumex japonicus Houtt on the porphyrin photooxidative reaction. J. Dermatology, 27, 761-768   DOI