• 제목/요약/키워드: miR-20a

검색결과 542건 처리시간 0.032초

신경병증 통증 모델의 백서에서 R-PIA의 기계적 항이질통 효과와 ATP-감수성 칼륨 통로와의 연관성에 대한 연구 (The Effect of ATP-sensitive Potassium Channel on R-PIA Induced Mechanical Antiallodynia in a Peripheral Neuropathic Rat)

  • 민홍기;성승혜;정성문;신진우;곽미정;임정길;이청
    • The Korean Journal of Pain
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    • 제18권2호
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    • pp.107-112
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    • 2005
  • Background: Nerve ligation injury may produce mechanical allodynia, but this can be reversed after an intrathecal administration of adenosine analogues. In many animal and human studies, ATP-sensitive potassium channel blockers have been known to reverse the antinociceptive effect of various drugs. This study was performed to evaluate the mechanical antiallodynic effects of spinal R-PIA (Adenosine A1 receptor agonist) and the reversal of these effects due to pretreatment with glibenclamide (ATP-sensitive potassium channel blocker). Thus, the relationship between the antiallodynic effects of R-PIA and ATP-sensitive potassium channel were investigated in a neuropathic model. Methods: Male Sprague Dawley rats were prepared by tightly ligating the left lumbar 5th and 6th spinal nerves and implantation of a chronic lumbar intrathecal catheter for drug administration. The mechanical allodynia was measured by applying von Frey filaments ipsilateral to the lesioned hind paw. And the thresholds for paw withdrawal assessed. In study 1, either R-PIA (0.5, 1 and $2{\mu}g$) or saline were administered intrathecally for the examination of the antiallodynic effect of R-PIA. In study 2, glibenclamide (2, 5, 10 and 20 nM) was administered intrathecally 5 min prior to an R-PIA injection for investigation of the reversal of the antiallodynic effects of R-PIA. Results: The antiallodynic effect of R-PIA was produced in a dose dependent manner. In study 1, the paw withdrawal threshold was significantly increased with $2{\mu}g$ R-PIA (P < 0.05). In study 2, the paw withdrawal threshold with $2{\mu}g$ R-PIA was significantly decreased almost dose dependently by intrathecal pretreatment of 5, 10 and 20 nM glibenclamide (P < 0.05). Conclusions: These results demonstrated that an intrathecal injection of ATP-sensitive potassium channel blockers prior to an intrathecal injection of adenosine A1 receptors agonist had an antagonistic effect on R-PIA induced antiallodynia. The results suggest that the mechanism of mechanical antiallodynia, as induced by an intrathecal injection of R-PIA, may involve the ATP-sensitive potassium channel at both the spinal and supraspinal level in a rat nerve ligation injury model.

간호사의 수면장애, 조직 내 지지, 건강증진행위가 소진에 미치는 영향 (The Influence of Clinical Nurses' Sleep Disorder, Organizational Support, Health promotion behaviors on Burn-out)

  • 장진숙;김미영
    • 문화기술의 융합
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    • 제7권2호
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    • pp.27-33
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    • 2021
  • 본 연구는 간호사의 수면장애, 조직 내지지, 건강증진행위가 소진에 미치는 영향을 파악하기 위해 시도된 서술적 상관관계연구이다. 연구대상자는 B와 G시에 소재한 200병상 이상 300병상 미만 병원에서 근무 중인 간호사 256명을 대상으로 하였다. 자료 수집은 2017년 9월 4일부터 9월 11일까지 이며, 수집된 자료는 SPSS WIN 20.0을 이용하여 분석하였다. 소진은 평균 28.90±4.00점이며, 소진은 수면장애(r=-.321, p<.001), 조직 내 지지(r=-.321, p<.001), 건강증진행위(r=-.519, p<.001), 소진에 미치는 영향요인은 조직 내 지지(β=-.113, p=.045), 수면장애(β=-.129, p<.040), 성별(β=-.131, p=.024), 건강증진행위(β=-.423, p<.001)이며, 설명력은 32.2%이었다. 간호사의 소진을 조절할 수 있는 각종 프로그램 개발이 필요하다.

사회복지전공 대학생의 죽음에 대한 태도의 영향요인 (Factors Affecting the attitude to death of Social Welfare Students)

  • 김보미
    • 디지털융복합연구
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    • 제19권11호
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    • pp.545-553
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    • 2021
  • 본 연구는 사회복지전공 대학생의 죽음에 대한 태도의 영향을 미치는 요인을 파악하기 위한 서술적 조사 연구이다. 연구대상자는 2개 대학에 재학 중인 사회복지전공 대학생 179명을 대상으로 시행하였으며, 구조화된 설문지를 통해 자료 수집을 하였다. 수집한 자료는 기술통계와 t-test, ANOVA, Pearson correlations, 다중회귀분석으로 분석하였다. 연구결과 사회복지전공 대학생의 삶의 의미(r=.34, p=.001)와 삶의 만족도(r=.61, p<.001), 회복탄력성(r=.65, p<.001)과 죽음에 대한 태도는 정적 상관관계를 보였다. 위계적 회귀분석을 실시한 결과 학년(β=.21, p=.002)과 삶의 만족도(β=.22, p=.013)가 주요 영향요인이었으며, 이 모델은 20.2%의 설명력을 나타내었다. 연구결과를 통해 사회복지 전공 대학생의 죽음에 대한 태도를 긍정적으로 변화시킬 수 있는 상담 및 지지프로그램과 죽음 관련 교육 프로그램의 개발이 이루어져야 할 것이다.

성상신경절 차단시 부착형 피부온도계의 사용 경험 (The Use of Sticker Type Temperature Indicator in Stellate Ganglion Block)

  • 윤덕미;오흥근;케이지 이시자키;후지타 타츠시
    • The Korean Journal of Pain
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    • 제7권1호
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    • pp.49-52
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    • 1994
  • Measurement of skin temperature is most frequently used to evaluate effect of sympathetic block. Sticker type skin temperature indicator, $ProChecker^{(R)}$, uses metamocolor, which changes the darkness of the color by giving and taking of electrons in response to temperature. We examined the accuracy of this skin temperature indicator in pain clinic patients who were treated with stellate ganglion block. Ten minutes before, and 10~20 minutes after stellate ganglion block, skin temperature on both dorsum of hand were measured using both $ProChecker^{(R)}$ and thermography concurrently. The results showed that skin temperature measured by $ProChecker^{(R)}$ was feasible, in correlation to thermography. Sticker type temperature indicator ($ProChecker^{(R)}$) is concluded as a useful monitor of skin temperature during nerve block in outpatient clinics.

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노인의 기억수행에 영향을 미치는 요인에 관한 연구 (A Study on the Factors of the Older Adults' Memory Performance)

  • 민혜숙
    • 재활간호학회지
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    • 제3권2호
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    • pp.181-195
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    • 2000
  • The purpose of this study is to find out the effects of personal characteristics, social support, depression, and metamemory on the older adults' memory performances. The subjects of the study consisted of 95 older adults over the age of 60 who are living in Busan. Some data were collected by means of the interview method, using questionnaires for metamemory (MIA questionnaire by Dixon, et al., 1988), and depression(GDS by Yesavage and Sheikl, 1986), social resoueces(Duke university, 1978), family support(Hyun-Sook Kang, 1985). The other data were collected by the testing method on the memory performance such as the immeadiate word recall task, the delayed word recall task, the word recognition task(Elderly Verbal Learning Test by Kyung Mi Choi, 1998), and the face recognition task(Face Recognition Task tool developed by Hye-Sook Min). The results of this study were as follows; 1. The level of metamemory is 3.4 points in the 5 point scale, the grades of the task and the achievement are relatively high and the grades of the change, the control, and the anxiety are relatively low in the sub-concepts. 2. Metamemory have significant relation with age(r=-.44), educational attainment(r=.46), depression(r=-.58), family support(r=.20), social resources(r=.20). 3. The significant variables to predict older adults' metamemory are educational attainment(22%), sex(11%), age (8.3%), depression(4.7%), and illness state(3%). 4. The strong variables to predict memory performances are metamemory, age, depression, social resources, educational attainment, illness state, and limitation of daily living activity related to illness. In conclusion, the enhancement strategies of metamemory and the social support and the prevention or reduction of depression are necessary to increase older adults' memory performances. Ultimately in this respect nurses' roles are very important in developing and performing some intervention programs for old adults' memory improvement, which have significant meanings in the field of nursing science.

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Current status of long-term care facility workers' physical function improvement activities for the elderly

  • Kim, Il-Ok;Kim, Mi-Ran;Shin, Jang-Hoon;Kim, Sun-Haeng
    • Physical Therapy Rehabilitation Science
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    • 제9권4호
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    • pp.261-268
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    • 2020
  • Objective: This study was conducted to provide basic data on physical function improvement activities of elderly care facilities by identifying the degree of physical improvement activities of elderly caregivers. Design: Descriptive correlational study. Methods: The instrument of this study consisted of 12 questions on the general characteristics of the subject. For the assessment of improvement in physical function activities, the measuring tool used for the elderly consisted of a total of 20 questions. For data analysis, Pearson's correlation coefficient & Spearman's rho and multiple regression were used. Results: The higher the age of the subjects, the lower their educational background (r=-0.273, p<0.05), and the higher the probability of having a religion (r=-0.258, p<0.05), the more stable the employment type (r=-0.333, p<0.05). The higher the level of education, the higher the monthly income (r=0.187, p<0.01), and the shorter the career (r=-0.204, p<0.05). The more stable employment, the more unstable duty (r=-0.245, p<0.05), and the more unstable work, the higher the monthly income (r=-0.206, p<0.05) and the longer the career, the higher the monthly income (r=0.247, p<0.05). The more stable the employment, the more activities to improve physical function were found (r=0.341, p<0.05), and the more unstable the duty, the more activities to improve physical function were found (r=0.321, p<0.05), and the higher monthly income, the less physical function improvement activities (r=-0.196, p<0.05). Conclusions: It is necessary to provide regular services by a dedicated physical therapist for physical function improvement activities in order to improve the quality of life of the elderly in the future.

병원규모에 따른 간호사의 조직문화유형과 직무만족 비교연구 (A Comparative Study on Nurses' Organizational Culture and Job Satisfaction according to the Hospital Size Differences)

  • 장인순;박승미
    • 한국직업건강간호학회지
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    • 제20권1호
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    • pp.1-13
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    • 2011
  • Purpose: This study was conducted to compare the characteristics of organizational structure and occupational satisfaction among nurses in general hospital and small to medium-sized hospital and to investigate the affecting factors on their occupational satisfaction. Methods: The study was based on the cross-sectional descriptive survey. A self-report questionnaire was used to collect data from 343 nurses between June and July, 2010. Data were analyzed by ${\chi}^2$-test, t-test, ANOVA, Scheffe's test, Pearson's correlation coefficient, and multiple regression using the SPSS/WIN 14.0 program. Results: Hierarchical structure was dominant in general hospital whereas relationship was highly valued in small to medium-sized hospital. Occupational satisfaction was positively correlated with work environment built on relationship, innovation and tasks. Factors significantly influencing on occupational satisfaction in general hospital included innovative work environment, nurses' income and their health status ($R^2$=40.3%). For the small to medium-sized hospital, they included innovative work environment, satisfaction in life, tasks and professionalism ($R^2$=40.4%). Conclusion: Organizational structure, especially innovative work environment and relationship-oriented attitude had a significant influence on nurses' occupational satisfaction. Therefore, nursing administrators have to develop and consider organizational structure to improve occupational satisfaction.

간호대학생의 자아존중감, 간호전문직관, 인지적 정서조절 전략이 임상실습스트레스에 미치는 영향 (Effects of Self-esteem, Nursing Professionalism, Cognitive Emotion Control Strategy on Clinical Practice Stress in Nursing Students)

  • 강미란;정경숙
    • 디지털융복합연구
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    • 제18권6호
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    • pp.353-361
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    • 2020
  • 본 연구의 목적은 간호대학생의 자아존중감, 간호전문직관, 인지적 정서조절 전략이 임상실습스트레스에 미치는 영향을 확인하기 위함이다. 연구대상은 B시 소재 간호대학에 재학 중이며 임상실습을 2학기 이상 경험한 학생 160명을 대상으로 하였으며, 자료수집은 2019년 12월 1일부터 15일까지 시행하였다. 자료분석은 기술통계, t-test, ANOVA, Pearson's corelation coefficient, Scheffe 사후검증과 다중회귀분석을 이용하였다. 연구결과, 임상실습스트레스는 5점 만점에 평균 3.19점이었다. 임상실습스트레스는 자아존중감(r=.22, p=.005), 간호전문직관(r=-.26, p=.001)과는 음의 상관관계를, 인지적 정서조절전략(r=.38, p<.001)과는 양의 상관관계를 보였다. 임상실습스트레스의 영향요인은 부적응적 인지적 정서조절전략(β=.46, p<.001), 간호전문직관(β=-.20, p<.001), 학년(β=.20, p=.002), 간호학 선택 동기(β=-.15, p=.019)이었으며 설명력은 총 35.5%로 나타났다. 따라서 임상실습에 대한 스트레스 감소를 위하여 간호전문직관 향상과 함께 스트레스 상황 시 부적응적 인지적 정서조절 전략을 낮출 수 있는 프로그램을 개발하고 적용해 불 것을 제언한다.

Sodium Lauryl Sulfate 함량에 따른 구강세치제의 구취변화 (Relationship of sodium lauryl sulfate content to the effects of dentifrice on halitosis)

  • 정미애
    • 한국산학기술학회:학술대회논문집
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    • 한국산학기술학회 2010년도 춘계학술발표논문집 2부
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    • pp.902-905
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    • 2010
  • 본 논문은 SLS의 함유정도를 다르게 한 A(0%), B(1.1%), C(2.2%)의 세가지 실험세치제를 제작하여 구취변화를 실험하였다. 대상은 전신질환이 없는 20대 성인 150명이었으며 50명씩 세 그룹( A, B, C )으로 나누어 진행되었다. SLS함량에 따른 세치제의 4주간사용 후 3집단의 구취변화를 황화물가스와 암모니아 양의 변화로 측정한 결과 3집단 모두 집단내의 변화는 있는 것으로 나타났지만 SLS함량에 따른 상관관계를 본 결과에서는 구강황(r=0.412)과 호기황(r=0.285)에서만 상관관계가 있는 것으로 나타났다. 이는 잇솔질의 개선으로 인한 변화라고 볼 수 있으며 SLS의 함량이 높을수록 타액분비율을 저하시켜, 구강건조를 유발하므로 구강 황화합물과 호기 황화합물의 수치가 높게 나온 것으로 생각된다.

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부모자녀 의사소통이 고등학생의 학업스트레스와 교우관계에 미치는 영향 (Effect of Parental-adolescent Communication on Academic Stress and Peer Relationship Perceived by High School Students)

  • 김유정;이은미
    • 한국간호교육학회지
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    • 제22권3호
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    • pp.326-333
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    • 2016
  • Purpose: The purpose of this study was to investigate the effect of parent-adolescent communication on academic stress and peer relationship perceived by high school students. Method: A total of 154 students were recruited from a high school in C city. Data were collected by means of self-reported questionnaires from September 1 to 18, 2015 and analyzed using descriptive statistics, t-test, ANOVA, Pearson correlation coefficients, and multiple regression analysis with SPSS 20.0. Results: Positive correlations were found between father-adolescent communication and peer relationship(r=.35, p<.001), and between mother-adolescent communication and peer relationship(r=.22, p=.006). Negative correlations were found between father-adolescent communication and academic stress (r=-.23, p=.004), and between mother-adolescent communication and academic stress(r=-.17, p=.039). Conclusion: These results suggest that identifying the effects of father-adolescent communication and parent-adolescent communication programs on academic stress and peer relationship is required.