• Journal of Microbiology and Biotechnology
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• 제27권2호
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• pp.234-241
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• 2017

Potato peels (PP) contain several bioactive compounds. These compounds are known to provide human health benefits, including antioxidant and antimicrobial properties. In addition, these compounds could have effects on human enteric viruses that have not yet been reported. The objective of the present study was to evaluate the phenolic composition, antioxidant properties in the acidified ethanol extract (AEE) and water extract of PP, and the antiviral effects on the inhibition of Av-05 and MS2 bacteriophages, which were used as human enteric viral surrogates. The AEE showed the highest phenolic content and antioxidant activity. Chlorogenic and caffeic acids were the major phenolic acids. In vitro analysis indicated that PP had a strong antioxidant activity. A 3 h incubation with AEE at a concentration of 5 mg/ml was needed to reduce the PFU/ml (plaque-forming unit per unit volume) of Av-05 and MS2 by 2.8 and $3.9log_{10}$, respectively, in a dose-dependent manner. Our data suggest that PP has potential to be a source of natural antioxidants against enteric viruses.

• 인터넷정보학회논문지
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• 제16권3호
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• pp.43-57
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• 2015

본 논문에서는 개념망을 이용한 효율적인 정보검색을 위한 방법을 제안한다. 본 논문은 일반적인 개념망을 기반으로 시스템을 설계하였기 때문에 온톨로지와 접근 방식은 같지만 사용자가 보다 효율적으로 정보검색을 하고자 하는 객체와 개념사이의 협업 관계를 구축하여 사용할 수 있도록 개념망을 제안한다. 제안한 시스템은 다음과 같다. 첫 번째, 입력 키워드 중심의 키워드 개념망과 전문가 그룹이 추천한 전문가 개념망 그리고 테마 개념망 이러한 세 종류의 개념을 이용하여 협업적 검색을 하며, 이를 기반으로 사용자가 원하는 정보를 검색할 수 있는 효율적인 검색 시스템을 제안한다. 그리고 전문가 개념과 키워드 개념이 결합되어 키워드의 빈도 및 카테고리의 빈도를 제공함으로써, 사용자가 입력한 검색어와 관련된 키워드를 추천하는 역할을 할 수 있다. 그리고 테마 개념망을 이용하여 사용자의 관심 테마에서 사용되는 키워드 또는 카테고리를 알려주는 기능도 제공한다. 두 번째, 사용자가 입력한 키워드가 없을 경우 2차 검색을 통해 입력 키워드와 관련 있는 키워드를 제공해줌으로써 관련키워드를 이용하여 검색의 목적달성이 가능하다. 세 번째, 이러한 정보들은 대부분 분산되어 관리되고 있기 때문에 이렇게 분산되어 관리되는 정보는 표현방식이 다를 뿐만 아니라 시간에 따라 정보가 변하게 된다. 따라서 분산된 정보의 효율적 데이터 접근 및 통합을 위해 XMDR(eXtended Mata-Data Registry)을 이용하였고, 본 논문에서는 분산된 데이터를 통합하기 위한 기법 및 검색 시스템을 제시한다.

• Journal of Preventive Medicine and Public Health
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• 제32권2호
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• pp.113-122
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• 1999

Objectives: The purpose of this study was to describe the trends of original research in the Korean Journal of Preventive Medicine, and to evaluate the quality of original articles about lead poisoning. Method: The data for the analysis of trends in preventive medicine research was taker from a total of 829 original articles published in the Korean Journal of Preventive Medicine from 1968 to 1997, The qualitative meta-analysis was measured against a checklist of evaluation criteria, which were divided into 10 categories, with 46 articles on lead poisoning. The evaluation process was performed independently by two evaluators, Results: The number of articles per 100 members over the study period increased by almost 4 pieces in the early 1980s, and by more than 9 pieces in the mid-1990s. In the major classifications of subjects, environmental and industrial health, epidemiology and health statistics, and health policy and management published 370 pieces (44.0%), 137 pisces (16.5%), 322 pieces (38.9%) respectively. In the order of the number of articles, five themes about health significance, including metal exposure (73 pieces), diseases associated with exposure to organic solvents (45 pieces), air pollution (36 pieces), maternal and child health (32 pieces), and occupational health (3D pieces) received consistent attention throughout the years $1968\sim1997$. The overall mean score of article qualify about lead poisoning was 37.8 out of 50. Of the articles any information on the purpose and hypothesis described well, Of those the originality of the subjects, the form of article's (including tables and figures), and the number of inappropriate words of abstracts showed very low score. For multiple regression analyses, the number of joint research institutes and the acceptance of research grants about the article quality were statistically significant. Conclusions: The number of original research reports in the Korean J Prev Med has recently increased and their subjects bave diversified. Of the basis of this study, the articles need improvement in the areas of abstracts, tables and illustrations (figures), etc. The Korean Society for Preventive Medicine will revise contribution regulations for manuscripts submitted to the Korean J Prev Med. Future studies should address these issues and perform the quantitative mata-analysis about the specific subjects including the quality of articles.

• Nutrition Research and Practice
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• 제15권sup1호
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• pp.32-40
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• 2021

BACKGROUND/OBJECTIVES: Considering the high number of deaths from coronavirus disease 2019 (COVID-19) in Latin American countries, together with multiple factors that increase the prevalence of vitamin D deficiency, we aimed to determine 25-hydroxyvitamin D (25[OH]D) levels and its association with mortality in patients with critical COVID-19. SUBJECTS/METHODS: This was a prospective observational study including adult patients with critical COVID-19. Data, including clinical characteristics and 25(OH)D levels measured at the time of intensive care unit admission, were collected. All patients were followed until hospital discharge or in-hospital death. The patients were divided into those surviving and deceased patient groups, and univariate and multivariate logistic regression analyses were performed to determine independent predictors of in hospital mortality. RESULTS: The entire cohort comprised 94 patients with critical COVID-19 (males, 59.6%; median age, 61.5 years). The median 25(OH)D level was 12.7 ng/mL, and 15 (16%) and 79 (84%) patients had vitamin D insufficiency and vitamin D deficiency, respectively. The median serum 25(OH)D level was significantly lower in deceased patients compared with surviving (12.1 vs. 18.7 ng/mL, P < 0.001). Vitamin D deficiency was present in 100% of the deceased patients. Multivariate logistic regression analysis revealed that age, body mass index, other risk factors, and 25(OH)D level were independent predictors of mortality. CONCLUSIONS: Vitamin D deficiency was present in 84% of critical COVID-19 patients. Serum 25(OH)D was independently associated with mortality in critical patients with COVID-19.

• 한국식품위생안전성학회지
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• 제29권4호
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• pp.305-311
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• 2014

본 연구는 정량적 미생물 위해평가(Quantitative microbial risk assessment: QMRA)에 절대적으로 필요한 9종의 식중독 세균, 2종의 바이러스, 1종의 원생동물에 대한 최소 감염량(minimum infective dose)을 선정한 연구이다. 주요 식중독 미생물들의 최소 감염량을 선정하기 위하여, 1980년부터 2012년까지 PubMed, ScienceDirect database 등에서 주요 식중독 미생물들의 최소 감염량 및 위해평가 자료 82종을 수집하였다. 수집된 자료는 메타분석(mata-analysis)에서 사용되고 있는 relative frequency(fi, 상대빈도 값)를 계산하여 가장 적정한 최소 감염량을 추정 및 선정하였다. 주요 식중독 미생물들의 최소 감염량은, B. cereus $10^5cells/g$ (fi = 0.32), C. jejuni 500 cells/g (fi = 0.57), Cl. perfringens $10^7cells/g$ (fi = 0.56), Pathogenic E. coli 중 EHEC 10 cells/g (fi = 0.47), ETEC $10^8cells/g$ (fi = 0.71), EPEC $10^6cells/g$ (fi = 0.70), EIEC $10^6cells/g$ (fi = 0.60), L. monocytogenes $10^2{\sim}10^3cells/g$ (fi = 0.23), Salmonella spp. 10 cells/g (fi = 0.30), Shigella spp. 100 cells/g (fi = 0.32), S. aureus $10^5cells/g$ (fi = 0.45), V. parahaemolyticus $10^6cells/g$ (fi = 0.64), Hepatitis A virus $10{\sim}10^2particles/g$ (fi = 0.33), Noro virus 10 particles/g (fi = 0.71), C. pavum $10{\sim}10^2oocyst/g$ (fi = 0.33)으로 나타났다. 본 연구결과는 향후 국내 QMRA를 통한 위해수준 추정결과의 정확성을 향상시키는데 기여할 수 있을 것으로 기대된다.