• Journal of Ginseng Research
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• 제46권4호
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• pp.601-608
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• 2022

Background: Various treatments are used to relieve menopausal symptoms for women. However, herbal substances are frequently used as complementary and alternative therapies as other treatments can increase ovarian and breast cancer risk. While the herbal substances' therapeutic effect is essential, the safety of their use is considered more important. This study aims to confirm the safety of red ginseng and herb extract complex (RHC), which are used to relieve menopausal symptoms. Methods: This randomized, double-blind, placebo-controlled clinical study recruited and divided 120 women experiencing menopausal symptoms into the RHC and placebo groups (60 women per group). Subjects were administered with 2 g RHC or placebo daily for 12 wk. Adverse reactions, female hormonal changes, and uterine thickness were observed and recorded on wk 0, 6, and 12. Hematologic and blood chemistry tests were also conducted. Results: The reactions of the subjects who received RHC or placebo at least once were analyzed. A total of six adverse reactions occurred in the RHC group, while nine occurred in the placebo group; common reactions observed in both groups were genital, subcutaneous tissue, and vascular disorders. However, there was no statistically significant difference between the administration groups (p = 0.5695), and no severe adverse reactions occurred in both groups.

• 대한한방부인과학회지
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• 제36권4호
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• pp.61-77
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• 2023

Objectives: This study aimed to identify the current use and investigate the clinical practice of Korean Medicine for climacteric syndrome and postmenopausal syndrome outpatients. Methods: We studied climactic syndrome and postmenopausal syndrome outpatients who visited Daejeon Korean Medicine Hospital of Daejeon University from January 1, 2019 to December 31, 2021 via an analysis of the medical records. Results: 130 patients were finally selected. Their average age was 51.91±4.57 years and the average number of visits was 7.51±11.40 times. Patients usually complained two or more addresses, and the most frequent symptoms were hot flushes. 126 patients took herbal medicines and 99 of them took herbal decoctions. 106 patients were treated by acupuncture. 58 patients were treated by pharmacopuncture and Hominis Placenta was used to 50 subjects. As for the improvement rate by symptoms, hot flushes were the highest at 65.5%. We compared the improvement rate of groups taking Guibi-tang-gami A and Guibi-tang-gami B, the common herbal decoction of Daejeon Korean Medicine Hospital of Daejeon University. In the group of Guibi-tang-gami A, the improvement rate of hot flushes was the highest and in the other, vaginal dryness was the highest. Urinary frequency of the group with Hominis Placenta pharmacopuncture showed more than three times higher improvement rate of the non-executive group. Conclusions: We analyzed general characteristics, clinical characteristics, types of Korean medicine treatment, improvement rates by symptoms of 130 outpatients diagnosed with climactic syndrome and postmenopausal syndrome. This study could be used as reference to provide practical data of outpatient treatment for Climacteric Syndrome and Postmenopausal Syndrome.

• 대한한방부인과학회지
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• 제31권1호
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• pp.84-98
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• 2018

Objectives: The purpose of this pilot study was to examine the feasibility of recruiting women into a clinical trial designed to examine the effects of acupuncture and electroacupuncture in treating overactive bladder (OAB) in menopause women. We tried to determine if there was preliminary evidence to suggest that acupuncture may be effective in reducing OAB symptoms and improving disease-specific quality of life. We also tried to determine the appropriate treatment duration of OAB, with safety of performing acupuncture and electroacupuncture treatment. Methods: This study was a randomized clinical trial. 7 menopause women were randomly assigned to a electroacupuncture group (EA group) (n=4) or acupuncture group (AC group) (n=3) and received electroacupuncture or acupuncture treatment twice a week (16 sessions) in 8 weeks, and follow up assessment was performed after the end of treatment. Overactive Bladder Symptom Score (OABSS), 3-day bladder diary, and King's Health Questionnaire (KHQ) were performed 4 times (at baseline (visit 0), the middle of treatment (visit 8), after the end of treatment (visit 16), and at 4 weeks of follow-up (visit 17)) and analyzed. 2 subjects were dropped out, and finally 5 subjects completed the study. Statistical analysis was performed using SPSS 18.0 for window program. Results: There was an significant improvement in night-time frequency after the treatment (visit 17) in PP (Per-protocol) group analysis (p=0.042). In additional ITT (Inter-to-treat) group analysis, the OABSS (p=0.042) and night-time frequency (p=p=0.017) were improved significantly after the treatment (visit 17). But there was no significant difference of KHQ before and after the treatment. Also there was no significant difference between EA and AC group after the treatment (visit 16, 17). Conclusions: The results of this pilot study suggested that it was feasible to recruit subjects and perform the study procedures, after reconstructing several details of study protocol in performing further clinical trial.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제7권1호
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• pp.52-60
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• 1996

본 연구는 월경전기에 불편감이 있다고 응답한 230명의 여고생을 대상으로 전향적인 매일 평가서를 사용하여 월경주기에 따른 신체적, 기분, 행동변화의 양상을 보고자 하였다 '월경전 불쾌기분장애'로 확인된 군과 전체대상군 모두에서 후기황체기에 신체적 , 심리적 증상들이 뚜렷한 악화를 보이기 시작하여 월경이 시작되면서 증상의 최고치를 나타냈으며, 월경시작4일째에 급격한 감소를 보였다. 또한 월경주기중에서 특히 월경기때에 보다많이 신체적인 불편감을 경험하고 있고, 이때 월경기간이 길수록 불편감이 큰 것으로 보여진다. 이러한 양상들은 젊은 여성의 월경전기 변화 양상을 대표할 수는 없으나, 본 대상군이 여고생임을 감안할 때 우리나라 청소년의 월경주기에 따른 고유한 증상의 변화양상을 보여주는 것이라고 할 수 있겠다.

• 대한한방부인과학회지
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• 제33권1호
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• pp.86-103
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• 2020

Objectives: The purpose of this study is to analyse the domestic trends of Traditional Korean Medicine on Hot flush in menopausal women. Methods: We searched six databases and selected relevant papers according to the criteria. Results: 12 papers included case report, literature review, randomized controlled clinical trials (RCTs), Non-RCTs, and retrospective chart analysis study design. 1. The daily diary, Kupperman's Index, Menopause Rating Scale, Menopause-specific Quality of Life Questionnaire, Digital Infrared Thermographic Imaging were used as a measure of the symptoms of hot flush. 2. There were significant correlations between Thermographic images, Pulse energy, Lifestyle Habits, Low frequency power/High frequency power (LF/HF) ratio and certain items of Menopausal Symptoms Measurement. 3. The case report using Er-Xian decoction and Hwangryunhaedoktang-Gamibang showed significant effect. 4. Domestic RCT studies using herbal or acupuncture treatments showed a significant value of 3.4 on average in the quality assessment conducted in the study. However, the number of domestic studies included was five, which is not enough compared to foreign countries. Conclusions: This study examined domestic research trends on hot flushes of menopausal women and found that various evaluation tools and diagnostic methods were applied. It is necessary to conduct various RCT studies in Korea, where the number of studies is insufficient compared to overseas.

• 대한간호학회지
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• 제22권4호
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• pp.569-588
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• 1992

This study examined the relationship between the experience of stressful life events and somatic symptoms of urban women. Data were collected by interviewing 200 women from June to July 1, 1991. Vsable data work obtained from 162 of the women. Modified version of a stressful life events measurement tool developed p.5. Lee (1984) and the Somatic Discomfort Inventory by Wittenborn were used to measure the variables. Data were processed by an 5.p.5.5. program and analyzed. statistically for percentage, T-test, ANOYA and Pearson Correlation coefficient. Result of the Study are as follows : 1) The group total mean score of stressful life events was 92.66 $\pm$ 10.41. The higher scores in the $\boxDr$Test and school$\boxUl$ of the Extrapersonal factor, in the $\boxDr$Health problems$\boxUl$ of the Intrapersonal factor and $\boxDr$Conflict and differences within the family$\boxUl$ of the Interpersonal factor, factors. which a suggested by Neuman's model. 2) The group total mean score for somatic symptoms was 100.41$\pm$9.74. The higher scores were for the factors of $\boxDr$Fatigue (1.94)$\boxUl$, $\boxDr$Menopause (1.74)$\boxUl$, $\boxDr$Muscular system(1.67)$\boxUl$ and $\boxDr$Sleeping (1.67)$\boxUl$ 3) The mean scores of stressful life events were higher in the 40~60 age group, for middle school graduates(P＜.05), career women and those in nuclear families (P＞.05). 4) The mean scores of somatic symptoms were higher in the 45~60 age group, for middle school graduates, non career women and women with 5 or more children(P＜.05). 5) There was a positive correlation between the scores of stressful life events and somatic symptoms (r＝.585 P＜.05). The higher the level of stressful life events the higher the score of somatic symptoms, the results were consistent with the Extrapersonal, Intrapersonal and Interpersonal stress factors of Neuman's Health Care Systems. This research assessed the stressful life events of women, who play the most important role in the family for illness prevention and health promotion and suggested the importance of programs in the Primary Health Services to build basic coping resources.

• 한국융합학회논문지
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• 제12권2호
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• pp.347-356
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• 2021

본 연구의 목적은 중년여성의 폐경증상, 폐경증상에 대한 주관적 인식, 폐경태도 및 폐경관리 정도를 확인한 후 변수 간의 관계와 폐경증상에 미치는 영향요인을 파악하고자 함이다. 본 연구의 대상자는 3개 도시에 거주하는 만 40세 ~60세 중년여성 중 연구의 목적을 이해하고 연구 참여에 동의한 242명이었으며 자료수집 기간은 2019년 4월 10일부터 2019년 5월 30일까지 이었다. 수집된 자료는 SPSS/WIN 25.0을 이용하여 t-test, ANOVA, Pearson's 상관계수 및 단계적 회귀분석으로 분석하였다. 본 연구결과 중년여성의 폐경증상에 영향을 주는 요인은 폐경증상에 대한 주관적 인식(β=. 51, p<.001), 월경상태(β=. 23, p<.001), 지각된 건강상태(β=. 19, p=. 002), 삶의 만족(β=. 14, p=. 019) 및 종교 유무(β=. 10, p= .045) 이었으며 그 중 가장 영향을 미치는 요인은 페경증상에 대한 주관적 인식으로 확인되었다. 따라서 중년여성의 폐경증상을 완화하기 위해서는 폐경증상에 대한 주관적 인식을 긍정적으로 변화시키기 위한 간호중재 전략이 필요할 것이다.

• Tuberculosis and Respiratory Diseases
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• 제63권4호
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• pp.362-367
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• 2007

폐경기 여성에서 호르몬 대체요법은 폐경기 증상의 경감, 골다공증에 의한 골절, 대장암의 위험도 감소 등의 효과가 인정되어 왔다. 현재도 많은 폐경기 여성에게 사용되어지고 있는 치료법이다. 그러나 그에 따른 부작용 또한 점차 밝혀지며 연구 되고 있다. 이러한 부작용 중 생명을 위협 할 수 있는 폐색전증은 호르몬요법을 사용할시 항상 각별한 주의를 요한다. 폐경기 호르몬대체요법이 필요할 경우 심부정맥혈전증과 폐색전증의 다른 위험인자나 환경적 요인 등을 가진 환자에게 그 사용에 있어 더욱 주위를 기울여야 한다. 또한 폐색전증의 가장 많은 증상인 호흡기 증상이 있을 경우 즉시 적절한 평가와 치료가 필요하다.

• 한국식품위생안전성학회지
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• 제25권1호
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• pp.79-82
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• 2010

석류는 오래전부터 임상치료 및 식품원료로 사용되었으며 많은 피토에스트로겐 성분을 함유하고 있다. 그 성분으로는 에스트론, 에스트라디올, 에스트리올, 베타-시토스테롤, 엘라그산 등이 였으며 이러한 성분으로 인해 과즙, 껍질, 오일 등은 약한 에스트로겐 활성을 나타낸다고 보고되었으며, 이로 인해 석류는 여성 갱년기 치료용 원료로 많이 사용되고 있다. 그러나 에스트로겐 성분의 존재 유무에 대한 견해의 차이가 나타나고 있어 본 연구는 LC/MS/MS를 이용하여 석류추출물 중의 에스트로겐 분석을 통해 이를 확인하고자 하였으며, 간편하고 정확한 분석법을 모색하고자 하였다. 3개 롯트 시료의 에스트로겐을 분석한 결과, 에스트론 83.5ppb, 에스트라디올 10.9ppb 및 에스트리올 38.6ppb로 검출되었다.

• 대한한방부인과학회지
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• 제30권3호
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• pp.117-127
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• 2017

Objectives: This study has been conducted on public health purposes for people with Menopausal disorders in rural areas. Methods: From February, 2017 to June, 2017, we performed the Korean Medicine in the "Menopausal Disorder Overcoming Program" conducted by the department of Health service, Imsil-Gun bogun Hospital. Menopausal women who participated were treated with acupuncture, moxibustion, Jaeumganghwa-tang for 20 weeks. Of the 34 patients, 16 patients were excluded due to absence of treatment at least once. And 18 treatment outcomes were analyzed. Results: The KI results showed that the average score decreased in 7 out of 11 questions after treatment. The results of BDI, the mean scores of the 17 questions except the 4 questions of the 21 questions after the treatment decreased. 12, 16, and BDI total score were statistically significantly reduced before and after treatment. Conclusions: The results of the Korean Medicine treatment seemed to be effective in alleviating facial flushing, insomnia, depressive symptoms and other symptoms in menopausal disorders.