Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Association between the XRCC3 Thr241Met Polymorphism and Breast Cancer Risk: an Updated Meta-analysis of 36 Case-control Studies

  • Mao, Chang-Fei (Department of Oncology, Nanjing Medical University Affiliated Jiangsu Cancer Hospital) ;
  • Qian, Wen-Yi (Department of Toxicology, School of Public Health, Nanjing University of Chinese Medicine) ;
  • Wu, Jian-Zhong (Department of Oncology, Nanjing Medical University Affiliated Jiangsu Cancer Hospital) ;
  • Sun, Da-Wei (Department of Breast Oncology, Affiliated Jiangsu Cancer Hospital, Nanjing University of Chinese Medicine) ;
  • Tang, Jin-Hai (Department of Oncology, Nanjing Medical University Affiliated Jiangsu Cancer Hospital)
  • Published : 2014.08.30
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Abstract

Background: The X-ray repair cross-complementing group 3 (XRCC3) is a highly suspected candidate gene for cancer susceptibility. Attention has been drawn upon associations of the XRCC3 Thr241Met polymorphism with breast cancer risk. However, the previous published findings remain controversial. Hence, we performed a meta-analysis to accurately evaluate any association between breast cancer and XRCC3 T241M (23, 812 cases and 25, 349 controls) in different inheritance models. Materials and Methods: PubMed and Web of Science databases were searched systematically until December 31, 2013 to obtain all the records evaluating the association between the XRCC3 Thr241Met polymorphism and breast cancer risk. Crude odds ratios (ORs) together with 95% confidence intervals (CIs) were used to assess the strength of associations. Results: When all eligible studies were pooled into the meta analysis of XRCC3 T241M polymorphism, a significantly increased breast cancer risk was observed in heterozygote comparison (OR=1.06, 95%CI=1.01-1.12). No significant associations were found in other models. In subgroup analysis, this polymorphism seemed to be associated with elevated breast risk in Asians. No publication bias was detected. Conclusions: This meta-analysis suggests that the T241M polymorphism confers a weakly increased breast cancer risk. A study with the larger sample size is needed to further evaluate gene-gene and gene-environment interactions of the XRCC3 T241M polymorphism with breast cancer risk.

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References

  1. Bewick M A, Conlon M S, Lafrenie R M (2006). Polymorphisms in XRCC1, XRCC3, and CCND1 and survival after treatment for metastatic breast cancer. J Clin Oncol, 24, 5645-51. https://doi.org/10.1200/JCO.2006.05.9923
  2. Breast Cancer Association C (2006). Commonly studied singlenucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium. J Natl Cancer Inst, 98, 1382-96. https://doi.org/10.1093/jnci/djj374
  3. Brooks J, Shore RE, Zeleniuch-Jacquotte A, et al (2008). Polymorphisms in RAD51, XRCC2, and XRCC3 are not related to breast cancer risk. Cancer Epidemiol Biomarkers Prev, 17, 1016-9. https://doi.org/10.1158/1055-9965.EPI-08-0065
  4. Costa S, Pinto D, Pereira D, et al (2007). DNA repair polymorphisms might contribute differentially on familial and sporadic breast cancer susceptibility: a study on a Portuguese population. Breast Cancer Res Treat, 103, 209-17. https://doi.org/10.1007/s10549-006-9364-z
  5. DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
  6. Dufloth R M, Costa S, Schmitt F, et al (2005). DNA repair gene polymorphisms and susceptibility to familial breast cancer in a group of patients from Campinas, Brazil. Genet Mol Res, 4, 771-82.
  7. Dufloth RM, Arruda A, Heinrich JK, et al (2008). The investigation of DNA repair polymorphisms with histopathological characteristics and hormone receptors in a group of Brazilian women with breast cancer. Genet Mol Res, 7, 574-82. https://doi.org/10.4238/vol7-3gmr376
  8. Economopoulos KP, Sergentanis TN (2010). XRCC3 Thr241Met polymorphism and breast cancer risk: a meta-analysis. Breast Cancer Res Treat, 121, 439-43. https://doi.org/10.1007/s10549-009-0562-3
  9. Egger M, Davey Smith G, Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  10. Falvo E, Strigari L, Citro G, et al (2011). Dose and polymorphic genes xrcc1, xrcc3, gst play a role in the risk of articledeveloping erythema in breast cancer patients following single shot partial breast irradiation after conservative surgery. BMC Cancer, 11, 291. https://doi.org/10.1186/1471-2407-11-291
  11. Figueiredo JC, Knight JA, Briollais L, et al (2004). Polymorphisms XRCC1-R399Q and XRCC3-T241M and the risk of breast cancer at the Ontario site of the Breast Cancer Family Registry. Cancer Epidemiol Biomarkers Prev, 13, 583-91.
  12. Forsti A, Angelini S, Festa F, et al (2004). Single nucleotide polymorphisms in breast cancer. Oncol Rep, 11, 917-22.
  13. Gage M, Wattendorf D, Henry L R (2012). Translational advances regarding hereditary breast cancer syndromes. J Surg Oncol, 105, 444-51. https://doi.org/10.1002/jso.21856
  14. Garcia-Closas M, Egan KM, Newcomb PA, et al (2006). Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses. Hum Genet, 119, 376-88. https://doi.org/10.1007/s00439-006-0135-z
  15. Goode EL, Ulrich CM, Potter JD (2002). Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiol Biomarkers Prev, 11, 1513-30.
  16. Han J, Hankinson S E, Ranu H, et al (2004). Polymorphisms in DNA double-strand break repair genes and breast cancer risk in the Nurses' Health Study. Carcinogenesis, 25, 189-95.
  17. Han S, Zhang H T, Wang Z, et al (2006). DNA repair gene XRCC3 polymorphisms and cancer risk: a meta-analysis of 48 case-control studies. Eur J Hum Genet, 14, 1136-44. https://doi.org/10.1038/sj.ejhg.5201681
  18. He X F, Wei W, Su J, et al (2012). Association between the XRCC3 polymorphisms and breast cancer risk: metaanalysis based on case-control studies. Mol Biol Rep, 39, 5125-34. https://doi.org/10.1007/s11033-011-1308-y
  19. He X F, Wei W, Li J L, et al (2013). Association between the XRCC3 T241M polymorphism and risk of cancer: evidence from 157 case-control studies. Gene, 523, 10-9. https://doi.org/10.1016/j.gene.2013.03.071
  20. Higgins J, Green S (2008). Cochrane handbook for systematic reviews of interventions version 5.0.1. The Cochrane Collaboration, Oxford.
  21. Jacobsen N R, Nexo B A, Olsen A, et al (2003). No association between the DNA repair gene XRCC3 T241M polymorphism and risk of skin cancer and breast cancer. Cancer Epidemiol Biomarkers Prev, 12, 584-5.
  22. Jara L, Dubois K, Gaete D, et al (2010). Variants in DNA doublestrand break repair genes and risk of familial breast cancer in a South American population. Breast Cancer Res Treat, 122, 813-22. https://doi.org/10.1007/s10549-009-0709-2
  23. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  24. Krupa R, Synowiec E, Pawlowska E, et al (2009). Polymorphism of the homologous recombination repair genes RAD51 and XRCC3 in breast cancer. Exp Mol Pathol, 87, 32-5. https://doi.org/10.1016/j.yexmp.2009.04.005
  25. Lee SA, Lee KM, Park SK, et al (2007). Genetic polymorphism of XRCC3 Thr241Met and breast cancer risk: case-control study in Korean women and meta-analysis of 12 studies. Breast Cancer Res Treat, 103, 71-6. https://doi.org/10.1007/s10549-006-9348-z
  26. Lengauer C, Kinzler KW, Vogelstein B (1998). Genetic instabilities in human cancers. Nature, 396, 643-9. https://doi.org/10.1038/25292
  27. Loizidou MA, Michael T, Neuhausen SL, et al (2008). Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus. Breast Cancer Res Treat, 112, 575-9. https://doi.org/10.1007/s10549-007-9881-4
  28. Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
  29. Millikan RC, Player JS, Decotret AR, et al (2005). Polymorphisms in DNA repair genes, medical exposure to ionizing radiation, and breast cancer risk. Cancer Epidemiol Biomarkers Prev, 14, 2326-34. https://doi.org/10.1158/1055-9965.EPI-05-0186
  30. Popanda O, Tan XL, Ambrosone CB, et al (2006). Genetic polymorphisms in the DNA double-strand break repair genes XRCC3, XRCC2, and NBS1 are not associated with acute side effects of radiotherapy in breast cancer patients. Cancer Epidemiol Biomarkers Prev, 15, 1048-50. https://doi.org/10.1158/1055-9965.EPI-06-0046
  31. Qin L Y, Chen X, Li P, et al (2013). Association between the XRCC3 Thr241Met polymorphism and cervical cancer risk: a meta-analysis. Asian Pac J Cancer Prev, 14, 6703-7. https://doi.org/10.7314/APJCP.2013.14.11.6703
  32. Romanowicz-Makowska H, Smolarz B, Zadrozny M, et al (2011). Single nucleotide polymorphisms in the homologous recombination repair genes and breast cancer risk in Polish women. Tohoku J Exp Med, 224, 201-8. https://doi.org/10.1620/tjem.224.201
  33. Romanowicz-Makowska H, Brys M, Forma E, et al (2012). Single nucleotide polymorphism (SNP) Thr241Met in the XRCC3 gene and breast cancer risk in Polish women. Pol J Pathol, 63, 121-5.
  34. Sangrajrang S, Schmezer P, Burkholder I, et al (2007). The XRCC3 Thr241Met polymorphism and breast cancer risk: a case-control study in a Thai population. Biomarkers, 12, 523-32. https://doi.org/10.1080/13547500701395602
  35. Santos RA, Teixeira AC, Mayorano MB, et al (2010). DNA repair genes XRCC1 and XRCC3 polymorphisms and their relationship with the level of micronuclei in breast cancer patients. Genet Mol Biol, 33, 637-40. https://doi.org/10.1590/S1415-47572010005000082
  36. Silva SN, Tomar M, Paulo C, et al (2010). Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51. Cancer Epidemiol, 34, 85-92. https://doi.org/10.1016/j.canep.2009.11.002
  37. Smith TR, Miller MS, Lohman K, et al (2003). Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer. Cancer Lett, 190, 183-90. https://doi.org/10.1016/S0304-3835(02)00595-5
  38. Smith TR, Levine EA, Freimanis R I, et al (2008). Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. Carcinogenesis, 29, 2132-8. https://doi.org/10.1093/carcin/bgn193
  39. Smith T R, Levine EA, Perrier N D, et al (2003). DNA-repair genetic polymorphisms and breast cancer risk. Cancer Epidemiol Biomarkers Prev, 12, 1200-4.
  40. Sterpone S, Mastellone V, Padua L, et al (2010). Singlenucleotide polymorphisms in BER and HRR genes, XRCC1 haplotypes and breast cancer risk in Caucasian women. J Cancer Res Clin Oncol, 136, 631-6. https://doi.org/10.1007/s00432-010-0791-1
  41. Thyagarajan B, Anderson KE, Folsom AR, et al (2006). No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study. Cancer Detect Prev, 30, 313-21. https://doi.org/10.1016/j.cdp.2006.07.002
  42. Ward JF (1988). DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. Prog Nucleic Acid Res Mol Biol, 35, 95-125. https://doi.org/10.1016/S0079-6603(08)60611-X
  43. Webb PM, Hopper JL, Newman B, et al (2005). Double-strand break repair gene polymorphisms and risk of breast or ovarian cancer. Cancer Epidemiol Biomarkers Prev, 14, 319-23. https://doi.org/10.1158/1055-9965.EPI-04-0335
  44. Yin QH, Liu C, Li L, et al (2012). Association between the XRCC3 T241M polymorphism and head and neck cancer susceptibility: a meta-analysis of case-control studies. Asian Pac J Cancer Prev, 13, 5201-5. https://doi.org/10.7314/APJCP.2012.13.10.5201
  45. Zhang L, Zhang Z, Yan W (2005). Single nucleotide polymorphisms for DNA repair genes in breast cancer patients. Clin Chim Acta, 359, 150-5. https://doi.org/10.1016/j.cccn.2005.03.047

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