• Preventive Nutrition and Food Science
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• 제16권3호
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• pp.236-241
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• 2011

Allium victorialis L. (A. victorialis) is a very popular vegetable in Korea. The most commonly used parts of this vegetable are the bulbs and young leaves. To determine if the mature leaves have any beneficial properties, we investigated antioxidant, anti-${\alpha}$-glucosidase, anti-inflammatory, and anticancer activities of water and ethanol extracts from A. victorialis. Antioxidant activity was evaluated by measuring total phenolic content, DPPH and superoxide radicals scavenging activities. The water extract from A. victorialis ($W{\cdot}A$. victorialis) exhibited higher antioxidant ability than the ethanol extract ($E{\cdot}A$. victorialis). Moreover, the water extract showed strong inhibitory effect on ${\alpha}$-glucosidase. On the other hand, the ethanol extract had greater anti-inflammatory activity on murine macrophage cells (RAW 264.7) and greater anticancer activities against human colon cancer cells (HT-29). These results suggest that mature leaves from E·A. victorialis may have health-enhancing effects.

• Journal of Microbiology
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• 제38권4호
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• pp.255-259
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• 2000

For rapid and sensitive measurement of antiviral activities, application of a recombinant virus containing firefly luciferase gene was attempted. Recombinant human cytomegalovirus (HCMV) containing luciferase gene driven by HCMV late gene pp28 promoter (HCMV/pp28-luc) was used to test the antiviral activities of three known compounds and the result was compared with results from the conventional plaque assay for measuring the production of infectious viruses. When human fibroblast cells were infected with HCMV/pp28-luc, luciferase activity was observed at 2 days after infection and reached maximum at 6 days after infection, whereas the production of infectious virus was maximal at 4 days after infection. The antiviral activities of ganciclovir, acyclovir, and papaverine were measured in HFF cells infected with HCMV/PP28-luc and the luciferase activity was compared with the infectious virus titers. Luciferase activity decreased as the concentration of ganciclovir or papaverine increased, while there was a slight decrease in luciferase activity with acyclovir. The level of the decrease in Luciferase activity was comparable to the level of decrease in the production of infectious virus. Therefore, the antiviral assay using recombinant virus HCMV/pp28-luc resulted in sensitivity similar to the conventional plaque assay with a significant reduction in assay time.

• Integrative Medicine Research
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• 제3권1호
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• pp.25-33
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• 2014

Background: Green tea contains numerous polyphenols, which have health-promoting effects. The purpose of this study was to evaluate the effect of tannase-converted green tea extract (TGE) formulation on the physical stability and activities of skin-related enzymes. Methods: Physical stability was evaluated by measuring the pH, precipitation, and colors at $25{\pm}2^{\circ}C$ /ambient humidity and at $40{\pm}2^{\circ}C$ \70%${\pm}$5% relative humidity for 4 months. Activities of collagenase, elastase, and tyrosinase as skin-related enzymes were assessed on TGE formulation. Results: The concentrations of epigallocatechin-3-gallate and epicatechin-3-gallate in green tea extract were greatly decreased to the extent of negligible level when treated with tannase. The formulation containing 5% tannase-converted green tea extract showed relatively stable pH, precipitation, and color features for 16 weeks. When TGE was added to the formulation, there was a significant increase in the inhibition of elastase and tyrosinase activities (p<0.05) compared with the formulation containing 5% normal green tea extract. Conclusion: The TGE could be used in cosmetics as skin antiwrinkling or depigmenting agent.

• 한국미생물·생명공학회지
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• 제49권2호
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• pp.167-173
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• 2021

Reactive oxygen species (ROS) disrupt the cellular redox balance, exert cytotoxic effects, and consequently promote the development of various diseases in humans. Previous studies have reported that antioxidants counteract the adverse effects of ROS. Several studies examine the whitening effects of various agents based on their ability to inhibit tyrosinase activity. Tyrosinase is a critical enzyme involved in the synthesis of melanin, which protects the skin against radiation. Various agents exhibiting antioxidant and tyrosinase inhibitory activities have been synthesized. However, these synthetic drugs are associated with toxicity, decreased safety, and poor skin penetration in vivo, which has limited the clinical application of synthetic drugs. This study examined the antioxidant and tyrosinase inhibitory activities of some microalgae. The methanol, dichloromethane, and ethyl acetate extracts of four microalgal species (Tetraselmis tetrathele, Dunaliella tertiolecta, Platymonas sp., and Chaetoceros simplex) were prepared. The physiological and whitening effects of microalgal extracts were investigated by measuring the antioxidant and tyrosinase inhibitory activities. The ethyl acetate extract of D. tertiolecta exhibited the highest antioxidant and tyrosinase inhibitory activities. Future studies must focus on examining the whitening effects of microalgae on cell lines to facilitate the development of microalga-based therapeutics for skin diseases, functional health foods, and whitening agents. Thus, microalgae have potential applications in the pharmaceutical, food, and cosmetic industries.

• 대한건축학회연합논문집
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• 제8권4호
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• pp.123-130
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• 2006

This paper discusses issues faced by individual building industry clients. These form the majority of clients but, because they do not possess high purchasing power, they attract less attention in the industry. Given that key decisions on project definition and procurement strategy are made at the pre-project stage, the industry would benefit from knowing relevant aspects of its clients' attitudes and behaviors, so that it can support them. There is a lack of research on this subject, and so we first describe a theoretical framework and research methodology that were developed for this specific group of clients. Theory adopted from consumer behavioral research was introduced to develop a general behavioral model of individual clients. In this model, individual clients are assumed to seek and then process information after acknowledging normative activities. To validate our model, a field survey was conducted using randomly selected individual clients. Their opinions on the importance and difficulty of 12 normative activities were analysed to establish a general attitude. Information seeking behaviour was investigated by measuring the frequency and type of source that they contacted to conduct the normative activities. The attitudes and information seeking behaviour presented in this research will contribute to the development of project tools for supporting these clients.

• The Journal of Korean Physical Therapy
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• 제36권2호
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• pp.53-60
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• 2024

Purpose: This study aimed to investigate changes in upper extremity joints and leisure satisfaction in children with brain lesions through sports stacking activities. Methods: A sports stacking program was conducted on three children with brain lesions who had upper extremity joint limitations and joint range of motion lower than the normal range. It was conducted 10 times, 1 to 2 times a week, 40 minutes each time. Upper extremity joint angles were measured using a goniometer in the order of shoulder, elbow, wrist, and fingers, and leisure satisfaction was measured using a smile evaluation. Results: As a result of measuring the upper extremity joint angles, all three children showed slight angle changes in the shoulder, elbow, and wrist areas. Differences in joint angles appeared differently for each child. Smile evaluation results were evaluated in various psychological, educational, and physical aspects. Only child A was evaluated for Smile Evaluation No. 1. Conclusion: Sports stacking activities changed the upper extremity function of children with brain lesion disorders and showed differences in psychological, physical, and educational aspects of leisure satisfaction. As this is a short-term study result, the change in upper extremity function is minimal, but if sports stacking activities are continued, it will be a rehabilitation program that can prevent upper extremity dysfunction and improve physical strength. Accordingly, continuous attention should be paid to increasing accessibility and enjoyment of daily life according to individual characteristics and level.

• 한국환경교육학회지:환경교육
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• 제19권2호
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• pp.96-107
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• 2006

Inquiry has great value in environmental education(EE). Being able to see the world environmentally through 'inquiry-based environmental education' can be an important value and goal of EE. In this study, we intended to develop an EE program of measuring activity of dissolved oxygen(DO), based on the theory of 'inquiry-based EE'. Especially, we recognized the potential that DO meter can be used in 'inquiry-based EE', and we tried to develop a model of inquiry-based EE using DO meter. As a result of this research, we present specific models of inquiry-based EE about how to perform measuring activity of DO and how to use the DO meter in laboratories and streams from the perspective of inquiry of water environment. In the process of program development, we considered organization of the inquiry process, use of concept and knowledge, scientific inquiry and insightful inquiry, integration, sustain-ability, content components of 'Environmental Studies for EE', developmental level and in-forest of students. The developed EE model is a scientific inquiry model, pursuing 'explanation' based on data collection. Through this model, we tried to make students see water environment more deeply. The developed program can be applied to various water environments, like laboratories, streams, ponds, etc. It can be more effective inquiry activity if we perform measuring activities simultaneously with PH, electrical conductivity, and turbidity meters.

• 대한수학교육학회지:학교수학
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• 제17권3호
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• pp.447-467
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• 2015

본 연구의 목적은 도(degree)와 라디안을 호의 측도로 해석하는 것이 라디안과 각의 측정에 대한 개념적 이해에 어떠한 영향을 미치는지 살펴보는 것이다. 이에 호의 길이를 이용한 각의 측도에 대한 내용지식을 26명의 예비중등교사를 대상으로 조사하였으며, 그 결과를 반영하여 두 명의 중학생들을 대상으로 실험을 진행하였다. 예비교사들과 두 중학생의 반응을 분석한 결과, 도(degree)의 개념을 호의 측도로 해석한 경험이 라디안의 이해에 긍정적인 영향을 미쳤으며, 호의 측도로 각의 측도를 파악하는 과정이 '선형 측정'에 대한 개념적 이해를 가능하게 하였다. 또한 각에 관한 다양한 문제에서 원의 맥락과 호의 등분 전략이 효과적인 문제해결전략으로 작용하였으며, 각과 호의 측도 사이의 관계를 탐구할 수 있는 직접적인 조작활동을 제공하는 것이 각의 측정 개념에 대한 이해에 도움을 줄 수 있다는 것을 확인하였다.

• 전기학회논문지
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• 제67권12호
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• pp.1690-1698
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• 2018

Recent advances in ICT technology have transformed many of our daily lives and attracted a lot of attention to personal health. Heart beat measurement that reflects cardiac activities has been used in various fields such as exercise evaluation and psychological state evaluation for a long time, but its utilization method is limited due to its differentiation from clinical electrocardiogram. Therefore, in this study, we could observe the change of the measured signal according to the change of the distance and the position of the measuring electrodes which are non-standard electrode configuration. Based on the electric dipole model of the heart, correlation with clinical electrocardiogram could be confirmed by synthesizing multiple surface potentials measured with a shorter electrode distance than standard one. From the electromagnetic point of view, the distance between the measuring electrodes corresponds to the distance that the electric potential by the cardiac electric dipole moves, and the electric potential measured at the body surface is proportional to the moving distance of the electric potential. Therefore, it is preferable to make the distance between electrodes as long as possible, and to position the measuring electrode close to the ventricle rather than the atrium. In addition, it was found that standard electrocardiographic waveforms could be synthesized by using arithmetic sum of multiple measuring electrodes due to the relationship of electrical dipole vectors, which is obtained by dividing and positioning a plurality of measuring electrodes on a reference electrode line, such as Lead-I, Lead-II direction. Also, we obtained a significant Pearson correlation coefficient ($r=0.9113{\pm}0.0169$) as a result of synthetic experiments on four subjects.

• 대한인간공학회지
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• 제35권4호
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• pp.225-235
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• 2016

Objective: The aim of this study is to model all levels of situation awareness (SA), which would be able to predict situation awareness quantitatively. Background: When measuring situation awareness, directly measuring SA methods such as SAGAT and SART have been utilized. Several approaches (cognitive modeling approaches) were introduced to model SA but level 3 SA was not completed. For real-life situation, however, it is necessary to detect the problematic level of SA rather than overall SA. Therefore, we proposed a new model of all levels of SA in this study. Method: In order to model all levels of SA, this study chose factors in ACT-R architecture through literature review. ATC (Air Traffic Control)-related simulation task was video-taped to analyze human behaviors in order to model all levels of SA including level 3. Results: As a result, regression analyses show that cognitive activities (neural activations) represented for all levels of SA were highly correlated with SAGAT. Conclusion: In conclusion, neural activations in ACT-R could be proved to be effective to model all levels of SA. Application: Our SA model could be used to predict all levels of SA quantitatively without directly measuring the SA of operators.