• 분석과학
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• 제34권1호
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• pp.23-35
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• 2021

In order to measure the volatile organic compounds (VOCs) of a sample which is too large to use commercially available chamber, a stainless steel vacuum chamber (VC) (with an internal diameter of 205 mm and a height of 50 mm) was manufactured and the temperature of the chamber was controlled using an oven. After concentrating the volatiles of the sample in the chamber by helium gas, it was made possible to remove residual volatile substances present in the chamber under reduced pressure ((2 ± 1) × 10-2 mmHg). The chamber was connected to a purge & trap (P&T) using a 6 port valve to concentrate the VOCs, which were analyzed by gas chromatography-mass spectrometry (GC-MS) after thermal desorption (VC-P&T-GC-MS). Using toluene, the toluene recovery rate of this device was 85 ± 2 %, reproducibility was 5 ± 2 %, and the detection limit was 0.01 ng L-1. The method of removing VOCs remaining in the chamber with helium and the method of removing those with reduced pressure was compared using Korean drinking water regulation (KDWR) VOC Mix A (5 μL of 100 ㎍ mL-1) and butylated hydroxytoluene (BHT, 2 μL of 500 ㎍ mL-1). In case of using helium, which requires a large amount of gas and time, reduced pressure ((2 ± 1) × 10-2 mmHg) only during the GC-MS running time, could remove VOCs and BHT to less than 0.1 % of the original injection concentration. As a result of analyzing volatile substances using VC-P&T-GC-MS of six types of cell phone case, BHT was detected in four types and quantitatively analyzed. Maintaining the chamber at reduced pressure during the GC-MS analysis time eliminated memory effect and did not affect the next sample analysis. The volatile substances in a cell phone case were also analyzed by dynamic headspace (HT3) and GC-MS, and the results of the analysis were compared with those of VC-P&T-GC-MS. Considering the chamber volume and sample weight, the VC-P&T configuration was able to collect volatile substances more efficiently than the HT3. The VC-P&T-GC-MS system is believed to be useful for VOCs measurement of inhomogeneous large sample or devices used inside clean rooms.

• 동의신경정신과학회지
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• 제32권2호
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• pp.81-93
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• 2021

Objectives: Mild cognitive impairment (MCI) is condition of cognitive decline shown in transition from normal aging to dementia. Hominis placenta pharmacopuncture (HPP) is a treatment that combines effects of medication and acupuncture by injecting Hominis placenta into acupoints. The objective of this study was to evaluate the efficacy and safety of HPP for MCI. Methods: This was a randomized, double-blind, placebo-controlled, two-center clinical trial. Eligible patients were randomly allocated to either the HPP group or the placebo group. HPP or saline as placebo was administered to participants for eight weeks. Changes in symptoms were observed. The primary outcome was difference in mean change of Korean Version of the Montreal Cognitive Assessment (MoCA-K) score between the HPP group and the placebo group. Cognitive function, overall status of mood and sleep, and quality of life (QoL) were also assessed. Safety assessment and economic analysis were then conducted. Results: Thirty participants were enrolled. One participant in the placebo group dropped out. The score of MoCA-K increased after treatment. Its mean change was smaller in the HPP group than in the control group. HPP ameliorated Global Deterioration Scale and Korean Dementia Rating Scale subtests for attention, organization, and memory compared to the placebo. However, none of them was significantly different between the two groups. Mood, sleep, and QoL all improved more in the HPP group than in the placebo group, although differences between the two groups were not statistically significant. There was no adverse event probably related to the drug. HPP treatment needed KRW 345,000 more than the placebo group in improving Geriatric Quality of Life scale-Dementia score by one point for one year. Conclusions: Although HPP treatment did not significantly improve cognition, it changed behavioral and psychological symptoms in MCI.

• 산업융합연구
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• 제20권4호
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• pp.23-30
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• 2022

최근 인공지능(AI)과 딥러닝 발전으로 대화형 인공지능 챗봇의 중요성이 부각되고 있으며 다양한 분야에서 연구가 진행되고 있다. 챗봇을 만들기 위해서 직접 개발해 사용하기도 하지만 개발의 용이성을 위해 오픈소스 플랫폼이나 상업용 플랫폼을 활용하여 개발한다. 이러한 챗봇 플랫폼은 주로 RNN (Recurrent Neural Network)과 응용 알고리즘을 사용하며, 빠른 학습속도와 모니터링 및 검증의 용이성 그리고 좋은 추론 성능의 장점을 가지고 있다. 본 논문에서는 RNN과 응용 알고리즘의 추론 성능 향상방법을 연구하였다. 제안 방법은 RNN과 응용 알고리즘 적용 시 각 문장에 대한 핵심단어의 단어그룹에 대해 확장학습을 통해 데이터에 내재된 의미를 넓히는 기법을 사용하였다. 본 연구의 결과는 순환 구조를 갖는 RNN, GRU (Gated Recurrent Unit), LSTM (Long-short Term Memory) 세 알고리즘에서 최소 0.37%에서 최대 1.25% 추론 성능향상을 달성하였다. 본 연구를 통해 얻은 연구결과는 관련 산업에서 인공지능 챗봇 도입을 가속하고 다양한 RNN 응용 알고리즘을 활용하도록 하는데 기여할 수 있다. 향후 연구에서는 다양한 활성 함수들이 인공신경망 알고리즘의 성능 향상에 미치는 영향에 관한 연구가 필요할 것이다.

• 대중서사연구
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• 제26권2호
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• pp.123-153
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• 2020

역사드라마에서 기록의 중요성이 약화되면서 다른 장르와의 결합 양상이 두드러지고 있다. 이 논문에서는 역사드라마에서 로맨스가 다루어지는 방식을 살펴봄으로써 역사드라마가 취택하는 역사적 사건의 속성과 사랑의 모티프가 어떻게 연관되는지, 그리고 사랑과 연애의 서사가 역사효과에 어떤 기여를 하는지 <미스터 션샤인>을 중심으로 고찰하였다. <미스터 션샤인>은 김은숙 작가가 처음으로 쓴 역사드라마로, 의도적으로 재배치된 역사와 김은숙 작가 특유의 로맨스 문법이 결합되어 있다. 드라마에 등장하는 실패한 의병 운동은 자기부정성에 기반 한 이루어질 수 없는 사랑과 병치된다. 일본 제국주의의 폭압성과 조선의 독립을 다루고 있는 이 드라마는 주요 인물과 사건을 허구적으로 배치하여 사랑의 욕망을 애국에 대한 정념으로 비약시킨다. <미스터 션샤인>에서 로맨스는 역사적 사건의 비극성을 강조하는 촉매 역할을 하며 문화적 기억을 재구성한다. 역사드라마에서 로맨스라는 가공의 플롯은 과거에서 미래로 흐르는 역사 속에 놓인 인간의 삶을 성찰하도록 이끈다. 개인의 내밀한 감정은 역사의 재현에 어떤 기여를 하는가. 이 논문은 역사드라마와 로맨스의 관련 양상을 다각도로 살펴보고자 하는 첫 시도로 의의를 가진다.

• 한국전기전자재료학회논문지
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• 제36권1호
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• pp.88-92
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• 2023

The ferroelectricity in Hf_0.5Zr_0.5O₂ (HZO) thin films is one of the most interesting topics for next-generation nonvolatile memory applications. It is known that a crystallization process is required at a temperature of 400℃ or higher to form an orthorhombic phase that results in the ferroelectric properties of the HZO film. However, to realize the integration of ferroelectric HZO films in the back-end-of-line, it is necessary to reduce the annealing temperature below 400℃. This study aims to comprehensively analyze the ferroelectric properties according to the annealing temperature (350-500℃) and time (1-5 h) using a furnace as a crystallization method for HZO films. As a result, the ferroelectric behaviors of the HZO films were achieved at a temperature of 400℃ or higher regardless of the annealing time. At the annealing temperature of 350℃, the ferroelectric properties appeared only when the annealing time was sufficiently increased (4 h or more). Based on these results, it was experimentally confirmed that the optimization of the annealing temperature and time is very important for the ferroelectric phase crystallization of HZO films and the improvement of their ferroelectric properties.

• Nutrition Research and Practice
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• 제17권2호
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• pp.371-385
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• 2023

BACKGROUND/OBJECTIVES: Soy isoflavone (SIF) and soy lecithin (SL) have beneficial effects on many chronic diseases, including neurodegenerative diseases. Regretfully, there is little evidence to show the combined effects of these soy extractives on the impairment of cognition and abnormal cerebral blood flow (CBF). This study examined the optimal combination dose of SIF + SL to provide evidence for improving CBF and protecting cerebrovascular endothelial cells. MATERIALS/METHODS: In vivo study, SIF50 + SL40, SIF50 + SL80 and SIF50 + SL160 groups were obtained. Morris water maze, laser speckle contrast imaging (LSCI), and hematoxylin-eosin staining were used to detect learning and memory impairment, CBF, and damage to the cerebrovascular tissue in rat. The 8-hydroxy-2'-deoxyguanosine (8-OHdG) and the oxidized glutathione (GSSG) were detected. The anti-oxidative damage index of superoxide dismutase (SOD) and glutathione (GSH) in the serum of an animal model was also tested. In vitro study, an immortalized mouse brain endothelial cell line (bEND.3 cells) was used to confirm the cerebrovascular endothelial cell protection of SIF + SL. In this study, 50 µM of Gen were used, while the 25, 50, or 100 µM of SL for different incubation times were selected first. The intracellular levels of 8-OHdG, SOD, GSH, and GSSG were also detected in the cells. RESULTS: In vivo study, SIF + SL could increase the target crossing times significantly and shorten the total swimming distance of rats. The CBF in the rats of the SIF50 + SL40 group and SIF50 + SL160 group was enhanced. Pathological changes, such as attenuation of the endothelium in cerebral vessels were much less in the SIF50 + SL40 group and SIF50 + SL160 group. The 8-OHdG was reduced in the SIF50 + SL40 group. The GSSG showed a significant decrease in all SIF + SL pretreatment groups, but the GSH showed an opposite result. SOD was upregulated by SIF + SL pretreatment. Different combinations of Genistein (Gen)+SL, the secondary proof of health benefits found in vivo study, showed they have effective anti-oxidation and less side reaction on protecting cerebrovascular endothelial cell. SIF50 + SL40 in rats experiment and Gen50 + SL25 in cell test were the optimum joint doses on alleviating cognitive impairment and regulating CBF through protecting cerebrovascular tissue by its antioxidant activity. CONCLUSIONS: SIF+SL could significantly prevent cognitive defect induced by β-Amyloid through regulating CBF. This kind of effect might be attributed to its antioxidant activity on protecting cerebral vessels.

• 재활치료과학
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• 제12권2호
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• pp.69-83
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• 2023

목적 : 본 연구는 예비연구로 65세 이상 노인을 대상으로 Information & Communication Technology(ICT) 홈 기반 프로그램을 적용하여 인지향상 프로그램의 효과를 확인하고, 원격재활 전달모델로서 가능성을 찾고자 한다. 연구방법 : 2022년 8월부터 10월까지 대상자 3인을 선정하여 약 2개월에 걸쳐 ICT 홈 기반 인지향상 프로그램 중재를 실시하였다. 본 중재는 프로그램 전·후 인지향상을 평가하기 위해 한국판 간이 정신상태 검사, 한국판 몬트리올 인지평가, 노인용 전산화 인지평가도구, Two shorter form of the Center for Epidemiologic Studies Depression scale을 사용하여 진행하였다. 치료사는 원격으로 대상자의 수준에 맞는 인지훈련의 난이도 조절을 매주 피드백을 통해 설정하고 프로그램 진행 시에는 매일 정해진 시간에 치료사의 도움 없이 진행하였다. 인지향상 프로그램에 대한 추가 의견을 위해 인터뷰를 진행하였다. 결과 : 중재 후, 사전 사후에 진행한 한국판 몬트리올 인지평가 대부분의 항목에서 모든 대상자가 향상된 점수를 보였다. 또한 Cotras-pro의 항목 중 상위인지, 언어능력, 주의집중, 시지각, 기억력이 향상되었다. 결론 : ICT 홈 기반 프로그램을 사용한 인지재활훈련은 치매를 예방할 뿐 아니라 원격재활에 대한 내적동기 또한 가질 수 있었다. 본 연구를 통해 노인을 대상으로 한 원격재활이 가능할 수 있음을 확인할 수 있었다.

• Journal of Ginseng Research
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• 제47권3호
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• pp.458-468
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• 2023

Background: As a complication of Type II Diabetes Mellitus (T2DM), the etiology, pathogenesis, and treatment of cognitive dysfunction are still undefined. Recent studies demonstrated that Ginsenoside Rg1 (Rg1) has promising neuroprotective properties, but the effect and mechanism in diabetes-associated cognitive dysfunction (DACD) deserve further investigation. Methods: After establishing the T2DM model with a high-fat diet and STZ intraperitoneal injection, Rg1 was given for 8 weeks. The behavior alterations and neuronal lesions were judged using the open field test (OFT) and Morris water maze (MWM), as well as HE and Nissl staining. The protein or mRNA changes of NOX2, p-PLC, TRPC6, CN, NFAT1, APP, BACE1, NCSTN, and Ab1-42 were investigated by immunoblot, immunofluorescence or qPCR. Commercial kits were used to evaluate the levels of IP3, DAG, and calcium ion (Ca²⁺) in brain tissues. Results: Rg1 therapy improved memory impairment and neuronal injury, decreased ROS, IP3, and DAG levels to revert Ca²⁺ overload, downregulated the expressions of p-PLC, TRPC6, CN, and NFAT1 nuclear translocation, and alleviated Aβ deposition in T2DM mice. In addition, Rg1 therapy elevated the expression of PSD95 and SYN in T2DM mice, which in turn improved synaptic dysfunction. Conclusions: Rg1 therapy may improve neuronal injury and DACD via mediating PLC-CN-NFAT1 signal pathway to reduce Aβ generation in T2DM mice.

• 한국엔터테인먼트산업학회논문지
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• 제13권8호
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• pp.479-493
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• 2019

본 연구는 중고령층 문해학습자의 흥미 유발 및 학습 효과를 높이는 문해교육 방법을 제시하는데 목적을 두었다. 이를 위해 충북 중고령층 문해교사, 기관 운영자, 평생교육사, 문해학습자 총11명을 면담 및 참여관찰 하였다. 연구결과 중고령층 학습자들은 배운 것을 쉽게 잊어버리고 받아쓰기를 통해 글씨를 정확하게 익히며, 높은 경쟁 심리 등 공부가 일상생활에서 1순위가 되고 있다. 글씨 형성 의미를 알게 하는 놀이활동, 실생활과 연결된 학습, 받아쓰기가 기억력 및 인지력 향상에 효과적이다. 또한 일상생활에서 익숙한 재료를 활용한 만들기, 교과서에 나오는 극과 시로 역할극, 글씨 큰 그림 동화책 활용, 팀 단위 게임 및 활동, 배우기 쉬운 악기 및 노래 부르기, 공연 및 발표회 등 무대 경험, 실생활 및 교육문화 시설 현장 체험 등이 중고령층의 흥미와 학습 효과를 높일 수 있다. 결과 공유 발표회 및 연합 행사, 자료 및 재료비, 문해교사 역량강화 교육 및 공유, 문해교육 연중 운영, 학력인정과정과 병행 및 보조강사 지원이 중요하다. 시사점으로는 문해교사 교육, 보조강사 활용, 학력인정 문해교육과정 활성화 방안에 대한 연구가 필요하다.

• Journal of Korean Dental Science
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• 제16권2호
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• pp.128-148
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• 2023

Dementia is an umbrella term that describes the loss of thinking, memory, attention, logical reasoning, and other mental abilities to the extent that it interferes with the activities of daily living. More than 50 million individuals worldwide live with dementia, which is expected to increase to 131 million by 2050. Recent research has shown that poor oral health increases the risk of dementia, while oral health declines with cognitive decline. In this narrative review, the literature was based on the "hypothesis" that dementia and oral health have a close relationship, and appropriate oral health and occlusal rehabilitation treatment can improve the quality of life of patients with dementia and prevent progression. We conducted a literature search in PubMed and Google Scholar databases, using the search terms "dementia," "major neurocognitive disorder," "dentition," "occlusion," "tooth loss," "dental prosthesis," "dental implant," and "occlusal rehabilitation" in the title field over the past 30 years. A total of 131 studies that scientifically addressed dementia, oral health, and/or oral rehabilitation were included. In a meta-analysis, the random effect model demonstrated significant tooth loss increasing the dementia risk 3.64-fold (pooled odds ratio=3.64, 95% confidence interval [2.50~5.32], P-value=0.0348). Tooth loss can be an important indicator of cognitive function decline. As the number of missing teeth increases, the risk of dementia increases. Loss of teeth can lead to a decrease in the ascending information to the brain and reduced masticatory ability, cerebral blood flow, and psychological atrophy. Oral microbiome dysbiosis and migration of key bacterial species to the brain can also cause dementia. Additionally, inflammation in the oral cavity affects the inflammatory response of the brain and the complete body. Conversely, proper oral hygiene management, the placement of dental implants or prostheses to replace lost teeth, and the restoration of masticatory function can inhibit symptom progression in patients with dementia. Therefore, improving oral health can prevent dementia progression and improve the quality of life of patients.