• 동서간호학연구지
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• 제23권1호
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• pp.18-25
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• 2017

Purpose: The purpose of this study was to identify factors which effect to female college student' reproductive health promoting behavior in female college students. Methods: The design of this study was correlational study and subjects were 127 female college students from two colleges in B metropolitan city. The data collection was carried out from June 1, 2016 to June 30, 2016. Data were collected using questionaires of characteristics of the subjects, sexual knowledge, sexual behavior, and self-efficacy(KGSE). Results: The subjects' reproductive health promoting behavior differed according to the grade, major, smoking, and experience of weight loss of more than 10 kg within the last 3 months. The subjects' reproductive health promoting behavior had positive correlations with sexual knowledge (r=.39, p<.001) and self-efficacy (r=.34, p<.001), and negative correlation with sexual behavior (r=-.23, p=.011). Sexual knowledge and sexual behavior were influencing factors on reproductive health promoting behavior accounting for 23.0%. Conclusion: This study showed that sexual knowledge and sexual behavior were factors affecting female college students' reproductive health promoting behavior and the most influential factor was sexual knowledge.

• 지역사회간호학회지
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• 제9권1호
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• pp.21-29
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• 1998

This study was undertaken in order to examine the relationship of hardiness and health-promoting behavior and the effects of hardiness on stress-related physical symptoms. The subjects were 104 female nursing students of one college in Kongju. The instruments used for this study were a survey of general characteristics, hardiness(25 items), health-promoting behavior(44 items), and physical symptoms(35 items), Analysis of data was done by use of mean, Pearson correlation coefficient, stepwise regression and a hierarchical multiple regression with an SAS program. The results of this study are as follows. 1) Significant correlations between health -promoting behavior and subscales of hardiness, that is, control(r=-.35, P<.00l), commitment(r= -.29, P<.0l), and challenge(r= -.23, p<.05) were found. 2) Control was the highest factor predicting health -promoting behavior. 3) Main and buffering effects of hardiness on current physical symptoms were not found.

• 대한간호학회지
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• 제41권5호
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• pp.642-651
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• 2011

Purpose: The purpose of this study was to explore the resilience of adult children of alcoholics (ACOA) who are college students, and examine factors contributing to their resilience. Methods: A total of 459 college students from a university in Incheon, participated in this study. Data were collected between April 6 to 30, 2010 using the Korean version of the Children of Alcoholics Screening Test (CAST-K), CAGE, Social Support, Self-Esteem, Family Adaptability and Cohesion, and Resilience measurements. Data were analyzed using the SPSS/WIN 18.0 program. Results: Overall, ACOA group showed lower scores of resilience, social support, self-esteem and family adaptability and cohesion compared to non-ACOA group. Resilience among the ACOA group showed significant relationships with self-esteem (r=.53, p<.001), social support (r=.43, p<.001), and family adaptability and cohesion (r=.25, p<.013). Multiple regression analysis showed that 45% of the variance for resilience in the ACOA group was accounted for by age, gender, social support, self-esteem, and religion. Conclusion: The results of the study show that self-esteem and social support are important determinants of resilience in ACOA, thus it is recommend that further resilience training programs for ACOA be developed to enhance their social support and self-esteem, and ultimately to increase their resilience.

• 한국보건간호학회지
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• 제37권2호
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• pp.193-204
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• 2023

Purpose: This study was undertaken to identify the association between CPR knowledge, attitude, and teacher efficacy on the performance confidence of CPR. We further investigated methods to enhance the performance ability of CPR among elementary, middle, and high school teachers. Methods: The study design was a descriptive survey conducted from October 15 to December 31, 2022, enrolling 155 elementary, middle, and high school teachers. The data were analyzed by applying Multiple regression, Pearson's correlation coefficient, one way ANOVA and Scheffé test using the SPSS/WIN 23.0 program. Results: The performance confidence of CPR among elementary, middle, and high school teachers showed a significant positive correlation with CPR knowledge (r=.49, p<.001), CPR attitude (r=.26, p<.001), and teacher efficacy (r=.25, p=.002). The factors affecting performance confidence in CPR were CPR knowledge (β=.49, p<.001), gender (β=-.26, p<.001), CPR attitude (β=.20, p=.003), health status (β=.14, p=.038), and teacher efficacy (β=.14, p=.032); these factors explained 40.5%. Conclusion: Results from the study indicate that performance confidence of CPR can be enhanced by providing frequent education on CPR knowledge and attitudes. Moreover, educational programs will aid in maintaining good health and enhance teacher efficacy.

• 한국미생물·생명공학회지
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• 제41권4호
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• pp.407-415
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• 2013

본 연구에서는 황칠나무 잎 추출물의 HaCaT 세포에서의 항산화 활성과 B16F1 melanoma 세포에서의 미백활성을 측정하였다. HaCaT 세포를 이용한 실험에서, 황칠나무 잎 추출물의 에틸아세테이트 분획과 아글리콘 분획은 각각 50 및 $25{\mu}g/ml$의 농도 이하에서 독성을 나타내지 않았다. UVB $800mJ/cm^2$를 HaCaT 세포에 조사하였을 때, 황칠나무 잎 추출물은 농도 의존적으로 자외선으로부터 세포를 보호하였다. 10 mM의 $H_2O_2$ 및 $4{\mu}M$의 rose bengal을 HaCaT 세포에 처리하였을 때, 에틸아세테이트 분획($6.25{\sim}50{\mu}g/ml$) 및 아글리콘 분획($6.25{\sim}25{\mu}g/ml$)은 우수한 세포 보호 효과를 나타내었다. 황칠나무 잎 추출물의 B16F1 melanoma 세포에서의 미백활성을 측정한 결과, 미백제로 알려진 알부틴 보다 더 우수한 멜라닌 합성 저해 활성을 보였다. 이상의 결과들은 황칠나무 잎 추출물이 ROS에 대항하여 세포를 보호함으로써 생체계, 특히 태양 자외선에 노출된 피부에서 세포보호제 및 천연항산화제로서 작용할 수 있음을 가르키며, ${\alpha}$-MSH로 유도된 멜라닌 생합성 저해 효과로부터 황칠나무 잎 추출물이 새로운 미백 화장품의 원료로써 이용 가능함을 알 수 있다.

• The Korean Journal of Physiology and Pharmacology
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• 제27권3호
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• pp.257-265
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• 2023

Kidney ischemia/reperfusion (I/R) injury, a common cause of acute kidney injury (AKI), is associated with the migration of inflammatory cells into the kidney. Ras-related C3 botulinum toxin substrate 1 (Rac1), a member of the Rho family of small GTPase, plays an important role in inflammatory cell migration by cytoskeleton rearrangement. Here, we investigated the role of Rac1 on kidney I/R injury and macrophage migration. Male mice were subjected to either 25 min of bilateral ischemia followed by reperfusion (I/R) or a sham operation. Some mice were administrated with either NSC23766, an inhibitor of Rac1, or 0.9% NaCl (vehicle). Kidney damage and Rac1 activity and expression were measured. The migration and lamellipodia formation of RAW264.7 cells, mouse monocyte/macrophage, induced by monocyte chemoattractant protein-1 (MCP-1, a chemokine) were determined using transwell migration assay and phalloidin staining, respectively. In sham-operated kidneys, Rac1 was expressed in tubular cells and interstitial cells. In I/R-injured kidneys, Rac1 expression was decreased in tubule cells in correlation with the damage of tubular cells, whereas Rac1 expression increased in the interstitium in correlation with an increased population of F4/80 cells, monocytes/macrophages. I/R increased Rac1 activity without changing total Rac1 expression in the whole kidney lysates. NSC23766 administration blocked Rac1 activation and protected the kidney against I/R-induced kidney damage and interstitial F4/80 cell increase. NSC23766 suppressed monocyte MCP-1-induced lamellipodia and filopodia formation and migration of RAW 264.7 cells. These results indicate Rac1 inhibition protects the kidney against I/R via inhibition of monocytes/macrophages migration into the kidney.

• 보건행정학회지
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• 제27권2호
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• pp.149-156
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• 2017

Background: This study was conducted to evaluate the performance of the Hierarchical Condition Category (HCC) model, identify potentially high-cost patients, and examine the effects of adding prior utilization to the risk model using Korean claims data. Methods: We incorporated 2 years of data from the National Health Insurance Services-National Sample Cohort. Five risk models were used to predict health expenditures: model 1 (age/sex groups), model 2 (the Center for Medicare and Medicaid Services-HCC with age/sex groups), model 3 (selected 54 HCCs with age/sex groups), model 4 (bed-days of care plus model 3), and model 5 (medication-days plus model 3). We evaluated model performance using $R^2$ at individual level, predictive positive value (PPV) of the top 5% of high-cost patients, and predictive ratio (PR) within subgroups. Results: The suitability of the model, including prior use, bed-days, and medication-days, was better than other models. $R^2$ values were 8%, 39%, 37%, 43%, and 57% with model 1, 2, 3, 4, and 5, respectively. After being removed the extreme values, the corresponding $R^2$ values were slightly improved in all models. PPVs were 16.4%, 25.2%, 25.1%, 33.8%, and 53.8%. Total expenditure was underpredicted for the highest expenditure group and overpredicted for the four other groups. PR had a tendency to decrease from younger group to older group in both female and male. Conclusion: The risk adjustment models are important in plan payment, reimbursement, profiling, and research. Combined prior use and diagnostic data are more powerful to predict health costs and to identify high-cost patients.

• Journal of Pharmaceutical Investigation
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• 제33권3호
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• pp.201-208
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• 2003

Pharmacokinetics and oral bioavailability of levosulpiride was determined in Korean healthy male volunteers. Thirty subjects received a single oral dose (25 mg) of a tablet in a randomized $2{\times}2$ cross-over design. The plasma concentrations of levosulpiride were measured by HPLC and compared with those reported in the literature. Pharmacokinetic parameters for $Isomeric^{\circledR}$ tablet (levosulpiride 25 mg) were revealed as follows: $AUC_{inf}\;737.1{\pm}176.9\;ng{\cdot}hr/ml,\;C_{max}\;56.4{\pm}20.1\;ng/ml,\;T_{max}\;4.2{\pm}1.6\;hr,\;K_a\;1.00{\pm}1.09\;hr^{-1},\;K_{el}\;0.08{\pm}0.02\;hr^{-1},\;and\;t_{1/2}\;8.8{\pm}1.9\;hr$. The rate constant of the absorption phase was obtained based on the first-order kinetics. In the aspect of bioavailability, $Isomeric^{\circledR}$ tablet was bioequivalent to the other product $(Levopride^{\circledR}\;tablet)$ available in the Korea market. Intersubject variations and race differences were show in comparison with the published data in the literature, even though there was a linear relationship between dose ad extent of bioavailability.

• 한국간호교육학회지
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• 제8권1호
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• pp.72-83
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• 2002

The purpose of this study was to investigate the level of social support, loneliness, alcohol use and perceived health status in college students and to explore the relationships between the variables. The convenience sample consisted of 473 students attending a college located at Chonnam province. Data were collected by a structured questionnaire which included the PRO85-partⅡ Social Support Scale, revised UCLA Loneliness Scale, Alcohol frequency, Perceived Health Status Scale from June 10 to 25, 2001. And data were analyzed by SPSS/PC+program including descriptive statistics, t-test, ANOVA, Pearson's Correlation Coefficients. The results are summarized as follows; 1. The mean scores of social support, loneliness and perceived health status were 3.01($SD={\pm}0.31$), 2.08($SD={\pm}0.34$), 1.64($SD={\pm}0.65$) respectively. 2. Students in use of alcohol mostly reported that they had started a drinking in the period of high school(35.7%), motivated with friendship(32.6%) and drank with their friends(56.9%) in drinking frequency of 2-3times per a month(49.6%). 3. The students who have friend of the opposite sex were significantly more likely to have higher than the students having no friend of the opposite sex in scores of social support. 4. The scores of loneliness were significantly lower in female students than male students, in students with friend of the opposite sex than with no friend of the opposite sex. 5. There were significant negative correlations between social support and loneliness(r=-5.25, p<.000), and between loneliness and perceived health status(r=-0.93, p<.05), while there was a significant positive correlation between social support and perceived health status(r=1.01, p<.05). The findings suggested that supportive social support, especially lowering loneliness, would be a powerful nursing intervention in maintaining good health of college students. And, more variables affecting health status in college students will be identified with further research.

• 대한의생명과학회지
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• 제25권1호
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• pp.75-82
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• 2019

We developed the multiplex LAMP assay using 16S rRNA, femA and mecA genes for direct detection of the methicillin resistance in Staphylococci from positive blood culture. To simultaneously recognize Staphylococci genus, S. aureus and methicillin resistance, three sets of six primers for 16S rRNA, femA and mecA were designed, respectively. The performance of LAMP assay was affirmed using VITEK system for the phenotypic methods of identification and for oxacillin and cefoxitin antimicrobial susceptibility. The optimal condition for LAMP assay was obtained under $64^{\circ}C$ for 50 min. The detection limit was determined to be of 20 copies and CFU/reaction ($10^4CFU/mL$). For clinical application of comparison with phenotypic methods, the sensitivity and specificity of the LAMP with femA gene for detecting S. aureus was 95.31% and 100%, respectively. The sensitivity and specificity of the LAMP with mecA gene for detecting methicillin resistance was 98.46% and 100%, respectively. The multiplex LAMP assay with femA and mecA gene successfully detected all of MRSA (38 isolates) isolates from 103 Staphylococci in blood cultures. The LAMP assay developed in this study is sensitive, specific, and of excellent agreement with the phenotypic methods.