• Journal of Microbiology and Biotechnology
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• v.11 no.4
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• pp.656-662
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• 2001

Angiogenesis is known as a crucial process in the growth and spreading of tumor cells. Accordingly, the effective inhibition of this process would appear to be a promising way to cure angiogenesis-related diseases, including cancer. This study demonstrates that acalycixenolide E (AX-E) from the marine organism Acalycigorgia inermis exhibits a potent anti-angiogenic activity both in vitro and in vivo. AX-E inhibits the bFGF-induced proliferation of HUVECs in a dose dependent manner, along with the bFGF-induced migration, invasion, and tube formation of HUVECs. Moreover, AX-E potently inhibits the in vivo neovascularization of the chorioallantoic membranes (CAMs) of growing chick embryos. interestingly, AX-E suppresses the expression of metalloproteases 2 and 9, yet shows no effect on their activities. The novel chemical structure and potent anti-angiogenic activity of AX-E will be of great value in elucidating the molecular mechanism of angiogenesis as well as in the development of a novel anti-angiogenic drug.

• Journal of the Society of Naval Architects of Korea
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• v.46 no.3
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• pp.362-371
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• 2009

Shipbuilding is a typical 'build to order' industry. It has a business model that generates revenues from building various ships and offshore products in accordance with owner's requirements at each production stage. Under uncertainty in shipping market, it is very essential for the shipbuilder to prepare the fast and competitive decision for product portfolio strategy in order to maximize contribution margin by exploiting production facilities and constraints. In this study, we introduce the unique decision supporting methodology for the optimal product portfolio sets based on Theory of Constraints(TOC). This methodology is established by adopting the concept of Drum Buffer Rope(DBR) in constraints planning and Throughput Accounting (TA) in management accounting of TOC. In addition, Decision Supporting System(DSS) is implemented. This DSS system provides a throughput estimator with reflecting the cost structure of shipbuilding industry and a resource simulator built on heuristic algorithms to operate major constraint-resources in shipyard such as dock, quay and pre-erection area etc. Several examples are presented to show that the proposed methodology and system can effectively support the strategic decision-making process of a global shipbuilding company.

• Journal of Applied Biological Chemistry
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• v.64 no.1
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• pp.49-55
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• 2021

The diet plays a fundamental role in the formation of the gut microbiota, determining the interrelationship between the gut microbiota and the host. The current study investigated the effect of Chlorella vulgaris on the gut microbiota by using simulated in vitro digestion and colonic fermentation. Bioaccessibility was measured after in vitro digestion, and SCFAs and microbial profiling were analyzed after colonic fermentation. The bioaccessibility of C. vulgaris was 0.24 g/g. The three major SCFAs (acetate, propionate, and butyrate) increased significantly when compared to the control group. In microbial profiling analysis, microorganisms such as Faecalibacterium, Dialister, Megasphaera, Dorea, Odoribacter, Roseburia, Bifidobacterium, Butyricmonas, and Veillonella were high in C. vulgaris group. Among them, Faecalibacterium, Dialister, Megasphaera, Roseburia, and Veillonella were thought to be closely associated with the increased level of SCFAs. Finally, it can be expected to help improve gut microbiota and health through ingestion of C. vulgaris. However, further studies are vital to confirm the changes in the gut microbiota in in vivo, when C. vulgaris is ingested.

• Journal of Fisheries and Marine Sciences Education
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• v.3 no.1
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• pp.21-26
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• 1991

The Korean economic condition needs continuous development of the marine product industries basically, and for this purpose a study on the education and training system of the technical manpower for this field is required. Moreover, the sea and its resources are not only to be utilized these days but also to be conserved for our descendants. To achieve this goal, the national support and the people's understanding on the marine product industries are very important at the first, and also the fisheries education must be activated to educate and train the technical manpower who will engage in this industrial field in the future. Especially it is necessary to develop and operate the most appropriate curricula drawn up inconsideration of each local characteristics for the fisheries education at the middle schools and high schools in Korea.

• Natural Product Sciences
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• v.9 no.3
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• pp.117-142
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• 2003

The sphingolipids isolated from marine organisms and their biological activities have been reviewed.

• Journal of Advanced Marine Engineering and Technology
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• v.32 no.4
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• pp.611-617
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• 2008

In ubiquitous environments, the content adaptable services can be dynamically provided to adapt the frequent changes of contexts. These services have common things that the kinds of context factors are limited to ubiquitous environment, though the contexts are flexible. To reuse service architecture can be reasonable for effective adaptable service. In this paper, we design a software architecture with product line techniques for content adaptable applications in ubiquitous environment. Description of product line is to define variation points and their variants, to find out the dependencies between them and to keep the model based architecture, their alternatives.

• Journal of Advanced Marine Engineering and Technology
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• v.23 no.1
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• pp.40-46
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• 1999

A self-tuning FPID(Fuzzy Proportional Intergral Derivative) controller fo load frequency control of 2-area power systemis proposed in this paper. The paramters of the proposed self-tuning FPID controller are self-tuned by the proposed fuzzy inference technique. Therefore in this paper the fuzzy inference technique of PID gains using PSGM(Product Sum Gravity Method) is presented and is applied to the load frequency control of 2-area power system. The computer simulation results show that the proposed controller give better more control characteristics than convention-al PID, FLC under load changes.

• Natural Product Sciences
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• v.21 no.4
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• pp.227-230
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• 2015

Chemical investigation of the fermentation broth of a Soft Coral-Derived fungus Pestalotiopsis sp., led to the isolation of a new phthalide derivative, pestalotiolide A (1), three known analogues (2, 3 and 4), along with 5'-O-acetyl uridine (5) first isolated as a natural product. The structure of the new compound (1) was established by comprehensive spectroscopic analysis and chemical methods. Compounds 1 - 4 possessed varying degrees of antiviral activities, which was reported for the first time. Compared to the positive control ribavirin ($IC_{50}=418.0{\mu}M$), pestalotiolide A (1) exhibited significant anti-EV71 activity in vitro, with an $IC_{50}$ value of $27.7{\mu}M$. Furthermore, the preliminary structure-activity relationship of antiviral activities was also discussed.

• Special Issue of the Society of Naval Architects of Korea
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• 2013.12a
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• pp.1-7
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• 2013

In past decades, a maximum standard vessel size for chemical tankers is not normally larger than 55,000 TDW due to the characteristic of chemical product shipment which is so variable but small quantity unlike single product carries such as crude oil tankers. These days, as demand of very large chemical tanker is rising due to the change of market trend of chemical product shipment, 75,000 TDW class chemical tanker has been developed. The newly developed vessel's structure has been designed based on CSR (Common Structural Rule) for double hull oil tankers (hereafter CSR) published by IACS (International Association of Classification Societies). However, due to the large difference from typical oil tankers, many items should be specially considered such as on deck transverse and corrugated bulkheads. In addition, two longitudinal bulkheads without upper stool have been constructed in order to maximise the number of cargo tanks and the volume of each cargo tanks. In this study, key word of the vessel has been briefly reviewed and the structural reliability of the proposed vessel has been investigated.

• ALGAE
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• v.29 no.2
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• pp.165-174
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• 2014

Ecklonia cava is a common edible brown algae that is plentiful in Jeju Island of Republic of Korea. Polyphenols from E. cava have strong anti-inflammatory activity. However, a large number of the by-products from E. cava processing are discarded. In the present study, to utilize these by-products, we assessed the anti-inflammatory activity of the polyphenol-rich fraction (PRF) from E. cava processing by-product (EPB) in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells. Four compounds, namely eckol, eckstolonol, dieckol, and phlorofucofuroeckol-A, were isolated and identified from PRF. We found that PRF suppressed the production of nitric oxide (NO), inducible nitric oxide synthase, and cyclooxygenase-2 in the LPS-induced cells. Furthermore, the protective effect of PRF was investigated in vivo in LPS-stimulated inflammation zebrafish model. PRF had a protective effect against LPS-stimulated toxicity in zebrafish embryos. In addition, PRF inhibited LPS-stimulated reactive oxygen species and NO generation. According to the results, PRF isolated from EPB could be used as a beneficial anti-inflammatory agent, instead of discard.