• Biomolecules & Therapeutics
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• 제23권2호
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• pp.99-109
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• 2015

Drug development groups are close to discovering another pot of gold-a therapeutic target-similar to the success of imatinib (Gleevec) in the field of cancer biology. Modern molecular biology has improved cancer therapy through the identification of more pharmaceutically viable targets, and yet major problems and risks associated with late-phase cancer therapy remain. Presently, a growing number of reports have initiated a discussion about the benefits of metabolic regulation in cancers. The Warburg effect, a great discovery approximately 70 years ago, addresses the "universality" of cancer characteristics. For instance, most cancer cells prefer aerobic glycolysis instead of mitochondrial respiration. Recently, cancer metabolism has been explained not only by metabolites but also through modern molecular and chemical biological techniques. Scientists are seeking context-dependent universality among cancer types according to metabolic and enzymatic pathway signatures. This review presents current cancer metabolism studies and discusses future directions in cancer therapy targeting bio-energetics, bio-anabolism, and autophagy, emphasizing the important contribution of cancer metabolism in cancer therapy.

• 비만대사연구학술지
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• 제1권1호
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• pp.33-38
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• 2022

Although it has been confirmed that excessive body fat increases health risks and all-cause mortality, several epidemiological studies have reported that overweight or obesity in patients with chronic diseases and in older adults is advantageous with respect to mortality. Several mechanisms have been proposed to explain the biological basis of this obesity paradox. The marked heterogeneity of findings observed across studies and the possibility of systematic errors in these studies have cast doubt on the actual existence of the obesity paradox. However, the obesity paradox questioned the validity of body mass index as the best indicator for obesity in terms of predicting its comorbidities and urges clinicians to focus more on changes in body composition and related metabolic derangements, rather than body weight per se.

• 생물정신의학
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• 제24권4호
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• pp.196-203
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• 2017

Objectives Childhood trauma increases substantial risks for later developing not only mental health issues including psychotic illnesses such as schizophrenia but also physical illness. In this study, possible associations of childhood trauma with metabolic syndrome and physical heath indices were tested among outpatients with schizophrenia. Methods A final sample of 46 adult outpatients with schizophrenia was recruited from an outpatient psychiatric unit of Hanyang University Guri Hospital. Participants completed the Childhood Trauma Questionnaire-Short Form (CTQ-SF), laboratory tests and physical measurement including Body Mass Index (BMI) and Waist to hip ratio (WHR). The Clinical Global Impression (CGI) scale and the Global Assessment of Functioning scale (GAF) were also administered. Results We did not find significant correlations between total scores of childhood trauma and any of these variables, but physical neglect was negatively associated with BMI (r = -0.329, p = 0.026) and waist circumference (r = -0.304, p = 0.040). Conclusions In this preliminary study, we noted that subtypes of childhood trauma could contribute to physical health status separately. Clinicians need to consider the possibility that childhood trauma may affect physical health as well as psychological aspect of schizophrenic illness.

• Clinical Nutrition Research
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• 제12권3호
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• pp.218-228
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• 2023

Recent studies have evaluated the association between specific beverage intake and metabolic risks in adults. However, more evidence is needed to examine the association between the Healthy Beverage Index (HBI) and metabolic factors. Therefore, this study investigated the relationship between HBI and metabolic factors in adults. In this cross-sectional study, 338 overweight and obese individuals living in Tabriz, Iran were selected. Data on beverage consumption, demographics, physical activity, and anthropometric characteristics were evaluated using validated standard protocols. The predefined HBI was calculated based on previous studies. The mean value of HBI index among all of the participants was 59.76 ± 6.51. Those at the higher HBI scores had significantly lower waist circumference, waist-to-hip ratio, fat mass, and weight (p < 0.05). HBI and triglyceride scores also had a significant relationship. It has been shown that at higher HBI scores compared to lower scores, high-density lipoprotein cholesterol levels increase while homeostatic model assessment for insulin resistance, low-density lipoprotein cholesterol, total cholesterol, and blood pressure decrease. HBI scores higher among Iranian adults were associated with a better chance of losing weight and weight loss and a better lipid profile, and lower blood pressure. Therefore, HBI can be a useful and helpful tool for assessing the overall quality of beverages adults consume. However, further studies are warranted to confirm the possible health effects of healthy beverage index.

• 대한지역사회영양학회:학술대회논문집
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• 대한지역사회영양학회 2004년도 추계학술대회
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• pp.121-121
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• 2004

• Journal of Nutrition and Health
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• 제40권sup권
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• pp.29-38
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• 2007

The purpose of this study was to establish an association between the percent of energy from total sugar and disease prevalence of obesity, hypertension, dyslipidemia, insulin resistance, and metabolic syndrome with the context of the current population dietary practice in Korea. The Korean National Health and Nutrition Survey, 2001 and 2002 dataset were used as the source of data for this research. Usual nutritional intakes for over 20 years old people were calculated from the two non-consecutive dietary intake data from KNHANES 2001 and 2002 dataset. SAS and SUDAAN were used for statistical analyses. Sample weighted means, standard errors, and population percentages were calculated, and multiple logistic regression model with adjustment for covariates were used to determine the odds ratios(ORs) and 95% confidence intervals. Subjects were categorized as 3 ways and compared the LS means and ORs for heath factors. First, subjects excluding pregnant women, were categorized according to percent of energy from the usual total sugar intakes as ${\leq}10%$, 11-15%, 16-20%, 21-25%, >25%. Risk of LDL cholesterol showed a tendency to increase in the '>25%' group compared to the '<10%' group. The risks of the other health effects did not show any significant differences. Second, the subjects were categorized considering both Acceptable Macronutrient Distribution Range(AMDR) from carbohydrate and %Energy from total sugar as 'CHO<55% & Total sugar ${\leq}10%$', 'CHO 55-70% & Total sugar 11-25%', and '$CHO{\geq}70%$ & Total sugar ${\geq}25%$'. The risk of obesity tended to increase in the '$CHO{\geq}70%$ & Total sugar ${\geq}25%$' group compared to the 'CHO<55% & Total sugar ${\leq}10%$'. Third, the subjects were categorized as 'CHO<55% & Total sugar ${\leq}10%$', 'CHO 55-70% & Total sugar 11-20%', and '$CHO{\geq}70%$ & Total sugar ${\geq}20%$'. The risk of obesity also tended to increase in the '$CHO{\geq}70%$ & Total sugar ${\geq}20%$' group compared to the 'CHO<55% & Total sugar ${\geq}20%$' group. In conclusion, risk of LDL cholesterol showed a tendency to increase in the over 25% total sugar intake group, and the risk of obesity tended to increase in the 20-25% total sugar intake and high carbohydrate intake group. The risks of hypertension, hyperlipidemia, insulin resistance, and metabolic syndrome were not associated with total sugar intakes. More research to elucidate the association for Korean between the intakes of total sugar, added sugar, glucose, fructose, and sweeteners and diseases prevalences shoud be excuted in the future.

• 한국콘텐츠학회논문지
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• 제17권12호
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• pp.558-568
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• 2017

본 연구의 목적은 노인 암 환자의 신체활동 부족의 영향요인을 파악하기 위하여 수행되었다. 본 연구를 위하여 2014년 노인실태조사 원시 자료가 사용되었으며, 이중 암을 진단 받고 현재 치료 중인 65세 이상 노인 암 환자 418명의 자료가 분석되었다. 신체활동 수준을 측정하기 위하여 연구대상자들이 자가보고한 신체활동의 종류, 일주일간 수행 빈도 및 시간을 이용하여 대사활동량(Metabolic Equivalent Tasks, MET hours)을 계산하였다. 단순 및 다중 로지스틱 회귀분석 방법을 이용하여 분석한 결과, 노인 암 환자의 신체 활동 부족 영향요인에는 일상생활수행능력 및 도구적 일상생활수행능력 제한, 현재 흡연자, 낮은 사회적 활동 참여 빈도, 우울증, 인지기능 저하, 낮은 사회여가활동 만족도 등이 포함되었다. 일반적 특성을 통제했을 때, 일상생활수행능력 제한이 있는 환자들은 제한이 없는 환자들보다 약 2.8배(OR=2.762, CI=1.110, 7.952), 현재 흡연자의 경우 비흡연자보다 약 2.4배(OR=2.426, CI=1.113, 5.288) 신체활동 부족 위험이 큰 것으로 나타났다.

• Journal of Nutrition and Health
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• 제45권6호
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• pp.552-561
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• 2012

Metabolic syndrome is a cluster of metabolic risk factors associated with increased risk of cardiovascular diseases. Recently, the prevalence of metabolic syndrome has increased in Korea. The aim of this study was to develop a Healthy Han-sik Nutrition Education Program (HHNEP) based on commonly recognized Korean foods in order to decrease metabolic syndrome risks. The target population of the HHNEP is adults with metabolic risk factors. The initial version of the HHNEP was developed based on a review of literature and various dietary guidelines by expert committees as well as the results of a survey on the perception of common Korean dishes and foods as Han-sik. The focus group discussion conducted of nine participants from the target population. After minor modification, the final version was developed. The contents included five sections: 1) aims, 2) introduction of Korean Food Guidance System, 3) cholesterol contents in food, 4) menu planning method using Han-sik, and 5) examples of daily Han-sik menu. The Han-sik list was selected based on the results from a Han-sik perception answered by 35 Korean adults aged 30-60 years using 517 frequently consumed Korean foods from the fourth Korea National Health and Nutrition Examination Survey. The nutrition education program was developed based on scientific evidence for the prevention of metabolic syndrome and focuses on tailoring education to an individual's dietary problems. Educational method was developed by a group of expert committees based in planned behavior theory and related research results. The education method consisted of assessment of current diet, four face-to-face nutrition education sessions over 8 weeks, and evaluation after 8 and 16 weeks. Initial version of nutrition education materials and methods was tested for feasibility by a select group of nine Korean healthy adults. Successful implementation of the program would include application by nutritional professionals at the health promotion center of the hospitals, public health center, and work sites. Intervention studies are needed to evaluate the feasibility and effectiveness of this program before large-scale applications.

• 대한방사선기술학회지:방사선기술과학
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• 제36권3호
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• pp.219-225
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• 2013

본 연구는 CIMT에 영향을 미치는 요인, 대사증후군 유병률과 위험요소들이 CIMT에 미치는 영향에 대한 연구로 2012년 6월부터 12월까지 건강검진을 목적으로 건강검진센터에 내원하여 경동맥 초음파를 시행한 279명(남자: 187명, 여자: 92명) 중 심혈관계 질환이 없는 사람을 대상으로 하였다. 피검자의 평균연령은 $50.3{\pm}12.3$세(30 ~ 79세)이었고, 남자 $49.5{\pm}11.7$세, 여자 $51.9{\pm}13.4$세였다. 피검자에 대한 일반적인 건강상태를 확인하기 위해 혈압과 신체계측을 하였고 8시간 금식 후 혈액을 채취하여 공복혈당, 총콜레스테롤, 중성지방 등을 측정하였다. 수집된 자료는 t-test, one-way ANOVA, 피어슨 카이제곱검정, 다중 로지스틱 회귀분석을 실시하였다. 연구결과 CIMT는 여자보다 남자가 유의하게 증가 되었고, 특히 연령이 CIMT에 큰 영향을 미쳤다. 전체대상자의 대사증후군 유병률은 30.5%이었고 정상군과 비교하여 대사증후군에서 CIMT가 통계적으로 유의하게 높았다. 또한 대사증후군의 대사 이상 및 대사 이상 항목 군집성이 증가 할수록 CIMT에 유의한 영향을 미쳤다. 심혈관질환 위험인자와 관련이 있는 구성요소를 가진 대사증후군과 CIMT는 양의 상관관계(r=0.378, P<0.01)가 있었고, 대사증후군과 Abnormal CIMT에 대한 다중 로지스틱 회귀분석을 실시한 결과 Abnormal CIMT는 대사증후군과 유의한 관련성을 보였다(Exp(B)=2.725, p<0.05). 이상의 결과는 대사증후군에서 심혈관질환의 효과적인 일차 예방 전략으로 B-mode 초음파를 이용하여 측정된 CIMT가 중요한 역할을 할 것이므로 경동맥 초음파 검사가 적극적으로 권고되어야 한다고 사료된다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제13권2호
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• pp.172-179
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• 2010

목 적: 성인에서 내장 지방은 대사 이상의 위험 요소와 밀접한 상관이 있다고 알려져 있으나 소아 청소년 연령에서의 연구는 미흡하다. 소아 청소년에서의 복부지방의 분포와 대사 이상의 위험 요소간에 상관성을 연구하고자 하였다. 방 법: 78명의 남아와 23명의 여아를 포함한 101명의 소아 청소년(평균 연령 10.8${\pm}$2.4세)을 대상으로 연구를 시행하였다. 신체 계측과 대사 증후군의 위험 요소에 대한 분석을 개별 환자에서 시행하였고, 복부 전산화 단층 촬영을 통해 내장 지방과 피하 지방의 양을 측정하였다. 연령을 보정한 편 상관 분석을 통해 내장 지방, 피하 지방의 양, 신체 계측 지표와 대사 이상의 위험요소 간의 상관관계를 분석하였다. 결 과: 남아와 여아 모두에서 피하 지방이 나이가 들어감에 따라서 내장 지방보다 급격히 증가하는 것을 확인할 수 있었다. 남아에서 내장 지방과 피하 지방은 신체 계측 지표와는 유의한 상관성을 보였고, 내장 지방은 낮은 수치의 HDL-C과 피하 지방은 높은 이완기 혈압과 유의한 연관성을 보였으나. 남아에서 내장 지방과 피하 지방, 신체 계측 지표는 모두 대사 이상의 위험요소의 수와 밀접한 관계가 있는 것으로 나타났다. 결 론: 남아에서 내장 지방은 낮은 수치의 HDL-C과, 피하 지방은 높은 이완기 혈압과 유의한 상관성을 나타내었으나 성인에서의 기존 연구에 비해 본 연구는 다른 대사 이상의 위험 요소들에 대한 상관성이 떨어지는 것으로 나타났다.