Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)

Korean Society of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회)
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Comparative study of 82Sr separation/purification methods used at Brookhaven National Laboratory and ARRONAX

  • Ha, Yeong Su (Korea Multi-purpose Accelerator Complex (KOMAC), Korea Atomic Energy Research Institute (KAERI)) ;
  • Yoon, Sang-Pil (Korea Multi-purpose Accelerator Complex (KOMAC), Korea Atomic Energy Research Institute (KAERI)) ;
  • Kim, Han-Sung (Korea Multi-purpose Accelerator Complex (KOMAC), Korea Atomic Energy Research Institute (KAERI)) ;
  • Kim, Kye-Ryung (Korea Multi-purpose Accelerator Complex (KOMAC), Korea Atomic Energy Research Institute (KAERI))
  • Received : 2019.12.12
  • Accepted : 2019.12.28
  • Published : 2019.12.30
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Abstract

Nuclear imaging is one of the most powerful measures for non-invasive diagnosis of myocardial vascular disease. Radionuclide such as 13N, 15O, 201Tl and 82Rb is used for the measurement of cardiac blood flow. 13N, 15O and 201Tl are produced in cyclotrons while 82Rb is obtained from generator. Rubidium (Rb), an alkali ion, behaves biologically like potassium, and accumulates in myocardial tissue. Rb has rapid blood clearance profile which allows the use of 82Rb with a short physical half-life of 75 s for non-invasive evaluation of regional myocardial perfusion. There are several advantages of 82Rb over other radioisotopes. An ultra-short half-life significantly reduces the exposure of patients to radiation and allows to repeat injections for studying the effects of medical intervention. As a positron emitter, 82Rb allows positron emission tomography (PET) imaging which have shown superior diagnostic performances. 82Rb can be produced from generator by decay of its parent 82Sr. However, the preparation of 82Sr is difficult, because appropriate purity is required to meet the specification of the product. Recently reported procedure from ARRONAX research institute showed that a Chelex-100 resin is sufficient for this purpose and additional column is not necessary. Whereas Brookhaven National Laboratory (BNL) procedure contains three ion exchange resin separation, including Chelex-100 resin. Currently, since 82Sr production site is non-existent in Korea, Korea Atomic Energy Research Institute (KAERI) has plan to produce 82Sr within specifications. We compared 82Sr purification procedures reported from ARRONAX and BNL to investigate the most suitable procedure for our conditions.

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References

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