• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6087-6094
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• 2014

Purpose: The aim of the present study was to invesitigate the impact of significant clinico-pathological prognostic factors on survival rates and to identify factors predictive of poor outcome in patients with ovarian carcinoma. Materials and Methods: A retrospective chart review of 74 women with pathologically proven ovarian carcinoma who were treated between January 2006 and April 2011 was performed. Patients were investigated with respect to survival to find the possible effects of age, gravida, parity, menstruel condition, pre-operative Ca-125, treatment period, cytologic washings, presence of ascites, tumor histology, stage and grade, maximal tumor diameter, adjuvan chemotherapy and cytoreductive success. Also 55 ovarian carcinoma patients were investigated with respect to prognostic factors for early 2-year survival. Results: The two-year survival rate was 69% and the 5-year survival rate was 25.5% for the whole study population. Significant factors for 2-year survival were preoperative CA-125 level, malignant cytology and FIGO clinical stage. Significant factors for 5-year survival were age, preoperative CA-125 level, residual tumor, lymph node metastases, histologic type of tumor, malignant cytology and FIGO clinical stage. Logistic regression revealed that independent prognostic factors of 5-year survival were patient age, lymph node metastasis and malignant cytology. Conclusions: We consider quality registries with prospectively collected data to be one important tool in monitoring treatment effects in population-based cancer research.

• 대한핵의학회지
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• 제19권2호
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• pp.69-79
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• 1985

To evaluate the effect of dopaminergic activity on aldosterone secretion, the plasma renin activity, serum cortisol and aldosterone were measured by radioimmunoassay in 6 normal controls and 12 patients who had hyponatremia and generalized edema or ascites with possible condition with secondary aldosteronism before and after(15, 30, and 60 min) 15 mg of metoclopramide by iv bolus injection and same method with 500 mg of L-dopa by per oral in 6 normal controls and 12 patients with edema ascites. The result were as follows; 1) The basal level of PRA was higher in patients rather than normal controls but PRA was not influenced by MC or L-dopa administration on both normal controls and patients group. 2) The serum cortisol level was significantly elevated at 30 min after MC injection compared with basal level in normal controls but no significant change was noted in patients group. After L-dopa administration the serum cortisol level was not changed in both normal controls and patients group. 3) The serum aldosterone level was significantly elevated in 15, 30 and 60 min after MC injection in normal controls, and there also same tendency of aldosterone secretion was noticed in patients group. On the other hands, there was no changes in aldosterone level in both normal controls and patients group with L-dopa administration. Above result means that MC stimulate aldosterone secretion by dopaminergic antagonist and aldosterone secretion in normal subject is controlled by maximal tonic dopaminergic inhibition. In edematous patients, however, both of the dopaminergic inhibitory and stimulating effect of PRA, ACTH etc on the aldosterone secretion seems to be variable.

• 복식문화연구
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• 제21권4호
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• pp.606-611
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• 2013

It has been reported that tight sportswear could have complicated influence on physiological function of human body. The purpose of this present study was to investigate the effect of wearing gradient compression tights (GCT) on muscle strength and EMG activity during repeated isokinetic muscle contractions. Four healthy male undergraduate students performed maximal voluntary isokinetic concentric muscle contractions on biomechanical test and training systems with GCT and loose pants as control (Cont) respectively. During each test, the peak torque of extensor and flexor contractions and the surface electromyography (sEMG) of the rectus femoris and medial gastrocnemius was recorded simultaneously, the peak torque was recorded as an indicator of muscle strength, and the average amplitude and mean power frequency of sEMG were calculated as indicators of EMG activity. The results showed that: the peak torque decreased gradually during continuous muscle contractions both when the Cont and GCT were worn, average sEMG and mean power frequency declined along with the repetitions of muscle contractions for both wearing conditions, and the change tendency was consistence with that of peak torque. There was no obvious difference between the peak torque recorded wearing the Cont or wearing GCT, but when GCT were worn, average sEMG was lower and mean power frequency was higher than the Cont condition. In 24 samples obtained from four subjects, 80% of results showed the same trend. So we could make a conclusion that wearing GCT had no obvious effect on the improvement of muscle strength, but it would affect the EMG activity positivly.

• 한국멀티미디어학회논문지
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• 제15권8호
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• pp.1031-1037
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• 2012

본 논문에서는 이기종 시스템이 동일 주파수 대역을 공유하는 경우의 상호 공존성 분석을 위한 파라미터로 단말간 이격거리에 따른 간섭 확률과 간섭 송신기의 최대출력이 제안되었다. 각각의 시스템들간의 간섭영향을 분석하기 위해, 두 경우를 고려하였다. 첫째로, 간섭 송신기에 WiBro, 희생 수신기이 WLAN인 경우와 두 번째로 간섭 송신기에 WLAN, 희생 수신기가 WiBro인 경우이다. 간섭 송신기가 WiBro, 또는 WLAN인 경우 그의 출력 전력 레벨을 각각 25dBm과 23dBm 으로 설정하여 이격거리에 따른 간섭확률을 분석하였다. 분석된 다양한 공유시나리오에서의 상호 공존 결과는 향후 동일 주파수 환경에서 다양한 통신 프로토콜을 이용하는 무선기기에 대한 상호 공존 조건을 마련하는 기술개발에 활용할 수 있을 것이다.

• 미생물학회지
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• 제48권1호
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• pp.48-51
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• 2012

세포외 단백질분해효소를 생산하는 신종세균 Chryseobacterium sp. JK1은 토양으로부터 분리되었다. JK1 균주는 $30-35^{\circ}C$에서 skim milk를 첨가한 고체배지상에서 가장 큰 투명환을 보여주었다. 액체배지에서 JK1 균주의 세포생육은 24시간에 최대이었고, 세포외 단백질분해효소의 최대활성은 정지기인 22시간에 560 unit/ml에 도달하였다. Nutrient 배지에 maltose 혹은 glucose, mannitol을 첨가하면 생육이 향상되었지만, 단백질 분해효소 생산은 64-77%로 저조하였다. Skim milk 혹은 beef extract, yeast extract, malt extract, tryptone의 첨가는 향상된 생육과 줄어든 효소생산을 보인 반면, $(NH_4)_2HPO_4$ 또는 $(NH_4)_2SO_4$의 첨가는 저조한 생육과 121-146%의 향상된 효소생산을 보여 주었다.

• 미생물학회지
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• 제45권1호
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• pp.69-73
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• 2009

단백질 분해효소는 아미노산 간에 존재하는 공유결합인 펩티드 결합을 절단하는 효소이며, 세계적으로 가장 많이 판매되는 효소이다. 해양 심층수로부터 분리된 Micrococcus sp. HJ19의 체외분비 단백질 분해효소를 생산하는 최적의 배지조건을 조사하기 위하여 기본배지로 변형 STY 배지(1% tryptone, 0.15% yeast extract, 0.01% NaCl, 여과살균한 바닷물)를 사용하였다. 탄소원으로 포도당보다 갈락토오스를 사용하였을 때 1.3배로 높은 활성을 보여주었으며, 질소원으로는 casamino acid를 사용하였을 때 가장 낮은 활성을 보여준 반면, 맥아추출물을 사용하였을 때 가장 높은 활성을 나타내었다. 생산된 체외단백질 분해효소는 $35^{\circ}C$에서 최적의 활성을 나타내었으며, 최적 pH는 8.5로 판명되었다.

• 한국자동차공학회논문집
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• 제20권5호
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• pp.26-35
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• 2012

This paper investigates the influence on the aerodynamic performance of a passenger cruising very fast by some specific car body parts such as side mirrors, wheel arches and wheels designed hardly regarding aerodynamics. The magnitude of the contribution of each part is analyzed via on the CFD simulations. YF SONATA, a sedan of Hyundai Motors Company, plays a major role as the baseline car in this research, representing all passenger car. The CFD analysis condition consists of 6 different cases depending on whether each part exists or not. According to the CFD results, there were confirmed that additionally to the body parts' own drag, the car body went through somewhat the consequential increment of the drag by them. Among the 3 parts, wheel is the magnate that not only has the maximal drag but drives the drag of the passenger car to increase most steeply and the next is the side mirror.

• 대한물리의학회지
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• 제10권4호
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• pp.113-121
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• 2015

PURPOSE: The purpose of this study was to determine the effect of shoulder external rotation on muscle activities of the scapular upward rotators during arm elevation. METHODS: Nineteen healthy subjects with no medical history of shoulder pain or upper extremity disorders were recruited for this study. Electromyography (EMG) was used to measure the muscle activities of the serratus anterior (SA), upper trapezius (UP), lower trapezius (LT) and infraspinatus (IS) muscles during arm elevation. The EMG activities were recorded while the subjects performed $90^{\circ}$ arm elevation with three different arm positions; palm down (PD), neutral position (NP), and palm up (PU). While seated in a chair, the subject was asked to raise the upper extremity in the sagittal plane in random order. Subjects performed $90^{\circ}$ arm elevations in three trials at each arm position. The mean EMG activity normalized by the maximal voluntary isometric contraction was analyzed across three arm positions. Repeated measures one-way ANOVA and the post hoc Bonferroni tests were used to determine the differences in muscle activities among the three arm positions. RESULTS: The EMG activities of the SA and IS were significantly greater in the PU condition than in the other conditions during arm elevation. No significant difference was noted between the NP and PD conditions during arm elevation. CONCLUSION: These results suggest that shoulder external rotation (palm up position) can be used to activate the SA. Therefore, we recommend a scapular protraction exercise in the palm up position for strengthening the SA.

• 한국식품과학회지
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• 제23권2호
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• pp.167-174
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• 1991

토양으로부터 생물고분자의 생산균주로 분리한 알칼리 내성 Bacillus sp.의 생물고분자 생산을 위한 최적 배양조건을 검토하였고, 반응 표면분석법에 의한 생산 최적화를 수행하였다. 최대의 생물고분자 생산은 soluble starch 8%, yeast extract 0.75%, $NaNO_3$ 0.1%, $MgSO_4\;7H_2O$ 0.05% 및 $Na_2CO_3$ 1%(pH 10)의 조성배지에서 배양온도 $30^{\circ}C$로 36시간 이상 진탕배양하였을 때 얻어졌으며, 이때의 생물고분자 생산량은 약 44g/l(대당수율로는 약 55%)이었다. C/N비, 온도 및 pH를 독립변수로 한 반응 표면분석에 의한 생물고분자 생산의 최적조건은 C/N비 15.16, 배양온도 $34.62^{\circ}C$ 및 pH 9.50의 정상점에서 얻어졌으며, 이 조건에서 생물고분자의 생산량은 66.84g/l로 추정 되었다.

• Applied Biological Chemistry
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• 제40권3호
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• pp.184-188
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• 1997

Inulin을 가수분해하여 di-D-fructofuranose dianhydride(DFA)를 생성하는 inulin frucroransferase를 분비하는 균주를 토양으로부터 분리하였으며, Bacillus sp로 동정하였다. 본 효소에 의하여 생성되는 DFA는 TLC 와 HPLC로 분석한 결과, fructose 두 분자가 ${\beta}\;1,2':{\alpha}2,3'$ 결합을 한 DFA III로 동정되었다. 본 균주는 탄소원으로 1.5% 돼지감자즙, 유기 질소원으로 1.0% peptone, 무기 질소원으로 $0.27%\;NH_4H_2PO_4$를 사용했을 떼 효소 생산이 2.709 units/ml로 최대였으며, inulin을 탄소원으로 사용할 경우는 1.0% yeast extract, $0.2%\;NaNO_3$를 첨가했을 때 효소 생산이 2.245units/ml로 최대를 나타내었다. 본 균주를 최적 액체 배지에서 72시간 배양한 결과 배양 45시간에 2.61 units/ml 최대 활성을 보였다.