• 한국전자통신학회논문지
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• 제7권4호
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• pp.925-930
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• 2012

최근 우리나라는 65세 이상의 고령자들을 위한 헬스 케어에 기초를 둔 고령 친화적인 주택을 마련하는 데 초점이 맞추어 지고 있다. 본 연구에서는 국내의 법을 근거로 타당한 분석을 이용하여 보다 더 진보된 개선안을 마련하고자 하였다. 그리하여 헬스 케어 관련법과 고령자 주택의 두 가지로 구분하여 분석하였다. 하지만 의료법의 중요도를 변화시키는 것이 한계가 있어서 헬스 케어에 기초를 둔 개요와 고령화에 따른 문제들을 고찰하였다. 이러한 결과, 헬스 케어 시스템 주택을 만들기 위한 개선책과 여러 분야에 걸친 관련부처를 하나로 통일해 다가오는 고령 시대를 준비하고자 하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제7권11호
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• pp.2874-2892
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• 2013

Since security plays an important role in several ZigBee applications, such as Smart Energy and medical sensor applications, ZigBee Specification includes various security mechanisms to protect ZigBee frames and infrastructure. Among them, the Join and Leave operations of ZigBee are investigated in this paper. The current Join-Leave operation is protected by the network key (a kind of group key). We claim it is not adequate to employ the network key for such purpose, and propose a new Join-Leave operation protected by the application link key (a kind of pairwise key), which is based on a more efficient key management scheme than that of ZigBee. Hence, the original Join operation consists of a total of 12 command frames, while the new Join operation consists of only 6 command frames. In particular, the security of the proposed Join-Leave operation is equivalent to or better than that of the original Join-Leave operation. The new Join-Leave operation is extensively analyzed in terms of security and efficiency, and compared with the original Join-Leave operation of ZigBee.

• 한국전자통신학회논문지
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• 제3권2호
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• pp.112-117
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• 2008

HL7은 병원정보 시스템에서 사용되는 정보와 관련된 표준화된 프로토콜이다. 생체 정보 웹 뷰어 시스템 또한 의료 영상 및 전송에 대해 표준화된 프로토콜이다. 원격 진료의 새로운 기술을 받아들이기 위해 병원에서 서로 다른 시스템들 사이의 표준화 프로토콜을 사용하는 것이 매우 중요하며, 또한 외부 병원과의 연동을 위한 통신방식도 중요하다. 본 논문에서 우리는 병원정보 시스템과 생체 정보 웹 뷰어 시스템사이의 통합 방법을 제안한다. 적절한 생체정보 데이터의 교환과 정보 관리의 수정을 통해 병원정보 시스템은 모든 병원 관계자의 보다 나은 업무처리를 향상시킬 수 있다.

• Journal of Microbiology and Biotechnology
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• 제14권3호
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• pp.607-611
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• 2004

Glycinin, one of the predominant storage proteins in soybeans, was examined as to whether it could be used as a calcium-binding mediator after chemical phosphorylation and enzymatic hydrolysis. Glycinin is composed of six subunits. One of the proglycinin subunits $(A_{la}B_{lb})$ was overexpressed in E. coli to obtain nonphosphorylated proteins with homogeneity. To investigate the enhanced calcium-binding properties of the phosphopeptides, the proglycinin was purified, phosphorylated, and hydrolyzed with trypsin. The proglycinin expressed in E. coli was purified by ammonium sulfate precipitation, ion-exchange chromatography, and cryoprecipitation. Chemical phosphorylation by sodium trimetaphosphate was performed to obtain phosphorylated proglycinin. After the phosphorylation, one-dimensional isoelectric focusing gel electroanalysis confirmed the phosphorylation of the proglycinin. The phosphorylated peptides were then hydrolyzed with trypsin, followed by a binding reaction with calcium chloride. The calcium-bound phosphopeptides were finally separated using immobilized metal $(Ca^{2+})$ chromatography. Consequently, a limited tryptic hydrolysate of the isolated phosphopeptides exhibited an enhanced calcium-binding ability, suggesting the potential of glycinin phosphopeptides as a calcium-binding mediator with greater availability.

• The Korean Journal of Physiology and Pharmacology
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• 제15권4호
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• pp.245-249
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• 2011

Amphetamine, a synthetic psychostimulant, is transported by the dopamine transporter (DAT) to the cytosol and increases the exchange of extracellular amphetamine by intracellular dopamine. Recently, we reported that the phosphorylation levels of ezrin-radixin-moesin (ERM) proteins are regulated by psychostimulant drugs in the nucleus accumbens, a brain area important for drug addiction. However, the significance of ERM proteins phosphorylation in response to drugs of abuse has not been fully investigated. In this study, using PC12 cells as an in vitro cell model, we showed that amphetamine increases ERM proteins phosphorylation and protein kinase C (PKC) ${\beta}$ inhibitor, but not extracellular signal-regulated kinase (ERK) or phosphatidylinositol 3-kinases (PI3K) inhibitors, abolished this effect. Further, we observed that DAT inhibitor suppressed amphetamine-induced ERM proteins phosphorylation in PC12 cells. These results suggest that $PKC{\beta}$-induced DAT regulation may be involved in amphetmaine-induced ERM proteins phosphorylation.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2006년도 춘계 종합학술대회 논문집
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• pp.479-482
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• 2006

Mobile Telemedicine은 의료진과 환자간의 정보교환을 제공하기위한 일반적인 기술로 사용되어지고 있다. 또한 유비쿼터스 센서 네트워크의 기술을 활용하여 의료진은 원격지 환자의 다양한 생체데이터를 획득하고자 한다. 본 논문은 임베디드 리눅스 운영체제를 기반으로 Intel X-Hyper PXA255 ARM CPU를 이용하여 구현한 RFID 리더 시스템에서 RFID 리더에서 수신되어진 환자의 태그 정보를 무선 LAN을 통하여 인터넷에 연결되어진 병원의 MySQL서버에 전달하는 기능을 수행하는 RFID 리더 플랫폼의 설계 및 구현을 위한 것이다. 구현되어진 임베디드 리눅스 기반의 RFID 리더는 크게 RFID 모듈, ARM 프로세서, RS-232 인터페이스, 무선 LAN 등으로 구성되고, 제안된 논문은 RFID의 개념 및 리더의 동작원리를 소개하고 임베디드 리눅스기반에서 QT 및 MySQL을 사용하여 구현되어진 리더플랫폼을 제안하고 구현한다.

• Journal of Chest Surgery
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• 제23권6호
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• pp.1049-1056
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• 1990

The OXYREX hollow fiber membrane oxygenator developed by joint work of KIST and Green Cross Medical company has been evaluated by experimental investigation and clinical application, In this oxygenator gas exchanges occur through small pores of 0.1pm size which are distributed on 70% of surface of polypropylene hollow fiber. The Oxyrex membrane oxygenator consists of 36 thousand hollow fibers and it has 3.3m2 of gas exchange surface. The Oxyrex membrane oxygenator has unique blood flow path: blood enters the oxygenator passes between the hollow fibers and exits through outlet ports, that provides low transmembrane pressure drop. In the animal experiment and in vitro investigations of Oxyrex oxygenator, it showed low transmembrane pressure difference, effective heat exchanger performance, stable gas transfer function and less blood trauma. The Oxyrex oxygenator been used from March, 1990, to October, 1990, in 40 patients undergoing open heart operations. In the clinical applications of Oxyrex, adequate oxygenation[PaO2, 283$\pm$70mmHg] and carbon dioxide removal[PaCO2, 27\ulcorner6mmHg]were maintained under the condition of FiO2: below 0.6, Hct; 25%, perfusion flow; 2.4 L/min, gas flow: 2.1 L/min. During maximum 365 minutes of cardiopulmonary bypass[CPB] time period, the Oxyrex oxygenator maintained stable condition of PaO2, PaCO2 respectively and it also kept low plasma hemoglobin level. The complement proteins C3 and CH50 were not significantly changed pre to post CPB. There were no complications related to the oxygenator during and after the CPB.

• Journal of Acupuncture Research
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• 제20권4호
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• pp.85-92
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• 2003

목적 : 허혈시 발생되는 저산소중 상태에서는 세포독성을 유발한다고 알려져 있으나 정확한 기전은 아직 규명되지 않았다. 본 연구에서는 뇌허혈로 인한 세포독성의 기전을 유전자 발현을 통하여 살펴보고자 하였다. 방법 : 본 실험에서는 BV-2 microglia 세포주에 12시간 동안의 저산소 상태에서의 유전자 발현을 분석하기 위하여 마이크로에레이를 시행하였다. 결과 : 저산소 상태에서는 정상에 비하여 cathepsin F, growth factor independent 1, calcitonin/calcitonin-related poly, leucine-rich repeat LGI family membrane, dublecortin, cyclohydrolase 1, Ia-associated invariant chain, carbohydrate kinase-like과 erythrocyte protein band 4.1-like 3 등의 유전자 발현이 3배 이상 증가하였다. 한편 neuronal guanine nucleotide exchange factor, Bcl-2-related ovarian killer protein, chemokine (C-X-C motif) ligand 5, RNA binding motif protein 3, interleukin 2 receptor, alpha chain, crystallin zeta, cytochrome P450 subfamily IV B, asparagine synthetase과 moesin 등의 유전자 발현은 0.2배 이하로 감소하였다. 결론 : 이상의 결과는 저산소중에 관여하는 유전자 및 저산소중과 관련된 뇌경색 등의 질환의 기전을 밝히는데 기초적 자료로 이용될 수 있을 것이다.

• 간호행정학회지
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• 제3권1호
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• pp.83-92
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• 1997

This study was designed to evaluate the current orientation and further to develop an effective orientation curriculum of new nurses by analyzing questionraire taken from 45 numbers of all nurses who have worked for 18 months below at one hospital located in C city on July, 1995. The results obtained are summarized as follows. 1. The subjects showed the high necessity of "emergency nursing", "cardiopulmunary resuscitation", "disinfection and infection" and "interpersonal relationship" in order, but relatively low necessity of "doctor supports" and "medical insurance affair" for the practical orientation. Therefore, the orientation should provide prepondently an education Which they really need, on the basis of their education experiences and/or requirements. 2. Practical training, individual teaching and performance will be an effective orientation more than theorical education. The educator should be selected from unit based persons being capable of providing technical education to trainee. Also, in order to develop the teaching method and to improve the corresponding ability, a special program is required for educators. 3. It will be desirable that task training is given at least one month before working at their unit. In addition, orientation schedule should be made to concentrate trainee on their task training fully. 4. The subjects showed that half of them had spent four to six months for work adaptation. A meeting of new nurses may be helpful not only to acclimate themselves to new circumstances. but also to provide an exchange of views and an emotional relationship. Furthermore, unit based staffs should exerts efforts to maintain the educational circumstances and warm concern for new nurse's adaptation.

• 간호행정학회지
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• 제9권1호
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• pp.5-18
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• 2003

Purpose : For improvement of nursing services in ambulatory unit, ambulatory nursing activity was identified and the required time by nursing activity was measured. Method : The data were collected from 4 tertiary hospitals and 2 secondary hospitals. The method of data collection was used the self-reporting method. The 123 nurse-work days and 137 nurse-aid-work days in 6 hospitals were analyzed. Results : As a result, 11 ambulatory nursing domains and 79 ambulatory nursing activities were confirmed. Above 50% of subjects performed the general outpatient affair domain. The percentage of total time spent in each domain were as follows : general outpatient affair domain, 58.3%, patient education ${\cdot}$ counseling domain, 10.8%, therapeutic care domain, 8.6% and so on. And the average hours were measured by activity and domain. Conclusion : For the improvement of ambulatory nursing care, the strategies that keep the legal standard of number of ambulatory nurse and exchange the nursing-aid for the nurse is needed. And it is also needed to standardize the ambulatory nursing services.