• Proceedings of the KAIS Fall Conference
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• 2011.05b
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• pp.1068-1071
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• 2011

Cyclooxygenases (COX)-2 has been highly expressed in a variety of tumor cells and involved inflammatory process, tumor-associated angiogenesis, and vascular functions but the underlying mechanism is not clearly elucidated. We here investigated the molecular mechanism by which COX-2 regulates tumor-associated angiogenesis. In vivo, we injected B16-F1 cells overexpressed with COX-2 or mock in wild type or eNOS-deficient mice. Tumor cells overexpressed with COX-2 increase tumor-associated angiogenesis and tumor growth compared with control cells and that the effect of COX-2 was lower in eNOS-deficient mice than wild type mice. These results may contribute to further understanding of the regulation of angiogenesis by COX during tumor metastasis and inflammation.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.21 no.3
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• pp.141-146
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• 2010

This summary of literature during the past year reviews published studies relating to risk factors for depressive disorders in children and adolescents. Risk factors include environmental toxins, socio-environmental, and genetic factors. As depression has a complex, multifactorial causal mechanism, it is likely that the accumulation and/ or interaction among multiple risk factors lead to depression. Findings related to the result of toxin exposure have been difficult to interpret given that risk factors tend to interact and that higher mental functions are not easily measurable. However, some findings have been consistent. Clinical research data has also shown that the risk for negative outcomes may be modified both by genetic and environmental factors through a gene environment interplay mechanism.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2006.05a
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• pp.45-48
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• 2006

The system that can generate biological brain information processing mechanism more precisely may have several abilities such as exact cognition, situation decision, learning and inference, and output decision. In this paper, to implement high level information processing and thinking ability in a complex system, the information processing layer based on the biological brain is introduced. The biological brain information processing mechanism, which is analyzed in this paper, provides fundamental information about intelligent engineering system, and the design of the layer that can mimic the functions of a brain through engineering definitions can efficiently introduce an intelligent information processing method having a consistent flow in various engineering systems. The applications proposed in this paper are expected to take several roles as a unified model that generates information process in various areas, such as engineering and medical field, with a dream of implementing humanoid artificial intelligent system.

• Journal of Advanced Marine Engineering and Technology
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• v.38 no.2
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• pp.175-181
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• 2014

Location awareness is one of the key functions to build an U-city. Recently, many of works for the location-aware systems are emerging to be applied to on-going large-scale apartment complex. For example, when dwellers or cars with active tags are move in the apartment complex, the active tags broadcast their own identifiers periodically and receivers such that routers use this information to calculate the location of the active tags. Since the active tags can actually move between routers and coordinators, it requires a hand-off mechanism. In this paper, we investigate the hand-off problem occurred in location awareness system based on ZigBee active tags. We propose and analyze a new approach for handling the hand-off problem. Through a mathematical analysis, we show that our approach diminishes the quantity of packet transfer than ZigBee's approach.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2005.03a
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• pp.469-476
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• 2005

To date, many viable smart base isolation systems have been proposed. In this study, a novel friction pendulum system (FPS) and an MR damper are employed as the isolator and supplemental damping device, respectively. A fuzzy logic controller (FLC) is used to modulate the MR damper. A genetic algorithm (GA) is used for optimization of the FLC. The main purpose of employing a GA is to determine appropriate fuzzy control rules as well to adjust parameters of the membership functions. To this end, a GA with a local improvement mechanism is applied. Neuro-fuzzy models are used to represent dynamic behavior of the MR damper and FPS. Effectiveness of the proposed method for optimal design of the FLC is judged based on computed responses to several historical earthquakes. It has been shown that the proposed method can find appropriate fuzzy rules and the GA-optimized FLC outperforms not only a passive control strategy but also a human-designed FLC and a conventional semi-active control algorithm.

• Proceedings of the KSR Conference
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• 2003.10a
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• pp.204-209
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• 2003

The railway vehicle is composed of many suspension components, such as 1st springs, 2nd dampers, that have an influence on the dynamic characteristics of high speed train. Also, the wheel/rail shapes and its contact mechanism affect the dynamic behavior of high speed train. but these geometric contact characteristics are nonlinear functions of the wheelset lateral displacement and it do not exact dynamic analysis for high speed train. there is a need to develop a new wheel/rail contact module for dynamic behavior and wheelset model is divided motor box, wheel box and wheel body. This wheel is moved by motor box and constrained by joint. It is almost same a train and its result is more exactly.

• Journal of The Korean Astronomical Society
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• v.46 no.2
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• pp.93-96
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• 2013

Modified Newtonian Dynamics (MOND) is a possible solution for the missing mass problem in galactic dynamics; its predictions are in good agreement with observations in the limit of weak accelerations. However, MOND does not derive from a physical mechanism and does not make predictions on the transitional regime from Newtonian to modified dynamics; rather, empirical transition functions have to be constructed from the boundary conditions and comparisons with observations. I compare the formalism of classical MOND to the scaling law derived from a toy model of gravity based on virtual massive gravitons (the "graviton picture") which I proposed recently. I conclude that MOND naturally derives from the "graviton picture" at least for the case of non-relativistic, highly symmetric dynamical systems. This suggests that-to first order-the "graviton picture" indeed provides a valid candidate for the physical mechanism behind MOND and gravity on galactic scales in general.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.1735-1736
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• 2008

In this research, a riding robot system named as "RideBot" is developed for health-care and entertainments. The developed riding robot can follow the intention of horseman and can simulate the motion of horse. The riding robot mechanisms are used for many functions of attitude detection, motion sensing, recognition, common interface and motion-generations. This riding robot can react on health conditions, bio-signals and intention informations of user. One of the objectives of this research is that the riding robot could catch user motion and operate spontaneous movements. In this paper, we develope the saddle mechanism which can generate 3 degrees-of-freedom riding motion based on the intention of horseman. Also, we develope reins and spur mechanism for the recognition of the horseman's intention estimation and the bio-signal monitoring system for the health care function of a horseman. In order to evaluate the performance of the riding robot system, we tested several riding motions including slow and normal step motion, left and right turn motion.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.920-924
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• 2002

This paper presents the reverse design of a cam mechanism using NURBS(Nonuniform Rational B-spline curve). Cam is very difficult to make the accurate shape on the design and the manufacture. Because the cam shape is commonly made in order to move in special functions. The reverse design can be used to check accuracy between the designed data and the manufactured data of the cam shape and also reproduce the cam without the design data. The reverse design procedures consist of motion analysis and curve fitting. The motion analysis is used the central difference method and the relative velocity method to find the displacement and velocity. The curve fitting is used NURBS to develope the whole curve. The central difference method is derived in the 3 dimensional space.

• Molecules and Cells
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• v.20 no.2
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• pp.167-172
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• 2005

Ceruloplasmin (Cp) is a copper protein with important functions in iron homeostasis and in inflammation. Cp mRNA expression is induced by interferon (IFN)-${\gamma}$ in U937 monocytic cells, but synthesis of Cp protein is halted after about 12 h by transcript-specific translational silencing. The silencing mechanism requires binding of a 4-component cytosolic inhibitor complex, IFN-gamma-activated inhibitor of translation (GAIT), to a defined structural element (GAIT element) in the Cp 3'-UTR. Translational silencing of Cp mRNA requires the essential proteins of mRNA circularization, suggesting that the translational inhibition requires end-to-end mRNA closure. These studies describe a new mechanism of translational control, and may shed light on the role that macrophage-derived Cp plays at the intersection of iron homeostasis and inflammation.