• Food Science and Biotechnology
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• 제16권4호
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• pp.557-564
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• 2007

We prepared caviar analogs encapsulated by calcium-alginate gel membranes as a means to replace higher priced natural caviars. Processing the caviar analogs (beluga type) was optimized by response surface methodology with central composite design. Concentrations of sodium alginate ($X_1$) and $CaCl_2\;(X_2)$ were chosen as the independent variables. In order to compare characteristics of the caviar analogs with the natural caviar, sphericity ($Y_1$), diameter ($Y_2$), membrane thickness ($Y_3$), rupture strength ($Y_4$), rupturing deformation ($Y_5$), and sensory score ($Y_6$) were used as the dependent variables. The sphericity of the caviar analogs showed a similar value to that of natural caviar (over 94%) in the range of independent variables. Generally, the $CaCl_2$ concentration ($X_2$) affected all dependent variables to a greater extent than the sodium alginate concentration ($X_l$), For the multiple response optimization of the 5 dependent variables ($Y_1,\;Y_2,\;Y_4,\;Y_5$, and $Y_6$), the desirability function was defined as the following conditions: target values ($Y_1\;=\;100%,\;Y_2\;=\;3.0\;mm,\;Y_4\;=\;1,470\;g,\;Y_5\;=\;1.1\;mm,\;and\;Y_6\;=\;10\;points$). Membrane thickness ($Y_3$) was eliminated from the dependent variables for multiple response optimization because it could not be measured with an image analyzer. The values of the independent variables as evaluated by multiple response optimization were $X_1\;=\;-0.093$ (78%) and $X_2\;=\;-0.322$ (1.07%), respectively.

• Journal of Chest Surgery
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• 제25권7호
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• pp.693-701
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• 1992

Extracorporeal cardiopulmonary bypass[CPB] has been associated with a wide variety of hematologic derangements, including a transient deformation and hemolysis of red blood cells[RBCs], which is supposed to be due to mechanical trauma and/or metabolic alterations. Since membrane integrity is, in part, maintained by energy requiring process, inadequate function of erythrocyte glycolytic pathway, which is inevitalble during CPB, may cause depletion of high energy phosphate pool and result in hemolysis. The authors performed an investigation to assess whether administration of Fructose-l, 6-diphsphate [FDP], which has been known to enhance intracellular glycolytic activities, could counteract erythrocyte hemolytic events caused by CPB. Sixty pateints with cyanotic congenital heart diseases, who underwent open heart surgery under CPB longer than 60 minutes, were randomly divided into two groups depending on whether use of FDP[Group FDP] or not[Group Control]. The age, sex, CPB time, preoperative hemoglobin level, disease entities were all similar[Table 1], and membrane type oxygenators were used in all patients. In Group, FDP, a dose of 250mg/kg body weight of FDP was administered by intravenous dripping every 12 hours from the morning of the operation to postoperative 48 hours, To demonstrate the degree and pattern of hemolysis of erythrocyte, reticulocyte count, indirect /direct bilirubin, haptoglobin, plasma hemoglobin, lactate dehydrogenase were measured every 12 hours from the time of cessation of CPB to 48 hours and RBC morphologic study, osmotic fragility test were done every 24 hours. All parameters revealed less hemolytic in group FDP [Fig. 1~5], though the differences between two groups were not significant, except plasma hemoglobin, lactate dehydrogenase changes. A pattern of sequential changes of plasma hemoglobin, lactate deh-ydrogenase showed the highest level at the time of CPB stop and abrupt decrease in following 24 hours in both groups, and statistically significant differences were demonstrated in group FDP at least for the first 12 hours postoperatively[p<0.05]. The authors conclude that they can expect the benificial effect of FDP on the maintenance of membrane stability of RBC probably by energy enhancement during the shock status of CPB, but FDP could not completely prevent the damaging effect on RBC by cardiopulmonary bypass

• IMMUNE NETWORK
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• 제23권3호
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• pp.29.1-29.23
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• 2023

Cholesterol (CL) is required for various biomolecular production processes, including those of cell membrane components. Therefore, to meet these needs, CL is converted into various derivatives. Among these derivatives is cholesterol sulfate (CS), a naturally produced CL derivative by the sulfotransferase family 2B1 (SULT2B1), which is widely present in human plasma. CS is involved in cell membrane stabilization, blood clotting, keratinocyte differentiation, and TCR nanocluster deformation. This study shows that treatment of T cells with CS resulted in the decreased surface expression of some surface T-cell proteins and reduced IL-2 release. Furthermore, T cells treated with CS significantly reduced lipid raft contents and membrane CLs. Surprisingly, using the electron microscope, we also observed that CS led to the disruption of T-cell microvilli, releasing small microvilli particles containing TCRs and other microvillar proteins. However, in vivo, T cells with CS showed aberrant migration to high endothelial venules and limited infiltrating splenic T-cell zones compared with the untreated T cells. Additionally, we observed significant alleviation of atopic dermatitis in mice injected with CS in the animal model. Based on these results, we conclude that CS is an immunosuppressive natural lipid that impairs TCR signaling by disrupting microvillar function in T cells, suggesting its usefulness as a therapeutic agent for alleviating T-cell-mediated hypersensitivity and a potential target for treating autoimmune diseases.

• 한국전산구조공학회논문집
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• 제30권6호
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• pp.485-493
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• 2017

본 연구에서는 LNG 저장시설의 외조를 구성하는 SCP(sandwich concrete panel)에 대한 충돌해석을 수행하고 그 거동을 분석하였다. 설계기준 중 하나인 BS7777에서 제시하는 충돌에너지와 동일한 값을 갖도록 두 종류의 충돌체와 다양한 충돌속도를 이용하여 충돌조건을 구성하고 이에 대한 비선형동적 해석모델을 구성하여 설정된 충돌조건에 대하여 수치해석을 수행하였다. 또한 1차 충돌 후에 동일한 지점에 같은 충돌에너지를 가진 2차 충돌이 일어나는 것을 가정하여 충돌거동을 분석하였다. 해석결과 동일한 충돌에너지를 갖는 충돌에서 충돌체의 크기가 작고, 충돌속도가 작을수록 큰 변형이 발생하는 것으로 나타났다. 충돌에너지는 외측강판과 내부 충진콘트리트가 6:4정도의 비율로 소산시키는 것으로 나타났다. 중복충돌해석에서는 2차 충돌체의 크기에 따라 최종충돌변형이 지배되는 것으로 나타났고 2차 충돌에 의한 변형량은 1차 충돌에 비하여 적은 값을 나타냈는데 이는 강판의 막거동 때문인 것으로 분석되었다. 이격된 중복충돌에서는 이격위치와 관계없이 2차 충돌점에서 가장 큰 변형이 발생하는 것으로 나타났다.

• Macromolecular Research
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• 제12권6호
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• pp.593-597
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• 2004

A new ionomeric polymer-metal composite (IPMC) was prepared using a cast membrane of acrylic copolymer, which was synthesized by radical copolymerization of fluoroalkyl acrylate and acrylic acid (AA). To examine its performance as a new electroactive polymer, the current and displacement responses to a step voltage applied across the IPMC were measured. The largest responses were observed when the AA content in the copolymer was $10.6\;wt\%$.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2001년도 추계학술대회 논문집
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• pp.89-92
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• 2001

A rigid-viscoplastic finite element code for superplastic forming processes has been developed The material is assumed to be isotropic and a modified Coulomb friction law is adopted to explain contact between tool and sheet. This code uses the triangular element based on the membrane approximation and a hierarchical contact searching method is implemented The optimum pressure-time relationships for target strain rate are calculated by several pressure control algorithms. By the analysis, optimum pressure-time curves and deformation behavior are predicted.

• 한국공작기계학회논문집
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• 제15권1호
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• pp.95-101
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• 2006

Minimum weight design of laminated composite panel under combined loading was studied using linear and nonlinear deformation theories and by closed-form analysis and finite difference energy methods. Various buckling load factors are obatined for laminated composite panels with rectangular type longitudinal stiffeners and various longitudinal length to radius ratios, which are made from Carbon/Epoxy USNl25 prepreg and are simply-supported on four edges under combined loading, and then for them, minimum weight design analyses are carried out by the nonlinear search optimizer, ADS. This minimum weight design analyses are constructed with various process such as the simple design process, test simulation process and sensitivity analysis. Subseguently, the buckling mode shapes are obtained by buckling and minimum weight analyses.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2008년도 추계학술대회논문집
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• pp.374-375
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• 2008

In this study, the nano-composite actuator based on Fullerene and Nafion was newly developed to improve the electro active polymer actuators. The tensile test was employed to define the mechanical stiffness and strength of the nano-composite membrane. Also, the bending displacement of the Fullerene-Nafion based nano-composite actuator was investigated under DC and AC excitations with various magnitudes and frequencies. As a result, the new nano-composite actuator based on Fullerene-Nafion shows much larger deformation than the pure Nafion based actuator and solves the straightening back Problem of the previous electro active polymer actuators.

• 설비공학논문집
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• 제23권1호
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• pp.23-31
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• 2011

An analysis has been conducted of the flow characteristics and pumping performance of a thermopneumatic micropump with electrically conducting fluid. In the present study, considered is a thermopneumatic micropump for electrically conducting fluids with electromagnetic resistance alternately exerted at the inlet and outlet by alternately applied magnetic fields. A model of Prescribed Deformation is used for the motion of the membrane. Here, the pumping performance of the micropump and flow characteristics of the electrically conducting fluid are investigated in the range of Hartmann number less than 30. The current numerical study shows that the net flow rate through the micropump is almost proportional to the strength of the applied magnetic field.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회A
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• pp.1469-1474
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• 2007

In recent years, research to machine large-surface micro-features has become important because of the light guide panel of a large-scale liquid crystal display and the bipolar plate of a high-capacity proton exchange membrane fuel cell. In this study, in order to realize the systematic design technology and performance improvements of an ultra-precision machine for machining the large-surface micro-features, a structural characteristic analysis was performed using its virtual prototype. The prototype consisted of gantry-type frame, hydrostatic feed mechanisms, linear motors, brushless DC servo motor, counterbalance mechanism, and so on. The loop stiffness was estimated from the relative displacement between the tool post and C-axis table, which was caused by a cutting force. Especially, the causes of structural stiffness deterioration were identified through the structural deformation analysis of sub-models.