• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.5967-5976
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• 2014

Treating the osteosarcoma (OSA) remains a challenge. Current strategies focus on the primary tumor and have limited efficacy for metastatic OSA. A better understanding of the OSA pathogenesis may provide a rational basis for innovative treatment strategies especially for metastases. The aim of this review is to give an overview of the molecular mechanisms of OSA tumorigenesis, OSA cell proliferation, apoptosis, migration, and chemotherapy resistance, and how improved understanding might contribute to designing a better treatment target for OSA.

• 대한디지털의료영상학회논문지
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• 제6권1호
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• pp.41-49
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• 2003

• 디지털산업정보학회논문지
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• 제11권4호
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• pp.25-31
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• 2015

Smart healthcare environments which merge medical and IT technology are getting ready for the third generation centering EHR from current second generation. As a basic technology for the introduction and activation of EHR systems it requires heterogeneous network interworking techniques between various wired and wireless medical devices. Interworking technology for heterogeneous network among various medical devices is needed to introduce EHR system. The heterogeneous network interworking technology is needed for construction of a reliable data system to convert each of unstructured data into structured data. Therefore, in this paper, we identify the domestic and international trends of smart medical field and analyze the characteristics of wired and wireless communication technology that is used in a heterogeneous network. and also suggest requirements needed for interworking technology and provide interworking technology based on them. we expect that proposed method which is designed for smart healthcare environments would provide a basic architecture needed for third smart medical technology generation.

• Journal of Microbiology and Biotechnology
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• 제25권7호
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• pp.1136-1145
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• 2015

The diverse microbial communities that colonize distinct segments of the gastrointestinal tract are intimately related to aspects of physiology and the pathology of human health. However, most recent studies have focused on the rectal or fecal microbiota, and the microbial signature of the duodenum is poorly studied. In this study, we compared the microbiota in duodenal and rectal samples to illustrate the characteristic microbial signatures of the duodenum in healthy adults. Nine healthy volunteers donated biopsies and luminal contents from the duodenum and rectum. To determine the composition and diversity of the microbiota, 454-pyrosequencing of bacterial 16S rRNA was performed and multiple bioinformatics analyses were applied. The α-diversity and phylogenetic diversity of the microbiota in the duodenal samples were higher than those of the rectal samples. There was higher biodiversity among the microbiota isolated from rectal biopsies than feces. Proteobacteria were more highly represented in the duodenum than in the rectum, both in the biopsies and in the luminal contents from the healthy volunteers (38.7% versus 12.5%, 33.2% versus 5.0%, respectively). Acinetobacter and Prevotella were dominant in the duodenum, whereas Bacteroides and Prevotella were dominant in the rectum. Additionally, the percentage of OTUs shared in biopsy groups was far higher than in the luminal group (43.0% versus 26.8%) and a greater number of genera was shared among the biopsies than the luminal contents. Duodenal samples demonstrated greater biological diversity and possessed a unique microbial signature compared with the rectum. The mucosa-associated microbiota was more relatively conserved than luminal samples.

• International Journal of Quality Innovation
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• 제9권3호
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• pp.29-56
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• 2008

Since the execution of National Health Insurance system in Taiwan, the competition of medical industry is becoming more and more severe. The ways the hospital operate knowledge management (KM) concept, combine current human resources and professional knowledge by information techniques and upgrade the competitiveness through reinvention of organizational culture have become the important issues. This research is based on the relationship between KM and organizational operation, integrates the characteristic of medical institutions and framework of medical knowledge cycle and starts the research subject by questionnaires from three dimensions: current situation of KM construction in medical organizations, executive effect of KM activities and the challenges faced by KM; subsequently, from qualitative interview, this research attempts to understand how a medical organization executes and adjusts in the consideration of theory and reality as well as quality and costs when actually operates the organization. This research accesses to KM system application of medical institutions and the empirical executive benefits and difficulties through questionnaires. The research results are as follows: (1) having initial understanding toward current KM establishment of medical institutions; (2) confirming the most important items of KM establishment of medical organizations; (3) understanding the most difficulty which the medical organizations encounter when executing KM; (4) establishing medical knowledge cycle figure of the hospitals receiving interviews. Through case interview, this research profoundly accessed to the actual operation of KM application of medical organizations. The target hospitals intended to try many medical KM measures; however, during to complicated hospital organizations and cultural characteristics, the promotion was not successful and the results were not apparent. The most difficulty was to change the employees’ behavior. The targets believed that only the continuous promotion of KM can allow it to be an important aspect of organizational culture and the competitiveness could constant be upgraded.

• 한국응급구조학회지
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• 제21권2호
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• pp.17-37
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• 2017

Purpose: This study describes current curricula for paramedic students in South Korea and proposes a standardization of the curriculum. Methods: Data were collected from 38 colleges and universities from March 1 to 31, 2016. Descriptive statistics were calculated using SPSS 23.0. Results: The proposed standard curriculum was below. Requisite liberal arts consisted of 2 subjects and 6 credits including biomedical ethics, communications and human relationships. Common major subjects were composed of 6 areas, 22 subjects, and 78 credits. The areas of basic medicine consisted of 6 subjects and 16 credits including medical terminology. Introduction to paramedicine consisted of 3 subjects and 7 credits. Emergency patient management consisted of 2 subjects and 9 credits. Particulars to paramedic care consisted of 8 subjects and 31 credits. The law area consisted of 1 subject and 3 credits. Other major areas consisted of 2 subjects and 12 credits including integrated simulation and physician assistance. Common field practice area consisted of 3 to 4 subjects and 9 to 12 credits. Conclusion: It is important to establish and adapt a standardized curriculum for paramedic students in order to ensure competence and to provide high quality emergency medical services.

• 대한방사성의약품학회지
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• 제6권2호
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• pp.102-115
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• 2020

In the state of Positronium (Ps), which is an unstable material created by the temporary combination of electrons and positrons, the imaging technology through photo-conversion methodology is emerging as a new research theme under resonance conditions through terahertz electromagnetic waves. Normally, Positronium can be observed in the positron emission computed tomography (PET) process when an unstable, separate state that remains after the pair annihilation of an electron and a positron remains. In this study, terahertz (THz) waves and Cherenkov radiation (CR) are generated using the principle of ponderomotive force in the plasma wake-field acceleration, and electrons and positrons are simultaneously generated by using a relativistic electron beam without using a PET device. We confirm the possibility of Positronium photoconversion technology in terahertz electromagnetic resonance conditions through experimental studies that generate an unstable state. Here, a relativistic electron beam (REB) energy of 0.5 MeV (γ=2) was used, and the terahertz wave frequencies is G-band. Meanwhile, a THz wave mode converting three-stepped axicon lens was used to apply the photoconversion technology. Through this, light emission in the form of a luminescence-converted Bessel beam can be verified. In the future, it can be used complementarily with PET in nuclear medicine in the field of medical imaging.

• 한국응급구조학회지
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• 제11권1호
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• pp.5-10
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• 2007

Purpose: It was to induce higher-level papers which can make Korea's Emergency Medical Service System better. Methods: This study was conducted by analysing of 250 papers published in the Journal of Korean Society of Emergency Medical Technology from 1997 to 2005. Results: Most of papers which dealt with non-clinic(94.4%), non-job description(76.8%), non-scope of practice(94.4%), other than AHA's recommendations such as response intervals and survival rates from cardiac arrest(90.4%) were written by professors(61.6%) and 1-2 authors(72.8%). Conclusion: It brought up some needs of enlargement of new members.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2009년도 춘계학술발표대회
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• pp.50-52
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• 2009

Ontology maintenance is a time consuming and costly process which requires special skill and knowledge. It requires joint effort of both ontology engineer and domain specialist to properly maintain ontology and update knowledge in it. This is specially true for medical domain which is highly specialized domain. This paper proposes a novel approach for maintenance and update of existing ontologies in a medical domain. The proposed approach is based on modified Ontology Maturing Process which was originally developed for web domain. The proposed approach provides way to populate medical ontology with new knowledge obtained from medical documents. This is achieved through use of natural language processing techniques and highly specialized medical knowledge bases such as Unified Medical Language System.

• 한국응급구조학회지
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• 제20권3호
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• pp.37-47
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• 2016

Purpose: The purpose of the study was to establish an education curriculum subject program design for the department of emergency medical technology based on National Competency Standards (NCS) key competencies. Methods: A self-reported questionnaire was completed by 180 level 1 emergency medical technicians in K area from June 15 to 20, 2016. Except for 14 incomplete questionnaires, 141 data were analyzed. The study instrument included general characteristics of the subjects (7 items) and importance and satisfaction levels for 10 key competencies including 34 items of subfactors by a Likert 5-point scale using Borich Needs Assessment Model. A locus for focus model (LF model) was used to derive the top priority key competencies for the education curriculum. Data were analyzed by SPSS v. 20.0. Results: The order of education needs of the program included interpersonal competency (1.442), communication competency (1.384), problem solving competency (1.185) and professional ethics competency (1.149). In the LF model, the required jey competencies included interpersonal competency, communication competency, professional ethics competency, and problem solving competency. Conclusion: The study results coincided with standard education curriculum guidelines. Our resluts can provide a valid reference for the department of emergency medical technology.