• Journal of Chest Surgery
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• v.18 no.2
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• pp.320-326
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• 1985

Pulmonary sequestration occurs when some disturbance produces a cystic mass of nonfunctioning lung tissue which lacks normal communication with the tracheobronchial tree. Between 1971 and 1985, pulmonary sequestration was diagnosed in 11 patients, ranging age from 3 to 29 years. All sequestration were intralobar type. Definitive diagnosis can only be obtained by aortography and/or surgical exploration in 10 cases. The other one was confirmed by pathologic examination postoperatively. The presenting complaints were mostly recurrent local pulmonary infection, but in 2 cases mediastinal mass with respiratory symptoms was presented, and cardiac murmur was only finding in one case. Preoperative diagnostic procedure revealed 3 associated anomalies which were funnel chest, right aortic arch, and pulmonic stenosis with vascular ring. Operative treatment for sequestration was lobectomy in 10 cases, and a segmentectomy in one. There was no operative mortality, but 3 complications [empyema, B-P fistula, post-op bleeding] which were controlled by subsequent operations or conservative measure. Aortography is strongly advocated not only for its diagnostic value, but for its preoperative localization of the aberrant vessels that are the major concern to the surgeon.

• Tuberculosis and Respiratory Diseases
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• v.68 no.5
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• pp.259-266
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• 2010

Background: Pulmonary tuberculosis (TB), requiring the intensive care unit (ICU) care, has been a high-mortality condition until now. In the present study, we aimed to investigate clinical features and parameters associated with TB mortality. Methods: From August 2003 to December 2008, patients with microbiologically or histologically confirmed pulmonary TB then admitted to the ICU, were retrospectively enrolled into the study. Upon enrollment, their medical records were reviewed. Results: Forty three patients (30 males, 13 females) were included and their mean age was 63.8 years (range: 17~87 years). Twelve patients died, an overall in-hospital mortality of 27.8%. The main reason for the ICU care was dyspnea or hypoxemia requiring mechanical ventilation (n=17). Other diagnoses for ICU care were hemoptysis, monitoring after procedures, neurologic dysfunction, shock, and gastrointestinal bleeding. On univariate analysis, the factors affecting the mortality were malnutrition-related parameters including low body mass index, hypoalbuminemia, lymphocytopenia, and hypocholersterolemia, as well as severity-related variables such as high acute physiology and chronic health evaluation (APACHE) score, number of involved lobes, and high C-reactive protein. In addition, respiratory failure requiring mechanical ventilation and acute respiratory distress syndrome contributed to patient fatality. It was shown on multivariate analysis that respiratory failure and hypoalbuminemia were significantly independent variables associated with the mortality. Conclusion: Acute respiratory failure is the most common reason for the ICU care and also the most important factor in predicting poor outcome. In addition, our data suggest that the parameters associated with malnutrition could be possible factors contributing to mortality.

• Nutrition Research and Practice
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• v.15 no.sup1
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• pp.32-40
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• 2021

BACKGROUND/OBJECTIVES: Considering the high number of deaths from coronavirus disease 2019 (COVID-19) in Latin American countries, together with multiple factors that increase the prevalence of vitamin D deficiency, we aimed to determine 25-hydroxyvitamin D (25[OH]D) levels and its association with mortality in patients with critical COVID-19. SUBJECTS/METHODS: This was a prospective observational study including adult patients with critical COVID-19. Data, including clinical characteristics and 25(OH)D levels measured at the time of intensive care unit admission, were collected. All patients were followed until hospital discharge or in-hospital death. The patients were divided into those surviving and deceased patient groups, and univariate and multivariate logistic regression analyses were performed to determine independent predictors of in hospital mortality. RESULTS: The entire cohort comprised 94 patients with critical COVID-19 (males, 59.6%; median age, 61.5 years). The median 25(OH)D level was 12.7 ng/mL, and 15 (16%) and 79 (84%) patients had vitamin D insufficiency and vitamin D deficiency, respectively. The median serum 25(OH)D level was significantly lower in deceased patients compared with surviving (12.1 vs. 18.7 ng/mL, P < 0.001). Vitamin D deficiency was present in 100% of the deceased patients. Multivariate logistic regression analysis revealed that age, body mass index, other risk factors, and 25(OH)D level were independent predictors of mortality. CONCLUSIONS: Vitamin D deficiency was present in 84% of critical COVID-19 patients. Serum 25(OH)D was independently associated with mortality in critical patients with COVID-19.

• Journal of Chest Surgery
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• v.57 no.4
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• pp.351-359
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• 2024

Background: Major pulmonary resection after neoadjuvant concurrent chemoradiation therapy (nCCRT) is associated with a substantial risk of postoperative complications. This study investigated postoperative complications and associated risk factors to facilitate the selection of suitable surgical candidates following nCCRT in stage IIIA-N2 non-small cell lung cancer (NSCLC). Methods: We conducted a retrospective analysis of patients diagnosed with clinical stage IIIA-N2 NSCLC who underwent surgical resection following nCCRT between 1997 and 2013. Perioperative characteristics and clinical factors associated with morbidity and mortality were analyzed using univariable and multivariable logistic regression. Results: A total of 574 patients underwent major lung resection after induction CCRT. Thirty-day and 90-day postoperative mortality occurred in 8 patients (1.4%) and 41 patients (7.1%), respectively. Acute respiratory distress syndrome (n=6, 4.5%) was the primary cause of in-hospital mortality. Morbidity occurred in 199 patients (34.7%). Multivariable analysis identified significant predictors of morbidity, including patient age exceeding 70 years (odds ratio [OR], 1.8; p=0.04), low body mass index (OR, 2.6; p=0.02), and pneumonectomy (OR, 1.8; p=0.03). Patient age over 70 years (OR, 1.8; p=0.02) and pneumonectomy (OR, 3.26; p<0.01) were independent predictors of mortality in the multivariable analysis. Conclusion: In conclusion, the surgical outcomes following nCCRT are less favorable for individuals aged over 70 years or those undergoing pneumonectomy. Special attention is warranted for these patients due to their heightened risks of respiratory complications. In high-risk patients, such as elderly patients with decreased lung function, alternative treatment options like definitive CCRT should be considered instead of surgical resection.

• Journal of the Korean Wood Science and Technology
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• v.46 no.2
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• pp.155-165
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• 2018

The objective of the research was to evaluate the effect of particle pre-treatment on physical, mechanical, and durability of jatropha fruit hulls (JFH) particleboard. The pre-treatments included were immersing in cold water, hot water, and acetic acid solution. After each treatment, the particles were dried up to 3% moisture content. Urea-formaldehyde (UF) resin was used to fabricate particleboards with board size, thickness and density target of 25 cm by 25 cm, 0.80 cm, and $0.70g/cm^3$, respectively. Board pressed at $130^{\circ}C$ for 10 minutes, and $25kg/cm^2$ pressure. The evaluation of particleboard followed the JIS A 5908-2003. Whilist their resistance to subterranean termite test (mass loss, mortality, antifeedant value and feeding rate) refers to the Indonesian standard (SNI 01.7207-2006). The physical and mechanical properties of particleboards showed that all pre-treatments decreased the pH of particles. Overall, all particle immersing treatments resulted of better physical and mechanical properties of particleboard than those of untreated ones. The acetic acid treatment resulted the best physical and mechanical properties of particleboard. Based on the mass loss of JFH particleboard, hot water and acetic acid treated particleboards were classified into weak resistance to subterranean attack. The other two treatments were classified into very weak resistance. Hot water treated particleboard provided the highest mortality and antifeedant as much as 87.40% and 34.20%, respectively. Based on antifeedant classification, hot water treated particleboards were classified into moderately strong resistance, while other treatments were categorized into weak resistance. The lowest feeding rate value ($45.30{\mu}g/termite/day$) was attained by hot water treatment.

• Journal of fish pathology
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• v.18 no.2
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• pp.157-165
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• 2005

A new disease causing mass mortality of farmed snakehead (Channa arga) has emerged in Korea over the summer of 2005. The affected fish showed no specific external signs with the exception of a distended abdomen and hemorrhaging around the anus. After opening the abdomen, the visceral organs, liver, spleen and kidney, present numerous white nodular structures. Histopathological examination revealed these nodules to be evidence of granulomas in the visceral organs. A Gram-positive, filamentous bacterium was isolated from all of the affected fish. Development of primers for a genus-specific peR assay for Nocardia, following analysis of the sequences of the complete 16S rRNA genes from Nocardia spp. and non-Nocardia bacterial genes, allowed identification of the causative organism as Nocardia. This is the first report of a nocardial infection of fish in Korea.

• The Journal of the Korea Contents Association
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• v.21 no.12
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• pp.322-330
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• 2021

In modern aquaculture, mass mortality is a very important issue that determines the success of aquaculture business. If a fish disease is not detected at an early stage in the farm, the disease spreads quickly because the farm is a closed environment. Therefore, early detection of diseases is crucial to prevent mass mortality of fish raised in farms. Recently deep learning-based automatic identification of fish diseases has been widely used, but there are many difficulties in identifying objects due to insufficient images of fish diseases. Therefore, this paper suggests a method to generate a large number of fish disease images by synthesizing normal images and disease images using SinGAN deep learning model in order to to solve the lack of fish disease images. We generate images from the three most frequently occurring Paralichthys Olivaceus diseases such as Scuticociliatida, Vibriosis, and Lymphocytosis and compare them with the original image. In this study, a total of 330 sheets of scutica disease, 110 sheets of vibrioemia, and 110 sheets of limphosis were made by synthesizing 10 disease patterns with 11 normal halibut images, and 1,320 images were produced by quadrupling the images.

• Korean Journal of Agricultural Science
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• v.48 no.4
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• pp.1003-1013
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• 2021

Thioredoxin (TRX) protein is an antioxidant responsible for reducing other proteins by exchanging cysteine thiol-disulfide and is also known for its anti-allergic and anti-aging properties. On the other hand, epidermal growth factor (EGF) is an important material used in the cosmetics industry and an essential protein necessary for dermal wound healing facilitated by the proliferation and migration of keratinocytes. EGF also assists in the formation of granulation tissues and stimulates the motility of fibroblasts. Hence, genetically modified soybeans were developed to overexpress these industrially important proteins for mass production. A single-dose oral-toxicity-based study was conducted to evaluate the potential toxic effects of TRX and EGF proteins, as safety assessments are necessary for the commercial use of seed-specific protein-expressing transgenic soybeans. To achieve this rationale, TRX and EGF proteins were mass purified from recombinant E. coli. The single-dose oral-toxicity tests of the TRX and EGF proteins were carried out in six-week old male and female Institute of Cancer Research (ICR) mice. The initial evaluation of the single-dose TRF and EGF treatments was based on monitoring the toxicity signatures and mortality rates among the mice, and the resultant mortality rates did not show any specific clinical symptoms related to the proteins. Furthermore, no significant differences were observed in the weights between the treatment and control groups of male and female ICR mice. After 14 days of treatment, no differences were observed in the autopsy reports between the various treatment and control groups. These results suggest that the minimum lethal dose of TRX and EGF proteins is higher than the allowed 2,000 mg·kg^-1 limit.

• The Journal of the Korean life insurance medical association
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• v.2 no.1
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• pp.260-266
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• 1985

Pregancy is a part of women's life and is common process experienced by most women. On the other hand, a few cannot be pregnant. There are many reasons of infertility and myoma uteri of pelvic mass is a rare reason of infertility. Complication of pregnancy accompanied with myoma uteri is largely affected by the size or location of mass and the incidence by myoma uteri in pregnancy rarely happened, but mass with long pedunculus causes torsion as uterus is getting bigger. In labor myoma uteri causes the abnormal condition of fetal presentation and results in the abnormal childbirth. In case of myoma uteri, maternal mortality is low and there by medical hazards also decrease, but as the life insurance medical is the extensive prediction science, we believe that the prediction of perinatal or the condition of afterbirth by knowing the location, size of myoma uteri contributes to the medical examination. We experienced one case of Elderly primigravida with myoma uteri in Med Dept of Dae Han Kyouk life Insurance Co. Ltd. which the insured with medical examination believe herself as menopause. So we report the observations with studies.

• Advances in pediatric surgery
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• v.4 no.1
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• pp.55-60
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• 1998

Six children with solid and papillary epithelial neoplasm of the pancreas were studied retrospectively. There were 2 boys and 4 girls. The mean age at operation was 11 years(range; 8-13years). Three patients had incidental abdominal mass, in two patients the mass was non-tender, in one patient the mass was tender. The minimum size of tumor was $6.5{\times}6.0$ cm and the maximum was $10.5{\times}8.0$ cm. Five tumors were located in the head of the pancreas, and the other one in the tail. Local invasion or metastasis was not noticed. Tumors were removed completely by performing the following operations: 3 pylorous preserving pancreaticoduodenectomy, 2 Whipple's operation and 1 distal pancreatectomy. There was no mortality. The histologic findings were characteristic. There were no recurrences during a follow-up of 0.5 to 12 years (mean; 5.0 years).