• 제목/요약/키워드: miR-200a

검색결과 96건 처리시간 0.029초

Plasma Flows and Bubble Properties Associated with the Magnetic Dipolarization in Space Close to Geosynchronous Orbit

  • Lee, Ji-Hee;Lee, Dae-Young;Park, Mi-Young;Lee, Eun-Hee
    • Journal of Astronomy and Space Sciences
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    • 제30권2호
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    • pp.95-100
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    • 2013
  • In this paper we examine a total of 16 dipolarization events that were observed by THEMIS spacecraft in space close to geosynchronous orbit, r < ${\sim}7\;R_E$. For the identified events, we examine the characteristics of the plasma flows and associated bubbles as defined based on $pV^{5/3}$, where p is the plasma pressure and V the volume of unit magnetic flux. First, we find that the flow speed in the near-geosynchronous region is very low, mostly within a few tens of km/s, except for a very few events for which the flow can rise up to ~200 km/s but only very near the dipolarization onset time. Second, the bubble parameter, $pV^{5/3}$, decreases by a much smaller factor after the dipolarization onset than for the events in the farther out tail region. We suggest that the magnetic dipolarization in the near-geosynchronous region generates or is associated with only very weak plasma bubbles. Such bubbles in the near-geosynchronous region would penetrate earthward only by a small distance before they stop at an equilibrium position or drift around the Earth.

수면의 질 영향 요인: 전기노인과 후기노인 비교 (Factors Relating Quality of Sleep: Comparison between Young-old People and Old-old People)

  • 서영미;김정숙;제남주
    • 한국산학기술학회논문지
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    • 제20권6호
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    • pp.332-341
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    • 2019
  • 본 연구는 전기노인과 후기노인의 수면의 질을 조사하고 수면의 질에 영향을 미치는 요인을 비교하기 위한 서술적 조사연구이다. 연구 대상은 편의표출법을 적용하여 G도에 거주하는 재가 노인을 대상자로 200명을 선정하였다. 구조화된 설문지를 이용하여 사회 인구학적 특성, 생활습관 및 건강관련 특성, 우울, 그리고 수면의 질을 조사하였다. 자료분석은 IBM SPSS WIN/21.0을 이용하여 ${\chi}^2-test$, t-test, ANOVA(Scheffe's test), Pearson's Correlation coefficient, Multiple Regression을 이용하여 분석하였다. 연구결과는 다음과 같았다. 수면의 질은 전기노인에 비해 후기노인이 통계적으로 유의하게 나빴다. 상관관계를 분석한 결과, 전기노인에서는 우울(r=-.22, p=.038)만이 수면의 질과 유의한 부적 상관관계가 나타났다. 후기노인에서는 우울(r=-.19, p=.045)과 주관적 건강상태(r=-.29, p=.002)가 수면의 질과 유의한 부적 상관관계가 있었다. 수면의 질에 영향을 미치는 요인을 분석한 결과, 전기노인에서는 직업, 만성질병 그리고 경제수준으로 나타났고, 후기노인에서는 만성질병, 주관적 건강상태 그리고 흡연이 유의하게 나타났다. 본 연구 결과는 노인의 수면 건강을 향상시킬 수 있는 연령별 맞춤형 전략 수립에 기초자료로 활용될 수 있을 것이다.

열가소성 가타퍼차 근관충전재료의 흐름성 특성 (Flow properties of thermoplasticized Gutta Percha obturation materials)

  • 백명현;송부석;최은미
    • 대한치과재료학회지
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    • 제45권4호
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    • pp.311-320
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    • 2018
  • 본 연구의 목적은 서로 다른 온도 설정을 받았을 때 열가소성 가타퍼차의 흐름성 특성을 평가 해보고자 현재 임상에서 사용되는 가타퍼차 4개 제품을 연질, 중질, 경질로 분류하여 실험하였으며, 실험시편은 24시간 동안 $(23{\pm}2)^{\circ}C$, ($50{\pm}5$) % 상대습도 조건으로 하여 ISO 1133-1:2011의 제시에 따라 레오미터(Melt flow indexer MFI-10, DAVENPORT, England)로 측정했다. 가타퍼차 재료의 열화 온도는 $108^{\circ}C$, $160^{\circ}C$, $200^{\circ}C$의 온도로 하고 하중은 2.16 ㎏, 3.8 ㎏으로 설정했으며 시편은 레오미터 가압과정에 적합하도록 약 5 mm 단위로 잘랐으며, Preheating time 5 분, Cutting time은 5~240초, 샘플은 10 g 으로 하여 실험한 결과 $108^{\circ}C$, $160^{\circ}C$의 온도에서는 흐름성 성질에 변화가 없었으나 $200^{\circ}C$까지 열화하면 흐름성 성질이 변화되는 것으로 나타났다. 가압 하중은 2.16 ㎏과 3.8 ㎏으로 하여 측정한 결과 하중은 흐름성 특성에 영향을 미치지 않았으나 열가소성 가타퍼차의 흐름성 측정의 경우 온도와 Cut-off time의 설정이 매우 중요한 것으로 조사 되었다.

How Can Customer Experience on CDJ Be Shaped?: Can Rose Be Tamed?

  • Lee, Sang mi;Han, Sang man
    • Asia Marketing Journal
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    • 제22권3호
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    • pp.87-105
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    • 2020
  • With the development of Information Technology, customers require promptly higher quality products and services. Companies try to make newly digital marketing strategies, but there are no empirical researches on them. This article empirically presents a new perspective that companies can shape the customer decision journey ahead by coordinating customer experience. In this article, based on Elaborated Likelihood Model (ELM) theory, customer experience consists of the emotional or cognitive experience. We surveyed about 200 subjects (N = 217) in their 20s and 30s based on the International Music Industry Association's Music Listening 2019 report, then analyzed four different models (before personalization-cognitive experience, before personalization-emotional experience, after personalization- cognitive experience, after personalization-emotional experience) by JASP and R Studio. We conducted Structural Equation Model (SEM) and paired t-test. Personalization factors are about recommendation systems in Spotify. The results of survey represent that companies can shape the Customer Decision Journey (CDJ) ahead especially through enhance cognitive experience. It empirically proves Elaborated Likelihood Model (ELM). The conclusion can be drawn that 'pulling' customer experience can be a new marketing strategies in the digital era.

중환자실 간호사의 전문직자율성, 의사소통만족도, 회복탄력성이 직무만족도에 미치는 영향 (Effect of Professional Autonomy, Communication Satisfaction, and Resilience on the Job Satisfaction of Intensive Care Unit Nurses)

  • 박은진;이윤미
    • 중환자간호학회지
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    • 제11권2호
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    • pp.63-74
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    • 2018
  • Purpose : This study aimed to identify the factors influencing job satisfaction in intensive care unit (ICU) nurses. Method : Using a cross-sectional design, data collected from 145 ICU nurses working at two university hospitals with more than 1,200 beds located in B and Y city were analyzed. The instruments used for this study assessed autonomy, communication satisfaction, resilience, and job satisfaction. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient, and multiple linear regression analysis. Results : Job satisfaction was significantly correlated with communication satisfaction (r=.60, p < .001) and resilience (r=.34, p < .001). Further, job satisfaction was influenced by communication satisfaction (${\beta}=.48$, p < .001), working at a surgery ICU (${\beta}=.21$, p =.008), and dissatisfaction with nursing (${\beta}=-.24$, p =.005). The explanatory power of this model was 44.7%. Conclusion : These results suggest the need for programs to improve communication satisfaction and nursing satisfaction.

Association of a miR-502-Binding Site Single Nucleotide Polymorphism in the 3'-Untranslated Region of SET8 and the TP53 Codon 72 Polymorphism with Cervical Cancer in the Chinese Population

  • Yang, Shao-Di;Cai, Yan-Lin;Jiang, Pei;Li, Wen;Tang, Jian-Xin
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권16호
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    • pp.6505-6510
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    • 2014
  • Objective: This study was conducted to identify whether polymorphic variants of set domain-containing protein 8 (SET8) and tumor protein p53 (TP53) codon 72, either independently or jointly, might be associated with increased risk for cervical cancer. Methods: We genotyped SET8 and TP53 codon 72 polymorphisms of peripheral blood DNA from 114 cervical cancer patients and 200 controls using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct DNA sequencing. Results: The frequency of SET8 CC (odds ratios (OR) = 2.717, 95% CI=1.436-5.141) or TP53 GG (OR=2.168, 95% CI=1.149-4.089) genotype was associated with an increased risk of cervical cancer on comparison with the SET8 TT or TP53 CC genotypes, respectively. In additional, interaction between the SET8 and TP53 polymorphisms increased the risk of cervical cancer in a synergistic manner, with the OR being 9.913 (95% CI=2.028-48.459) for subjects carrying both SET8 CC and TP53 GG genotypes. Conclusion: These data suggest that there are significant associations between the miR-502-binding site SNP in the 3'-UTR of SET8 and the TP53 codon 72 polymorphism with cervical cancer in Chinese, and there is a gene-gene interaction.

Transcervical or Laparoscopic Insemination of Frozen-thawed Semen in Estrus-synchronized Himalayan Tahrs (Hemitragus jemlahicus)

  • Yong, Hwan-Yul;Park, Jung-Eun;Kim, Min-Ah;Bae, Bok-Soo;Kim, Seung-Dong;Ha, Yong-Hee;Oh, Chang-Sik;Kim, Doo-Hee;Kim, Myoung-Ho;Yoo, Mi-Hyun;Jeong, Yu-Jeong;Ro, Sang-Chul
    • 한국수정란이식학회지
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    • 제25권4호
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    • pp.291-295
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    • 2010
  • Four estrus-induced Himalayan tahrs (Hemitragus jemlahicus) were inseminated with frozen-thawed semen by laparoscopic or transcervical insemination techniques with no regard to the site of ovulation in non-breeding season. In June and July, 2009, estrus was synchronized by Eazi-Breed $CIDR^{(R)}$ (Controlled internal drug release; Pfizer Animal Health, New Zealand) insertion for 16 days and PG 600 (PMSG 400IU, hCG 200 IU; Intervet, Netherlands) injection (IM) a day before removing $CIDR^{(R)}$. Forty eight hours later, laparoscopic or transcervical insemination was done to each of two tahrs under anesthetic condition inducted by ketamine (1.5 mg/kg) and medetomidine (0.09 mg/kg). For examination of estradiol and progesterone, blood was collected right before $CIDR^{(R)}$ insertion, PG 600 injection, $CIDR^{(R)}$ removal and insemination. Estradiol levels of four tahrs (No. 1, 2, 3, 4) before $CIDR^{(R)}$ insertion and insemination were 13.3, 8.8, 14.3, 12 pg/ml and 23.5, 25.5, 21.1, 11.5 pg/ml, respectively. Progesterone levels of four tahrs (No. 1, 2, 3, 4) before $CIDR^{(R)}$ insertion and insemination were 1.8, 0.05, 0.63, 0.61 ng/ml and 1.03, 0.37, 1.48, 2.12 ng/ml. Except for No. 4 tahr, cervices showed cervical mucus and opened enough to penetrate with embryo transfer gun sheet usually used for cows. Therefore, No.4 was laparoscopically inseminated together with No. 1. In conclusion, none of four Himalayan tahrs was pregnant. However, we proved that estrus could be induced by CIDR and PG 600 injection in non-breeding season, and laparoscopic or transcervical insemination with frozen-thawed semen could be one of assisted reproductive techniques in Himalayan Tahr.

FAAS를 이용한 혈중 Cisplatin의 분석법 개발 (The Development of Cisplatin Analysis Method in Plasma by Flameless Atomic Absorption Spectrometry)

  • 백만정;임호섭;정미진;이경옥;신호상
    • 분석과학
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    • 제11권4호
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    • pp.243-247
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    • 1998
  • 백금을 함유한 항암제로 신장과 신경계에 심각한 부작용을 일으키는 cisplatin의 혈중 농도를 flameless atomic absorption spectrometry법(FAAS)으로 분석하였다. 이 방법은 시료전처리 과정이 필요 없어 신속하고 간단한 분석법이다. 검정곡선에 대한 직선성을 조사한 결과 20~1000ng/mL 농도 범위에서 r=0.999로 나타났으며, 정확도는 50 ng/mL 이상의 농도에서 상대표준편차가 5.0% 이하 이었다. 그리고, 혈장시료 $200{\mu}L$에 대한 검출한계는 10 ng/mL 이었다. 본 방법은 cisplatin의 최적 치료 조건과 독성 경감을 위한 혈중 모니터링에 그 활용이 크게 기대된다.

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우리나라 양식 쥐치, Stephanolepis cirrhifer에서 분리된 비브리오의 특성 (Characteristics of Vibrio isolated from cultured file fish, Stephanolepis cirrhifer in Korea)

  • 지보영;방종득;조미영;김진우;원경미;조영아
    • 한국어병학회지
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    • 제24권2호
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    • pp.103-112
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    • 2011
  • 본 연구는 실험을 위해 저수온에서 순치 중이던 쥐치에서 체표의 백탁을 보이며 폐사하여 그 원인을 밝히고자 하였다. 순수 배양된 균체를 확인하여 계대 배양하여 생화학적 성상과 16S rRNA유전자와 recA 유전자의 염기서열 분석 결과 Vibrio anguillarum으로 나타났다. 빈사어 (체장 4~6 cm)의 약 30%는 체표 백탁 증상을 보였으며 약 10%는 폐사하였다. 이에 약제 감수성 시험 후, oxolinic acid 200 ppm을 1시간 동안 약욕시켰으며, 2일 경과 후 폐사가 중단되고 증상이 호전되었다.

중년여성의 우울 영향요인 (Factors Influencing Middle-aged Women's Depression)

  • 전소자;이선미;김수아;김희경
    • 지역사회간호학회지
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    • 제15권2호
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    • pp.266-276
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    • 2004
  • Purpose: This study purposed to supply basic data for nursing intervention plan for middle-aged women healthcare and for finding solutions to nursing problems through understanding middle-aged women's depression, and to examine whether middle-aged women's depression is related with self-concept, self-efficacy, physical condition and social support. Method: The subjects were 200 middle-aged women aged between 35 and 60 and living in Daejon city and K city in Chungcheongnam-do, and the questionnaire survey was conducted from the 15th of August to the 18th of September in 2003 using a structured questionnaire. Collected data were analyzed through descriptive statistics, t-test, ANOVA. Pearson's correlation coefficient and stepwise multiple regression. Result: Middle- aged women's depression was found to be in a negative correlation at a statistically significant level with self-concept (r=-.679, p=0.000), self-efficacy(r=-.489, p= 0.000), physical condition(r=-.650, p=0.000) and social support(r=-.526, p=0.000). The most significant variables of middle-aged women's depression was self-concept(46.2%). Combining with physical condition(13.2%) and self-efficacy(0.9%), the three variables together explained 60.3% of middle-aged women's depression. Conclusion: The results show that middle-aged women's depression is closely related with self-concept, self-efficacy and physical condition. Thus this study suggests that the goal of nursing intervention for middle-aged women to overcome depression should be to help them to have positive self-concept, high self-efficacy and sound physical condition.

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