• 척추신경추나의학회지
• /
• 제12권2호
• /
• pp.63-71
• /
• 2017

Objectives : The purpose of this study is to report the effect of muscle energy technique(MET) on idiopathic scoliosis with double curved thoracolumbar spine. Methods : Two patients with idiopathic scoliosis with double curved thoracolumbar spine were treated by MET. To investigate the outcome of the patients' improvement, we observed the standing X-ray of cervical, thoracic, lumbar spine. And Cobb's angle, correctability and visual analog scale(VAS) were used to measure changes during treatment. Results : After treatment, Cobb's angle, correctability and VAS were improved significantly. Conclusions : MET showed significant improvement to idiopathic scoliosis with double curved thoracolumbar spine. There is limitation on this study due to insufficient number of cases. Further research should be followed.

• 대한유전성대사질환학회지
• /
• 제12권1호
• /
• pp.49-53
• /
• 2012

X 연관 부신백질이영양증(adrenoleukodystrophy, ALD)은 과산화소체베타산화과정(peroxisomal ${\beta}$-oxidation)의 장애로 매우긴사슬지방산(very long chain fatty acids, VLCFA)이 신경계의 백질과 부신피질 및 고환에 축척된다. 이 질환은 과산화소체막단백질(peroxisomal membrane protein)을 형성하는 Xq28에 위치하는 ATP-binding cassette, subfamily D, member 1 (ABCD1) 유전자 돌연변이에 의해 주로 발생한다. X 연관 ALD는 다양한 임상양상을 보이는데 전형적인 소아대뇌형 부신백질이영양증은 10세 이전의 남아에서 대뇌백질에 빠르게 진행하는 탈수초현상을 보인다. 8세 된 남자 환아로 정상발달과정을 보이던 중 초등학교 입학 후에 집중장애와 산만한 모습으로 인해 주의력결핍과다활동장애로 진단받고 치료를 받았었다. 환아는 내원 8개월 전부터 말이 어눌해 지고 걸을 때 오른 발을 끌며 자주 넘어지는 모습을 보여 내원하였고 오른쪽 상, 하지의 근력이 떨어지는 양상이 관찰되었다. 검사상 부신기능저하증 소견을 보였으며 혈청 지방산 분석검사에서는 C26:0, C42:0/C22:0, C26:0/C22:0가 증가하였다. 뇌 자기공명영상에서는 T2와 FLAIR 강조영상에서 양측의 두정후두부의 백질과 소뇌의 백질에서 대칭적으로 고신호강도를 보였다. 환아는 부신백질이영양증로 진단하였고 ABCD1 유전자 분석 검사에서 새로운 c.983delT (p.Met329CysfsX7) 돌연변이가 확인되었다. X 연관 ALD는 유전자형과 표현형에 연관성이 없으며 다양한 임상양상을 보이기 때문에 환자들마다 임상증상을 잘 관찰해야 하며 향후 유전자 기능을 좀 더 파악하고 임상증상에 영향을 주는 다른 요소에 대한 연구가 필요할 것이라 사료된다.

• Asian-Australasian Journal of Animal Sciences
• /
• 제20권5호
• /
• pp.733-741
• /
• 2007

The effects of intra-duodenal infusion of methionine (Met), lysine (Lys) and leucine (Leu) on dry matter intake (DMI), the concentrations of insulin-like growth factor I (IGF-I), growth hormone (GH) and insulin in plasma, and liver IGF-I mRNA level were investigated in two experiments for Liuyang Black growing wether goats. In Experiment 1, three goats ($10.0{\pm}0.1$ kg) were fitted with ruminal, proximal duodenal and terminal ileal fistulaes to determine the infusion amounts of Met, Lys and Leu at the duodenum according to essential amino acid flows into the duodenum and their apparent digestibility. The infusion amounts were 0.77 g/d, 0.91 g/d and 0.58 g/d respectively. In Experiment 2, 4 groups of goats (($10.0{\pm}0.2$ kg) for each group, were cannulated at the duodenum, and were infused with a mixture of Met, Lys and Leu (Control), or mixtures with 21% Met, Lys or Leu replaced with glutamate respectively on a nitrogenous basis. The replacement of 21% Met, Lys or Leu with glutamate did not affect intakes of maize stover, concentrate or both (p>0.05) when compared with the control. The replacement of 21% Met or Lys significantly (p<0.05) reduced plasma GH, insulin and IGF-I concentrations and liver IGF-I mRNA level. The replacement of 21% Leu with glutamate reduced (p<0.05) plasma IGF-I concentration only, but not plasma insulin and GH, as well as liver IGF-I mRNA level (p>0.05). The close relationships between supplying Met and Lys in the lumen of the duodenum and plasma IGF-I, GH and insulin concentrations, as well as liver IGF-I mRNA level in this study indicate that the effects of the limiting amino acids on nutrition of animals are likely intermediated via their effects on these hormones, and these hormone profiles could be used as intermediate markers for the limiting order of amino acids.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권16호
• /
• pp.6613-6618
• /
• 2014

Background: The X-ray repair cross-complementing group 3 (XRCC3) is a highly suspected candidate gene for cancer susceptibility. Attention has been drawn upon associations of the XRCC3 Thr241Met polymorphism with breast cancer risk. However, the previous published findings remain controversial. Hence, we performed a meta-analysis to accurately evaluate any association between breast cancer and XRCC3 T241M (23, 812 cases and 25, 349 controls) in different inheritance models. Materials and Methods: PubMed and Web of Science databases were searched systematically until December 31, 2013 to obtain all the records evaluating the association between the XRCC3 Thr241Met polymorphism and breast cancer risk. Crude odds ratios (ORs) together with 95% confidence intervals (CIs) were used to assess the strength of associations. Results: When all eligible studies were pooled into the meta analysis of XRCC3 T241M polymorphism, a significantly increased breast cancer risk was observed in heterozygote comparison (OR=1.06, 95%CI=1.01-1.12). No significant associations were found in other models. In subgroup analysis, this polymorphism seemed to be associated with elevated breast risk in Asians. No publication bias was detected. Conclusions: This meta-analysis suggests that the T241M polymorphism confers a weakly increased breast cancer risk. A study with the larger sample size is needed to further evaluate gene-gene and gene-environment interactions of the XRCC3 T241M polymorphism with breast cancer risk.

• Asian-Australasian Journal of Animal Sciences
• /
• 제23권6호
• /
• pp.757-761
• /
• 2010

This study was conducted to assess the effects of organic and inorganic copper on performance in growing pigs. A total of 100 pigs, average age 63 d and initial body weight 21.46${\pm}$1.13 kg, were assigned to five treatment groups. Dietary treatments included i) CON (basal diet, 0 ppm Cu), ii) T1 (basal diet with 67 ppm Cu as cupric sulfate, $CuSO_4$), iii) T2 (basal diet with 134 ppm Cu as $CuSO_4$), iv) T3 (basal diet with 67 ppm Cu as cupric methionate, CuMet) and v) T4 (basal diet with 134 ppm Cu as CuMet). Throughout the entire experimental period, ADG (average daily gain), ADFI (average daily feed intake) and G/F (gain: feed) ratios showed no significant differences. The dry matter digestibility was improved in the T1, T2, T3, and T4 treatments (p<0.05), as compared with CON. Nitrogen digestibility was improved in the T3 treatment group as compared with CON (p<0.05). As compared with the T1 treatment group, fecal pH values were improved in the CON, T3, and T4 treatment groups (p<0.05). Fecal Cu concentrations were significantly lower in the CON, T3, and T4 treatment groups than in T1 and T2 (p<0.05). The incidence of diarrhea was reduced when the pigs were fed on the T2, T3, and T4 diets as compared with CON. In conclusion, diets supplemented with 67 or 134 ppm Cu as CuMet may prove effective in improving nutrient digestibility and fecal pH value in growing pigs, and fecal Cu concentrations may be reduced by CuMet supplementation.

• 한국수소및신에너지학회논문집
• /
• 제17권1호
• /
• pp.55-61
• /
• 2006

신규 $Nb_2Zr_6O_{17-x}N_x$ 광촉매를 고상합성법처리(solid state synthesis) 후 암모니아가스($NH_3$)에 의한 기상처리법(ammonolysis)으로 합성하였다. 합성된 신규 광촉매 및 이를 다시 Pt 및 $RuO_2$를 도핑 하여 $H_2S$를 광분해하여 수소를 발생 실험을 수행하였다. 이 신규 oxynitrid계 광촉매는 가시광하에서 $H_2S$를 광분해하여 수소를 발생하는(Quantum yield = 13.5 %) 우수한 광촉매 활성을 보여주었다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권7호
• /
• pp.4243-4247
• /
• 2013

The relationship between the X-ray repair cross-complementing group 3 (XRCC3) Thr241Met polymorphism and gliomas remains inclusive or controversial. For better understanding of the effect of XRCC3 Thr241Met polymorphism on glioma risk, a meta-analysis was performed. All eligible studies were identified through a search of PubMed, Elsevier Science Direct, Excerpta Medica Database (Embase) and Chinese Biomedical Literature Database (CBM) before May 2013. The association between the XRCC3 Thr241Met polymorphism and gliomas risk was conducted by odds ratios (ORs) and 95% confidence intervals (95% CIs). A total of nine case-control studies including 3,533 cases and 4,696 controls were eventually collected. Overall, we found that XRCC3 Thr241Met polymorphism was significantly associated with the risk of gliomas (T vs. C: OR=1.10, 95%CI=1.01-1.20, P=0.034; TT vs. CC: OR=1.30, 95%CI=1.03-1.65, P=0.027; TT vs. TC/CC: OR=1.29, 95%CI=1.01-1.64, P=0.039). In the subgroup analysis based on ethnicity, the significant association was found in Asian under four models (T vs. C: OR=1.17, 95%CI=1.07-1.28, P=0.00; TT vs. CC: OR=1.79, 95%CI=1.36-2.36, P=0.00; TT vs. TC/CC: OR=1.75, 95%CI=1.32-2.32, P=0.00; TT/TC vs. CC: OR=1.11,95% CI=1.02-1.20). This meta-analysis suggested that the XRCC3 Thr241Met polymorphism is a risk factor for gliomas, especially for Asians. Considering the limited sample size and ethnicities included in the meta-analysis, further large scale and well-designed studies are needed to confirm our results.

• Journal of the Korean Data and Information Science Society
• /
• 제22권1호
• /
• pp.29-35
• /
• 2011

결점수를 모니터링하기 위한 통계적 공정관리는 생산공정에 널리 사용된다. 결점 수를 모니터링 하는데는 c-관리도가 사용된다. 전통적인 c-관리도는 표본에서 결점의 발생은 포아송분포를 따른다는 가정 하에서 만들어진다. 포아송분포에 대한 가정이 맞지 않을 때에는 X-관리도가 사용될 수 있다. 누적합 관리도는 공정의 작은 변화를 찾는데 유용한 것으로 알려져 있다. 본 논문에서는 다양한 Katz 분포족으로부터 생성된 계수자료에 대하여 3시그마 X-관리도와 누적합 관리도의 효율을 평균런의길이에 근거하여 비교 한다. 즉, 자료가 어떤 분포로부터 생성되었는지 알 수 없을 때, X-관리도와 누적합 관리도를 비교하는 것이다.

• 전자공학회논문지A
• /
• 제29A권2호
• /
• pp.33-40
• /
• 1992

The design method of signal delay line system using indirect frequency synthesizer is presented. The variable signal delay line system with 2[nsec] step of delay time at center frequency 60[MHz], bandwidth 500[KHz] and range 5.24-5.81[x10S0-6Tsec] is designed and fabricated. The results were met with good characteristics to be variable delay time of average 2.01[nsec] per step.

• Journal of the Korean Data and Information Science Society
• /
• 제21권4호
• /
• pp.681-688
• /
• 2010

통계적 공정관리에서 결점수를 모니터링 하는데는 c-관리도가 사용된다. 전통적인 c-관리도는 표본에서 결점의 발생은 포아송분포를 따른다는 가정 하에서 만들어진다. 포아송 분포에 대한 가정이 맞지 않을 때에는 X-관리도가 사용될 수 있다. 지수가중이동평균관리도는 공정의 작은 변화를 찾는 데 유용한 것으로 알려져 있다. 본 논문에서는 다양한 카즈분포족으로부터 생성된 계수자료에 대하여 3시그마 X-관리도와 지수가중이동평균관리도의 효율을 평균 런의 길이에 근거하여 비교한다. 즉, 자료가 어떤 분포로부터 생성되었는지 알 수 없을 때, X-관리도와 지수가중이동평균관리도를 비교하는 것이다.