• Journal of Pharmaceutical Investigation
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• v.40 no.5
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• pp.285-289
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• 2010

Manufacturing a multi-layered tablet such as Xatral XL$^{(R)}$ is more complex and expensive than monolayered tablets, but mono-layered tablets may have less favorable release properties depending on the pharmacodynamics and pharmacokinetics of the active ingredient. We therefore sought to develop a monolayer tablet with a similar dissolution profile to the commercial alfuzosin sustained-release triple layered tablet (Xatral XL$^{(R)}$). We prepared four different mono-layered alfuzosin tablets with different concentrations of hydroxypropyl methycellulose and PVP K-90. Fomulation III with alfuzosion/mg-stearate/ HPMC/ PVP K-90 (10/5/110/95 mg/tab) has a similar dissolution rate to Xatral XL$^{(R)}$, with a similarity factor score of 81.4. However, the swelling and erosion rates of the two formulations were different, and NIR analysis showed differences in the mechanisms of drug release. Thus, although formulation III and Xatral XL$^{(R)}$ show similar dissolution rates, the mechanisms of drug release are different.

• Journal of the Society of Naval Architects of Korea
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• v.53 no.5
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• pp.428-434
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• 2016

A lot of drawings for pipe construction and installation are needed to construct plant process system on the offshore plant structures. Depending on their scale or complexity, the required number of drawings related pipes sometimes amounts to several hundreds of thousands. Most major shipyards, therefore, have their own system which can automatically depict pipes’ geometric, manufacturing, and BOM(Bill of Material) information on the drawings. However, as the complexity and absolute quantity in the isometric region on the drawings is increased, the information extraction from the customized DB and positioning at the typical locations does not get to be enough to avoid the overlap between geometric contours, labels, and symbols. For this reason, the novel methods to arrange additional annotations without overlaps are presented in the paper. This approach is expected to increase the readability and legibility of the drawing and prevent the human error, and finally decrease the time-consuming and tedious jobs which are unnecessarily required to designers.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2002.05a
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• pp.363-370
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• 2002

This paper presents a production planning algorithm for minimizing the costs of production and subcontracting in SCM (supply chain management) environment. In our SCM environment, the several local plants that aye dispersed geographically produce parts and products. In this environment, we have to decide the production volumes of both parts and products considering the BOM (bill-of-material) structure to meet the fixed order quantity or forecasted demand quantity. Each plant produces the specified parts of product with finite production capacity. There exist subcontracting decisions relevant to the production capacity of each plant except the core process plant, and when we use the subcontractor's capacities we should be charged for the fixed subcontracting fees. The objective of this study is to solve the production planning problem, which minimizes the total costs of production, inventory, setup, and subcontracting under constraints of production and subcontracting capacity. For this problem, an integrated production planning model based on the multi-level capacitated lot sizing problem was formulated, and efficient decomposition algorithm was proposed. The experimental investigation shows that the proposed heuristic generates quite good solutions at very low computational costs.

• Journal of the Korean Society of Systems Engineering
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• v.2 no.2
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• pp.5-10
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• 2006

It was difficult that each enterprise clearly defines PDM in domestic vehicle manufacturing industry and decides investment for the successful foundation in the mid-90s. Also, it was true that most investments to success repeat a process of trial and error even if they decide and propel. Now, PDM is not a luxurious system. Because the company is operated well even if it manages business manually, the company may not be interested in PDM introduction. Problem is business efficiency and product competitiveness. Now, we must consider that introduction and drive of PDM became necessary as instrumentation for Re-Engineering of business process concerning innovative dimension restructuring that is not reorganization, development and improvement of business for enterprise's survival. This indicates that now is when level of infra construction for an IT technology dominates competitiveness of business management. Enterprise can expect effects of PDM by implementation that manages Intellectual Properties through administration of knowledge and information finally.

• IE interfaces
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• v.16 no.1
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• pp.70-84
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• 2003

Recently, object-oriented techniques have been used more and more for developments of an information system. But, established object-oriented methodologies are hard to express a business process of various abstract degrees in the analysis level and independent components of the system. They have difficulties in developing a large-scale information system of manufacturing industry such as PDM and CIM. This paper proposes an information system development methodology that imports the object-oriented IDEF0 (OOIDEF0) function model in analysis level. This methodology is made up of requirements gathering, system analysis, system design, and implementation. In requirements gathering level, organization diagram and interview technique are used for input data of OOIDEF0 function model. The OOIDEF0 function model, the interface model and function descriptions are made out in analysis level. Information objects and implementation objects are designed on the basis of the OOIDEF0 function model in design level. The database is built and programming is accomplished in implementation level. In order to prove the consistency and efficiency of the proposed methodology, the PDM system for ship production is modeled and prototyped.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.38 no.8
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• pp.823-829
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• 2014

In the present study, simple models were proposed to predict the capillary-driven flow length in a surfactant-added poly(dimethylsiloxane) (PDMS) rectangular microchannel. Owing to the hydrophobic nature of PDMS, it is difficult to transport water in a conventional PDMS microchannel by means of the capillary force alone. To overcome this problem, microchannels with a hydrophilic surface were fabricated using surfactant-added PDMS. By measuring the contact angle change on the surfactant-added PDMS surface, the behavior was investigated to establish a simple model. In order to predict the filling length induced by the capillary force, the Washburn equation was modified in the present study. From the investigation, it was found that the initial rate-of-change of the contact angle affected the filling length. Simple models were developed for three representative cases, and these can be useful tools in designing microfluidic manufacturing techniques including MIcroMolding In Capillaries (MIMIC).

• Journal of the Society of Naval Architects of Korea
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• v.42 no.6 s.144
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• pp.686-697
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• 2005

The current challenge with which most shipyards are faced is to reduce the design time and the time-to-delivery benefits of new information technologies such as ERP, APS, and SCM system. These technologies should integrate the information that flows in the enterprise wide activities. First of all we should maintain control of ship design and product data such as bill of material, product structure, drawing, 30 modeling and manufacturing information for the integration. The product data management (POM) system copes with these requirements. All the product data is stored in POM database and vaults in a structured manner and all the changes of product data are monitored, controlled and recorded. This study discusses how POM system can be implemented in shipyard. The procedure is surveyed to apply a POM system for the ship design data management. This study also presents several examples in order to make a practical guidance for ship POM implementation. Proposed studies can be useful for shipyards planning to adopt POM systems in enterprise wide manner.

• Journal of the Economic Geographical Society of Korea
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• v.1 no.2
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• pp.85-102
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• 1998

The Changing Characteristics of Office Location in Central Seoul In recent years, central Seoul has been experiencing a dynamic transformation. In the process of reorganization of urban industrial structure including tertiarization and quaternarization of the economic base of Seoul, business services are growing very rapidly and large scale urban renewal projects are agilely implemented. Downtown office activities become a nucleus for economic performance of Seoul and high-rise office buildings steer the landscape transformation of central Seoul. Even though there appear to exist some evidences that office districts have dispersed to several subcenters, major office activities are still concentrated in the central Seoul. This paper redefines office industry in a narrow meaning comprising only relevant economic sectors and office buildings as office activity-functioning units. It then explores the industrial networking and territorial specialization of office activities focusing on the dual process of concentration and dispersion in Seoul. The changing characteristics of the downtown linkages of office activities in this post-industrial era transforms the spatial economy of central Seoul into more flexible and volatile, while territorial concentration of power and control functions are fortified at the same time. Finally, the paper addresses the development of manufacturing-tertiary-quaternary industrial complex, which can be regarded as new industrial clusters, selling cultural economy of urban space and possessing placeness or images for clients and customers, in relation to urban competitiveness and territorial specialization of large metropolitan areas.

• Korean Journal of Microbiology
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• v.52 no.1
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• pp.74-83
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• 2016

Bacillus subtilis SRCM 101269 having safety and amo gene isolated from Korean traditional fermented food and their investigated characterization to apply the cow manure such as cellulase and xylanase activities, 16S rRNA sequencing, and ability of removal of livestock manure odor. Cow manure application results for the removal of livestock manure odor, the ammonia gas was reduced more than two-folder compared to the control group after 6 days, and reduced to less than 10 ppm after 9 days. In the case of cow manure added fowl droppings and other wood-based mixture components, ammonia gas maintained constant after 3 days of fermentation. However, in the case of sample inoculated B. subtilis SRCM 101269, ammonia gas reduced in course of fermentation time, and concentration of hydrogen sulfide also reduced for 65 ppm. Changes of nitrite concentration according to fermentation time no showed different for cow manure, however nitrite concentration in mixed livestock manure increased when compared to control. And then sulfate concentration in cow manure decreased, and no showed different when compared to the initial fermentation. No apparent change of sulfate concentration in mixed livestock manure detected. Through the previously studies, B. subtilis SRCM 101269 has high potential in industrial application manufacturing the cow manure as removal of livestock manure odor.

• Journal of the Economic Geographical Society of Korea
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• v.1 no.1
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• pp.151-172
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• 1998

Over the past two decades, the process of globalization of multinational corporations has increased at a rapid rate. One manifestation of this process is the establishment of corporate head offices in a variety of international centers to administer and coordinate, the day-to-day operations in the host countries. In establishing a subsidiary overseas a firm creates a direct link between the operations of the domestic corporate center and the foreign host center This paper investigates elements of stability and change in the international linkage patterns among domestic parent corporations and host subsidiaries over the past several decades. In particular, it seeks answers to a number of question related to stability and change in linkages among foreign centers of control and those Canadian centers selected to administer the subsidiary operations from 1970 to 1991 over the four primary sectors, namely, resources, manufacturing, services, and finance. By confirming the core stability and dispersed linkages hypotheses, the papar offers some generalizations with respect to the location and stability of subsidiary headquarters centers in Canada and their respective subsector specialties. Finally, it addresses further research avenues fer the quaternary place study.