• The Korean Journal of Nuclear Medicine Technology
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• v.15 no.1
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• pp.39-44
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• 2011

Purpose: $^{18}F$-FDG PET/CT has been known a useful modality to diagnose high-glucose-using cells such as cancer cells by glucose metabolism of FDG. Mainly, FDG takes on cancer and inflammatory cells; However, There have been FDG uptakes on normal tissues by individual physiological characteristics, occasionally. Especially, in fertile females, unusual FDG uptake of breast changes as the menstrual cycle, and disturb diagnosis. Therefore, the study aimed to evaluate the change of breast FDG uptake in menstrual cycle on $^{18}F$-FDG PET/CT. Materials and Methods: 160 females ($34{\pm}3.5$ years old) who do not undergo a gynecologic anamnesis and have regular menstrual cycle over the previous 6 months were examined, from March 2009 to February 2010. They were divided 4 groups (each 40 patients) as flow phase, proliferative phase, ovulatory phase and secretory phase using Pregnancy Calculator 0.14. and history taking. Discovery Ste (GE Healthcare, Milwaukee, Mi, USA) was used as PET/CT. We analyzed SUVs on accumulated region on breast, and 3 nuclear medicine specialists did the Blind test. Results: SUVs on the Breast were flow phase ($1.64{\pm}0.25$), proliferative phase ($0.93{\pm}0.28$), ovulatory phase ($1.66{\pm}0.26$) and secretory phase ($1.77{\pm}0.28$). It showed high uptake value in secretory, flow phase and ovulatory phase (p<0.05). In gross analysis, the accumulation of breast was divided into 3 grades as comparing with lung and liver. The breast's uptake was equal to lung (Grade I); between lung and liver (Grade II); equal to or greater than liver (Grade III). The results showed high uptake value in secretory, flow phase and ovulatory phase (p<0.05). Conclusion: In fertile females, FDG uptake of breast changed as menstrual cycle, and it available to diagnose breast disease. Therefore, we consider reducing false-negative finding of breast disease, by doing examination on appropriate period through history taking about individual menstrual cycle.

• The Journal of the Korean life insurance medical association
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• v.16
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• pp.77-82
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• 1997

• The Korean Journal of Physiology and Pharmacology
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• v.17 no.6
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• pp.499-503
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• 2013

This study tested the hypothesis that effects of the menstrual cycle on resting blood pressure carry over to dynamic exercise. Eleven healthy females were studied during the early (EP; low estrogen, low progesterone) and late follicular (LP; high estrogen, low progesterone) menstrual phases. Stroke volume (SV), heart rate (HR), cardiac output (CO), systolic blood pressure (SBP), diastolic blood pressure (DBP), and total vascular conductance (TVC) were assessed at rest and in response to mild and moderate cycling exercise during EP and LP. During EP, compared to LP, baseline SBP ($111{\pm}1$ vs. $103{\pm}2$ mmHg), DBP ($71{\pm}2$ vs. $65{\pm}2$ mmHg) and mean arterial pressure (MAP) ($84{\pm}2$ vs. $78{\pm}1$ mmHg) were higher and TVC ($47.0{\pm}1.5$ vs. $54.9{\pm}4.2$ ml/min/mmHg) was lower (p<0.05). During exercise, absolute values of SBP (Mild: $142{\pm}4$ vs. $127{\pm}5$ mmHg; Moderate: $157{\pm}4$ vs. $144{\pm}5$ mmHg) and MAP (Mild: $100{\pm}3$ vs. $91{\pm}3$ mmHg; Moderate: $110{\pm}3$ vs. $101{\pm}3$ mmHg) were also higher, while TVC was lower (Mild: $90.9{\pm}5.1$ vs. $105.4{\pm}5.2$ ml/min/mmHg; Moderate: $105.4{\pm}5.3$ vs. $123.9{\pm}8.1$ ml/min/mmHg) during EP (p<0.05). However, exercise-induced increases in SBP, MAP and TVC at both work intensities were similar between the two menstrual phases, even though norepinephrine concentrations were higher during LP. Results indicate that blood pressure during dynamic exercise fluctuates during the menstrual cycle. It is higher during EP than LP and appears to be due to additive effects of simultaneous increases in baseline blood pressure and reductions in baseline TVC.

• Clinical and Experimental Reproductive Medicine
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• v.25 no.2
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• pp.153-160
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• 1998

The objective of this retrospective study was to evaluate whether the transvaginal ultrasonographic analysis of endometrial pattern and thickness could predict the stage of menstrual cycle. Endometrial pattern and thickness were observed in those patients receiving infertility work up from April, 1994 to July, 1998 at Seoul National University Hospital. The study group was 185 patients with normal regular menstrual cycles. Among them, 44 patients received endometrial biopsy, and the date of endometrium was compared with the observed endometrial pattern and thickness. The observed endometrial pattern was presence or absence of central cavity echogenicity, triple line sign, endometrial hypoechogenicity, ring sign, endometrial hyperechogenicity and posterior acoustic sonic enhancement. The results were as follows; Central cavity echogenicity was seen throughout menstrual cycle. Triple line sign was observed in 81.1% of patients during early secretory phase. However, in mid to late secretory phase, triple line sign was appeared in only 6.8%. The percentage of positive endometrial hypoechogenicity was highest in early secretory phase. In contrast to hypoechogenicity, positive endometrial hyperechogenicty was highest in mid to late secretory phase. Ring sign was observed in 73.5% of the patients during early secretory phase with peak incidence. Posterior acoustic enhancement was seen in 72.7% of the patients during late secretory phase. The sensitivity and specificity of being a secretory phase if the patients showed hyperechogenic endometrium, were 84.2%, 83.3% respectively. The sensitivity and specificity of being a secretory phase if the patients showed posterior acoustic enhancement were 93.8%, 58.3% respectively. Endometrial thickness was not correlated with endometrial dating. In conclusion, transvaginal ultrasonographical delineation of the endometrial pattern might be useful tool in predicting endometrial status during normal menstrual cycle. But, endometrial thickness could not predict the endometrial dating.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.4
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• pp.183-193
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• 2008

Purpose: To research the changes of Skin Resistance Variability(SRV) over the period of ovarian cycle of healthy young women with normal and regular menstrual cycles using Oriental Medical Diagnose Autonomic system-3000 (OMD-3000). Methods: We measured SRV of 15 women who were working at O O Oriental Hospital from July to Oct. 2008. Each woman took the OMD-3000 test 8 times during 2 menstrual cycles. Each cycle consists of 4 phases-follicular phase, ovulation, luteal phase and menstruation. We analyse the data by SPSS 12.0 for windows. the one-way ANOVA by Repeated Measure(p<0.05). Results: 1. (1) The Factor AA means at zone 1 were 0.77$\pm$0.40, at zone 2 were 1.07$\pm$0.68, at zone 3 were 0.77$\pm$0.35, at zone 4 were 0.68$\pm$0.32, at zone 5 were 0.74$\pm$0.29, at zone 6 were 0.85$\pm$0.30, and at zone 7 were 0.74$\pm$0.29. The Factor AA means were lower than normal range at zone 1,3,4,5,6 and 7. The graph pattern of M shape was caused by the Factor AA means at zone 2 and zone 6 were higher than others. (2) The Factor AA means at zone 1 and zone 3 show abnormal regulation state. 2. During the menstruation. the Factor AA means were higher at zone 1,2 and 3 than other zones. During the ovulation, the Factor AA means were higher at zone 4,5,6 and 7 than other zones. Especially at the menstruation phase in zone 2 and at the ovulation phase in zone 6 tend to be highest means than other phases respectively. 3. However there were no significant difference of means during 4 ovarian phases in 7 zones except ovulation phase to luteal phase at zone 4(p = 0.013). Conclusion: The results suggest that changes of SRV during 4 menstrual cycles are not variables in reading 7-zone-diagnostic system. Further study will be needed.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.2
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• pp.554-560
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• 2007

This study was aimed to identify the effect of abdominal moxibustion on premenstrual syndrome and dysmenorrhea in university students. The data were collected by using questionnaires from April 25, 2005 to June 20, 2005. The subjects were university students from in the Pusan metropolitan area who had complained of menstrual discomfort. Thirteen students were assigned to the experimental group and fourteen students to the control group. The research design of this study was a nonequivalent control group pretest-posttest design. In the research method pretest were conducted through measurement based on scores of general character, menstrual character, premenstrual syndrome and dysmenorrhea in the experimental group and the control group. Experimentation was conducted by abdominal moxibustion being applied on the kwan-won hole and Ki-hae hole for 25 minutes at a time, three times a week, form the ending of one menstrual cycle to the beginning of the next menstrual cycle were in the experimental group. After treatment was finished, post tests conducted through measurement based on scores of premenstrual syndrome and dysmenorrhea in the experimental group. The control group conducted a point of same time and same measurement with the experimental group. The instruments used in this study MDQ(Menstual Distress Questionnaire) developed by moos(1968) and the VAS(Visual Analogue Scale) developed by Cline(1992). The data were analysed by SPSS/ win 12.0 program with ${\chi}$2-test and t-test to verify identification among subjects' general characteristics and menstrual characteristics. Hypothesis verification was analysed with t-test. The results of the study are as follows: The hypothesis, 'the experimental group who received abdominal moxibustion will decrease premenstrual symptoms more than the control group', was supported (t= -2.121, p=.022). The hypothesis, 'the experimental group who received adbominal moxibustion will decrease dysmenorrhea compared to the control group', was supported (t=-4.424, p=.001). As a result of this study, abdominal moxibustion will be used as a nursing aide to improve and prevent menstrual discomfort of university students who have premenstrual syndrome and dysmenorrhea.

• The Journal of Korean Medicine
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• v.21 no.4
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• pp.93-103
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• 2000

Objective: Stress is assumed to have many effects on menstruation of highschool senior female students, and it is expected to cause many problems and low efficiency during their studies. Therefore, through analyzing the menstruation state of highschool senior female students, the effects of stress on their menstruation and their education were studied. Methods: We made a survey of 583 senior female students of 'N' highschool located in Taegu. The survey was composed of the degrees of stress they were undergoing, menstrual problems caused by stress. Results: The survey results showed that 96.7% of the candidates were experiencing stress. 51.6% of them experienced an altered menstrual cycle, and menstrual irregularity was brought out in 32.1 % among them. 18.1 % of them were experiencing dysfunctional uterine bleeding. In sustaining period of menstruation, 17.5% of them had a shortened menstruation period, and 8.9% had a prolonged period. In case of menstrual quantity, less than normal quantity was reported by 26.9% of respondents and more than normal quantity was reported by 8.8%. 26.6% of respondents reported their menstrual blood was impure and the color was dark. Blood clots were increased in 27.5% of respondents. 86.6% went through premenstrual syndrome, and 34.3% had worsened menstrual pain. Studying was affected by menstrual pain in 83.9% of respondents. Of treating the disorder, 66.2% of them said they just waited till the pain went away, and 26.9% of them said they went to a pharmacy, and 2.4% of them said they went to an oriental medical clinic. Conclusions: From the above results, it is concluded that stress has a close connection with menstrual disorders. And it affects senior highschool female students' education, while they don't take proper treatments. Hence we think that we must have a lot of concern about senior female students and they must receive proper treatments.

• Korean Journal of Community Nutrition
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• v.18 no.6
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• pp.577-587
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• 2013

This study aimed to elicit the variability of appetite and food intake patterns in female college students during different menstrual phases. The craving for certain foods and physiological and psychological symptoms of menstrual phase (pre- and post-menstrual) were investigated by self-administered questionnaire. Three hundred and sixty six students who were 20.9 years old and had $19.8kg/m^2$ of BMI volunteered to participate in this study. Most of the subjects (89.5%) experienced the premenstrual syndrome (PMS) such as irritation, bodily fatigue, nervosity. Symptoms such as tiredness, stomachache, changes in taste and increased appetite were pointed out to be experienced at the onset of the menstrual cycle. The variability of food intake in premenstrual phase, 11.0% of subjects had decreased food intake where as 68.8% had experienced increased intake. The postmenstrual phase, 20.1% had decreased food intake while 45.2% had experienced increased intake due to changes in the appetite. Before starting menstruation, most of the subjects craved for sweets. The group who had experienced abnormal appetite during menstrual phase was significantly high ratio in overweight and obese students (p<0.05). We also observed an association between the PMS score and the variability of eating patterns during the menstrual phase. The students who experienced changing appetite and food intake had significantly high PMS score in the premenstrual phase (p<0.01) and postmenstrual phase (p<0.05). These results suggested a need for future study related to changes in the actual nutrient intake and activity level during the menstrual phase.

• The Journal of Korean Obstetrics and Gynecology
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• v.24 no.1
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• pp.99-108
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• 2011

Objectives: The purpose of this study is to recognize the relation of menstrual pattern and dysmenorrhea affected by obesity of first-year female college students. Methods: From March 22th to April 2nd, 2010 we researched 251 first-year female students at OOcollege, aged 19(born after March 1991 to February 1992) by questionnaires to investigate their Body Mass Index(BMI), menstruation and dysmenorrhea. The BMI range of normal group is 18.5~25, abnormal group is over 25. Results: 1. The normal group was 227 people(90.4%) and the abnormal group(over BMI 25) was 24 people(9.6%). 2. In the mean of BMI, the normal group was $21.08{\pm}1.64$ and the abnormal group was $27.94{\pm}2.19$. 3. There was no statistical difference between the normal group and the abnormal group in menstrual cycle, menstrual amount, menstrual color and menstrual blood clot. 4. There was statistical difference between the normal group and the abnormal group in menarcheal age, menstrual duration and dysmenorrhea. 5. In the mean of VAS, the normal group was $3.68{\pm}2.45$ and the abnormal group was $3.21{\pm}2.05$, and two groups were not different statistically. Conclusion: This study showed the relation of menstrual pattern and dysmenorrhea affected by obesity. The normal group and the abnormal group were different statistically in menarcheal age, menstrual duration and dysmenorrhea. In consequence of this study, it was supposed that obesity had an effect on menstruation.

• CELLMED
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• v.5 no.3
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• pp.18.1-18.4
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• 2015

Dysmenorrhea is the most common gynecological disorder in women of reproductive age. The prevalence of menstrual pain is relatively high and has been shown to be related to many factors like age, age at menarche, menstrual cycle regularity, parity, cigarette smoking, and dietary habits etc. This study was conducted to determine the possible link between dysmenorrhea and the factors related to it. We investigated the associated risk factors that could influence menstrual pain. This Cross Sectional Study was conducted at Dept. of OBG, NIUM, Bangalore. The study consisted of 230 women between the ages of 20 - 49 years. Included volunteers were newly married, nulliparious and parous women. The detailed reproductive history was recorded and was analyzed statistically. It was observed that there were only two factors that were influencing Dysmenorrhea namely the early age at menarche and increase parity. It was hypothesis that earlier start to reproductive life in some way decreases the sensitivity of the uterus to prostaglandin, whereas delayed menarche and postponing reproductive life increase sensitivity of the uterus to prostaglandins and cause severe menstrual pain. It is concluded that early age at menarche and high parity decrease menstrual pain.