• Korean Journal of Plant Resources
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• v.24 no.4
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• pp.472-481
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• 2011

In order to reuse remnants of medicinal herb extracts as an environment-friendly manure, fermented compost made from medicinal herb waste (MHWC), poultry manure compost (PMC) and MHWC+PMC (1:1, w/w) were applied on upland soil cultivated with 2 year-old Bokbunja plants. The results of the changes of soil chemical properties on upland soil, the yield and the sugar contents of the fruit harvested were summarized as follows. The pH in soils treated with composts (STCs) was significantly changed (p<0.05) compared with untreated control (UC) group. The electrical conductivity (EC) in MHWC group was decreased 0.46-0.56 times compared with UC, and it was different from PMC groups. The contents of organic matter and total nitrogen were increased in all of the treatments and MHWC group was the highest among the all groups. The content of available phosphorous was different by types and amounts of the composts. The content of heavy metal in all groups did not exceed the standard content for soil contamination. The yield and the sugar contents of the fruit harvested were the highest in the treatments of MHWC. In conclusion, MHWC is an effective compost resource on improvement of soil environment and promoting the fruit qualities.

• Korean Journal of Medicinal Crop Science
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• v.8 no.4
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• pp.378-385
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• 2000

This study was conducted to investigate the sulfur effects on the yield of safflower (Carthamus tinctorius L.) and the chemical properties of soil after sulfur treatment. Sulfur application was conducted with two chemical forms of sulfur powder and potassium sulfate. Sulfur powder was applied to the soil with levels of 0, 10, 20, 40 kg/10a and potassium sulfate was applied to the soil with levels of 10, 20 kg/10a as sulfur content. After sulfur application in soils, pH and available $P_2O_5$ content of soils tend to decrease after experiment, whereas the contents of $SO_4^{2-}$ and active Fe increased in soils. By the application of sulfur, the yields of safflower seed were increased by about $6{\sim}17$ percent compared to the control. It is apparent that seed yield and plant growth of safflower were increased by the sulfur application.

• Korean Journal of Medicinal Crop Science
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• v.28 no.2
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• pp.95-110
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• 2020

Background: In Korea, Agastache rugosa (Fisch. & C. A. Mey.) O. Kuntze is one of the well-known perennial plants belonging to Lamiaceae. This mint-fragranced plant has long been used for the treatment of abdominal pain, congestion, chills, and diarrhea since the Goryeo Dynasty. Although this plant has various medicinal properties, it is only used as a spice and for landscape purposes. Methods and Results: The objective of this paper was to review the chemical composition and biological properties of the essential oil of A. rugosa. Several studies reported that the essential oil contains more than 60 different chemical components of monoterpene and sesquiterpene hydrocarbons and oxygenated hydrocarbons. The major component is methyl chavicol (estragole), accounting for 64% - 88% of the oil. The chemical composition of this essential oil vaired widely according to the planting time, environmental conditions, planting distance, fertilizer application, and harvesting time. Conclusions: The essential oil of A. rugosa possesses various pharmacological properties such as antioxidant, antibacterial, anticancer, antiviral, nematicidal, antifungal, insecticidal, wrinkle improver, stress reliever, and Alzheimer's disease alleviator. Hence, the essential oil from A. rugosa could be used for the development of high value-added industrial products in the near future.

• The Korea Journal of Herbology
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• v.33 no.5
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• pp.19-37
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• 2018

Objectives : Oryeong-san was composed of Alismatis Rhizoma, Atractylodis Rhizoma Alba, Poria Sclerotium, Polyporus, Cinnamomi Cortex, and known to have hundreds of chemical compounds. The aim of this study was to screen chemical compounds constituting Oryeong-san with the drug-likeness and oral bioavailability from the analysis of their physicochemical properties. Methods : A list of chemical compounds of Oryeong-san was obtained from TM-MC(database of medicinal materials and chemical compounds in Northeast Asian traditional medicine). To remove redundant compounds, the SMILES (Simplified Molecular Input Line Entry System) strings of each compound were identified. All of the physicochemical properties for the compounds were calculated using the DruLiTo(Drug Likeness Tool). Drug-likeness was estimated by QED(Quantitative Estimate of Druglikeness) and OB(Oral bioavailability) was checked based on the Veber's rules. Results : A total of 475 compounds were obtained by eliminating duplication among 544 compounds of 5 medicinal materials. Analysis of the physicochemical properties revealed that the most common values were MW(molecular weight) 200~300 g/mol, ALOGP(octanol-water partition coefficient) 1~2, HBA(number of hydrogen bond acceptors) 0~1, HBD(number of hydrogen bond donors) 0, PSA(polar surface area) 0~50 angstrom, ROTB(number of rotatable bonds) 1, AROM(number of aromatic rings) 0, and ALERT(number of structural alerts) 1. QED had 93% of the values between 0.2 and 0.7, and OB had 90% of the value of TRUE. Conclusions : We in this paper screened the candidate active compounds of Oryeong-san using the QED and Veber's rules. In the future, we will use the screening results to analyze the mechanism of Oryeong-san based on systems pharmacology.

• Korean Journal of Medicinal Crop Science
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• v.24 no.1
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• pp.27-30
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• 2016

Background : This text was conducted to evaluate the distribution, shape characteristics and habitat condition of Crypsinus hastatus in Buyeo Korea. Methods and Results : In Buyeo, Crypsinus hastatus was distributed at an altitude of 31.2 m, a slope of 82.5% and a distance from river water of 27.2 m. The leaf blade was oblong, 2.7 cm long, 1.2 cm wide with a petiole length of 2.3 cm. The total population comprised 2,100 individuals, with the highest proportion being individuals with a leaf blade of length 0.5 - 1 cm. The temperature and light intensity of the growth point were lower, but the humidity higher, than that of growth around. The chemical properties of the soil were as follows: pH 4.42, organic matter 77.99 g/kg, electrical conductivity 0.50 dS/m, nitrate nitrogen 20.50 mg/kg and available phosphate 165.7 mg/kg. Exchangeable cation content of potassium, magnesium, sodium and calcium was 0.35, 0.70, 0.09 and $2.04cmol^+/kg$, respectively. Conclusions : In Buyeo, Crypsinus hastatus was distributed in $5.3m^2$ area of Nakhwaam, Naeseongri and Jeongamri. However, the population of the medicinal resources seemed to decrease owing to the poor environmental conditions of the habitat.

• Journal of Mushroom
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• v.12 no.2
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• pp.77-81
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• 2014

Mushrooms are considered not only as food but also for source of physiologically beneficial medicines. The culinary-medicinal mushrooms may important role in the prevention of age-associated neurological dysfunctions, including Alzheimer's and Parkinson's diseases. Hericium erinaceus (H. erinaceus), is edible mushrooms, is a parasitic fungus that grows hanging off of logs and trees and well established candidate for brain and nerve health. H. erinaceus contains high amounts of antioxidants, beta-glucan, polysaccharides and a potent catalyst for brain tissue regeneration and helps to improve memory and cognitive functions. Its fruiting bodies and the fungal mycelia exhibit various pharmacological activities, including the enhancement of the immune system, antitumor, hypoglycemic and anti-aging properties. H. erinaceus stimulates the synthesis of Nerve Growth Factor (NGF) which is the primary protein nutrient responsible for enhancing and repairing neurological disorders. Especially hericenones and erinacines isolated from its fruitin body stimulate NGF, synthesis. This fungus is also utilized to regulate blood levels of glucose, triglycerides and cholesterol. H. erinaceus can be considered as useful therapeutic agents in the management and/or treatment of neurodegeneration diseases. However, this review focuses on in vitro, in vivo and clinical trials for neurodegerative disease.

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2005.11a
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• pp.88-94
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• 2005

Plant tissue culture studies have been done for the preservation of medicinal plant resources and efficient production of pharmaceutically important secondary metabolites. Micropropagation methods for Cephaelis ipecacuanha have been established and these methods enabled much more efficient propagation of the plants than the conventional methods using seedling or layering. The C. ipecacuanha plants derived from tissue culture grew uniformly in the field and they showed higher alkaloid contents compared to the plants grown from seedlings. Hairy root cultures of C. ipecacuanha and Panax ginseng have been established by infection with Agrobacterium rhizogenes, and the production of important pharmaceuticals by these cultures have been successfully demonstrated. In the case of C. ipecacuanha, the highest alkaloid yields from the hairy roots cultured for 8 weeks were 2.75-fold cephaeline (5.5 mg) and one third emetine (0.7 mg) compared with those from the roots of one-year old plant propagated through shoot-tip culture and cultivated in a greenhouse (2.0 mg cephaeline and 2.0 mg emetine). In the case of P. ginseng, ginsenoside contents in the hairy roots optimally cultured for 4 weeks were much higher than those in the roots of 4-year old field-grown plant. Thus our medicinal plant tissue cultures demonstrate desirable properties. However, they are always exposed to danger of microbial contamination or unexpected trouble of culture facilities. Cryopreservation of plant tissue cultures is a reliable method for long-term preservation. Cryopreservation studies on these cultures are also presented.

• The Korea Journal of Herbology
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• v.31 no.4
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• pp.27-33
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• 2016

Objective : For the purpose of developing Korean herbology of the plants to Fumariaceae in Korea, the literatures of the successive generations have been thoroughly investigated to prepare this article.Methods : Books and research papers about Herbology which published at home and abroad were examined.Results : A list was made about Fumariaceae plant which were cultivated or grew naturally in Korea, after investigated the data on domestic and foreign Fumariaceae plants. Out of those lists, serviceable plants were selected and with those available plants, their distributions were analysed and parts which can be used as medicines were divided into 3 categories such as oriental medicine name, scientific name and non-official name. Fumariaceae's properties flavor, channels they use, effects, and toxicity were also noted. Fumariaceae (grew in Korea) were divided into 3 classes with 23 species. Out of those, 2 classes with 9 species were found serviceable which indicates 39% of all. Out of all 23 species of Fumariaceae family, Corydalis genus were found 21 species, which were shown the most. Among Fumariaceae species, Corydalis genus were found 8 medicinal plants, which were shown the most. Out of all serviceable parts in Fumariaceae, Herba and Tuber parts took first place as 5 species. There are 2 toxic species and 3 toxic medicinal parts, the survey said.Conclusion : There were totaled to 3 genera and 23 species in Fumariaceae in Korea and among them medicinal plants are 2 genera, 9 species, some 39 in total.

• Journal of Plant Biotechnology
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• v.47 no.4
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• pp.273-282
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• 2020

In Vietnam, Celastrus hindsii Benth, a medicinal plant rich in secondary metabolites, has been used to alleviate distress caused by ulcers, tumors, and inflammation for generations. The occurrence of two phenotypes, Broad Leaf (BL) and Narrow Leaf (NL), has raised questions about the selection of appropriate varieties for conservation and crop improvement to enhance medicinal properties. This study examined molecular differences in C. hindsii by comparing protein profiles between the NL and BL types using 2D-PAGE and MS. Peptide sequences and proteins were identified by matching MS data against the MSPnr100 databases and verified using the MultiIdent tool on ExPASy and the Blast2GO software. Our results revealed notable variations in protein abundance between the NL and BL proteomes. Selected proteins were confidently identified from 12 protein spots, thereby highlighting the molecular variation between NL and BL proteomes. Upregulated proteins in BL were found to be associated with flavonoid and amino acid biosynthesis as well as nuclease metabolism, which probably attributed to the intraspecific variations. Several bioactive proteins identified in this study can have applications in cancer therapeutics. Therefore, the BL phenotype characterized by healthier external morphological features has higher levels of bioactive compounds and could be better suited for medicinal use.

• Korean Journal of Medicinal Crop Science
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• v.6 no.2
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• pp.91-95
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• 1998

Some physical properties and chemical compositions of Lycii Cortex depending on the various extracting conditions were investigated for their changes during extraction with ethanol and water. Solid matter and contents of total sugar in water extracts were higher than those of ethanol extract. but contents of tannic acid in ethanol extracts was higher than that in water extracts. The methanol extract of the Lycii Cortex were fractionated with ethyl ether. ethyl acetate. n-butanol and water. The yield was higher in the order of water > n - butanol > ethyl ether and ethyl acetate fraction. Turbidity of water extraction was higher than that of ethanol extraction.