• Korean Journal of Acupuncture
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• 제23권2호
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• pp.1-18
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• 2006

Objectives: The subject of this research is the catechism on medicine between the doctors of Joseon and Japan in the 18th century through Choson Delegation(朝鮮通信使 ). Methods: The author intended to review and analyze the contents of catechism related to Acupuncture and Moxibustion and determined the characteristics of Joseon and Japan ?s Acupuncture and Moxibustion. Results: At the time, Japanese doctors had a grasp on most theories of Acupuncture and Moxibustion and were very specialized clinically. They usually used filiform needles with various techniques, and already they had many different schools in practice. However, they wanted to know if their Acupuncture and Moxibustion skills were up to the international standard, especially to Joseon, whom they regarded as a country advanced in Acupuncture and Moxibustion. They wanted to com- pare and contrast their Acupuncture and Moxibustion with Joseon's. 18th century Joseon was high time for Acupuncture and Moxibustion. Various tools were used in surgery, and varieties of needles were used to stimulate acupuncture points. The development of tools evinces the precision of Joseon's Acupuncture and Moxibustion at the time. Also, comprehensive works such as DongUiBoGam(東醫寶鑑) and UiHaklpMun( 醫學入門) greatly influenced Acupuncture and Moxibustion. Because of this impact, it can be deduced that Acupuncture and Moxibustion emphasizing Jang(臟) and Bu(腑) organs and Internal Injury developed greatly. In addition, acupuncturist Holm(許任)'s fame continued from the 17th century into the 18th century, and his medical practice left a huge mark on not only Joseon but other eastern Asian countries as well. Conclusions: We found out the evidences that there were a lot of exchanges of acupuncture and moxibustion between Korea and Japan based of the Joseon TongShinSa (Emissary)'s record of catechism on medicine in the 18th century.

• Molecules and Cells
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• 제37권11호
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• pp.777-784
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• 2014

Epidemiologic studies have shown that low-density lipoprotein cholesterol (LDL-C) is a strong risk factor, whilst high-density lipoprotein cholesterol (HDL-C) reduces the risk of coronary heart disease (CHD). Therefore, strategies to manage dyslipidemia in an effort to prevent or treat CHD have primarily attempted at decreasing LDL-C and raising HDL-C levels. Cholesteryl ester transfer protein (CETP) mediates the exchange of cholesteryl ester for triglycerides between HDL and VLDL and LDL. We have published the first report indicating that a group of Japanese patients who were lacking CETP had extremely high HDL-C levels, low LDL-C levels and a low incidence of CHD. Animal studies, as well as clinical and epidemiologic evidences, have suggested that inhibition of CETP provides an effective strategy to raise HDL-C and reduce LDL-C levels. Four CETP inhibitors have substantially increased HDL-C levels in dyslipidemic patients. This review will discuss the current status and future prospects of CETP inhibitors in the treatment of CHD. At present anacetrapib by Merck and evacetrapib by Eli Lilly are under development. By 100mg of anacetrapib HDL-C increased by 138%, and LDL-C decreased by 40%. Evacetrapib 500 mg also showed dramatic 132% increase of HDL-C, while LDL-C decreased by 40%. If larger, long-term, randomized, clinical end point trials could corroborate other findings in reducing atherosclerosis, CETP inhibitors could have a significant impact in the management of dyslipidemic CHD patients. Inhibition of CETP synthesis by antisense oligonucleotide or small molecules will produce more similar conditions to human CETP deficiency and may be effective in reducing atherosclerosis and cardiovascular events. We are expecting the final data of prospective clinical trials by CETP inhibitors in 2015.

• 보건행정학회지
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• 제31권3호
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• pp.261-271
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• 2021

Background: In 2018, the government increased the fee for the magnetic resonance imaging (MRI) image deciphering services of the external hospital to discourage the redundant MRI scan and to induce appropriate use of the MRI services. It is important to evaluate the effect of the policy to provide the basis for establishing other MRI-related policies. Methods: The healthcare data of the patients who had brain MRI scans were organized by episode and analyzed using the panel study in order to find out the effect of the MRI-related policy on the substitution effect and the medical expenses. Results: As a result of the increase in the fee of deciphering the MRI image, there has been an uplift in deciphering the MRI scan of the external hospital. It implies that more hospitals chose to use the MRI scan taken by other clinics or hospitals, rather than the MRI scan taken at their own facilities. Conclusion: The research results imply that a policy that facilitates the exchange of the medical image data between the hospitals is needed in order to establish an efficient management system of the healthcare resources. Such improvement is expected to reduce the social cost and contribute to the stability in the finance of national health insurance.

• 정보관리학회지
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• 제41권1호
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• pp.283-311
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• 2024

전자의무기록 공유를 추진하기 위해서는 사람들의 인식을 이해할 필요가 있다. 이에 본 연구는 합리적 행동 이론과 프라이버시 계산 모형에 기반하여 전자의무기록 공유에 영향을 미치는 요인을 검증하였다. 또한 직업과 개인 병력 등 인구통계학적 특성에 따라 공유 의도가 달라지는지에 대해서 알아보았다. 145명을 대상으로 온라인 설문조사를 실시한 결과, 이타적 즐거움과 개인정보 보호 인식, 법·제도적 역할 인식 및 건강에 관한 관심 정도가 전자의무기록 공유 의도에 긍정적 영향을 미치고 있었으며 의료기관에 대한 신뢰가 법·제도적 역할 인식과 공유 의도 간의 관계를 긍정적으로 조절하였다. 이에 사람들이 공유 과정에 의료기관뿐만 아니라 정부의 역할도 중요하게 인식하고 있음을 확인할 수 있었다. 전자의무기록 공유에 대한 사람들의 참여와 수용을 촉진하기 위해서는 공유로 인한 공익적 혜택을 강조해야 할 것이며 법적으로 개인정보의 보안과 올바른 활용을 보장하는 가이드라인을 마련하는 것이 필요하다는 점을 제시하였다.

• 대한방사성의약품학회지
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• 제5권2호
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• pp.71-78
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• 2019

Nuclear imaging is one of the most powerful measures for non-invasive diagnosis of myocardial vascular disease. Radionuclide such as ¹³N, ¹⁵O, ²⁰¹Tl and ⁸²Rb is used for the measurement of cardiac blood flow. ¹³N, ¹⁵O and ²⁰¹Tl are produced in cyclotrons while ⁸²Rb is obtained from generator. Rubidium (Rb), an alkali ion, behaves biologically like potassium, and accumulates in myocardial tissue. Rb has rapid blood clearance profile which allows the use of ⁸²Rb with a short physical half-life of 75 s for non-invasive evaluation of regional myocardial perfusion. There are several advantages of ⁸²Rb over other radioisotopes. An ultra-short half-life significantly reduces the exposure of patients to radiation and allows to repeat injections for studying the effects of medical intervention. As a positron emitter, ⁸²Rb allows positron emission tomography (PET) imaging which have shown superior diagnostic performances. ⁸²Rb can be produced from generator by decay of its parent ⁸²Sr. However, the preparation of ⁸²Sr is difficult, because appropriate purity is required to meet the specification of the product. Recently reported procedure from ARRONAX research institute showed that a Chelex-100 resin is sufficient for this purpose and additional column is not necessary. Whereas Brookhaven National Laboratory (BNL) procedure contains three ion exchange resin separation, including Chelex-100 resin. Currently, since ⁸²Sr production site is non-existent in Korea, Korea Atomic Energy Research Institute (KAERI) has plan to produce ⁸²Sr within specifications. We compared ⁸²Sr purification procedures reported from ARRONAX and BNL to investigate the most suitable procedure for our conditions.

• 대한방사선치료학회지
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• 제11권1호
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• pp.6-10
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• 1999

The field size can be beam output, therefore MonitorUnit can be varied due to field size dependence The purpose of this study is to evaluate and compare the dose variation according to exchange of collimator The measurements were perfomed with Wellhofer dosimetry system(water phantom. ion chamber. electrometer. system controller. build up cap. etc)and two types of linear accerlerator (Mevatron KD, MevatronMX) Scatter can be affected to field size dependence and scatter correction is separated into collimator and phantom components, scatter components can affect by exchanging of collimator Measurements of collimator scatter factor(Sc) was done in air with build up cap. 1)Square field (5cm2 to 40cm2) was measured 2)and then keeping the upper jaw constant at loom and varing lower jaw from 5cm to 40cm, 3)keeping the lower jaw constant at 10cm and varing upper jaw from 5cm to 40cm Measurements of total scatter factor(Scp) was done in water at Dmax as the procedure of collimator scatter factor measurements in water Dmax The total scatter factors were obtained to the following equation(Sp=Scp/Sc) The measured data is normalized to the data of reference field size($10{\times}10$), rectangular field is inverted to equivalent field to compare three field size data As the collimator setting is varied, the output was changed In conclusion, the error was obtained small but it must be eliminated if we intend to reach the common stated goal of $5\%$ overall uncertainty in dose determination

• 대한의용생체공학회:의공학회지
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• 제24권5호
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• pp.391-399
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• 2003

혈관내 산화는 급성 호흡 곤란 증후군 (ARDS)의 치료를 위해 관심을 갖고 있는 호흡보조방법이다. 그러나 ARDS 치료에 효과적인 임상적용을 위해서는 더 많은 기체교환을 통한 혈관내 산화가 필요했다. 본 연구에서는 헤모글로빈의 미세캡슐화가 혈액의 손상을 줄여줌으로 미세캡슐화를 통하여 진동형 혈관내 폐보조장치 (VIVLAD)의 기체교환을 향상시키고자 시도하였으며 또한 perfluorocarbone 유화액(PFC 유화액)을 사용하여 기체교환을 향상시키고자 하였다. 혈액 기체 측정은 순환장치의 정맥혈과 동맥혈 시료 채취구에서 채취하여 혈액./기체 분석기를 이용하여 수행하였다. Hemosome. 혈액/hemosome 혼합액과 혈액/PFC 유화액 혼합액의 기능은 혈액/기체 분석기를 사용한 산소 해리 곡선에 의하여 평가되었다. 그 결과. hemosome과 혈액/hemosome 혼합액의 산소 전달은 전혈의 산소전달보다 각각 더 효과적이었으며 또한 PFC 유화액의 이산화탄소 전달속도는 다른 용액들보다 우수하였다. 그러므로 hemosome 용액과 PFC 유화액은 산소전달속도와 이산화탄소 전달속도를 각각 향상시킬 수 있으리라 판단하였다.

• 한국지능시스템학회논문지
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• 제22권4호
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• pp.507-514
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• 2012

PHR(Personal Health Record)의 표현, 통합, 교류를 위해 CCD(Continuity of Care Document)와 CCR(Continuity of Care Record)과 같은 XML 기반의 표준들이 개발되었고, 이들 표준에 기반하여 PHR 교환을 위한 다양한 연구들이 수행되고 있다. 이들 연구에서는 각기 다른 방법으로 CCD/CCR 문서의 처리 도구를 개발하여 사용하고 있으나, 이들 표준이 구조적으로 복잡하여 도구의 개발 및 수정이 쉽지 않다. 또한 PHR 관련 의료정보시스템의 상호운용을 위해서는 CCD와 CCR 문서간의 상호 변환이 필요하다. 따라서 본 논문에서는 XML에 기반하여 작성된 CCD와 CCR과 같은 의료정보 표준 문서를 처리하고 관리하기 위한 프로그램 설계 방법을 제안하였다. 그리고 제안한 방법에 기반하여 CCD/CCR 처리 도구를 개발하고, 이 도구를 이용하여 CCD를 CCR로 변환하기 위한 변환기를 개발하였다. 개발한 도구의 효용성 확인을 위해 경북대학교병원에서 만성질환 입원자를 대상으로 수집한 개인건강정보를 이용하여 CCD 문서를 생성하고, CCD 문서를 CCR 문서로 변환하는 실험을 수행하였다.

• 한국통신학회논문지
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• 제38C권5호
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• pp.464-470
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• 2013

현재 헬스케어에 대한 관심이 높아지면서 건강정보측정기기에 필수적으로 적용되어야 할 표준에 대한 연구가 활발히 진행되고 있다. 이러한 표준화 및 시험/인증은 IEEE 11073 PHD, Health Level Seven 그리고 Continua Health Alliance를 통해 진행되고 있으며, 앞으로 더 많은 연구와 실험이 계속될 것이라고 생각된다. 본 논문에서는 원격 건강 정보의 교환을 위한 표준인 IEEE 11073 PHD와 Bluetooth의 건강정보측정기기를 위한 프로파일인 Bluetooth Health Device Profile(HDP)을 소개하고, HDP가 적용된 스마트 디바이스와 건강정보측정기기 간 개인의 건강 정보를 교환하는 실험을 진행하였다. 실험을 통해 HDP를 이용하여 IEEE 11073 PHD 표준 프로토콜의 송수신으로 스마트 디바이스와 건강정보측정기기 간에 상호연결 및 운용이 가능함을 확인할 수 있었고, 향후 이를 지원하는 기기를 통해 다양한 원격 의료 서비스가 구현될 수 있을 것이라 기대한다.

• 대한의용생체공학회:의공학회지
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• 제36권6호
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• pp.241-250
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• 2015

Noninvasive temperature monitoring is feasible with Magnetic Resonance Imaging (MRI) based on temperature sensitive MR parameters such as $T_1$ and $T_2$ relaxation times, Proton Resonance Frequency shift (PRFs), diffusion, exchange process, magnetization transfer contrast, chemical exchange saturation transfer, etc. While the temperature monitoring is very useful to guide the thermal treatment such as RF hyperthermia or thermal ablation, the optimization of the MR thermometry method is essential because the range of temperature measurement depends on the choice of the measurement methods. Useful temperature range depends on the purpose of treatment methods, for example, $42^{\circ}C$ to $45^{\circ}C$ for RF hyperthermia and over $50^{\circ}C$ for thermal ablation. In this paper, MR thermometry methods using $T_1$ and $T_2$ relaxation times and PRFs-based MR thermometry are tried on a 3.0 T MRI system and their results are reported and compared. In addition, the scanning protocol and temperature calculation algorithms from $T_1$ and $T_2$ relaxation times and PRFs are optimized for the different temperature ranges for the purpose of RF hyperthermia and/or thermal ablation.