• Journal of Life Science
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• v.31 no.8
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• pp.736-744
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• 2021

Artemisia princeps Pampanini is an herbal medicine widely used to immune function-related diseases, such as anti-oxidative, anti-inflammatory, and antibacterial agents. In this study, we investigated the anti-inflammatory effects of AP extract and underlying mechanisms were evaluated in RAW 264.7 cells. The effects of AP extract were also studied in a complete Freund's adjuvant (CFA)-induced arthritis and lipopolysaccharide (LPS)-induced inflammation mouse model. In RAW 264.7 cells, AP extracts significantly inhibited the LPS-induced nitric oxide (NO) production and inducible NO synthase and cyclooxygenase-2 protein expression. The LPS-induced phosphorylation of mitogen-activated protein kinases and nuclear factor-κB was also significantly blocked by AP extract in RAW 264.7 cells. Oral administration of AP extract suppressed the increase in mouse paw edema and spleen index compared to CFA-treated mice group. Histologically, the infiltration of inflammatory cells was increased in cartilage and synovium in the CFA-treated mouse group, whereas it was suppressed in the AP extract-administered group. Furthermore, AP extract treatment significantly reduced the inflammatory cytokine, tumor necrosis factor-α, levels in CFA and LPS-treated mouse. In conclusion, the anti-inflammatory and anti-arthritis effect of AP extract was confirmed in both in vitro and in vivo models, suggesting that Artemisia princeps Pampanini may be a candidate material for arthritis treatment.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.29 no.1
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• pp.157-165
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• 2011

This study is to be used as a fundamental material of rural amenity resources researches, such as excavating, establishing and modifying national agricultural landscape resources, so as to efficiently manage them. It is carried out with targeting traditional Darangyi-Rice terrace which has design factors of agricultural landscape resources. We have set up the standard range with practicable similar standard(Marginal Farmland and Less Favored Areas and etc), those of Japan, and the results of analyzing the characteristics of Darangyi-Rice terrace already known. As a result of the field investigation, it has been revealed that a great deal of Darangyi-Rice terrace are being used for not corresponding purposes, or damaged and disappeared. For preserving and well-managing Darangyi-Rice terrace as a rural landscape resource which has rural design factors, it should be advanced detailed and accurate studies on present conditions and changes of Darangyi-Rice terrace, with researches on significances, values, utilities and economical efficiency of Darangyi-Rice terrace by regions. In addition, we utilized various spatial imagery data in the researching process. Consequently, it is concluded that if high resolution imagery data is used, it can establish rather minute and accurate large-scale DB, and monitor elaborate changes as well. It is therefore thought that its application can be higher as actualizing DB hereafter.

• (The) Korean Journal of Educational Psychology
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• v.22 no.2
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• pp.461-478
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• 2008

This study attempted to test whether or not students' collaborative argumentation and explanation activity while using concept mapping did improve understanding on texts. Total of 52 college students participated in this study. They were randomly assigned to one of four experimental conditions. The experiment lasted for two or three weeks and students were tested on comprehension level of a text material that they have studied over the period. As a result, with two independent factors of explanation and collaboration, there was a significant interaction effect without main effects. That is, individual did better when they did have to explain what they were doing. However, this is not the case when students collaborate. Students in the paired condition, they did better when they do not have to explain what they were doing with concept maps. This study showed efficiency with using computerized software does not always guarantee higher understanding on text materials. Instructional contexts and variables, collaboration and explanation, needs to be considered. Collaborating with others and explaining their own learning processes should be carefully designed when they are combined with concept mapping contexts. How to minimize learning obstacles from discussing ideas with others are a critical issue for future research.

• Korean Journal of Metals and Materials
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• v.49 no.8
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• pp.628-634
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• 2011

SA508 Gr.4N Ni-Cr-Mo low alloy steel, in which Ni and Cr contents are higher than in commercial SA508 Gr.3 Mn-Mo-Ni low alloy steels, may be a candidate reactor pressure vessel (RPV) material with higher strength and toughness from its tempered martensitic microstructure. The inner surface of the RPV is weld-cladded with stainless steels to prevent corrosion. The goal of this study is to evaluate the microstructural properties of the clad interface between Ni-Cr-Mo low alloy steel and stainless weldment, and the effects of post weld heat treatment (PWHT) on the properties. The properties of the clad interface were compared with those of commercial Mn-Mo-Ni low alloy steel. Multi-layer welding of model alloys with ER308L and ER309L stainless steel by the SAW method was performed, and then PWHT was conducted at $610^{\circ}C$ for 30 h. The microstructural changes of the clad interface were analyzed using OM, SEM and TEM, and micro-Vickers hardness tests were performed. Before PWHT, the heat affected zone (HAZ) showed higher hardness than base and weld metals due to formation of martensite after welding in both steels. In addition, the hardness of the HAZ in Ni-Cr-Mo low alloy steel was higher than that in Mn-Mo-Ni low alloy steel due to a comparatively high martensite fraction. The hardness of the HAZ decreased after PWHT in both steels, but the dark region was formed near the fusion line in which the hardness was locally high. In the case of Mn-Mo-Ni low alloy steel, formation of fine Cr-carbides in the weld region near the fusion line by diffusion of C from the base metal resulted in locally high hardness in the dark region. However, the precipitates of the region in the Ni-Cr-Mo low alloy steel were similar to that in the base metal, and the hardness in the region was not greatly different from that in the base metal.

• The Journal of the Korea Contents Association
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• v.21 no.6
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• pp.104-112
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• 2021

In this study, emotional analysis was conducted based on the basic attribute data of music and the emotional model in psychology, and the result was applied to the visualization rules in the formative arts. In the existing studies using musical parameter, there were many cases with more practical purposes to classify, search, and recommend music for people. In this study, the focus was on enabling sound data to be used as a material for creating artworks and used for aesthetic expression. In order to study the music visualization as an art form, a method that can include human emotions should be designed, which is the characteristics of the arts itself. Therefore, a well-structured basic classification of musical attributes and a classification system on emotions were provided. Also, through the shape, color, and animation of the visual elements, the visualization of the musical elements was performed by reflecting the subdivided input parameters based on emotions. This study can be used as basic data for artists who explore a field of music visualization, and the analysis method and work results for matching emotion-based music components and visualizations will be the basis for automated visualization by artificial intelligence in the future.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.2
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• pp.802-809
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• 2021

To cope with the increasing maintenance costs due to aging, the maintenance cost was evaluated from the perspective of asset management. The maintenance cost can be predicted based on the condition of the bridge, and the life cycle cost is used as an index. In general, the condition of a bridge has a wide distribution characteristic depending on the deterioration, load, and material characteristics. In this paper, to evaluate the effect of the bridge conditions on the life cycle cost, condition prediction models were constructed considering the service life, deterioration rate, and inspection error, which are the main variables of the bridge condition and life cycle cost calculation. In addition, condition prediction models were constructed based on the distribution of the health index to estimate the upper and lower bounds of the life cycle costs that can occur in individual bridges. Life cycle cost analysis showed that the life cycle cost differed significantly according to the condition of the bridge. Accordingly, research will be needed to increase the reliability of predicting the life cycle cost of individual bridges.

• Journal of Food Hygiene and Safety
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• v.36 no.1
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• pp.77-85
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• 2021

Glucosylceramides (GluCer) are known to play an important role in both water retention and epidermal permeability barrier function in the mammalian stratum corneum. In this study, we investigated the effects of pineapple fruit extract containing glucosylceramides (PFEG) on the maintenance and recovery of skin barrier function using atopic dermatitis-induced animal models. Five-week-old male Hos:HR-1 mice were divided into four groups fed on standard diet, unsaturated fatty acids-deficient (HR-AD) diet, and HR-AD diet supplemented with 0.01% or 0.1% pineapple-GluCer. Skin barrier function was evaluated by transepidermal water loss (TEWL), dermal moisture content, moisture content of the stratum corneum and wrinkle formation. The control group (HR-AD administration group) showed increased transepidermal water loss (TEWL), while the epidermal moisture content and the moisture content of the stratum corneum slowly decreased. However, in the PFEG groups (with 0.1% or 0.01% glucosylceramide), the TEWL levels were significantly reduced at 2 weeks. The PFEG also helped maintain skin moisturizing function by significantly suppressing the decrease of the epidermal moisture content and the moisture content of the stratum corneum. These results show that the PFEG is effective for maintaining and improving the function of the skin barrier. Therefore, this study suggests that PFEG is a potential candidate material for skin functional foods.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.34 no.1
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• pp.43-50
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• 2021

A Leg Mating Unit (LMU) is a device utilized during the float-over installation of offshore structures that include hyperelastic pads and mating part. The hyperelastic pads absorb the loads, whereas the mating part works as guidance between topside and supporting structures during the mating sequence of float-over installation. In this study, the design optimization of an LMU for the float-over installation of floating-type offshore structures is conducted to enhance the performance and to satisfy the requirements defined by classification society regulations. The initial dimensions of the LMU are referred to the dimensions of those used in fixed-type float-over installation because only the location and the number of LMUs are known. The two-parameter Mooney-Rivlin model is adopted to describe the hyperelastic pads under given material parameters. Geometric variables, such as the thickness, height, and width of members, as well as configuration variables, such as the angle and number of members, are defined as design variables and are parameterized. A sampling-based design sensitivity analysis based on latin hypercube sampling method is performed to filter the important design variables. The design optimization problem is formulated to minimize the total mass of the LMU under maximum von Mises stress and reaction force constraints.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.4
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• pp.349-360
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• 2020

Bio-conversion manufacturing technology has been developed to produce ginsenoside Rd which is increasingly in demand as a cosmetic material due to various possibilities related to improving skin function. In order to convert ginsenoside Rb1 which is contained in red ginseng saponin (RGS) into Rd, several commercial enzymes were tested. Viscoflow MG was found to be the most efficient. In order to optimize the conversion of RGS to ginsenoside Rd by enzymatic transition was carried out using response surface methodology (RSM) based on Box-Behnken design (BBD). The main independent variables were RGS concentration, enzyme concentration, and reaction time. Conversion of ginsenoside Rd was performed under 17 conditions selected according to BBD model and optimization conditions were analyzed. The concentration of the converted ginsenoside Rd ranged from 0.3113 g/L to 0.5277 g/L, and the highest production volume was obtained under condition of reacting 2% RGS and 1.25% enzyme for 13.5 hours. Consequently, RGS concentration, enzyme concentration which is 0.05 less than p-value and among the interactions between the independent variables, the interaction between enzyme concentration and reaction time was confirmed to be the most influential.

• Composites Research
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• v.35 no.5
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• pp.303-308
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• 2022

PIC (Piecewise Integrated Composite) is a new concept for designing a composite structure with mosaically assigning various types of stacking sequences in order to improve mechanical properties of laminated composites. Also, machine learning is a sub-category of artificial intelligence, that refers to the process by which computers develop the ability to continuously learn from and make predictions based on data, then make adjustments without further programming. In the present study, the tapered box beam type PIC robot arm for carrying and transferring wide and thin LCD display was designed based on the machine learning in order to increase structural stiffness. Essential training data were collected from the reference elements, which were intentionally designated elements among finite element models, during preliminary FE analysis. Additionally, triaxiality values for each finite element were obtained for judging the dominant external loading type, such as tensile, compressive or shear. Training and evaluating machine learning model were conducted using the training data and loading types of elements were predicted in case the level accuracy was fulfilled. Three types of stacking sequences, which were to be known as robust toward specific loading types, were mosaically assigned to the PIC robot arm. Henceforth, the bending type FE analysis was carried out and its result claimed that the PIC robot arm showed increased stiffness compared to conventional uni-stacking sequence type composite robot arm.