• Title/Summary/Keyword: miR-20a

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Clinical Application of Hydrophilic Polyurethane Foam in a Dog with Secondary Infection in the Burned Area (화상부위에 이차감염이 발생한 개에서 Hydrophilic Polyurethane Foam의 임상적 적용)

  • Kim, Se-Eun;Shim, Kyung-Mi;Bae, Chun-Sik;Choi, Seok-Hwa;Kang, Seong-Soo
    • Journal of Veterinary Clinics
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    • v.27 no.1
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    • pp.121-124
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    • 2010
  • Thermal burn occurred in the anesthetized dog as a result of using hot pack to treat hypothermia. After hospital discharge, thermal burn leaded to secondary infection due to dog bites of the other dog in the house. After secondary infection, the treatment was performed with medication and bandaging. Because of the pain and infection from the wound, carprofen (2 mg/kg bid) and amoxicillin (20 mg/kg bid) were administrated orally for 40 days. And for 35 days, wet-to-dry gauze dressing was used to absorb purulent exudate. During this period, the burn eschar was removed completely from the burn site. After 35 days, the hydrophilic polyurethane foam ($Medifoam^{(R)}$, Ildong Pharm, Co., Korea) was admitted to the burn site for 30 days. $Medifoam^{(R)}$ made healing rate of the wound faster because the inner layer did not adhered to the wound, and newly formed tissue was protected. The second layer, hydrophilic absorptive layer absorbed excessive fluid and kept the wound surface moist. After 65 days after thermal burn, the wound was healed completely.

Baking Qualities of Bread Dough Substituted with High Amount of ${\beta}-Glucan$ from Agrobacterium spp. R259 KCTC 10197Bp (Agrobacterium spp. R259 KCTC 10197BP로부터 생산된 ${\beta}-glucan$ 고함유 식빵 반죽의 특성)

  • Kang, Eun-Young;Yang, Yun-Hyoung;Oh, Sang-Hee;Lee, Jeung-Hee;Kim, Hye-Yooung;Kim, Mi-Kyoung;Cho, Han-Young;Kim, Mee-Ree
    • Korean Journal of Food Science and Technology
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    • v.38 no.3
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    • pp.348-354
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    • 2006
  • Baking quality of dough made of flour substituted with insoluble ${\beta}-glucan$ (10, 20, and 30%), functional food material produced from Agrobacterium spp. R259 KCTC 10197BP, was evaluated. Optimum time to reach 1st stage of dough fermentation decreased with increasing ${\beta}-glucan$ content, whereas mixing time increased. Addition of ${\beta}-glucan$ did not affect pH of dough. Hunter color L, a, and b values of dough added with up to 20% ${\beta}-glucan$ were not significantly different from those of control. Rheology properties such as cohesiveness and springiness of ${\beta}-glucan$ added dough increased, while hardness and gumminess decreased. Amylogram showed addition of ${\beta}-glucan$ to flour lowered setback and consistency, which are suggested to delay retrogradation.

Convergence Effects of Positive Psychological Capital and Social Support in Adolescents on Depression (청소년의 긍정심리자본과 사회적 지지가 우울에 미치는 융복합적 효과)

  • Jeong, Eun;Jung, Mi-Ra
    • Journal of Digital Convergence
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    • v.15 no.9
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    • pp.365-373
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    • 2017
  • The purpose of this study was to examine relationships among positive psychological capital and social support on depression and identify the factors that influence on depression in the adolescents. The data were collected from 140 adolescents in the two middle school located J city using self-reported questionnaires and May 9 2017 to May 19 2017. The data were analyzed by descriptive statistics, T-test, ANOVA, Pearson's correlation coefficient, and stepwise multiple regression with SPSS 20.0 program. Depression was found to be in a significant negative correlation with positive psychological capital and social support. The result of the stepwise multiple regression indicates the positive psychological capital, social support and economic status predict 22.4% (F=14.38, p<.001) of depression. Therefore, it is necessary to develop convergence positive psychological capital and social support strategy program for decrease and prevents depression in adolescents.

Effect of Anti-inflammation on Oryeong-san Formulation for Mix Extract Tablet (오령산 정제 개발 및 항염증 효과)

  • Kim, Se Jin;Leem, Hyun Hee;Nam, Won Hee;Son, Su Mi;Choi, Hye Min;Kim, Myung Jin;Kim, Jung Ok;Lee, Hwa Dong
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.34 no.6
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    • pp.348-354
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    • 2020
  • Oryeong-san (ORS) is a traditional Korean herbal medicine widely used for renal associated diseases, composed of five medicine herbs; Atractylodes japonica Koidzumi, Cinnamomum cassia Presl, Polyporus umbellatus Fries, Poria cocos Wolf and Alisma orientale Juzepzuk. We studied to improve the convenience of intake and portability by developing modernized dosage forms, and examined the effect on anti-inflammation of ORS. In order to develop the tablet formulation of ORS (ORS-F), the tablets were evaluated on the basis of physical characteristics include diameter, thickness, weight variation, hardness, friability and disintegration. To analyze the marker components of ORS-F, eight index markers from five herbal medicines were chosen. And the method using high performance liquid chromatography (HPLC) with diode-array detector method was established for the simultaneous analysis. The biological activities were examined the effect of ORS-F on pro-inflammation mediated by LPS-stimulation. The production of nitric oxide (NO) and cytokines were determined by reacting cultured medium with griess reagent and enzyme-linked immunosorbent assay (ELISA). The expression of cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS) were investigated by Western blot and RT-PCR. The anti-oxidant activities of OJS-F increased markedly, in a dose-dependent manner. and, The total phenolic compound and flavonoids contents of OJS-F were 10.20±0.09 ㎍/㎎ and 12.86±0.86 ㎍/㎎. OJS-F which is LPS has diminished in the LPS-induced release of inflammatory mediators (NO, iNOS, COX2 and PGE2) and pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) from the RAW264.7 macrophages. Therefore, the developed formulation for tablet of ORS-F provide efficiency and usability, and indicated effect of anti-inflammation.

Symptom Experiences, Sleep Quality and Quality of Life for Patients with Asthma (천식환자의 증상경험, 수면의 질 및 삶의 질에 관한 연구)

  • Chung, Mi-Ha;Park, Hyojung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.11
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    • pp.616-628
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    • 2016
  • The purpose of this study was to examine symptom experiences, sleep quality, and quality of life in asthma patients and investigate any correlation among these factors. The study was conducted on 146 asthma patients that visited the Internal Medicine Department of Allergies at a hospital in Korea from March to June, 2015. Tools that were originally developed by Oh (1999) were used to measure the symptom experience of asthma patients. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI) while quality of life was measured by the Short Form 36-Items Heath Survey (SF-36). The dates were analyzed by t-test, ANOVA, Scheffe test, and Pearson's correlation coefficient using the SPSS 20.0 program. Symptom experiences of asthma patients showed a positive relation with sleep quality (r=.468, p<.001) and negative relationship with quality of life; PCS (r=-495, p<.001) and MCS (r=-.411, p<.001). The symptom experiences of an asthma patient along with sleep quality and quality of life turned out to be correlated. Therefore, this study is expected to be utilized as a basis for the development of assessment tools and arbitration programs to elucidate symptom experiences of asthma patients from various aspects and enhance their sleep quality and quality of life.

THE EFFECT OF NAOCL TREATMENT AND STERILIZATION PROCEDURES ON THE CORROSION OF ENDODONTIC FILES (차아염소산나트륨 처리와 멸균법이 근관 치료용 파일의 부식에 미치는 영향에 관한 연구)

  • Yang, Won-Kyung;Ra, Yoon-Sik;Lee , Young-Kyoo;Son, Ho-Hyun;Kim, Mi-Ri
    • Restorative Dentistry and Endodontics
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    • v.30 no.2
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    • pp.121-127
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    • 2005
  • A variety files made of stainless steel (S-S) or nickel-titanium (Ni-Ti) are used during endodontic treatment. The purpose of tt)is study was to evaluate the corrosion susceptibility of S-S and Ni-Ti endodontic files. Three brands of files were used for this study: $K-flex^{(R)}$ S-S files (Maillefer, USA), $Profile^{(R)}$ Ni-Ti files (Maillefer, USA), $K-3^{(R)}$ Ni-Ti files (SybronEndo. USA). 120 files of each brands (21mm, ISO size $\#20$) were divided into 12 groups according to 1) sterilization methods using Autoclave or Ethylene Oxide (E-O) gas, 2) Irrigation solutions using $5.25\%$ NaOCl or Saline, 3) the number of sterilization (1, 5, 10 times), After above procedures, each of the files was inspected by three examiners with a light microscope and camera at X25. Each file was judged and ranked according to the following criteria: 0;, no corrosion, 1; mild corrosion, 2; moderate corrosion, and 3; severe corrosion. The files of high score were examined under the Scanning Electron Microscope. Data were statistically analyzed with the Kruskal-Wallis test (p < 0.05). Most of the ten time-autoclaved files had showed mild to moderate corrosion. But, one or five time-autoclaved files did not show corrosive surface. NaOCl treatment and E-O gas sterilization did not influence on corrosion. There was a significant difference in corrosion susceptibility between sterilization methods and the number of autoclaving. However, there was no significant difference between brands and file materials.

The Relationship between Communication Competency, Interpersonal Relationship Ability and Self-Management Competency of Nursing College Students in Graduation Year (졸업학년 간호대학생의 의사소통능력, 대인관계능력과 자기관리역량 간의 관계)

  • Yu, Mi-Ok
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.7
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    • pp.406-413
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    • 2019
  • This study is a descriptive study to investigate the relationship between communication competency, interpersonal relationship ability and self-management competency of nursing college students in graduation year. Data collection was conducted from November 1, 2016, to December 9, 2016, in 135 students of 4th grade nursing students in M and K areas. The collected data were analyzed using the SPSS WIN 21.0 program. The result of this study showed that average degree of communication competency was $3.55{\pm}.34$(5 point-scale), interpersonal relationship ability was $3.79{\pm}.50$(5 point-scale), self-management competency was $3.67{\pm}.47$(5 point-scale). The communication competency of nursing college students in graduation year showed a significant positive correlation with interpersonal relationship ability(r=.65, p<.001) and self-management competency(r=.70, p<.001). In addition, interpersonal relationship ability also showed a significant positive correlation(r=.69, p<.001) with self-management competency. Therefore, this study proposes an intervention program to help nursing graduates maintain efficient interpersonal relationships through smooth communication with patients, guardians and staff at the job site after graduation by building their own management competency in their academic life.

Factors affecting the Problem-Solving Ability of Nursing Students who have received Online Psychiatric Nursing Practicum (온라인 정신간호학실습교육을 받은 간호학생의 문제해결능력에 미치는 영향요인)

  • Kim, Mi Ja;Oh, Hyun Joo
    • Journal of Industrial Convergence
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    • v.20 no.6
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    • pp.93-104
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    • 2022
  • This study was done to identify the factors affecting the problem-solving ability of nursing students who have received online psychiatric nursing practice. The subjects of the study were 280 fourth-grade nursing students. The data were subjected to descriptive statistics, 𝑥2-test, t-test, one-way ANOVA, Pearson's correlation analysis, and multiple regression analysis using the SPSS 24.0 program. As a result of the analysis, the mean of each variable was learning satisfaction 4.03±.70, self-efficacy in learning 5.69±.82, transfer motivation 5.52±.86, and problem-solving ability was 3.65±.41. Learning satisfaction and problem-solving ability (r=.387, p<.001), self-efficacy in learning and problem-solving ability (r=.576, p<.001), transfer motivation and problem-solving ability (r=.536, p <.001) showed a significant correlation. Factors affecting problem-solving ability were gender (𝛽=.11), grade point average (𝛽=.12), motivation of personal major choice (𝛽=-.12), satisfaction of major (𝛽=.13), self-efficacy in learning (𝛽=.36) and transfer motivation (𝛽=.16), and the explanatory power of variables was 41.4%. Based on the results of this study, a follow-up study is required to identify the causal relationship between variables related to problem-solving ability.

The Effects of Nursing Students' Moral Sensitivity and Nursing Professionalism Standard Precautions (간호대학생의 도덕적민감성과 간호전문직관이 표준주의 수행도에 미치는 영향)

  • Hwang, Hye Jeong;Lim, Mi Ran
    • Journal of Industrial Convergence
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    • v.20 no.1
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    • pp.97-105
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    • 2022
  • The purposes of this study is attempted to determine the effects of Moral sensitivity and nursing Professionalism on Standard Precautions among nursing students. Data collection is executed from November 15th to 30th of 2021, from 170 4th grade nursing students at one school city D. And the data answered to the questionnaire were analyzed by descriptive analysis, t-test, One-way ANOVA, Pearson's correlation coefficient, and Hierarchical Multiple Regression Analysis. As a result of the study, Moral sensitivity of nursing students was 4.96±0.68 out of 7 points, the average of Nursing Professionalism was 3.93±0.61 out of 5 points and the average of Standard precautions was 4.55±0.61 out of 5 points. There was a correlation between moral sensitivity and standard precautions(r=.336, p<.001), between moral sensitivity and nursing professionalism(r=.384, p<.001) and there was a correlation between nursing professionalism and standard precautions(r=.518, p<.001). In additon, It was confirmed that the higher the nursing professionalism of nursing students, the higher the standard precautions(𝛽=.399. p<.001). The explainatoy power of the variables Standard Precautions was 35.7%. Based on the results of this study, it is suggest that develop education program increasing the Standard Precautions by enhancing Nursing Professionalism for infection management educational program among the students.

Efficient approach for determining four-dimensional computed tomography-based internal target volume in stereotactic radiotherapy of lung cancer

  • Yeo, Seung-Gu;Kim, Eun Seog
    • Radiation Oncology Journal
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    • v.31 no.4
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    • pp.247-251
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    • 2013
  • Purpose: This study aimed to investigate efficient approaches for determining internal target volume (ITV) from four-dimensional computed tomography (4D CT) images used in stereotactic body radiotherapy (SBRT) for patients with early-stage non-small cell lung cancer (NSCLC). Materials and Methods: 4D CT images were analyzed for 15 patients who received SBRT for stage I NSCLC. Three different ITVs were determined as follows: combining clinical target volume (CTV) from all 10 respiratory phases ($ITV_{10Phases}$); combining CTV from four respiratory phases, including two extreme phases (0% and 50%) plus two intermediate phases (20% and 70%) ($ITV_{4Phases}$); and combining CTV from two extreme phases ($ITV_{2Phases}$). The matching index (MI) of $ITV_{4Phases}$ and $ITV_{2Phases}$ was defined as the ratio of $ITV_{4Phases}$ and $ITV_{2Phases}$, respectively, to the $ITV_{10Phases}$. The tumor motion index (TMI) was defined as the ratio of $ITV_{10Phases}$ to $CTV_{mean}$, which was the mean of 10 CTVs delineated on 10 respiratory phases. Results: The ITVs were significantly different in the order of $ITV_{10Phases}$, $ITV_{4Phases}$, and $ITV_{2Phases}$ (all p < 0.05). The MI of $ITV_{4Phases}$ was significantly higher than that of $ITV_{2Phases}$ (p < 0.001). The MI of $ITV_{4Phases}$ was inversely related to TMI (r = -0.569, p = 0.034). In a subgroup with low TMI (n = 7), $ITV_{4Phases}$ was not statistically different from $ITV_{10Phases}$ (p = 0.192) and its MI was significantly higher than that of $ITV_{2Phases}$ (p = 0.016). Conclusion: The $ITV_{4Phases}$ may be an efficient approach alternative to optimal $ITV_{10Phases}$ in SBRT for early-stage NSCLC with less tumor motion.