[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.4490/algae.2014.29.2.165

Polyphenol-rich fraction from Ecklonia cava (a brown alga) processing by-product reduces LPS-induced inflammation in vitro and in vivo in a zebrafish model

Kim, Seo-Young (Department of Marine Life Science, Jeju National University)
Kim, Eun-A (Department of Marine Life Science, Jeju National University)
Kang, Min-Cheol (Department of Marine Life Science, Jeju National University)
Lee, Ji-Hyeok (Department of Marine Life Science, Jeju National University)
Yang, Hye-Won (Department of Marine Life Science, Jeju National University)
Lee, Jung-Suck (Industry-Academic Cooperation Foundation, Jeju National University)
Lim, Tae Il (Taerim Trading Co., Ltd.)
Jeon, You-Jin (Department of Marine Life Science, Jeju National University)

Publication Information

ALGAE / v.29, no.2, 2014 , pp. 165-174 More about this Journal

Abstract

Ecklonia cava is a common edible brown algae that is plentiful in Jeju Island of Republic of Korea. Polyphenols from E. cava have strong anti-inflammatory activity. However, a large number of the by-products from E. cava processing are discarded. In the present study, to utilize these by-products, we assessed the anti-inflammatory activity of the polyphenol-rich fraction (PRF) from E. cava processing by-product (EPB) in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells. Four compounds, namely eckol, eckstolonol, dieckol, and phlorofucofuroeckol-A, were isolated and identified from PRF. We found that PRF suppressed the production of nitric oxide (NO), inducible nitric oxide synthase, and cyclooxygenase-2 in the LPS-induced cells. Furthermore, the protective effect of PRF was investigated in vivo in LPS-stimulated inflammation zebrafish model. PRF had a protective effect against LPS-stimulated toxicity in zebrafish embryos. In addition, PRF inhibited LPS-stimulated reactive oxygen species and NO generation. According to the results, PRF isolated from EPB could be used as a beneficial anti-inflammatory agent, instead of discard.

Keywords

anti-inflammation; by-product; Ecklonia cava; polyphenol; seaweeds;

Citations & Related Records

Times Cited By KSCI : 6 (Citation Analysis)

Reference
Cited By KSCI

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